Result of FASTA (omim) for
pFN21AE4424
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4424, 439 aa
1>>>pF1KE4424 439 - 439 aa - 439 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.0313+/-0.000403; mu= 14.4664+/- 0.025
mean_var=90.5062+/-17.592, 0's: 0 Z-trim(112.1): 186 B-trim: 0 in 0/56
Lambda= 0.134814
statistics sampled from 20745 (20939) to 20745 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.605), E-opt: 0.2 (0.246), width: 16
Scan time: 9.080
The best scores are: opt bits E(85289)
NP_002795 (OMIM: 186852) 26S protease regulatory s ( 439) 2826 560.1 4e-159
XP_016873515 (OMIM: 186852) PREDICTED: 26S proteas ( 461) 2599 516.0 8.2e-146
NP_001317141 (OMIM: 602706) 26S protease regulator ( 367) 1120 228.3 2.7e-59
XP_016876959 (OMIM: 602706) PREDICTED: 26S proteas ( 367) 1120 228.3 2.7e-59
NP_002793 (OMIM: 602706) 26S protease regulatory s ( 440) 1120 228.3 3.1e-59
NP_001186092 (OMIM: 601681) 26S protease regulator ( 398) 1055 215.6 1.8e-55
NP_002796 (OMIM: 601681) 26S protease regulatory s ( 406) 1055 215.6 1.9e-55
NP_694546 (OMIM: 602707) 26S protease regulatory s ( 387) 1018 208.4 2.6e-53
NP_006494 (OMIM: 602707) 26S protease regulatory s ( 418) 1018 208.4 2.8e-53
NP_002794 (OMIM: 154365) 26S protease regulatory s ( 433) 982 201.5 3.7e-51
NP_002797 (OMIM: 602708) 26S protease regulatory s ( 403) 944 194.0 5.8e-49
XP_016876961 (OMIM: 602708) PREDICTED: 26S proteas ( 288) 894 184.2 3.8e-46
NP_009057 (OMIM: 167320,601023,613954,616687) tran ( 806) 640 135.1 6.4e-31
XP_011523903 (OMIM: 604581,610246,614487) PREDICTE ( 730) 631 133.3 2e-30
NP_006787 (OMIM: 604581,610246,614487) AFG3-like p ( 797) 631 133.4 2.1e-30
XP_011515297 (OMIM: 611941) PREDICTED: ATPase fami ( 953) 584 124.3 1.4e-27
NP_001304728 (OMIM: 613940,616577) spermatogenesis ( 695) 581 123.6 1.6e-27
XP_011515296 (OMIM: 611941) PREDICTED: ATPase fami (1260) 584 124.3 1.8e-27
XP_011529981 (OMIM: 613940,616577) PREDICTED: sper ( 790) 581 123.6 1.8e-27
XP_016863317 (OMIM: 613940,616577) PREDICTED: sper ( 819) 581 123.6 1.9e-27
NP_054828 (OMIM: 611941) ATPase family AAA domain- (1390) 584 124.4 1.9e-27
NP_001332785 (OMIM: 613940,616577) spermatogenesis ( 892) 581 123.7 2e-27
NP_660208 (OMIM: 613940,616577) spermatogenesis-as ( 893) 581 123.7 2e-27
NP_001230075 (OMIM: 602426) nuclear valosin-contai ( 667) 578 123.0 2.4e-27
XP_011542502 (OMIM: 602426) PREDICTED: nuclear val ( 765) 578 123.0 2.6e-27
XP_011542501 (OMIM: 602426) PREDICTED: nuclear val ( 765) 578 123.0 2.6e-27
XP_011542500 (OMIM: 602426) PREDICTED: nuclear val ( 777) 578 123.0 2.7e-27
XP_016856871 (OMIM: 602426) PREDICTED: nuclear val ( 839) 578 123.1 2.8e-27
XP_016856870 (OMIM: 602426) PREDICTED: nuclear val ( 839) 578 123.1 2.8e-27
XP_016856875 (OMIM: 602426) PREDICTED: nuclear val ( 738) 577 122.8 2.9e-27
XP_011542498 (OMIM: 602426) PREDICTED: nuclear val ( 883) 578 123.1 3e-27
NP_996671 (OMIM: 602426) nuclear valosin-containin ( 750) 577 122.8 3e-27
XP_016856869 (OMIM: 602426) PREDICTED: nuclear val ( 889) 578 123.1 3e-27
NP_001230076 (OMIM: 602426) nuclear valosin-contai ( 765) 577 122.8 3e-27
XP_016856867 (OMIM: 602426) PREDICTED: nuclear val ( 917) 578 123.1 3.1e-27
XP_016856872 (OMIM: 602426) PREDICTED: nuclear val ( 812) 577 122.9 3.2e-27
NP_002524 (OMIM: 602426) nuclear valosin-containin ( 856) 577 122.9 3.3e-27
XP_016856868 (OMIM: 602426) PREDICTED: nuclear val ( 890) 577 122.9 3.4e-27
NP_001303242 (OMIM: 601498,614862,614863,616617) p ( 892) 573 122.1 5.9e-27
XP_011512963 (OMIM: 601498,614862,614863,616617) P ( 952) 573 122.1 6.2e-27
NP_000278 (OMIM: 601498,614862,614863,616617) pero ( 980) 573 122.1 6.3e-27
NP_003110 (OMIM: 602783,607259) paraplegin isoform ( 795) 571 121.7 7e-27
XP_006721327 (OMIM: 602783,607259) PREDICTED: para ( 809) 571 121.7 7.1e-27
XP_016879087 (OMIM: 602783,607259) PREDICTED: para ( 561) 565 120.4 1.2e-26
XP_016863319 (OMIM: 613940,616577) PREDICTED: sper ( 593) 562 119.9 1.9e-26
XP_016879086 (OMIM: 602783,607259) PREDICTED: para ( 618) 562 119.9 1.9e-26
XP_011531234 (OMIM: 615347) PREDICTED: ATPase fami ( 791) 562 119.9 2.3e-26
XP_011531233 (OMIM: 615347) PREDICTED: ATPase fami ( 837) 562 119.9 2.5e-26
XP_011531232 (OMIM: 615347) PREDICTED: ATPase fami ( 841) 562 119.9 2.5e-26
XP_011531231 (OMIM: 615347) PREDICTED: ATPase fami ( 843) 562 119.9 2.5e-26
>>NP_002795 (OMIM: 186852) 26S protease regulatory subun (439 aa)
initn: 2826 init1: 2826 opt: 2826 Z-score: 2977.7 bits: 560.1 E(85289): 4e-159
Smith-Waterman score: 2826; 100.0% identity (100.0% similar) in 439 aa overlap (1-439:1-439)
10 20 30 40 50 60
pF1KE4 MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDY
370 380 390 400 410 420
430
pF1KE4 MEGILEVQAKKKANLQYYA
:::::::::::::::::::
NP_002 MEGILEVQAKKKANLQYYA
430
>>XP_016873515 (OMIM: 186852) PREDICTED: 26S protease re (461 aa)
initn: 2599 init1: 2599 opt: 2599 Z-score: 2738.8 bits: 516.0 E(85289): 8.2e-146
Smith-Waterman score: 2599; 100.0% identity (100.0% similar) in 403 aa overlap (1-403:1-403)
10 20 30 40 50 60
pF1KE4 MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDY
:::::::::::::::::::::::::::::::::::::::::::
XP_016 ARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAVSGQLGWVRCFVPSCPL
370 380 390 400 410 420
430
pF1KE4 MEGILEVQAKKKANLQYYA
XP_016 PGQDGGIWLVETAEGRGLSLREPGKAFRRSDLDSVCPGCRA
430 440 450 460
>>NP_001317141 (OMIM: 602706) 26S protease regulatory su (367 aa)
initn: 1107 init1: 1107 opt: 1120 Z-score: 1185.6 bits: 228.3 E(85289): 2.7e-59
Smith-Waterman score: 1135; 45.5% identity (76.2% similar) in 378 aa overlap (55-432:1-358)
30 40 50 60 70 80
pF1KE4 EQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNK
:. : .: .... ...: .:. :. .
NP_001 MEEEFIRNQEQMKPLEEKQEEERSKVDDLR
10 20 30
90 100 110 120 130 140
pF1KE4 TLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEK
:. :... :..: :.. :...::. . ... ....:: .
NP_001 GTPMSVGTLEEIID---------------DNH-----AIVSTSVGSEHYVSILSFVDKDL
40 50 60 70
150 160 170 180 190 200
pF1KE4 LKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVL
:.:: : .:. . .. .: . : : .:.:.. : : :.::::::.::::. :.. :
NP_001 LEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVEL
80 90 100 110 120 130
210 220 230 240 250 260
pF1KE4 PMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDG
:..: : .:..::.:::::..::::::::::::.: : ::.::::...: .:.: ..:::
NP_001 PLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDG
140 150 160 170 180 190
270 280 290 300 310 320
pF1KE4 AKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNT
::::. : .:.:.::::.::::.:::::::.::...:.::.::::::::::::::.
NP_001 PKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRG
200 210 220 230 240 250
330 340 350 360 370 380
pF1KE4 QVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEEL
.:::: ::::.. :::::.: ::.:::::::.:.:... ::.:::. .:... ::. ..:
NP_001 DVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDL
260 270 280 290 300 310
390 400 410 420 430
pF1KE4 ARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA
::..::. ::.:.:::..:::. ..:.::. .. .: ::.
NP_001 IMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
320 330 340 350 360
>>XP_016876959 (OMIM: 602706) PREDICTED: 26S protease re (367 aa)
initn: 1107 init1: 1107 opt: 1120 Z-score: 1185.6 bits: 228.3 E(85289): 2.7e-59
Smith-Waterman score: 1135; 45.5% identity (76.2% similar) in 378 aa overlap (55-432:1-358)
30 40 50 60 70 80
pF1KE4 EQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNK
:. : .: .... ...: .:. :. .
XP_016 MEEEFIRNQEQMKPLEEKQEEERSKVDDLR
10 20 30
90 100 110 120 130 140
pF1KE4 TLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEK
:. :... :..: :.. :...::. . ... ....:: .
XP_016 GTPMSVGTLEEIID---------------DNH-----AIVSTSVGSEHYVSILSFVDKDL
40 50 60 70
150 160 170 180 190 200
pF1KE4 LKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVL
:.:: : .:. . .. .: . : : .:.:.. : : :.::::::.::::. :.. :
XP_016 LEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVEL
80 90 100 110 120 130
210 220 230 240 250 260
pF1KE4 PMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDG
:..: : .:..::.:::::..::::::::::::.: : ::.::::...: .:.: ..:::
XP_016 PLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDG
140 150 160 170 180 190
270 280 290 300 310 320
pF1KE4 AKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNT
::::. : .:.:.::::.::::.:::::::.::...:.::.::::::::::::::.
XP_016 PKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRG
200 210 220 230 240 250
330 340 350 360 370 380
pF1KE4 QVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEEL
.:::: ::::.. :::::.: ::.:::::::.:.:... ::.:::. .:... ::. ..:
XP_016 DVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDL
260 270 280 290 300 310
390 400 410 420 430
pF1KE4 ARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA
::..::. ::.:.:::..:::. ..:.::. .. .: ::.
XP_016 IMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
320 330 340 350 360
>>NP_002793 (OMIM: 602706) 26S protease regulatory subun (440 aa)
initn: 1107 init1: 1107 opt: 1120 Z-score: 1184.4 bits: 228.3 E(85289): 3.1e-59
Smith-Waterman score: 1146; 42.8% identity (72.2% similar) in 432 aa overlap (5-432:27-431)
10 20 30
pF1KE4 MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMST
: . . : ...: . : : . : . :
NP_002 MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASK-------LPLVT
10 20 30 40 50
40 50 60 70 80 90
pF1KE4 EEIIQRTRLLDSE-IK---IMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVI
. : .:: : :: .:. : .: .... ...: .:. :. . :. :...
NP_002 PHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLE
60 70 80 90 100 110
100 110 120 130 140 150
pF1KE4 ELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVN
:..: :.. :...::. . ... ....:: . :.:: : .:
NP_002 EIID---------------DNH-----AIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLN
120 130 140 150
160 170 180 190 200 210
pF1KE4 KDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFEN
. . .. .: . : : .:.:.. : : :.::::::.::::. :.. ::..: : .:.
NP_002 HKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEE
160 170 180 190 200 210
220 230 240 250 260 270
pF1KE4 LGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFAL
.::.:::::..::::::::::::.: : ::.::::...: .:.: ..::: ::::. : .
NP_002 MGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRV
220 230 240 250 260 270
280 290 300 310 320 330
pF1KE4 AKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNR
:.:.::::.::::.:::::::.::...:.::.::::::::::::::. .:::: ::::
NP_002 AEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNR
280 290 300 310 320 330
340 350 360 370 380 390
pF1KE4 VDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGA
.. :::::.: ::.:::::::.:.:... ::.:::. .:... ::. ..: ::..::
NP_002 IETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGA
340 350 360 370 380 390
400 410 420 430
pF1KE4 QCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA
. ::.:.:::..:::. ..:.::. .. .: ::.
NP_002 DIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
400 410 420 430 440
>>NP_001186092 (OMIM: 601681) 26S protease regulatory su (398 aa)
initn: 1041 init1: 1019 opt: 1055 Z-score: 1116.7 bits: 215.6 E(85289): 1.8e-55
Smith-Waterman score: 1055; 45.1% identity (73.7% similar) in 377 aa overlap (55-430:12-385)
30 40 50 60 70 80
pF1KE4 EQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNK
... : .::: . . ..: .......
NP_001 MELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQR
10 20 30 40
90 100 110 120 130 140
pF1KE4 TLPYLVSNVIELLDVDPNDQEEDGANI-DLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAE
. .. ..:: . . .:.:. . .. : ...:. . . . : .: .
NP_001 NE---LNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDIN
50 60 70 80 90
150 160 170 180 190 200
pF1KE4 KLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIV
. :. :.. .::: . . ::.. : :. : :.. : : ::::::::.:. :.:
NP_001 DVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIE
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE4 LPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGD
::..: : :: ::: :::::.:::::::::::::: : .: ::....: .::: :::.
NP_001 LPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGE
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE4 GAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPN
::..::. :..:.:.::::::.::.:.::..:... ..:: ::::::::::::::::. .
NP_001 GARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEAT
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE4 TQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEE
..::: ::::.:::: :::: ::.::::::: :::::: :..:::::::.. .: ..
NP_001 KNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRK
280 290 300 310 320 330
390 400 410 420 430
pF1KE4 LARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA
.:. .::. :.::.:::: :::. ...:.::. .. .:. :
NP_001 IAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
340 350 360 370 380 390
>>NP_002796 (OMIM: 601681) 26S protease regulatory subun (406 aa)
initn: 1041 init1: 1019 opt: 1055 Z-score: 1116.6 bits: 215.6 E(85289): 1.9e-55
Smith-Waterman score: 1055; 45.1% identity (73.7% similar) in 377 aa overlap (55-430:20-393)
30 40 50 60 70 80
pF1KE4 EQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNK
... : .::: . . ..: .......
NP_002 MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQR
10 20 30 40
90 100 110 120 130 140
pF1KE4 TLPYLVSNVIELLDVDPNDQEEDGANI-DLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAE
. .. ..:: . . .:.:. . .. : ...:. . . . : .: .
NP_002 NE---LNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDIN
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE4 KLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIV
. :. :.. .::: . . ::.. : :. : :.. : : ::::::::.:. :.:
NP_002 DVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIE
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE4 LPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGD
::..: : :: ::: :::::.:::::::::::::: : .: ::....: .::: :::.
NP_002 LPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGE
170 180 190 200 210 220
270 280 290 300 310 320
pF1KE4 GAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPN
::..::. :..:.:.::::::.::.:.::..:... ..:: ::::::::::::::::. .
NP_002 GARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEAT
230 240 250 260 270 280
330 340 350 360 370 380
pF1KE4 TQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEE
..::: ::::.:::: :::: ::.::::::: :::::: :..:::::::.. .: ..
NP_002 KNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRK
290 300 310 320 330 340
390 400 410 420 430
pF1KE4 LARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA
.:. .::. :.::.:::: :::. ...:.::. .. .:. :
NP_002 IAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
350 360 370 380 390 400
>>NP_694546 (OMIM: 602707) 26S protease regulatory subun (387 aa)
initn: 997 init1: 959 opt: 1018 Z-score: 1078.0 bits: 208.4 E(85289): 2.6e-53
Smith-Waterman score: 1020; 42.0% identity (73.0% similar) in 374 aa overlap (65-438:33-386)
40 50 60 70 80 90
pF1KE4 KMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVI
: . ..: .. .:..: ...: .... .
NP_694 EIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKEEVKRIQSIPLVIGQFL
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE4 ELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVN
: :: : :.. ..: ..:.. ... .: : :::. :...
NP_694 E--AVDQNT------------------AIVGSTTGSNYYVRILSTIDRELLKPNASVALH
70 80 90 100
160 170 180 190 200 210
pF1KE4 KDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFEN
: : ....:: : :: . . :..: .:.::::.: : ::. ::. ::..: : ...
NP_694 KHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQ
110 120 130 140 150 160
220 230 240 250 260 270
pF1KE4 LGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFAL
.::.::.::::::::: :::.::.: : .: :.:....: ..:: ..:.: ..:::.: :
NP_694 IGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRL
170 180 190 200 210 220
280 290 300 310 320 330
pF1KE4 AKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNR
:::.::.::::::.:::.:::::.. ..:::::: .::::::.:::. :..:::: ::::
NP_694 AKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNR
230 240 250 260 270 280
340 350 360 370 380 390
pF1KE4 VDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGA
.: ::::::: ::::::::::.:... . :.. . :::.: .:. :. . : ..::
NP_694 ADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGA
290 300 310 320 330 340
400 410 420 430
pF1KE4 QCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA
. ...: :.::.:.:.. . .:. .. : : . . ..:
NP_694 DINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
350 360 370 380
>>NP_006494 (OMIM: 602707) 26S protease regulatory subun (418 aa)
initn: 959 init1: 959 opt: 1018 Z-score: 1077.5 bits: 208.4 E(85289): 2.8e-53
Smith-Waterman score: 1049; 40.2% identity (72.5% similar) in 400 aa overlap (39-438:38-417)
10 20 30 40 50 60
pF1KE4 SPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQA
:.. .: . :..:..... . . : .
NP_006 VEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 MKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTST
.: .. . .:..: ...: .... .: :: : :.. ..:
NP_006 LKKEFLHAQEEVKRIQSIPLVIGQFLE--AVDQNT------------------AIVGSTT
70 80 90 100
130 140 150 160 170 180
pF1KE4 RQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDI
..:.. ... .: : :::. :...: : ....:: : :: . . :..: .:.::
NP_006 GSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADI
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 GGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATF
::.: : ::. ::. ::..: : ....::.::.::::::::: :::.::.: : .: :.:
NP_006 GGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAF
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE4 LKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQR
....: ..:: ..:.: ..:::.: ::::.::.::::::.:::.:::::.. ..::::::
NP_006 IRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQR
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE4 TMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQI
.::::::.:::. :..:::: ::::.: ::::::: ::::::::::.:... . :..
NP_006 ILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFST
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 HSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQ
. :::.: .:. :. . : ..::. ...: :.::.:.:.. . .:. .. :
NP_006 ITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVI
350 360 370 380 390 400
430
pF1KE4 AKKKANLQYYA
: . . ..:
NP_006 KKDEQEHEFYK
410
>>NP_002794 (OMIM: 154365) 26S protease regulatory subun (433 aa)
initn: 981 init1: 958 opt: 982 Z-score: 1039.5 bits: 201.5 E(85289): 3.7e-51
Smith-Waterman score: 984; 40.4% identity (66.8% similar) in 416 aa overlap (27-427:3-416)
10 20 30 40 50
pF1KE4 MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRT-RLLD-SEIKIMKS-
: .: . : . .: .. : :: ..: ..:.
NP_002 MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTY
10 20 30
60 70 80 90 100
pF1KE4 -------EVLRVTHELQAMKDKIKE-----NSEKIKVNKTLPYLVSNVIELLDVDPNDQE
.. .: ..: . ::.: .:. . .: :... : . .: .
NP_002 GQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVA
40 50 60 70 80 90
110 120 130 140 150 160
pF1KE4 EDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLP
. :. ::. .:... . . . : .. : :::....: : ::
NP_002 RCTKIINADSEDPKY--IINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLP
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE4 TEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLM
. : : :.:.:.: :::.:: .::..: :.. :. : :.: ::::.::::::.
NP_002 PKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLL
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE4 YGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFI
.::::::::: ::: : .: : :... : .::: ..:.::..::. : .:. : .::.
NP_002 FGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFF
220 230 240 250 260 270
290 300 310 320 330 340
pF1KE4 DELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRS
::.:::: :::. .:: :::::::::.::::::.: ..::. :::: : :::::.:
NP_002 DEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRP
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE4 GRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGM
::::::::: .:. :.:..:..::.:.:.: :. .: ::: . .::. ..::.::::
NP_002 GRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGM
340 350 360 370 380 390
410 420 430
pF1KE4 IALRRGATELTHEDYMEGILEVQAKKKANLQYYA
.:.: :..:..:.. .:
NP_002 FAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN
400 410 420 430
439 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:12:28 2016 done: Sun Nov 6 01:12:29 2016
Total Scan time: 9.080 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]