FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE4435, 452 aa
  1>>>pF1KE4435 452 - 452 aa - 452 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.3349+/-0.00094; mu= 17.1812+/- 0.056
 mean_var=60.6155+/-12.082, 0's: 0 Z-trim(104.1): 18  B-trim: 0 in 0/49
 Lambda= 0.164734
 statistics sampled from 7713 (7721) to 7713 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.609), E-opt: 0.2 (0.237), width:  16
 Scan time:  2.770

The best scores are:                                      opt bits E(32554)
CCDS10359.1 IDH2 gene_id:3418|Hs108|chr15          ( 452) 3074 739.3 1.9e-213
CCDS76792.1 IDH2 gene_id:3418|Hs108|chr15          ( 400) 2726 656.6 1.3e-188
CCDS2381.1 IDH1 gene_id:3417|Hs108|chr2            ( 414) 1934 468.3 6.3e-132


>>CCDS10359.1 IDH2 gene_id:3418|Hs108|chr15               (452 aa)
 initn: 3074 init1: 3074 opt: 3074  Z-score: 3945.6  bits: 739.3 E(32554): 1.9e-213
Smith-Waterman score: 3074; 100.0% identity (100.0% similar) in 452 aa overlap (1-452:1-452)

               10        20        30        40        50        60
pF1KE4 MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE4 IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE4 ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE4 ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE4 QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE4 SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE4 GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
              370       380       390       400       410       420

              430       440       450  
pF1KE4 GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
       ::::::::::::::::::::::::::::::::
CCDS10 GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
              430       440       450  

>>CCDS76792.1 IDH2 gene_id:3418|Hs108|chr15               (400 aa)
 initn: 2726 init1: 2726 opt: 2726  Z-score: 3499.4  bits: 656.6 E(32554): 1.3e-188
Smith-Waterman score: 2726; 100.0% identity (100.0% similar) in 400 aa overlap (53-452:1-400)

             30        40        50        60        70        80  
pF1KE4 PAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYF
                                     ::::::::::::::::::::::::::::::
CCDS76                               MDGDEMTRIIWQFIKEKLILPHVDIQLKYF
                                             10        20        30

             90       100       110       120       130       140  
pF1KE4 DLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 DLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNI
               40        50        60        70        80        90

            150       160       170       180       190       200  
pF1KE4 LGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 LGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGS
              100       110       120       130       140       150

            210       220       230       240       250       260  
pF1KE4 GVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 GVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRF
              160       170       180       190       200       210

            270       280       290       300       310       320  
pF1KE4 KDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 KDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQ
              220       230       240       250       260       270

            330       340       350       360       370       380  
pF1KE4 GFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 GFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHR
              280       290       300       310       320       330

            390       400       410       420       430       440  
pF1KE4 GKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 GKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIK
              340       350       360       370       380       390

            450  
pF1KE4 SNLDRALGRQ
       ::::::::::
CCDS76 SNLDRALGRQ
              400

>>CCDS2381.1 IDH1 gene_id:3417|Hs108|chr2                 (414 aa)
 initn: 1912 init1: 1134 opt: 1934  Z-score: 2481.9  bits: 468.3 E(32554): 6.3e-132
Smith-Waterman score: 1934; 70.8% identity (88.4% similar) in 397 aa overlap (50-445:10-405)

      20        30        40        50        60        70         
pF1KE4 AWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQL
                                     ::::.:::::::::..::::::.:.:...:
CCDS23                      MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDL
                                    10        20        30         

      80        90       100       110       120       130         
pF1KE4 KYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTI
       . .:::. ::: :.:::: :.: : .:..:.:::::::::: ::::::::.:::::::::
CCDS23 HSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTI
      40        50        60        70        80        90         

     140       150       160       170       180       190         
pF1KE4 RNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPK
       ::::::::::: :::::::::: ::.::: :::::.::::.:::::.   :  ....::.
CCDS23 RNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPS
     100       110       120       130       140       150         

     200       210        220       230       240       250        
pF1KE4 DGSGVKEWEVYNFP-AGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAY
       ::.    . :.::  .:::.::::: :.::  :::: ::.:..: ::::.:::::::: :
CCDS23 DGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKY
     160       170       180       190       200       210         

      260       270       280       290       300       310        
pF1KE4 DGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSD
       :::::::::::.::.::..:. .:::::::::::::::..:: :::.:::::::::::::
CCDS23 DGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSD
     220       230       240       250       260       270         

      320       330       340       350       360       370        
pF1KE4 ILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRG
        .:::.::::.::::::::::::.:::::::::::::: .:::. :::::::::::::::
CCDS23 SVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRG
     280       290       300       310       320       330         

      380       390       400       410       420       430        
pF1KE4 LEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFL
       : ::.:::.:..:  ::. ::.: .::.:.: ::::::.::.:: ::. .. .::: .:.
CCDS23 LAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD-YLNTFEFM
     340       350       360       370       380       390         

      440       450    
pF1KE4 DTIKSNLDRALGRQ  
       : .  ::         
CCDS23 DKLGENLKIKLAQAKL
      400       410    




452 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 01:09:11 2016 done: Sun Nov  6 01:09:12 2016
 Total Scan time:  2.770 Total Display time:  0.010

Function used was FASTA [36.3.4 Apr, 2011]