FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE4431, 450 aa
  1>>>pF1KE4431 450 - 450 aa - 450 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.8740+/-0.0012; mu= 1.8194+/- 0.071
 mean_var=237.7205+/-47.701, 0's: 0 Z-trim(108.8): 22  B-trim: 0 in 0/52
 Lambda= 0.083184
 statistics sampled from 10415 (10423) to 10415 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.678), E-opt: 0.2 (0.32), width:  16
 Scan time:  3.110

The best scores are:                                      opt bits E(32554)
CCDS11441.1 BECN1 gene_id:8678|Hs108|chr17         ( 450) 2989 372.1 6.5e-103
CCDS81433.1 BECN2 gene_id:441925|Hs108|chr1        ( 431) 1559 200.5 2.9e-51
CCDS82132.1 BECN1 gene_id:8678|Hs108|chr17         ( 279) 1201 157.3 1.8e-38


>>CCDS11441.1 BECN1 gene_id:8678|Hs108|chr17              (450 aa)
 initn: 2989 init1: 2989 opt: 2989  Z-score: 1961.2  bits: 372.1 E(32554): 6.5e-103
Smith-Waterman score: 2989; 100.0% identity (100.0% similar) in 450 aa overlap (1-450:1-450)

               10        20        30        40        50        60
pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN
              370       380       390       400       410       420

              430       440       450
pF1KE4 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK
       ::::::::::::::::::::::::::::::
CCDS11 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK
              430       440       450

>>CCDS81433.1 BECN2 gene_id:441925|Hs108|chr1             (431 aa)
 initn: 1539 init1: 1146 opt: 1559  Z-score: 1033.9  bits: 200.5 E(32554): 2.9e-51
Smith-Waterman score: 1559; 56.1% identity (76.8% similar) in 435 aa overlap (14-447:4-429)

               10        20        30        40        50        60
pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
                    . :.:::: : :::. :    .  ..    ::  :..::.::.:.: 
CCDS81           MSSIRFLCQRCHQALKLSGS---SESRSLPAAPAP--TSGQAEPGDTREP
                         10        20           30          40     

               70        80        90       100       110       120
pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
        ... :    :  .:::.: :  :    .:   :: :::.::    :.:. ::   :..:
CCDS81 GVTTREVTDAEE-QQDGASSRSPPGDGSVSKGHANIFTLLGEL---GAMHMLSSIQKAAG
          50         60        70        80           90       100 

              130       140       150       160       170          
pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILE-QMNEDDSEQ
       :.:::.:::. :::::::::::.::.::: :: .:: . :::.::::  :   .::..  
CCDS81 DIFDIVSGQAVVDHPLCEECTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAA
             110       120       130       140       150       160 

     180       190       200       210       220       230         
pF1KE4 LQMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQ
       :. ::..: ::: ::.::::::..:   .: .:. .:::: .:::.: :. :.:: .:::
CCDS81 LRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQ
             170       180       190       200       210       220 

     240       250       260       270       280       290         
pF1KE4 QLELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVE
       :::: :.: .::::..::..: :.::. : :.:::.::  : .:.::::::::::.: : 
CCDS81 QLELLDQLGNVENQLQYARVQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVG
             230       240       250       260       270       280 

     300       310       320       330       340       350         
pF1KE4 WNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRF
       :::::.::::..::: .::: .::.::::::.: ::::::.::::   ::::.: ::   
CCDS81 WNEINTAWGQAALLLLTLANTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDV
             290       300       310       320       330       340 

     360       370       380       390       400       410         
pF1KE4 FWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQF
       : .::.:.::::::::.::::::.::::  . ::: ..:: : .::.:: :  :::.:..
CCDS81 FLNNKYDRAMVAFLDCMQQFKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHL
             350       360       370       380       390       400 

     420       430       440       450
pF1KE4 NSEEQWTKALKFMLTNLKWGLAWVSSQFYNK
       :..: ::::::::: :.::.: ::.:..   
CCDS81 NTQELWTKALKFMLINFKWSLIWVASRYQK 
             410       420       430  

>>CCDS82132.1 BECN1 gene_id:8678|Hs108|chr17              (279 aa)
 initn: 1775 init1: 1198 opt: 1201  Z-score: 804.2  bits: 157.3 E(32554): 1.8e-38
Smith-Waterman score: 1604; 77.9% identity (78.2% similar) in 348 aa overlap (1-348:1-272)

               10        20        30        40        50        60
pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
       :::::::::::::::::::::::::::                                 
CCDS82 ETNSGEEPFIETPRQDGVSRRFIPPAR---------------------------------
               70        80                                        

              130       140       150       160       170       180
pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
                                                  :::::::::::::::::
CCDS82 -------------------------------------------RCLEILEQMNEDDSEQL
                                                   90       100    

              190       200       210       220       230       240
pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
          110       120       130       140       150       160    

              250       260       270       280       290       300
pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
          170       180       190       200       210       220    

              310       320       330       340       350       360
pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF
       :::::::::::::::::::::::::::::::::::::::::::::::.            
CCDS82 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKDGCGERQD     
          230       240       250       260       270              

              370       380       390       400       410       420
pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN




450 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 00:39:45 2016 done: Sun Nov  6 00:39:46 2016
 Total Scan time:  3.110 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]