Result of FASTA (omim) for
pFN21AE4436
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4436, 453 aa
1>>>pF1KE4436 453 - 453 aa - 453 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.2984+/-0.000447; mu= -12.6489+/- 0.028
mean_var=407.7331+/-82.362, 0's: 0 Z-trim(121.7): 23 B-trim: 151 in 1/58
Lambda= 0.063516
statistics sampled from 38672 (38695) to 38672 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.749), E-opt: 0.2 (0.454), width: 16
Scan time: 10.390
The best scores are: opt bits E(85289)
NP_001924 (OMIM: 126063) dihydrolipoyllysine-resid ( 453) 2963 285.4 2.1e-76
NP_001231812 (OMIM: 126063) dihydrolipoyllysine-re ( 166) 971 102.5 8.7e-22
XP_011518692 (OMIM: 245349,608769) PREDICTED: pyru ( 441) 452 55.3 3.8e-07
NP_001128496 (OMIM: 245349,608769) pyruvate dehydr ( 486) 452 55.3 4.2e-07
NP_003468 (OMIM: 245349,608769) pyruvate dehydroge ( 501) 452 55.3 4.3e-07
XP_005270602 (OMIM: 248600,248610) PREDICTED: lipo ( 301) 436 53.7 7.9e-07
XP_016855958 (OMIM: 248600,248610) PREDICTED: lipo ( 301) 436 53.7 7.9e-07
XP_016855957 (OMIM: 248600,248610) PREDICTED: lipo ( 301) 436 53.7 7.9e-07
NP_001909 (OMIM: 248600,248610) lipoamide acyltran ( 482) 435 53.8 1.2e-06
XP_011540949 (OMIM: 245348,608770) PREDICTED: dihy ( 611) 412 51.7 6.3e-06
NP_001922 (OMIM: 245348,608770) dihydrolipoyllysin ( 647) 395 50.2 1.9e-05
NP_001159630 (OMIM: 245349,608769) pyruvate dehydr ( 274) 321 43.1 0.0011
>>NP_001924 (OMIM: 126063) dihydrolipoyllysine-residue s (453 aa)
initn: 2963 init1: 2963 opt: 2963 Z-score: 1492.6 bits: 285.4 E(85289): 2.1e-76
Smith-Waterman score: 2963; 100.0% identity (100.0% similar) in 453 aa overlap (1-453:1-453)
10 20 30 40 50 60
pF1KE4 MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPAN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 GVIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 PTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 AQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHNLKLGFMSAFVKASAFALQEQPVVNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHNLKLGFMSAFVKASAFALQEQPVVNA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 VIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 IEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRPVAIGGKVEVRPMMYVAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRPVAIGGKVEVRPMMYVAL
370 380 390 400 410 420
430 440 450
pF1KE4 TYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL
:::::::::::::::::::::::::::::::::
NP_001 TYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL
430 440 450
>>NP_001231812 (OMIM: 126063) dihydrolipoyllysine-residu (166 aa)
initn: 971 init1: 971 opt: 971 Z-score: 512.2 bits: 102.5 E(85289): 8.7e-22
Smith-Waterman score: 971; 100.0% identity (100.0% similar) in 147 aa overlap (1-147:1-147)
10 20 30 40 50 60
pF1KE4 MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPAN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 GVIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPI
:::::::::::::::::::::::::::
NP_001 GVIEALLVPDGGKVEGGTPLFTLRKTGGKEVLLVVKVSSVPSWDWD
130 140 150 160
>>XP_011518692 (OMIM: 245349,608769) PREDICTED: pyruvate (441 aa)
initn: 503 init1: 239 opt: 452 Z-score: 249.2 bits: 55.3 E(85289): 3.8e-07
Smith-Waterman score: 510; 28.3% identity (54.0% similar) in 448 aa overlap (76-446:2-437)
50 60 70 80 90 100
pF1KE4 RKVVINNSVFSVRFFRTTAVCKDDLVTVKTPAFAESVTEGD-VRWEKAVGDTVAEDEVVC
:... .. ::. :.: : :..:. ...:
XP_011 MPSLSPTMEEGNIVKWLKKEGEAVSAGDALC
10 20 30
110 120 130 140 150
pF1KE4 EIETDKTSVQVPSPANGVIEALLVPDGGK-----------VEGGTPLFTL---RKTGAAP
::::::. : . . .:.. ..: .:.: :: : . . .: :
XP_011 EIETDKAVVTLDASDDGILAKIVVEEGSKNIRLGSLIGLIVEEGEDWKHVEIPKDVGPPP
40 50 60 70 80 90
160 170
pF1KE4 AKAKPAEAPAAAAPKAE-PTAAAVPP--------PAA-----------------------
.::.: . :. :. : :::
XP_011 PVSKPSEPRPSPEPQISIPVKKEHIPGTLRFRLSPAARNILEKHSLDASQGTATGPRGIF
100 110 120 130 140 150
180 190 200 210
pF1KE4 -----------------------PIPTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEPGA
: :: : .::: : .: : : .: : ::.. ::
XP_011 TKEDALKLVQLKQTGKITESRPTPAPTATPTAPSPLQATAG-P-SYPRP-VIPPVSTPGQ
160 170 180 190 200
220 230 240 250 260 270
pF1KE4 GKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHN
... . . . .:. ::.:: :...: . . :.. . ..: : : .
XP_011 PNAVGTFTEIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRQD-----LVKDD
210 220 230 240 250 260
280 290 300 310 320 330
pF1KE4 LKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNV
.:.. . ..::.: .:...: ::. : . . .::::::::: .::..:.:...
XP_011 IKVSVNDFIIKAAAVTLKQMPDVNVSWDGEGPKQL--PFIDISVAVATDKGLLTPIIKDA
270 280 290 300 310 320
340 350 360 370 380 390
pF1KE4 EAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILG
: .. .: .. :..::: ..: :...::.:.::: :.:: : .:::::. ::.
XP_011 AAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNLGMFGIDEFTAVINPPQACILA
330 340 350 360 370 380
400 410 420 430 440
pF1KE4 MHGIFDRPVAI-------GGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRV
. : : ::: ..:.. : .. :... : :..: . :. ::...:: .:.:
XP_011 V-GRF-RPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDDELATRFLKSFKANLENPIR
390 400 410 420 430
450
pF1KE4 LLLDL
XP_011 LA
440
>>NP_001128496 (OMIM: 245349,608769) pyruvate dehydrogen (486 aa)
initn: 503 init1: 239 opt: 452 Z-score: 248.6 bits: 55.3 E(85289): 4.2e-07
Smith-Waterman score: 517; 27.9% identity (54.1% similar) in 455 aa overlap (69-446:40-482)
40 50 60 70 80 90
pF1KE4 GPGYPNSRKVVINNSVFSVRFFRTTAVCKDDLVTVKTPAFAESVTEGD-VRWEKAVGDTV
: . . :... .. ::. :.: : :..:
NP_001 PGAGRTGRGPGSGKAPPAEISSGAPDFPGGDPIKILMPSLSPTMEEGNIVKWLKKEGEAV
10 20 30 40 50 60
100 110 120 130 140
pF1KE4 AEDEVVCEIETDKTSVQVPSPANGVIEALLVPDGGK-----------VEGGTPLFTL---
. ...:::::::. : . . .:.. ..: .:.: :: : .
NP_001 SAGDALCEIETDKAVVTLDASDDGILAKIVVEEGSKNIRLGSLIGLIVEEGEDWKHVEIP
70 80 90 100 110 120
150 160 170
pF1KE4 RKTGAAPAKAKPAEAPAAAAPKAE-PTAAAVPP--------PAA----------------
. .: : .::.: . :. :. : :::
NP_001 KDVGPPPPVSKPSEPRPSPEPQISIPVKKEHIPGTLRFRLSPAARNILEKHSLDASQGTA
130 140 150 160 170 180
180 190 200
pF1KE4 ------------------------------PIPTQMPPVPSPSQPPSGKPVSAVKPTVAP
: :: : .::: : .: : : .:.. :
NP_001 TGPRGIFTKEDALKLVQLKQTGKITESRPTPAPTATPTAPSPLQATAG-P-SYPRPVI-P
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE4 PLAEPGAGKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQEMRARHKE
:.. :: ... . . . .:. ::.:: :...: . . :.. . ..:
NP_001 PVSTPGQPNAVGTFTEIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRQD---
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE4 AFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYIDISVAVATPRGLV
: : ..:.. . ..::.: .:...: ::. : . . .::::::::: .::.
NP_001 --LVKDDIKVSVNDFIIKAAAVTLKQMPDVNVSWDGEGPKQL--PFIDISVAVATDKGLL
310 320 330 340 350
330 340 350 360 370 380
pF1KE4 VPVIRNVEAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINP
.:.:... : .. .: .. :..::: ..: :...::.:.::: :.:: : .:::
NP_001 TPIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNLGMFGIDEFTAVINP
360 370 380 390 400 410
390 400 410 420 430 440
pF1KE4 PQSAILGMHGIFDRPVAI-------GGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKA
::. ::.. : : ::: ..:.. : .. :... : :..: . :. ::...::
NP_001 PQACILAV-GRF-RPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDDELATRFLKSFKA
420 430 440 450 460 470
450
pF1KE4 AVEDPRVLLLDL
.:.:
NP_001 NLENPIRLA
480
>>NP_003468 (OMIM: 245349,608769) pyruvate dehydrogenase (501 aa)
initn: 503 init1: 239 opt: 452 Z-score: 248.4 bits: 55.3 E(85289): 4.3e-07
Smith-Waterman score: 543; 28.3% identity (53.6% similar) in 498 aa overlap (27-446:22-497)
10 20 30 40 50
pF1KE4 MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGP-GYPNSRKVVINNSVFSVRF
:::: :.: .: :. :: . . :.
NP_003 MAASWRLGCDPRLLRYLVGFPGRRS---VGLVKGALGWSVSRGA-------NWRW
10 20 30 40
60 70 80 90 100 110
pF1KE4 FRTTAVCKDDLVTVKTPAFAESVTEGD-VRWEKAVGDTVAEDEVVCEIETDKTSVQVPSP
:..: . : . . :... .. ::. :.: : :..:. ...:::::::. : . .
NP_003 FHSTQWLRGDPIKILMPSLSPTMEEGNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDAS
50 60 70 80 90 100
120 130 140 150 160
pF1KE4 ANGVIEALLVPDGGK-----------VEGGTPLFTL---RKTGAAPAKAKPAEAPAAAAP
.:.. ..: .:.: :: : . . .: : .::.: . :
NP_003 DDGILAKIVVEEGSKNIRLGSLIGLIVEEGEDWKHVEIPKDVGPPPPVSKPSEPRPSPEP
110 120 130 140 150 160
170
pF1KE4 KAE-PTAAAVPP--------PAA-------------------------------------
. :. : :::
NP_003 QISIPVKKEHIPGTLRFRLSPAARNILEKHSLDASQGTATGPRGIFTKEDALKLVQLKQT
170 180 190 200 210 220
180 190 200 210 220
pF1KE4 ---------PIPTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNR
: :: : .::: : .: : : .: : ::.. :: ... . . .
NP_003 GKITESRPTPAPTATPTAPSPLQATAG-P-SYPRP-VIPPVSTPGQPNAVGTFTEIPASN
230 240 250 260 270 280
230 240 250 260 270 280
pF1KE4 MRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHNLKLGFMSAFVKASA
.:. ::.:: :...: . . :.. . ..: : : ..:.. . ..::.:
NP_003 IRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRQD-----LVKDDIKVSVNDFIIKAAA
290 300 310 320 330
290 300 310 320 330 340
pF1KE4 FALQEQPVVNAVIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVEAMNFADIERTITE
.:...: ::. : . . .::::::::: .::..:.:... : .. .: ..
NP_003 VTLKQMPDVNVSWDGEGPKQL--PFIDISVAVATDKGLLTPIIKDAAAKGIQEIADSVKA
340 350 360 370 380 390
350 360 370 380 390 400
pF1KE4 LGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRPVAI---
:..::: ..: :...::.:.::: :.:: : .:::::. ::.. : : :::
NP_003 LSKKARDGKLLPEEYQGGSFSISNLGMFGIDEFTAVINPPQACILAV-GRF-RPVLKLTE
400 410 420 430 440 450
410 420 430 440 450
pF1KE4 ----GGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL
..:.. : .. :... : :..: . :. ::...:: .:.:
NP_003 DEEGNAKLQQRQLITVTMSSDSRVVDDELATRFLKSFKANLENPIRLA
460 470 480 490 500
>>XP_005270602 (OMIM: 248600,248610) PREDICTED: lipoamid (301 aa)
initn: 438 init1: 297 opt: 436 Z-score: 243.6 bits: 53.7 E(85289): 7.9e-07
Smith-Waterman score: 441; 30.4% identity (61.6% similar) in 289 aa overlap (167-453:29-300)
140 150 160 170 180 190
pF1KE4 GTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPIPTQMPPVPSPSQPPSG
: ..:. ::. : ::: :.:..
XP_005 MENNIKLSEVVGSGKDGRILKEDILNYLEKQTGAILPPS-PKVEIMPPPPKPKDMTV-
10 20 30 40 50
200 210 220 230 240 250
pF1KE4 KPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDM
:. . :: : .:: .. : .. ... ... .. : . . .:::.
XP_005 -PILVSKPPVF-------TGK----DKTEPIKGFQKAMVKTMSAALKI-PHFGYCDEIDL
60 70 80 90 100
260 270 280 290 300 310
pF1KE4 SNIQEMRARHKE-AFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYI
... ..: . : :: . ..::.:: :.::....: . :..:: .:.. ....:.
XP_005 TELVKLREELKPIAFAR--GIKLSFMPFFLKAASLGLLQFPILNASVDENCQNITYKASH
110 120 130 140 150 160
320 330 340 350 360 370
pF1KE4 DISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGG
.:..:. : .::.:: ..::. .. :: ...: . . ..:. :. :::::.:: :
XP_005 NIGIAMDTEQGLIVPNVKNVQICSIFDIATELNRLQKLGSVSQLSTTDLTGGTFTLSNIG
170 180 190 200 210 220
380 390 400 410 420 430
pF1KE4 VFGSLFGTPIINPPQSAILGMHGIFDRP-VAIGGKVEVRPMMYVALTYDHRLIDGREAVT
.:. :. :.: ::. :: .. .: : :.: .: :. . :::.:::
XP_005 SIGGTFAKPVIMPPEVAIGALGSIKAIPRFNQKGEVYKAQIMNVSWSADHRVIDGATMSR
230 240 250 260 270 280
440 450
pF1KE4 FLRKIKAAVEDPRVLLLDL
: :. .:.: .::::
XP_005 FSNLWKSYLENPAFMLLDLK
290 300
>>XP_016855958 (OMIM: 248600,248610) PREDICTED: lipoamid (301 aa)
initn: 438 init1: 297 opt: 436 Z-score: 243.6 bits: 53.7 E(85289): 7.9e-07
Smith-Waterman score: 441; 30.4% identity (61.6% similar) in 289 aa overlap (167-453:29-300)
140 150 160 170 180 190
pF1KE4 GTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPIPTQMPPVPSPSQPPSG
: ..:. ::. : ::: :.:..
XP_016 MENNIKLSEVVGSGKDGRILKEDILNYLEKQTGAILPPS-PKVEIMPPPPKPKDMTV-
10 20 30 40 50
200 210 220 230 240 250
pF1KE4 KPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDM
:. . :: : .:: .. : .. ... ... .. : . . .:::.
XP_016 -PILVSKPPVF-------TGK----DKTEPIKGFQKAMVKTMSAALKI-PHFGYCDEIDL
60 70 80 90 100
260 270 280 290 300 310
pF1KE4 SNIQEMRARHKE-AFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYI
... ..: . : :: . ..::.:: :.::....: . :..:: .:.. ....:.
XP_016 TELVKLREELKPIAFAR--GIKLSFMPFFLKAASLGLLQFPILNASVDENCQNITYKASH
110 120 130 140 150 160
320 330 340 350 360 370
pF1KE4 DISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGG
.:..:. : .::.:: ..::. .. :: ...: . . ..:. :. :::::.:: :
XP_016 NIGIAMDTEQGLIVPNVKNVQICSIFDIATELNRLQKLGSVSQLSTTDLTGGTFTLSNIG
170 180 190 200 210 220
380 390 400 410 420 430
pF1KE4 VFGSLFGTPIINPPQSAILGMHGIFDRP-VAIGGKVEVRPMMYVALTYDHRLIDGREAVT
.:. :. :.: ::. :: .. .: : :.: .: :. . :::.:::
XP_016 SIGGTFAKPVIMPPEVAIGALGSIKAIPRFNQKGEVYKAQIMNVSWSADHRVIDGATMSR
230 240 250 260 270 280
440 450
pF1KE4 FLRKIKAAVEDPRVLLLDL
: :. .:.: .::::
XP_016 FSNLWKSYLENPAFMLLDLK
290 300
>>XP_016855957 (OMIM: 248600,248610) PREDICTED: lipoamid (301 aa)
initn: 438 init1: 297 opt: 436 Z-score: 243.6 bits: 53.7 E(85289): 7.9e-07
Smith-Waterman score: 441; 30.4% identity (61.6% similar) in 289 aa overlap (167-453:29-300)
140 150 160 170 180 190
pF1KE4 GTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPIPTQMPPVPSPSQPPSG
: ..:. ::. : ::: :.:..
XP_016 MENNIKLSEVVGSGKDGRILKEDILNYLEKQTGAILPPS-PKVEIMPPPPKPKDMTV-
10 20 30 40 50
200 210 220 230 240 250
pF1KE4 KPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDM
:. . :: : .:: .. : .. ... ... .. : . . .:::.
XP_016 -PILVSKPPVF-------TGK----DKTEPIKGFQKAMVKTMSAALKI-PHFGYCDEIDL
60 70 80 90 100
260 270 280 290 300 310
pF1KE4 SNIQEMRARHKE-AFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYI
... ..: . : :: . ..::.:: :.::....: . :..:: .:.. ....:.
XP_016 TELVKLREELKPIAFAR--GIKLSFMPFFLKAASLGLLQFPILNASVDENCQNITYKASH
110 120 130 140 150 160
320 330 340 350 360 370
pF1KE4 DISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGG
.:..:. : .::.:: ..::. .. :: ...: . . ..:. :. :::::.:: :
XP_016 NIGIAMDTEQGLIVPNVKNVQICSIFDIATELNRLQKLGSVSQLSTTDLTGGTFTLSNIG
170 180 190 200 210 220
380 390 400 410 420 430
pF1KE4 VFGSLFGTPIINPPQSAILGMHGIFDRP-VAIGGKVEVRPMMYVALTYDHRLIDGREAVT
.:. :. :.: ::. :: .. .: : :.: .: :. . :::.:::
XP_016 SIGGTFAKPVIMPPEVAIGALGSIKAIPRFNQKGEVYKAQIMNVSWSADHRVIDGATMSR
230 240 250 260 270 280
440 450
pF1KE4 FLRKIKAAVEDPRVLLLDL
: :. .:.: .::::
XP_016 FSNLWKSYLENPAFMLLDLK
290 300
>>NP_001909 (OMIM: 248600,248610) lipoamide acyltransfer (482 aa)
initn: 545 init1: 296 opt: 435 Z-score: 240.2 bits: 53.8 E(85289): 1.2e-06
Smith-Waterman score: 509; 27.8% identity (56.0% similar) in 439 aa overlap (59-453:53-481)
30 40 50 60 70 80
pF1KE4 RSLPGVSLCQGPGYPNSRKVVINNSVFSVRFFRTTAVCKDDLVTVKTPAFAESVTEGDVR
:..:::. . ..: : ..:.. : :.
NP_001 FQTCGNVHVLKPNYVCFFGYPSFKYSHPHHFLKTTAALRGQVVQFKLSDIGEGIREVTVK
30 40 50 60 70 80
90 100 110 120 130 140
pF1KE4 -WEKAVGDTVAEDEVVCEIETDKTSVQVPSPANGVIEALLVPDGGKVEGGTPLFTLRKTG
: ::::.. . .::...::.:: . : .:::. : . : :: .. .
NP_001 EWYVKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKKLYYNLDDIAYVGKPLVDIETEA
90 100 110 120 130 140
150 160 170 180
pF1KE4 AAPAKAKPAEAPAAAAP-------KAEPTAA--AVPPPAAPIPTQMPPV-----------
.. .:.::.. :.. : : :: : .. :
NP_001 LKDSEEDVVETPAVSHDEHTHQEIKGRKTLATPAVRRLAMENNIKLSEVVGSGKDGRILK
150 160 170 180 190 200
190 200 210 220
pF1KE4 ----------------PSPS---QPPSGKPVSAVKPTVA--PPLAEPGAGKGLRSEHREK
:::. .:: :: . . : .. ::. .:: .. :
NP_001 EDILNYLEKQTGAILPPSPKVEIMPPPPKPKDMTVPILVSKPPVF---TGK----DKTEP
210 220 230 240 250
230 240 250 260 270 280
pF1KE4 MNRMRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQEMRARHKE-AFLKKHNLKLGFMSAFV
.. ... ... .. : . . .:::.... ..: . : :: . ..::.:: :.
NP_001 IKGFQKAMVKTMSAALKI-PHFGYCDEIDLTELVKLREELKPIAFAR--GIKLSFMPFFL
260 270 280 290 300 310
290 300 310 320 330 340
pF1KE4 KASAFALQEQPVVNAVIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVEAMNFADIER
::....: . :..:: .:.. ....:. .:..:. : .::.:: ..::. .. ::
NP_001 KAASLGLLQFPILNASVDENCQNITYKASHNIGIAMDTEQGLIVPNVKNVQICSIFDIAT
320 330 340 350 360 370
350 360 370 380 390 400
pF1KE4 TITELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRP-V
...: . . ..:. :. :::::.:: : .:. :. :.: ::. :: .. .: :
NP_001 ELNRLQKLGSVGQLSTTDLTGGTFTLSNIGSIGGTFAKPVIMPPEVAIGALGSIKAIPRF
380 390 400 410 420 430
410 420 430 440 450
pF1KE4 AIGGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL
:.: .: :. . :::.::: : :. .:.: .::::
NP_001 NQKGEVYKAQIMNVSWSADHRVIDGATMSRFSNLWKSYLENPAFMLLDLK
440 450 460 470 480
>>XP_011540949 (OMIM: 245348,608770) PREDICTED: dihydrol (611 aa)
initn: 537 init1: 234 opt: 412 Z-score: 227.4 bits: 51.7 E(85289): 6.3e-06
Smith-Waterman score: 559; 31.6% identity (58.5% similar) in 405 aa overlap (73-451:221-611)
50 60 70 80 90 100
pF1KE4 PNSRKVVINNSVFSVRFFRTTAVCKDDLVTVKTPAFAESVTEGDV-RWEKAVGDTVAEDE
: ::.. ..: : : :::: ::. ..: .
XP_011 AAPAPTPAATASPPTPSAQAPGSSYPPHMQVLLPALSPTMTMGTVQRWEKKVGEKLSEGD
200 210 220 230 240 250
110 120 130 140 150
pF1KE4 VVCEIETDKTSVQVPSPANGVIEALLVPDGGK-VEGGTPLFTLRKTGA---APAKAKPAE
.. ::::::... .: . .:::.: . : :::: . . : : : .:.:
XP_011 LLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGTPLCIIVEKEADISAFADYRPTE
260 270 280 290 300 310
160 170 180 190 200 210
pF1KE4 AP---AAAAPKAEPTAAAVPPPAAPI-PTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEP
. . : . : .::::: :. :: : .: :. : . : :.: . .:
XP_011 VTDLKPQVPPPTPPPVAAVPPTPQPLAPT--PSAPCPATPAGPKGRVFVSPLAKKLAVEK
320 330 340 350 360
220 230 240 250
pF1KE4 GAG----KGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLT----------TFNEIDMSNI
: :: . : . . . . ... : . . : .:..: .:::
XP_011 GIDLTQVKGTGPDGRITKKDIDSFVPSKVAPAPAAVVPPTGPGMAPVPTGVFTDIPISNI
370 380 390 400 410 420
260 270 280 290 300 310
pF1KE4 QEMRARHKEAFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYI-DIS
... :. .. :.. . ..::::.: . : .:. :: :. .... :.:
XP_011 RRI--------LEGRS-KISVNDFIIKASALACLKVPEANSSWMDT---VIRQNHVVDVS
430 440 450 460 470
320 330 340 350 360 370
pF1KE4 VAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGGVFG
:::.:: ::..:.. :.. . : .. :. :::...: ....:::::::: :.::
XP_011 VAVSTPAGLITPIVFNAHIKGVETIANDVVSLATKAREGKLQPHEFQGGTFTISNLGMFG
480 490 500 510 520 530
380 390 400 410 420 430
pF1KE4 SLFGTPIINPPQSAILGMHGIFDRPVAIGGK--VEVRPMMYVALTYDHRLIDGREAVTFL
. ::::::. ::.. . :. : .. .: :: :.:. :::..:: .. .:
XP_011 IKNFSAIINPPQACILAIGASEDKLVPADNEKGFDVASMMSVTLSCDHRVVDGAVGAQWL
540 550 560 570 580 590
440 450
pF1KE4 RKIKAAVEDPRVLLLDL
... .: : ..::
XP_011 AEFRKYLEKPITMLL
600 610
453 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:08:33 2016 done: Sun Nov 6 01:08:34 2016
Total Scan time: 10.390 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]