Result of FASTA (omim) for
pFN21AE4434
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4434, 452 aa
1>>>pF1KE4434 452 - 452 aa - 452 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7051+/-0.000416; mu= 15.2255+/- 0.026
mean_var=64.1998+/-12.793, 0's: 0 Z-trim(110.4): 41 B-trim: 255 in 1/52
Lambda= 0.160069
statistics sampled from 18699 (18721) to 18699 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.594), E-opt: 0.2 (0.22), width: 16
Scan time: 9.000
The best scores are: opt bits E(85289)
NP_000268 (OMIM: 261600,612349) phenylalanine-4-hy ( 452) 3019 706.3 4.3e-203
NP_775489 (OMIM: 607478,608516,613003) tryptophan ( 490) 1675 395.9 1.2e-109
NP_004170 (OMIM: 191060) tryptophan 5-hydroxylase ( 444) 1617 382.5 1.2e-105
XP_016874859 (OMIM: 261600,612349) PREDICTED: phen ( 240) 1571 371.8 1.1e-102
NP_000351 (OMIM: 191290,605407) tyrosine 3-monooxy ( 497) 1507 357.1 6e-98
XP_011518637 (OMIM: 191290,605407) PREDICTED: tyro ( 501) 1507 357.1 6.1e-98
NP_954987 (OMIM: 191290,605407) tyrosine 3-monooxy ( 524) 1507 357.1 6.3e-98
NP_954986 (OMIM: 191290,605407) tyrosine 3-monooxy ( 528) 1507 357.1 6.4e-98
>>NP_000268 (OMIM: 261600,612349) phenylalanine-4-hydrox (452 aa)
initn: 3019 init1: 3019 opt: 3019 Z-score: 3767.2 bits: 706.3 E(85289): 4.3e-203
Smith-Waterman score: 3019; 99.8% identity (99.8% similar) in 452 aa overlap (1-452:1-452)
10 20 30 40 50 60
pF1KE4 MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 NLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVPW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 FPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 EEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGF
:: :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 RLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 QFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 KPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQR
370 380 390 400 410 420
430 440 450
pF1KE4 IEVLDNTQQLKILADSINSEIGILCSALQKIK
::::::::::::::::::::::::::::::::
NP_000 IEVLDNTQQLKILADSINSEIGILCSALQKIK
430 440 450
>>NP_775489 (OMIM: 607478,608516,613003) tryptophan 5-hy (490 aa)
initn: 1637 init1: 1488 opt: 1675 Z-score: 2089.2 bits: 395.9 E(85289): 1.2e-109
Smith-Waterman score: 1675; 54.1% identity (81.3% similar) in 455 aa overlap (1-451:31-484)
10 20 30
pF1KE4 MSTAVLENPGLGRKLSDFGQETSYIEDNCN
.....:..:. :.. .: :.. : .. .
NP_775 MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKN-DDKGNKGSSKREAAT
10 20 30 40 50
40 50 60 70 80
pF1KE4 QNGAISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLD--KRSL
..: ...::::.:::.:.:.::::.:. ::..::::: :: ...: :.:. . : .
NP_775 ESGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEF
60 70 80 90 100 110
90 100 110 120 130 140
pF1KE4 PALTNIIKILRHDIGATVHE--LSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADH
: ...:. . . : ..... . :::::: :.:::. ....: ::.::::::
NP_775 NELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADH
120 130 140 150 160 170
150 160 170 180 190 200
pF1KE4 PGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEGKKTWGTVFKTLKSLYKTHACYEY
::::: ::: ::: :.:.:..:..::::::::: :: ::::.::. :..:: :::: ::
NP_775 PGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREY
180 190 200 210 220 230
210 220 230 240 250 260
pF1KE4 NHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCT
. :::: ::::..:::.:::::::.::. .:: .::::: :: ::::.:::.::::::
NP_775 LKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCT
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE4 QYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYW
::::::: :.:::::: ::::::::::..: .::::::::::::::: :: ..:::: :.
NP_775 QYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYF
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE4 FTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLY
::.::::::: ...:::::::::.:::.. ::.: . .. . : .:. .: :: :
NP_775 FTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAY
360 370 380 390 400 410
390 400 410 420 430 440
pF1KE4 YVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCS
.:.:::..::::.:.:: .: ::::: ..:::: ::.: .:.... ..... :... .:.
NP_775 FVSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCD
420 430 440 450 460 470
450
pF1KE4 ALQKIK
::.:.
NP_775 ALNKMNQYLGI
480 490
>>NP_004170 (OMIM: 191060) tryptophan 5-hydroxylase 1 [H (444 aa)
initn: 1613 init1: 1449 opt: 1617 Z-score: 2017.5 bits: 382.5 E(85289): 1.2e-105
Smith-Waterman score: 1617; 56.1% identity (80.3% similar) in 431 aa overlap (26-451:9-438)
10 20 30 40 50 60
pF1KE4 MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDV
.:. . : :::::::.:::.: :.:..:.:. :
NP_004 MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHV
10 20 30 40
70 80 90 100 110
pF1KE4 NLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRD--KKKD--
:: ::::: :. ...:.:.:. : :..:...:. .. .: . :.:
NP_004 NLLHIESRKSKRRNSEFEIFVDCDINR-EQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGM
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE4 -TVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIP
::::::. :..::. ::..: ::.::::::::::: ::: ::: :::.:.::.::.:::
NP_004 ETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIP
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE4 RVEYMEEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQ
.::. :: :::::::. :..:: :::: :: . .::: ::::..:::::::::::.::.
NP_004 KVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLK
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE4 TCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFS
::: .::::: :: ::::.::::::::::::.::.: :.:::::: ::::::::::..
NP_004 ERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLA
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE4 DRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQ
. :::::::::::::::: .: ..:::: :.:::::::::: .....:::::::..::.
NP_004 EPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELK
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE4 YCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYD
. :: . :. :.. . : :. .: :: .:.:.:::.:::::.:.:. :: :::.:.:.
NP_004 HALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYN
350 360 370 380 390 400
420 430 440 450
pF1KE4 PYTQRIEVLDNTQQLKILADSINSEIGILCSALQKIK
:::. :..: .:... . .. .. .. .:: :.
NP_004 PYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
410 420 430 440
>>XP_016874859 (OMIM: 261600,612349) PREDICTED: phenylal (240 aa)
initn: 1571 init1: 1571 opt: 1571 Z-score: 1964.5 bits: 371.8 E(85289): 1.1e-102
Smith-Waterman score: 1571; 99.6% identity (99.6% similar) in 235 aa overlap (1-235:1-235)
10 20 30 40 50 60
pF1KE4 MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 NLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVPW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 FPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 EEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGF
:: ::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQIPAVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 RLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFA
>>NP_000351 (OMIM: 191290,605407) tyrosine 3-monooxygena (497 aa)
initn: 1512 init1: 1433 opt: 1507 Z-score: 1879.4 bits: 357.1 E(85289): 6e-98
Smith-Waterman score: 1507; 53.0% identity (78.0% similar) in 423 aa overlap (35-451:82-496)
10 20 30 40 50 60
pF1KE4 VLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKE-EVGALAKVLRLFEENDVNLT
..:.:: . . .::......:: ....
NP_000 AVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIH
60 70 80 90 100 110
70 80 90 100 110
pF1KE4 HIESRPS---RLKKDEYEFFTHLDKR--SLPALTNIIKILRHDIGATVHELSRDKKKDTV
:.:.::. : . :.:..:. : .: :: . .. . .:. :. :
NP_000 HLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDV--------RSPAGPKV
120 130 140 150 160
120 130 140 150 160 170
pF1KE4 PWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVE
::::: ..:::. . . .. .:: :::::.: ::: ::: .:.::..::::.::::::
NP_000 PWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVE
170 180 190 200 210 220
180 190 200 210 220 230
pF1KE4 YMEEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCT
: : :: :. :::.:: :::: :. . : :::.. :..:::::::::::.::. :
NP_000 YTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERT
230 240 250 260 270 280
240 250 260 270 280 290
pF1KE4 GFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRS
::.:::::::::.::::..::::::.:::::::.:.::..:::: :::::::::...::.
NP_000 GFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRT
290 300 310 320 330 340
300 310 320 330 340 350
pF1KE4 FAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCL
::::::.:::::::: :: ::::.:.::::::::::::. .::::::::::.::: .::
NP_000 FAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCL
350 360 370 380 390 400
360 370 380 390 400 410
pF1KE4 SEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYT
::.:.. .. : .:.: : .: .:.:.:::.:::.:.:..:. : :::::..::::
NP_000 SEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYT
410 420 430 440 450 460
420 430 440 450
pF1KE4 QRIEVLDNTQQLKILADSINSEIGILCSALQKIK
:.:::. : .. .....:. : ::. :
NP_000 LAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
470 480 490
>>XP_011518637 (OMIM: 191290,605407) PREDICTED: tyrosine (501 aa)
initn: 1512 init1: 1433 opt: 1507 Z-score: 1879.4 bits: 357.1 E(85289): 6.1e-98
Smith-Waterman score: 1507; 53.0% identity (78.0% similar) in 423 aa overlap (35-451:86-500)
10 20 30 40 50 60
pF1KE4 VLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKE-EVGALAKVLRLFEENDVNLT
..:.:: . . .::......:: ....
XP_011 AVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIH
60 70 80 90 100 110
70 80 90 100 110
pF1KE4 HIESRPS---RLKKDEYEFFTHLDKR--SLPALTNIIKILRHDIGATVHELSRDKKKDTV
:.:.::. : . :.:..:. : .: :: . .. . .:. :. :
XP_011 HLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDV--------RSPAGPKV
120 130 140 150 160
120 130 140 150 160 170
pF1KE4 PWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVE
::::: ..:::. . . .. .:: :::::.: ::: ::: .:.::..::::.::::::
XP_011 PWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVE
170 180 190 200 210 220
180 190 200 210 220 230
pF1KE4 YMEEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCT
: : :: :. :::.:: :::: :. . : :::.. :..:::::::::::.::. :
XP_011 YTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERT
230 240 250 260 270 280
240 250 260 270 280 290
pF1KE4 GFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRS
::.:::::::::.::::..::::::.:::::::.:.::..:::: :::::::::...::.
XP_011 GFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRT
290 300 310 320 330 340
300 310 320 330 340 350
pF1KE4 FAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCL
::::::.:::::::: :: ::::.:.::::::::::::. .::::::::::.::: .::
XP_011 FAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCL
350 360 370 380 390 400
360 370 380 390 400 410
pF1KE4 SEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYT
::.:.. .. : .:.: : .: .:.:.:::.:::.:.:..:. : :::::..::::
XP_011 SEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYT
410 420 430 440 450 460
420 430 440 450
pF1KE4 QRIEVLDNTQQLKILADSINSEIGILCSALQKIK
:.:::. : .. .....:. : ::. :
XP_011 LAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
470 480 490 500
>>NP_954987 (OMIM: 191290,605407) tyrosine 3-monooxygena (524 aa)
initn: 1512 init1: 1433 opt: 1507 Z-score: 1879.1 bits: 357.1 E(85289): 6.3e-98
Smith-Waterman score: 1507; 53.0% identity (78.0% similar) in 423 aa overlap (35-451:109-523)
10 20 30 40 50 60
pF1KE4 VLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKE-EVGALAKVLRLFEENDVNLT
..:.:: . . .::......:: ....
NP_954 AVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIH
80 90 100 110 120 130
70 80 90 100 110
pF1KE4 HIESRPS---RLKKDEYEFFTHLDKR--SLPALTNIIKILRHDIGATVHELSRDKKKDTV
:.:.::. : . :.:..:. : .: :: . .. . .:. :. :
NP_954 HLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDV--------RSPAGPKV
140 150 160 170 180 190
120 130 140 150 160 170
pF1KE4 PWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVE
::::: ..:::. . . .. .:: :::::.: ::: ::: .:.::..::::.::::::
NP_954 PWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVE
200 210 220 230 240 250
180 190 200 210 220 230
pF1KE4 YMEEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCT
: : :: :. :::.:: :::: :. . : :::.. :..:::::::::::.::. :
NP_954 YTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERT
260 270 280 290 300 310
240 250 260 270 280 290
pF1KE4 GFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRS
::.:::::::::.::::..::::::.:::::::.:.::..:::: :::::::::...::.
NP_954 GFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRT
320 330 340 350 360 370
300 310 320 330 340 350
pF1KE4 FAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCL
::::::.:::::::: :: ::::.:.::::::::::::. .::::::::::.::: .::
NP_954 FAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCL
380 390 400 410 420 430
360 370 380 390 400 410
pF1KE4 SEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYT
::.:.. .. : .:.: : .: .:.:.:::.:::.:.:..:. : :::::..::::
NP_954 SEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYT
440 450 460 470 480 490
420 430 440 450
pF1KE4 QRIEVLDNTQQLKILADSINSEIGILCSALQKIK
:.:::. : .. .....:. : ::. :
NP_954 LAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
500 510 520
>>NP_954986 (OMIM: 191290,605407) tyrosine 3-monooxygena (528 aa)
initn: 1512 init1: 1433 opt: 1507 Z-score: 1879.0 bits: 357.1 E(85289): 6.4e-98
Smith-Waterman score: 1507; 53.0% identity (78.0% similar) in 423 aa overlap (35-451:113-527)
10 20 30 40 50 60
pF1KE4 VLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKE-EVGALAKVLRLFEENDVNLT
..:.:: . . .::......:: ....
NP_954 AVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIH
90 100 110 120 130 140
70 80 90 100 110
pF1KE4 HIESRPS---RLKKDEYEFFTHLDKR--SLPALTNIIKILRHDIGATVHELSRDKKKDTV
:.:.::. : . :.:..:. : .: :: . .. . .:. :. :
NP_954 HLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDV--------RSPAGPKV
150 160 170 180 190
120 130 140 150 160 170
pF1KE4 PWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVE
::::: ..:::. . . .. .:: :::::.: ::: ::: .:.::..::::.::::::
NP_954 PWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVE
200 210 220 230 240 250
180 190 200 210 220 230
pF1KE4 YMEEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCT
: : :: :. :::.:: :::: :. . : :::.. :..:::::::::::.::. :
NP_954 YTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERT
260 270 280 290 300 310
240 250 260 270 280 290
pF1KE4 GFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRS
::.:::::::::.::::..::::::.:::::::.:.::..:::: :::::::::...::.
NP_954 GFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRT
320 330 340 350 360 370
300 310 320 330 340 350
pF1KE4 FAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCL
::::::.:::::::: :: ::::.:.::::::::::::. .::::::::::.::: .::
NP_954 FAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCL
380 390 400 410 420 430
360 370 380 390 400 410
pF1KE4 SEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYT
::.:.. .. : .:.: : .: .:.:.:::.:::.:.:..:. : :::::..::::
NP_954 SEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYT
440 450 460 470 480 490
420 430 440 450
pF1KE4 QRIEVLDNTQQLKILADSINSEIGILCSALQKIK
:.:::. : .. .....:. : ::. :
NP_954 LAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
500 510 520
452 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:09:51 2016 done: Sun Nov 6 01:09:53 2016
Total Scan time: 9.000 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]