Result of FASTA (omim) for
pFN21AE4428
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4428, 445 aa
1>>>pF1KE4428 445 - 445 aa - 445 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4037+/-0.000378; mu= 17.1425+/- 0.023
mean_var=70.4237+/-14.561, 0's: 0 Z-trim(114.3): 13 B-trim: 1123 in 2/50
Lambda= 0.152832
statistics sampled from 24036 (24049) to 24036 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.282), width: 16
Scan time: 8.730
The best scores are: opt bits E(85289)
NP_000178 (OMIM: 203500,607474) homogentisate 1,2- ( 445) 3129 699.1 5.9e-201
XP_005247470 (OMIM: 203500,607474) PREDICTED: homo ( 338) 2348 526.9 3.2e-149
XP_016861766 (OMIM: 203500,607474) PREDICTED: homo ( 304) 2130 478.8 8.7e-135
XP_011511048 (OMIM: 203500,607474) PREDICTED: homo ( 294) 2052 461.6 1.3e-129
XP_005247471 (OMIM: 203500,607474) PREDICTED: homo ( 233) 1525 345.3 1e-94
XP_005247469 (OMIM: 203500,607474) PREDICTED: homo ( 370) 1330 302.4 1.3e-81
>>NP_000178 (OMIM: 203500,607474) homogentisate 1,2-diox (445 aa)
initn: 3129 init1: 3129 opt: 3129 Z-score: 3728.8 bits: 699.1 E(85289): 5.9e-201
Smith-Waterman score: 3129; 99.8% identity (100.0% similar) in 445 aa overlap (1-445:1-445)
10 20 30 40 50 60
pF1KE4 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LYRILPSVSHKPFESIDEGHVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
NP_000 LYRILPSVSHKPFESIDEGQVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 GGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKWGLKASRCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKWGLKASRCLD
370 380 390 400 410 420
430 440
pF1KE4 ENYHKCWEPLKSHFTPNSRNPAEPN
:::::::::::::::::::::::::
NP_000 ENYHKCWEPLKSHFTPNSRNPAEPN
430 440
>>XP_005247470 (OMIM: 203500,607474) PREDICTED: homogent (338 aa)
initn: 2348 init1: 2348 opt: 2348 Z-score: 2799.9 bits: 526.9 E(85289): 3.2e-149
Smith-Waterman score: 2348; 99.7% identity (100.0% similar) in 335 aa overlap (1-335:1-335)
10 20 30 40 50 60
pF1KE4 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LYRILPSVSHKPFESIDEGHVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
XP_005 LYRILPSVSHKPFESIDEGQVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPG
:::::::::::::::::::::::::::::::::::
XP_005 LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHNLA
310 320 330
370 380 390 400 410 420
pF1KE4 GGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKWGLKASRCLD
>>XP_016861766 (OMIM: 203500,607474) PREDICTED: homogent (304 aa)
initn: 2130 init1: 2130 opt: 2130 Z-score: 2540.8 bits: 478.8 E(85289): 8.7e-135
Smith-Waterman score: 2130; 100.0% identity (100.0% similar) in 304 aa overlap (142-445:1-304)
120 130 140 150 160 170
pF1KE4 FVSGLHTLCGAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGK
::::::::::::::::::::::::::::::
XP_016 MENRCFYNSDGDFLIVPQKGNLLIYTEFGK
10 20 30
180 190 200 210 220 230
pF1KE4 MLVQPNEICVIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLVQPNEICVIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPI
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE4 AWYEDRQVPGGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AWYEDRQVPGGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFD
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE4 HADPSIFTVLTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HADPSIFTVLTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYE
160 170 180 190 200 210
360 370 380 390 400 410
pF1KE4 AKQGGFLPGGGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKQGGFLPGGGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKW
220 230 240 250 260 270
420 430 440
pF1KE4 GLKASRCLDENYHKCWEPLKSHFTPNSRNPAEPN
::::::::::::::::::::::::::::::::::
XP_016 GLKASRCLDENYHKCWEPLKSHFTPNSRNPAEPN
280 290 300
>>XP_011511048 (OMIM: 203500,607474) PREDICTED: homogent (294 aa)
initn: 2052 init1: 2052 opt: 2052 Z-score: 2448.1 bits: 461.6 E(85289): 1.3e-129
Smith-Waterman score: 2052; 99.7% identity (100.0% similar) in 293 aa overlap (1-293:1-293)
10 20 30 40 50 60
pF1KE4 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LYRILPSVSHKPFESIDEGHVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
XP_011 LYRILPSVSHKPFESIDEGQVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHAI
250 260 270 280 290
310 320 330 340 350 360
pF1KE4 LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPG
>>XP_005247471 (OMIM: 203500,607474) PREDICTED: homogent (233 aa)
initn: 1524 init1: 1524 opt: 1525 Z-score: 1821.6 bits: 345.3 E(85289): 1e-94
Smith-Waterman score: 1525; 96.0% identity (97.8% similar) in 227 aa overlap (1-227:1-225)
10 20 30 40 50 60
pF1KE4 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LYRILPSVSHKPFESIDEGHVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
XP_005 LYRILPSVSHKPFESIDEGQVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP
:::::::::::::::::::::::::::::::::::: . :: :. .
XP_005 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIDSLGL--PKRYQTGNAVNL
190 200 210 220 230
250 260 270 280 290 300
pF1KE4 GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV
>>XP_005247469 (OMIM: 203500,607474) PREDICTED: homogent (370 aa)
initn: 1330 init1: 1330 opt: 1330 Z-score: 1586.2 bits: 302.4 E(85289): 1.3e-81
Smith-Waterman score: 2453; 82.9% identity (83.1% similar) in 445 aa overlap (1-445:1-370)
10 20 30 40 50 60
pF1KE4 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LYRILPSVSHKPFESIDEGHVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
XP_005 LYRILPSVSHKPFESIDEGQVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP
:::
XP_005 VIQ---------------------------------------------------------
250 260 270 280 290 300
pF1KE4 GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV
::::::::::::::::::::::::::::::::::::::::::
XP_005 ------------------DVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV
190 200 210 220
310 320 330 340 350 360
pF1KE4 LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPG
230 240 250 260 270 280
370 380 390 400 410 420
pF1KE4 GGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKWGLKASRCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKWGLKASRCLD
290 300 310 320 330 340
430 440
pF1KE4 ENYHKCWEPLKSHFTPNSRNPAEPN
:::::::::::::::::::::::::
XP_005 ENYHKCWEPLKSHFTPNSRNPAEPN
350 360 370
445 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:40:22 2016 done: Sun Nov 6 00:40:23 2016
Total Scan time: 8.730 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]