Result of FASTA (omim) for
pFN21AE4431
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4431, 450 aa
1>>>pF1KE4431 450 - 450 aa - 450 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.9637+/-0.00049; mu= 1.7546+/- 0.030
mean_var=265.7926+/-53.863, 0's: 0 Z-trim(116.3): 25 B-trim: 279 in 1/54
Lambda= 0.078669
statistics sampled from 27428 (27444) to 27428 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.678), E-opt: 0.2 (0.322), width: 16
Scan time: 9.370
The best scores are: opt bits E(85289)
NP_001300927 (OMIM: 604378) beclin-1 isoform a [Ho ( 450) 2989 352.9 1e-96
NP_003757 (OMIM: 604378) beclin-1 isoform a [Homo ( 450) 2989 352.9 1e-96
NP_001300928 (OMIM: 604378) beclin-1 isoform b [Ho ( 355) 2267 270.9 3.9e-72
XP_016880753 (OMIM: 604378) PREDICTED: beclin-1 is ( 355) 2267 270.9 3.9e-72
XP_005257817 (OMIM: 604378) PREDICTED: beclin-1 is ( 355) 2267 270.9 3.9e-72
XP_011523723 (OMIM: 604378) PREDICTED: beclin-1 is ( 388) 2265 270.7 4.9e-72
XP_016880751 (OMIM: 604378) PREDICTED: beclin-1 is ( 388) 2265 270.7 4.9e-72
XP_016880752 (OMIM: 604378) PREDICTED: beclin-1 is ( 382) 2133 255.7 1.6e-67
XP_005257816 (OMIM: 604378) PREDICTED: beclin-1 is ( 382) 2133 255.7 1.6e-67
NP_001277622 (OMIM: 615687) beclin-2 [Homo sapiens ( 431) 1559 190.6 6.9e-48
NP_001300929 (OMIM: 604378) beclin-1 isoform c [Ho ( 279) 1201 149.8 8.7e-36
>>NP_001300927 (OMIM: 604378) beclin-1 isoform a [Homo s (450 aa)
initn: 2989 init1: 2989 opt: 2989 Z-score: 1857.6 bits: 352.9 E(85289): 1e-96
Smith-Waterman score: 2989; 100.0% identity (100.0% similar) in 450 aa overlap (1-450:1-450)
10 20 30 40 50 60
pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN
370 380 390 400 410 420
430 440 450
pF1KE4 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK
::::::::::::::::::::::::::::::
NP_001 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK
430 440 450
>>NP_003757 (OMIM: 604378) beclin-1 isoform a [Homo sapi (450 aa)
initn: 2989 init1: 2989 opt: 2989 Z-score: 1857.6 bits: 352.9 E(85289): 1e-96
Smith-Waterman score: 2989; 100.0% identity (100.0% similar) in 450 aa overlap (1-450:1-450)
10 20 30 40 50 60
pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN
370 380 390 400 410 420
430 440 450
pF1KE4 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK
::::::::::::::::::::::::::::::
NP_003 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK
430 440 450
>>NP_001300928 (OMIM: 604378) beclin-1 isoform b [Homo s (355 aa)
initn: 2290 init1: 2267 opt: 2267 Z-score: 1416.0 bits: 270.9 E(85289): 3.9e-72
Smith-Waterman score: 2267; 99.7% identity (100.0% similar) in 348 aa overlap (1-348:1-348)
10 20 30 40 50 60
pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF
:::::::::::::::::::::::::::::::::::::::::::::::.
NP_001 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKDGCGERQD
310 320 330 340 350
370 380 390 400 410 420
pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN
>>XP_016880753 (OMIM: 604378) PREDICTED: beclin-1 isofor (355 aa)
initn: 2290 init1: 2267 opt: 2267 Z-score: 1416.0 bits: 270.9 E(85289): 3.9e-72
Smith-Waterman score: 2267; 99.7% identity (100.0% similar) in 348 aa overlap (1-348:1-348)
10 20 30 40 50 60
pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF
:::::::::::::::::::::::::::::::::::::::::::::::.
XP_016 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKDGCGERQD
310 320 330 340 350
370 380 390 400 410 420
pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN
>>XP_005257817 (OMIM: 604378) PREDICTED: beclin-1 isofor (355 aa)
initn: 2290 init1: 2267 opt: 2267 Z-score: 1416.0 bits: 270.9 E(85289): 3.9e-72
Smith-Waterman score: 2267; 99.7% identity (100.0% similar) in 348 aa overlap (1-348:1-348)
10 20 30 40 50 60
pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF
:::::::::::::::::::::::::::::::::::::::::::::::.
XP_005 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKDGCGERQD
310 320 330 340 350
370 380 390 400 410 420
pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN
>>XP_011523723 (OMIM: 604378) PREDICTED: beclin-1 isofor (388 aa)
initn: 2265 init1: 2265 opt: 2265 Z-score: 1414.3 bits: 270.7 E(85289): 4.9e-72
Smith-Waterman score: 2265; 100.0% identity (100.0% similar) in 347 aa overlap (1-347:1-347)
10 20 30 40 50 60
pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF
:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKAEVQWHDLGLLQP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN
XP_011 PPPGFKQFPCLSLLSIWDYRHAPPRPAN
370 380
>>XP_016880751 (OMIM: 604378) PREDICTED: beclin-1 isofor (388 aa)
initn: 2265 init1: 2265 opt: 2265 Z-score: 1414.3 bits: 270.7 E(85289): 4.9e-72
Smith-Waterman score: 2265; 100.0% identity (100.0% similar) in 347 aa overlap (1-347:1-347)
10 20 30 40 50 60
pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKAEVQWHDLGLLQP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN
XP_016 PPPGFKQFPCLSLLSIWDYRHAPPRPAN
370 380
>>XP_016880752 (OMIM: 604378) PREDICTED: beclin-1 isofor (382 aa)
initn: 2133 init1: 2133 opt: 2133 Z-score: 1333.4 bits: 255.7 E(85289): 1.6e-67
Smith-Waterman score: 2358; 84.9% identity (84.9% similar) in 450 aa overlap (1-450:1-382)
10 20 30 40 50 60
pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF
:::::::::::::::::::::::::::
XP_016 NEINAAWGQTVLLLHALANKMGLKFQR---------------------------------
310 320
370 380 390 400 410 420
pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN
:::::::::::::::::::::::::
XP_016 -----------------------------------MDVEKGKIEDTGGSGGSYSIKTQFN
330 340 350
430 440 450
pF1KE4 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK
::::::::::::::::::::::::::::::
XP_016 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK
360 370 380
>>XP_005257816 (OMIM: 604378) PREDICTED: beclin-1 isofor (382 aa)
initn: 2133 init1: 2133 opt: 2133 Z-score: 1333.4 bits: 255.7 E(85289): 1.6e-67
Smith-Waterman score: 2358; 84.9% identity (84.9% similar) in 450 aa overlap (1-450:1-382)
10 20 30 40 50 60
pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF
:::::::::::::::::::::::::::
XP_005 NEINAAWGQTVLLLHALANKMGLKFQR---------------------------------
310 320
370 380 390 400 410 420
pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN
:::::::::::::::::::::::::
XP_005 -----------------------------------MDVEKGKIEDTGGSGGSYSIKTQFN
330 340 350
430 440 450
pF1KE4 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK
::::::::::::::::::::::::::::::
XP_005 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK
360 370 380
>>NP_001277622 (OMIM: 615687) beclin-2 [Homo sapiens] (431 aa)
initn: 1539 init1: 1146 opt: 1559 Z-score: 980.7 bits: 190.6 E(85289): 6.9e-48
Smith-Waterman score: 1559; 56.1% identity (76.8% similar) in 435 aa overlap (14-447:4-429)
10 20 30 40 50 60
pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
. :.:::: : :::. : . .. :: :..::.::.:.:
NP_001 MSSIRFLCQRCHQALKLSGS---SESRSLPAAPAP--TSGQAEPGDTREP
10 20 30 40
70 80 90 100 110 120
pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
... : : .:::.: : : .: :: :::.:: :.:. :: :..:
NP_001 GVTTREVTDAEE-QQDGASSRSPPGDGSVSKGHANIFTLLGEL---GAMHMLSSIQKAAG
50 60 70 80 90 100
130 140 150 160 170
pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILE-QMNEDDSEQ
:.:::.:::. :::::::::::.::.::: :: .:: . :::.:::: : .::..
NP_001 DIFDIVSGQAVVDHPLCEECTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAA
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE4 LQMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQ
:. ::..: ::: ::.::::::..: .: .:. .:::: .:::.: :. :.:: .:::
NP_001 LRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQ
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE4 QLELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVE
:::: :.: .::::..::..: :.::. : :.:::.:: : .:.::::::::::.: :
NP_001 QLELLDQLGNVENQLQYARVQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVG
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE4 WNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRF
:::::.::::..::: .::: .::.::::::.: ::::::.:::: ::::.: ::
NP_001 WNEINTAWGQAALLLLTLANTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDV
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE4 FWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQF
: .::.:.::::::::.::::::.:::: . ::: ..:: : .::.:: : :::.:..
NP_001 FLNNKYDRAMVAFLDCMQQFKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHL
350 360 370 380 390 400
420 430 440 450
pF1KE4 NSEEQWTKALKFMLTNLKWGLAWVSSQFYNK
:..: ::::::::: :.::.: ::.:..
NP_001 NTQELWTKALKFMLINFKWSLIWVASRYQK
410 420 430
450 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:39:46 2016 done: Sun Nov 6 00:39:47 2016
Total Scan time: 9.370 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]