Result of FASTA (omim) for
pFN21AE4412
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4412, 425 aa
1>>>pF1KE4412 425 - 425 aa - 425 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4315+/-0.000468; mu= 16.2132+/- 0.029
mean_var=62.8359+/-12.833, 0's: 0 Z-trim(108.5): 59 B-trim: 277 in 1/51
Lambda= 0.161797
statistics sampled from 16591 (16650) to 16591 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.552), E-opt: 0.2 (0.195), width: 16
Scan time: 5.800
The best scores are: opt bits E(85289)
NP_001287816 (OMIM: 607309) AP-1 complex subunit m ( 425) 2744 649.7 4e-186
NP_005489 (OMIM: 607309) AP-1 complex subunit mu-2 ( 423) 2709 641.5 1.2e-183
NP_115882 (OMIM: 603535) AP-1 complex subunit mu-1 ( 423) 2273 539.8 5e-153
XP_016882910 (OMIM: 603535) PREDICTED: AP-1 comple ( 397) 2149 510.8 2.4e-144
XP_016882909 (OMIM: 603535) PREDICTED: AP-1 comple ( 409) 1321 317.5 3.8e-86
NP_001123996 (OMIM: 603535) AP-1 complex subunit m ( 435) 1321 317.6 4e-86
NP_001020376 (OMIM: 601024) AP-2 complex subunit m ( 433) 1116 269.7 1e-71
NP_004059 (OMIM: 601024) AP-2 complex subunit mu i ( 435) 769 188.7 2.5e-47
NP_001298127 (OMIM: 601024) AP-2 complex subunit m ( 460) 769 188.7 2.6e-47
NP_001307193 (OMIM: 610366) AP-3 complex subunit m ( 418) 525 131.7 3.3e-30
NP_036227 (OMIM: 610366) AP-3 complex subunit mu-1 ( 418) 525 131.7 3.3e-30
NP_996895 (OMIM: 610366) AP-3 complex subunit mu-1 ( 418) 525 131.7 3.3e-30
NP_001307192 (OMIM: 610366) AP-3 complex subunit m ( 418) 525 131.7 3.3e-30
NP_006794 (OMIM: 610469) AP-3 complex subunit mu-2 ( 418) 490 123.6 9.6e-28
NP_001127768 (OMIM: 610469) AP-3 complex subunit m ( 418) 490 123.6 9.6e-28
XP_016868466 (OMIM: 610469) PREDICTED: AP-3 comple ( 418) 490 123.6 9.6e-28
NP_001307194 (OMIM: 610366) AP-3 complex subunit m ( 364) 331 86.4 1.3e-16
XP_016868467 (OMIM: 610469) PREDICTED: AP-3 comple ( 303) 326 85.2 2.4e-16
XP_016868468 (OMIM: 610469) PREDICTED: AP-3 comple ( 303) 326 85.2 2.4e-16
XP_016868279 (OMIM: 602296,612936) PREDICTED: AP-4 ( 284) 324 84.8 3.2e-16
XP_005250747 (OMIM: 602296,612936) PREDICTED: AP-4 ( 385) 324 84.8 4.1e-16
NP_004713 (OMIM: 602296,612936) AP-4 complex subun ( 453) 273 72.9 1.8e-12
XP_006716238 (OMIM: 602296,612936) PREDICTED: AP-4 ( 419) 260 69.9 1.4e-11
XP_005250746 (OMIM: 602296,612936) PREDICTED: AP-4 ( 460) 260 69.9 1.5e-11
XP_011514987 (OMIM: 602296,612936) PREDICTED: AP-4 ( 460) 260 69.9 1.5e-11
XP_006720342 (OMIM: 608467) PREDICTED: stonin-2 is ( 898) 204 56.9 2.3e-07
NP_149095 (OMIM: 608467) stonin-2 isoform 1 [Homo ( 905) 204 56.9 2.4e-07
NP_001243359 (OMIM: 608467) stonin-2 isoform 2 [Ho ( 920) 204 56.9 2.4e-07
XP_011535544 (OMIM: 608467) PREDICTED: stonin-2 is ( 955) 204 57.0 2.5e-07
XP_011535543 (OMIM: 608467) PREDICTED: stonin-2 is ( 962) 204 57.0 2.5e-07
XP_011535542 (OMIM: 608467) PREDICTED: stonin-2 is ( 977) 204 57.0 2.5e-07
XP_016868280 (OMIM: 602296,612936) PREDICTED: AP-4 ( 228) 173 49.5 1.1e-05
NP_001185524 (OMIM: 605357) stonin-1 [Homo sapiens ( 735) 171 49.2 4.1e-05
NP_006864 (OMIM: 605357) stonin-1 [Homo sapiens] ( 735) 171 49.2 4.1e-05
XP_006720259 (OMIM: 614368) PREDICTED: AP-5 comple ( 387) 148 43.7 0.00096
NP_060699 (OMIM: 614368) AP-5 complex subunit mu-1 ( 490) 148 43.8 0.0012
XP_011535242 (OMIM: 614368) PREDICTED: AP-5 comple ( 504) 148 43.8 0.0012
>>NP_001287816 (OMIM: 607309) AP-1 complex subunit mu-2 (425 aa)
initn: 2744 init1: 2744 opt: 2744 Z-score: 3462.4 bits: 649.7 E(85289): 4e-186
Smith-Waterman score: 2744; 99.8% identity (99.8% similar) in 425 aa overlap (1-425:1-425)
10 20 30 40 50 60
pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGLSGSKNKSVELEDVKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGLSGSKNKSVELEDVKF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 HQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 GQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 HFGLPRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDY
::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFGLPSVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDY
370 380 390 400 410 420
pF1KE4 QLRTS
:::::
NP_001 QLRTS
>>NP_005489 (OMIM: 607309) AP-1 complex subunit mu-2 iso (423 aa)
initn: 1430 init1: 1430 opt: 2709 Z-score: 3418.3 bits: 641.5 E(85289): 1.2e-183
Smith-Waterman score: 2709; 99.1% identity (99.1% similar) in 425 aa overlap (1-425:1-423)
10 20 30 40 50 60
pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGLSGSKNKSVELEDVKF
:::::::::::::::::::::::::::::::::::::::::::: : ::::::::::::
NP_005 LLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGRS--KNKSVELEDVKF
190 200 210 220 230
250 260 270 280 290 300
pF1KE4 HQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAK
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 GQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRA
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 HFGLPRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDY
::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HFGLPSVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDY
360 370 380 390 400 410
pF1KE4 QLRTS
:::::
NP_005 QLRTS
420
>>NP_115882 (OMIM: 603535) AP-1 complex subunit mu-1 iso (423 aa)
initn: 1175 init1: 1175 opt: 2273 Z-score: 2868.3 bits: 539.8 E(85289): 5e-153
Smith-Waterman score: 2273; 79.0% identity (94.3% similar) in 424 aa overlap (1-424:1-422)
10 20 30 40 50 60
pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI
::::::..::.::: :: :::.::: ::..:::::.:...:::: :.:.:.:: :.:.::
NP_115 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF
::.:::::::..::: .:::.:::::...:: :::::::::::::::::.::::::::::
NP_115 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN
:.:::::::::::::::...::::: : : :::::::::::::::.:::::.:::::::
NP_115 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGLSGSKNKSVELEDVKF
:::.:::.:: :::::.::..:::::::::::::::.:::. :: . :.::::::::::
NP_115 LLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRG--KSKSVELEDVKF
190 200 210 220 230
250 260 270 280 290 300
pF1KE4 HQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAK
:::::::::.::::::::::::.::::::::.:.::::::::::::: ::::.: :.:::
NP_115 HQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAK
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 GQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRA
.:::..:.::.::: .:::.:::::.:::.:::.:.::: . ..::::::::::::::::
NP_115 SQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRA
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 HFGLPRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDY
::::: :: :. ::.:::.:::::::::.:::::::.:::::::::::::::::::.:::
NP_115 HFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDY
360 370 380 390 400 410
pF1KE4 QLRTS
::::
NP_115 QLRTQ
420
>>XP_016882910 (OMIM: 603535) PREDICTED: AP-1 complex su (397 aa)
initn: 1125 init1: 1125 opt: 2149 Z-score: 2712.3 bits: 510.8 E(85289): 2.4e-144
Smith-Waterman score: 2149; 79.4% identity (94.7% similar) in 398 aa overlap (27-424:1-396)
10 20 30 40 50 60
pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI
::..:::::.:...:::: :.:.:.:: :.:.::
XP_016 MSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
10 20 30
70 80 90 100 110 120
pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF
::.:::::::..::: .:::.:::::...:: :::::::::::::::::.::::::::::
XP_016 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN
:.:::::::::::::::...::::: : : :::::::::::::::.:::::.:::::::
XP_016 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE4 LLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGLSGSKNKSVELEDVKF
:::.:::.:: :::::.::..:::::::::::::::.:::. :: . :.::::::::::
XP_016 LLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRG--KSKSVELEDVKF
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE4 HQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAK
:::::::::.::::::::::::.::::::::.:.::::::::::::: ::::.: :.:::
XP_016 HQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAK
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE4 GQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRA
.:::..:.::.::: .:::.:::::.:::.:::.:.::: . ..::::::::::::::::
XP_016 SQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRA
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE4 HFGLPRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDY
::::: :: :. ::.:::.:::::::::.:::::::.:::::::::::::::::::.:::
XP_016 HFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDY
340 350 360 370 380 390
pF1KE4 QLRTS
::::
XP_016 QLRTQ
>>XP_016882909 (OMIM: 603535) PREDICTED: AP-1 complex su (409 aa)
initn: 1940 init1: 1125 opt: 1321 Z-score: 1667.6 bits: 317.5 E(85289): 3.8e-86
Smith-Waterman score: 2115; 77.1% identity (92.0% similar) in 410 aa overlap (27-424:1-408)
10 20 30 40 50 60
pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI
::..:::::.:...:::: :.:.:.:: :.:.::
XP_016 MSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
10 20 30
70 80 90 100 110 120
pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF
::.:::::::..::: .:::.:::::...:: :::::::::::::::::.::::::::::
XP_016 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN
:.:::::::::::::::...::::: : : :::::::::::::::.:::::.:::::::
XP_016 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN
100 110 120 130 140 150
190 200 210 220
pF1KE4 LL------------VNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGLSGS
:: :.:::.:: :::::.::..:::::::::::::::.:::. :: .
XP_016 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRG--
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE4 KNKSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKF
:.:::::::::::::::::::.::::::::::::.::::::::.:.:::::::::::::
XP_016 KSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKH
220 230 240 250 260 270
290 300 310 320 330 340
pF1KE4 SHSRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIK
::::.: :.:::.:::..:.::.::: .:::.:::::.:::.:::.:.::: . ..::::
XP_016 SHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIK
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE4 SFPGGKEYLMRAHFGLPRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQAL
::::::::::::::::: :: :. ::.:::.:::::::::.:::::::.:::::::::::
XP_016 SFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQAL
340 350 360 370 380 390
410 420
pF1KE4 PWVRYITQSGDYQLRTS
::::::::.:::::::
XP_016 PWVRYITQNGDYQLRTQ
400
>>NP_001123996 (OMIM: 603535) AP-1 complex subunit mu-1 (435 aa)
initn: 2064 init1: 1125 opt: 1321 Z-score: 1667.1 bits: 317.6 E(85289): 4e-86
Smith-Waterman score: 2239; 76.8% identity (91.7% similar) in 436 aa overlap (1-424:1-434)
10 20 30 40 50 60
pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI
::::::..::.::: :: :::.::: ::..:::::.:...:::: :.:.:.:: :.:.::
NP_001 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF
::.:::::::..::: .:::.:::::...:: :::::::::::::::::.::::::::::
NP_001 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN
:.:::::::::::::::...::::: : : :::::::::::::::.:::::.:::::::
NP_001 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN
130 140 150 160 170 180
190 200 210 220
pF1KE4 LL------------VNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGLSGS
:: :.:::.:: :::::.::..:::::::::::::::.:::. :: .
NP_001 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRG--
190 200 210 220 230
230 240 250 260 270 280
pF1KE4 KNKSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKF
:.:::::::::::::::::::.::::::::::::.::::::::.:.:::::::::::::
NP_001 KSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKH
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 SHSRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIK
::::.: :.:::.:::..:.::.::: .:::.:::::.:::.:::.:.::: . ..::::
NP_001 SHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIK
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 SFPGGKEYLMRAHFGLPRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQAL
::::::::::::::::: :: :. ::.:::.:::::::::.:::::::.:::::::::::
NP_001 SFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQAL
360 370 380 390 400 410
410 420
pF1KE4 PWVRYITQSGDYQLRTS
::::::::.:::::::
NP_001 PWVRYITQNGDYQLRTQ
420 430
>>NP_001020376 (OMIM: 601024) AP-2 complex subunit mu is (433 aa)
initn: 1064 init1: 380 opt: 1116 Z-score: 1408.6 bits: 269.7 E(85289): 1e-71
Smith-Waterman score: 1116; 39.2% identity (74.5% similar) in 431 aa overlap (6-423:5-432)
10 20 30 40 50 60
pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI
.:: . ::. :::: :. :.. . .. : ... ... . .:. . ... :. .
NP_001 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ-VRSPVTNIARTSFFHV
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF
:.::..:.:.:..:.::..:. :::: .:. :: .. ::.:..:::..::::::..::
NP_001 KRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDF
60 70 80 90 100 110
130 140 150 160 170
pF1KE4 GFPQTTDSKILQEYITQQSNKLETG--KSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIES
:.::.... :. .::::. : .: .:.. ::. ..:: :::::..::.:.::.::
NP_001 GYPQNSETGALKTFITQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLES
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 VNLLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTG------LSGSKNKS
::::.. .:.:: ... : . .: .:::::: ..:.::....: : : : ..:
NP_001 VNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQS
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 VELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSR
. ..: ::::::::.::..:.::::::::.:::: :: . .. . . .... ....
NP_001 IAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTK
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE4 VEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPG
.:. : :..:: . .:. .:. .:.: .... . :.::: .:...:.:: . :
NP_001 LEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAG
300 310 320 330 340 350
360 370 380 390 400
pF1KE4 GKEYLMRAHFGL-PRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEK----SGYQA
:: . :.. : : .:.. .::::...::.: :. ::..:::.:..: : ...
NP_001 MKESQISAEIELLPTNDKKKW-ARPPISMNFEVP-FAPSGLKVRYLKVFEPKLNYSDHDV
360 370 380 390 400 410
410 420
pF1KE4 LPWVRYITQSGDYQLRTS
. ::::: .:: :. :
NP_001 IKWVRYIGRSGIYETRC
420 430
>>NP_004059 (OMIM: 601024) AP-2 complex subunit mu isofo (435 aa)
initn: 1087 init1: 380 opt: 769 Z-score: 970.8 bits: 188.7 E(85289): 2.5e-47
Smith-Waterman score: 1106; 38.8% identity (73.9% similar) in 433 aa overlap (6-423:5-434)
10 20 30 40 50 60
pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI
.:: . ::. :::: :. :.. . .. : ... ... . .:. . ... :. .
NP_004 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ-VRSPVTNIARTSFFHV
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF
:.::..:.:.:..:.::..:. :::: .:. :: .. ::.:..:::..::::::..::
NP_004 KRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDF
60 70 80 90 100 110
130 140 150 160 170
pF1KE4 GFPQTTDSKILQEYITQQSNK----LETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVI
:.::.... :. .::::. : . .:.. ::. ..:: :::::..::.:.::.
NP_004 GYPQNSETGALKTFITQQGIKSQHQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 ESVNLLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTG------LSGSKN
::::::.. .:.:: ... : . .: .:::::: ..:.::....: : : : .
NP_004 ESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 KSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSH
.:. ..: ::::::::.::..:.::::::::.:::: :: . .. . . .... ..
NP_004 QSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGR
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE4 SRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSF
...:. : :..:: . .:. .:. .:.: .... . :.::: .:...:.:: .
NP_004 TKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRM
300 310 320 330 340 350
360 370 380 390 400
pF1KE4 PGGKEYLMRAHFGL-PRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEK----SGY
: :: . :.. : : .:.. .::::...::.: :. ::..:::.:..: : .
NP_004 AGMKESQISAEIELLPTNDKKKW-ARPPISMNFEVP-FAPSGLKVRYLKVFEPKLNYSDH
360 370 380 390 400 410
410 420
pF1KE4 QALPWVRYITQSGDYQLRTS
... ::::: .:: :. :
NP_004 DVIKWVRYIGRSGIYETRC
420 430
>>NP_001298127 (OMIM: 601024) AP-2 complex subunit mu is (460 aa)
initn: 1077 init1: 380 opt: 769 Z-score: 970.4 bits: 188.7 E(85289): 2.6e-47
Smith-Waterman score: 1048; 40.1% identity (74.7% similar) in 392 aa overlap (47-423:70-459)
20 30 40 50 60 70
pF1KE4 ISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWIKHSNLYLVATTSKNAN
.:. . ... :. .:.::..:.:.:..:.:
NP_001 PFPGEWLEANRRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKRSNIWLAAVTKQNVN
40 50 60 70 80 90
80 90 100 110 120 130
pF1KE4 ASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDFGFPQTTDSKILQEYIT
:..:. :::: .:. :: .. ::.:..:::..::::::..:::.::.... :. .::
NP_001 AAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQNSETGALKTFIT
100 110 120 130 140 150
140 150 160 170 180 190
pF1KE4 QQSNK----LETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVNLLVNANGSVLLS
::. : . .:.. ::. ..:: :::::..::.:.::.::::::.. .:.:: .
NP_001 QQGIKSQHQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVNLLMSPQGQVLSA
160 170 180 190 200 210
200 210 220 230 240
pF1KE4 EIVGTIKLKVFLSGMPELRLGLNDRVLFELTG------LSGSKNKSVELEDVKFHQCVRL
.. : . .: .:::::: ..:.::....: : : : ..:. ..: :::::::
NP_001 HVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRL
220 230 240 250 260 270
250 260 270 280 290 300
pF1KE4 SRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAKGQFKKQ
:.::..:.::::::::.:::: :: . .. . . .... .....:. : :..:: .
NP_001 SKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPS
280 290 300 310 320 330
310 320 330 340 350 360
pF1KE4 SVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRAHFGL-P
.:. .:. .:.: .... . :.::: .:...:.:: . : :: . :.. : :
NP_001 LLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELLP
340 350 360 370 380 390
370 380 390 400 410 420
pF1KE4 RVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEK----SGYQALPWVRYITQSGDYQ
.:.. .::::...::.: :. ::..:::.:..: : .... ::::: .:: :.
NP_001 TNDKKKW-ARPPISMNFEVP-FAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGIYE
400 410 420 430 440 450
pF1KE4 LRTS
:
NP_001 TRC
460
>>NP_001307193 (OMIM: 610366) AP-3 complex subunit mu-1 (418 aa)
initn: 522 init1: 190 opt: 525 Z-score: 663.2 bits: 131.7 E(85289): 3.3e-30
Smith-Waterman score: 697; 29.5% identity (64.2% similar) in 441 aa overlap (5-424:4-418)
10 20 30 40 50 60
pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI
..:... .: .. ...:. :..: ..:. . . . :..: . ... :
NP_001 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISI
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF
...:..:.. . .. .: ::... ..: .:: : : .:.:: :::::::.:..:
NP_001 YRDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDN
60 70 80 90 100 110
130 140 150 160 170
pF1KE4 GFPQTTDSKILQEYITQQS------NKLETGKSRV----PPTVTNAVSWRSEGIKYKKNE
::: .:.:.::.: : . :.. ::.: : : . . :: :.:: .::
NP_001 GFPLATESNILKELIKPPTILRSVVNSI-TGSSNVGDTLPTGQLSNIPWRRAGVKYTNNE
120 130 140 150 160 170
180 190 200 210 220
pF1KE4 VFIDVIESVNLLVNANGSVLLSEIVGTIKLKVFLSGMPELRLG-LNDRVLFELTGLSGSK
...::.: .. ... .::....:: :.: . :::::.: :. .: :.:
NP_001 AYFDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLL----------
180 190 200 210 220
230 240 250 260 270 280
pF1KE4 NKSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQ--VKPLIWIESVI--
.::.:: :.:..:....:..:::::::.:.:.:::.:.: : .... :
NP_001 ------DDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISF
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE4 -EKFSHSRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVI
:. : .: .: . : .. : . .:. ..: .:. . . . . :: . : .:.
NP_001 KENSSCGRFDITIGPKQNMGK--TIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLT
290 300 310 320 330 340
350 360 370 380 390
pF1KE4 WSI-----KSFPGGKEYLMRAHFGLPRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKI
:.. ...:. : :. . : :. :.. : ....:.: ...::..: . .
NP_001 WDVGKITPQKLPSLKG-LVNLQSGAPKPEEN-----PSLNIQFKIQQLAISGLKVNRLDM
350 360 370 380 390
400 410 420
pF1KE4 IEKSGYQALPWVRYITQSGDYQLRTS
.. :. . :.:.:..: .:.::
NP_001 YGEK-YKPFKGVKYVTKAGKFQVRT
400 410
425 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:16:49 2016 done: Sun Nov 6 01:16:50 2016
Total Scan time: 5.800 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]