Result of FASTA (omim) for
pFN21AE4386
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4386, 406 aa
1>>>pF1KE4386 406 - 406 aa - 406 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.0334+/-0.000343; mu= 8.8477+/- 0.021
mean_var=126.0441+/-25.489, 0's: 0 Z-trim(117.9): 84 B-trim: 30 in 1/54
Lambda= 0.114239
statistics sampled from 30322 (30421) to 30322 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.734), E-opt: 0.2 (0.357), width: 16
Scan time: 8.540
The best scores are: opt bits E(85289)
NP_647475 (OMIM: 605910,615881) angiopoietin-relat ( 406) 2806 473.7 3.6e-133
XP_005272541 (OMIM: 605910,615881) PREDICTED: angi ( 424) 2369 401.7 1.8e-111
NP_001034756 (OMIM: 605910,615881) angiopoietin-re ( 368) 1322 229.1 1.4e-59
XP_005272542 (OMIM: 605910,615881) PREDICTED: angi ( 386) 1211 210.8 4.7e-54
NP_055310 (OMIM: 604774,605019) angiopoietin-relat ( 460) 699 126.5 1.4e-28
XP_016868807 (OMIM: 601922) PREDICTED: angiopoieti ( 443) 608 111.5 4.3e-24
NP_001112359 (OMIM: 601922) angiopoietin-2 isoform ( 495) 608 111.5 4.7e-24
NP_001112360 (OMIM: 601922) angiopoietin-2 isoform ( 444) 606 111.1 5.4e-24
NP_001138 (OMIM: 601922) angiopoietin-2 isoform a ( 496) 606 111.2 5.9e-24
XP_005245634 (OMIM: 603874) PREDICTED: angiopoieti ( 491) 591 108.7 3.3e-23
NP_004664 (OMIM: 603874) angiopoietin-related prot ( 491) 591 108.7 3.3e-23
XP_011527541 (OMIM: 603705) PREDICTED: angiopoieti ( 451) 581 107.0 9.5e-23
NP_057069 (OMIM: 603705) angiopoietin-4 isoform 1 ( 503) 581 107.0 1e-22
NP_001300980 (OMIM: 601667) angiopoietin-1 isoform ( 298) 577 106.2 1.1e-22
NP_001186788 (OMIM: 601667) angiopoietin-1 isoform ( 497) 577 106.4 1.6e-22
NP_001137 (OMIM: 601667) angiopoietin-1 isoform 1 ( 498) 577 106.4 1.6e-22
NP_036230 (OMIM: 605001) angiopoietin-related prot ( 493) 561 103.7 1e-21
NP_003656 (OMIM: 604973,613860) ficolin-3 isoform ( 299) 545 101.0 4.2e-21
NP_001138578 (OMIM: 613357) fibrinogen C domain-co ( 461) 548 101.6 4.2e-21
NP_116232 (OMIM: 613357) fibrinogen C domain-conta ( 461) 548 101.6 4.2e-21
XP_011526649 (OMIM: 609336) PREDICTED: angiopoieti ( 470) 548 101.6 4.3e-21
NP_001308340 (OMIM: 609336) angiopoietin-related p ( 470) 548 101.6 4.3e-21
XP_016882836 (OMIM: 609336) PREDICTED: angiopoieti ( 470) 548 101.6 4.3e-21
XP_011526652 (OMIM: 609336) PREDICTED: angiopoieti ( 470) 548 101.6 4.3e-21
NP_114123 (OMIM: 609336) angiopoietin-related prot ( 470) 548 101.6 4.3e-21
XP_011526650 (OMIM: 609336) PREDICTED: angiopoieti ( 537) 548 101.6 4.8e-21
XP_011526651 (OMIM: 609336) PREDICTED: angiopoieti ( 537) 548 101.6 4.8e-21
XP_005260148 (OMIM: 609336) PREDICTED: angiopoieti ( 551) 548 101.6 4.9e-21
NP_001994 (OMIM: 601252) ficolin-1 precursor [Homo ( 326) 539 100.0 8.9e-21
XP_006717078 (OMIM: 601624) PREDICTED: ficolin-2 i ( 264) 533 99.0 1.5e-20
NP_056652 (OMIM: 601624) ficolin-2 isoform b precu ( 275) 533 99.0 1.5e-20
XP_011516694 (OMIM: 601624) PREDICTED: ficolin-2 i ( 302) 533 99.0 1.7e-20
NP_004099 (OMIM: 601624) ficolin-2 isoform a precu ( 313) 533 99.0 1.7e-20
NP_775628 (OMIM: 604973,613860) ficolin-3 isoform ( 288) 522 97.2 5.6e-20
NP_002395 (OMIM: 600596) microfibril-associated gl ( 255) 494 92.5 1.2e-18
NP_001185624 (OMIM: 600596) microfibril-associated ( 279) 494 92.5 1.3e-18
NP_006673 (OMIM: 605351) fibroleukin precursor [Ho ( 439) 469 88.5 3.4e-17
NP_001315564 (OMIM: 601995) tenascin-R isoform 2 [ (1025) 423 81.2 1.3e-14
XP_011508251 (OMIM: 601995) PREDICTED: tenascin-R (1199) 423 81.3 1.4e-14
XP_016857708 (OMIM: 601995) PREDICTED: tenascin-R (1358) 423 81.3 1.6e-14
XP_016857707 (OMIM: 601995) PREDICTED: tenascin-R (1358) 423 81.3 1.6e-14
NP_003276 (OMIM: 601995) tenascin-R isoform 1 prec (1358) 423 81.3 1.6e-14
NP_115859 (OMIM: 600985,606408,615963) tenascin-X ( 673) 402 77.6 1e-13
XP_005252032 (OMIM: 187380,615629) PREDICTED: tena (1564) 397 77.0 3.5e-13
XP_005252031 (OMIM: 187380,615629) PREDICTED: tena (1655) 397 77.1 3.6e-13
XP_006717164 (OMIM: 187380,615629) PREDICTED: tena (1655) 397 77.1 3.6e-13
XP_011516931 (OMIM: 187380,615629) PREDICTED: tena (1746) 397 77.1 3.8e-13
XP_011516930 (OMIM: 187380,615629) PREDICTED: tena (1746) 397 77.1 3.8e-13
XP_005252030 (OMIM: 187380,615629) PREDICTED: tena (1837) 397 77.1 4e-13
XP_011516928 (OMIM: 187380,615629) PREDICTED: tena (1929) 397 77.1 4.1e-13
>>NP_647475 (OMIM: 605910,615881) angiopoietin-related p (406 aa)
initn: 2806 init1: 2806 opt: 2806 Z-score: 2511.9 bits: 473.7 E(85289): 3.6e-133
Smith-Waterman score: 2806; 100.0% identity (100.0% similar) in 406 aa overlap (1-406:1-406)
10 20 30 40 50 60
pF1KE4 MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 RTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 HKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 HKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 LHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 WEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 WEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 SLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 SLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLN
310 320 330 340 350 360
370 380 390 400
pF1KE4 GQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAAEAAS
::::::::::::::::::::::::::::::::::::::::::::::
NP_647 GQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAAEAAS
370 380 390 400
>>XP_005272541 (OMIM: 605910,615881) PREDICTED: angiopoi (424 aa)
initn: 2369 init1: 2369 opt: 2369 Z-score: 2122.4 bits: 401.7 E(85289): 1.8e-111
Smith-Waterman score: 2760; 95.8% identity (95.8% similar) in 424 aa overlap (1-406:1-424)
10 20 30 40 50 60
pF1KE4 MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 HKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 WEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAY
250 260 270 280 290 300
310 320 330 340
pF1KE4 SLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLS--------------
::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSAPSVAQRPDHVPSP
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE4 ----GGWWFGTCSHSNLNGQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTPAGGWWFGTCSHSNLNGQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAA
370 380 390 400 410 420
pF1KE4 EAAS
::::
XP_005 EAAS
>>NP_001034756 (OMIM: 605910,615881) angiopoietin-relate (368 aa)
initn: 2513 init1: 1316 opt: 1322 Z-score: 1190.7 bits: 229.1 E(85289): 1.4e-59
Smith-Waterman score: 2441; 90.4% identity (90.6% similar) in 406 aa overlap (1-406:1-368)
10 20 30 40 50 60
pF1KE4 MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 HKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRP
::. :::::::::::::::::::
NP_001 LHH--------------------------------------GGWTVIQRRHDGSVDFNRP
190 200
250 260 270 280 290 300
pF1KE4 WEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAY
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE4 SLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLN
270 280 290 300 310 320
370 380 390 400
pF1KE4 GQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAAEAAS
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAAEAAS
330 340 350 360
>>XP_005272542 (OMIM: 605910,615881) PREDICTED: angiopoi (386 aa)
initn: 2076 init1: 1211 opt: 1211 Z-score: 1091.5 bits: 210.8 E(85289): 4.7e-54
Smith-Waterman score: 2395; 86.6% identity (86.8% similar) in 424 aa overlap (1-406:1-386)
10 20 30 40 50 60
pF1KE4 MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 HKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRP
::. :::::::::::::::::::
XP_005 LHH--------------------------------------GGWTVIQRRHDGSVDFNRP
190 200
250 260 270 280 290 300
pF1KE4 WEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAY
210 220 230 240 250 260
310 320 330 340
pF1KE4 SLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLS--------------
::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSAPSVAQRPDHVPSP
270 280 290 300 310 320
350 360 370 380 390 400
pF1KE4 ----GGWWFGTCSHSNLNGQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTPAGGWWFGTCSHSNLNGQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAA
330 340 350 360 370 380
pF1KE4 EAAS
::::
XP_005 EAAS
>>NP_055310 (OMIM: 604774,605019) angiopoietin-related p (460 aa)
initn: 738 init1: 371 opt: 699 Z-score: 634.4 bits: 126.5 E(85289): 1.4e-28
Smith-Waterman score: 699; 35.4% identity (67.2% similar) in 314 aa overlap (93-404:153-458)
70 80 90 100 110 120
pF1KE4 RSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLFHK
::. ::: ::.: .. :.. :..:..
NP_055 KLESLLEEKILLQQKVKYLEEQLTNLIQNQPETPEHPEVT-SLKTFVEKQDNSIKDLLQT
130 140 150 160 170 180
130 140 150 160 170 180
pF1KE4 VAQQQRHLEKQHLRIQHLQSQFGLLD-HKHLDHEVAKPARRKRLPEMAQPVDPAHNVSRL
: .: ..:..:: .:.....:. . .. . ... : : . : .. .:: .
NP_055 VEDQYKQLNQQHSQIKEIENQLRRTSIQEPTEISLSSKPRAPRTTPFLQ-LNEIRNV-KH
190 200 210 220 230
190 200 210 220 230 240
pF1KE4 HRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRPW
.: .: ... ::. ::.. :.:..: : : : . : . ::.::.: ::: .::. :
NP_055 DGIPAECTTIYNRGEHTSGMYAIRPSNSQVFHVYCDVISGSPWTLIQHRIDGSQNFNETW
240 250 260 270 280 290
250 260 270 280 290 300
pF1KE4 EAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAYS
: :: ::: :::::::::..::. . : : ..:.:: : . ...: .::...: :.
NP_055 ENYKYGFGRLDGEFWLGLEKIYSIVKQSNYVLRIELEDWKDNKHYIEYSFYLGNHETNYT
300 310 320 330 340 350
310 320 330 340 350 360
pF1KE4 LQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWF-GTCSHSNLN
:.:.: ..:.. . : . .. ::::: : . :: .. :::::. :...:::
NP_055 LHLVA-ITGNVPNAI--PENKDLVFSTWD--HKAKGHFNCPEGYSGGWWWHDECGENNLN
360 370 380 390 400 410
370 380 390 400
pF1KE4 GQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAAEAAS
:.: . ... . ..:. ::. :: : ...: :::.: .:.
NP_055 GKYNKPRAKSKPERRRGLSWKSQNGRLYSIKSTKMLIHPTDSESFE
420 430 440 450 460
>>XP_016868807 (OMIM: 601922) PREDICTED: angiopoietin-2 (443 aa)
initn: 462 init1: 285 opt: 608 Z-score: 553.5 bits: 111.5 E(85289): 4.3e-24
Smith-Waterman score: 608; 33.4% identity (63.5% similar) in 356 aa overlap (60-399:100-440)
30 40 50 60 70 80
pF1KE4 SKSPRFASWDEMNVLAHGLLQLGQGLREHAERTRSQLSALERRLSACGSACQGTEGSTDL
. :: .:. ::. ::. : . ....
XP_016 PLEYDDSVQRLQVLENIMENNTQWLMKVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEI
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE4 PLAPE--SRVDPEVL-----HSLQTQ-LKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQ
. : .. .:: : .: : .: .....: : :..:. .:. . .:
XP_016 NKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVL---VSKQNSIIEELEKKIVTAT
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE4 SQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSRLHRLP-RDCQELFQVGERQSG
. ..:.... :.. . . . : :. . .:.. ... ::: :.:. :. .:
XP_016 VNNSVLQKQQ--HDLMETVN-NLLTMMSTSNSKDPTVAKEEQISFRDCAEVFKSGHTTNG
190 200 210 220 230 240
210 220 230 240 250
pF1KE4 LFEIQ-PQGSPPFLVNCKMTSDGG-WTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLG
.. . :... . . : : . :: ::.::::.::::::.: :. ::.:::.: ::.:::
XP_016 IYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLG
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE4 LEKVHSITGDRNSRLAVQLRDWDGN-AELLQFSVHLGGEDTAYSLQLTA--PVAGQLGAT
: : ..:... : ..:.::.:: : : .:..:. : ..: . .::....
XP_016 NEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSI
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE4 TVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLNGQYFRSIPQQRQKLK
. : . ::: : :.: . .:.. :.::::: .:. :::::.:. :: ::. .
XP_016 SQPGN----DFSTKDGDND-KCICKCSQMLTGGWWFDACGPSNLNGMYY---PQ-RQNTN
370 380 390 400 410
380 390 400
pF1KE4 K--GIFWKTWRGRYYPLQATTMLIQPMAAEAAS
: :: : :.: : :.::::.:.:
XP_016 KFNGIKWYYWKGSGYSLKATTMMIRPADF
420 430 440
>>NP_001112359 (OMIM: 601922) angiopoietin-2 isoform b p (495 aa)
initn: 462 init1: 285 opt: 608 Z-score: 552.8 bits: 111.5 E(85289): 4.7e-24
Smith-Waterman score: 608; 33.4% identity (63.5% similar) in 356 aa overlap (60-399:152-492)
30 40 50 60 70 80
pF1KE4 SKSPRFASWDEMNVLAHGLLQLGQGLREHAERTRSQLSALERRLSACGSACQGTEGSTDL
. :: .:. ::. ::. : . ....
NP_001 AVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEI
130 140 150 160 170 180
90 100 110 120 130 140
pF1KE4 PLAPE--SRVDPEVL-----HSLQTQ-LKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQ
. : .. .:: : .: : .: .....: : :..:. .:. . .:
NP_001 NKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVL---VSKQNSIIEELEKKIVTAT
190 200 210 220 230
150 160 170 180 190 200
pF1KE4 SQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSRLHRLP-RDCQELFQVGERQSG
. ..:.... :.. . . . : :. . .:.. ... ::: :.:. :. .:
NP_001 VNNSVLQKQQ--HDLMETVN-NLLTMMSTSNSKDPTVAKEEQISFRDCAEVFKSGHTTNG
240 250 260 270 280 290
210 220 230 240 250
pF1KE4 LFEIQ-PQGSPPFLVNCKMTSDGG-WTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLG
.. . :... . . : : . :: ::.::::.::::::.: :. ::.:::.: ::.:::
NP_001 IYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLG
300 310 320 330 340 350
260 270 280 290 300 310
pF1KE4 LEKVHSITGDRNSRLAVQLRDWDGN-AELLQFSVHLGGEDTAYSLQLTA--PVAGQLGAT
: : ..:... : ..:.::.:: : : .:..:. : ..: . .::....
NP_001 NEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSI
360 370 380 390 400 410
320 330 340 350 360 370
pF1KE4 TVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLNGQYFRSIPQQRQKLK
. : . ::: : :.: . .:.. :.::::: .:. :::::.:. :: ::. .
NP_001 SQPGN----DFSTKDGDND-KCICKCSQMLTGGWWFDACGPSNLNGMYY---PQ-RQNTN
420 430 440 450 460
380 390 400
pF1KE4 K--GIFWKTWRGRYYPLQATTMLIQPMAAEAAS
: :: : :.: : :.::::.:.:
NP_001 KFNGIKWYYWKGSGYSLKATTMMIRPADF
470 480 490
>>NP_001112360 (OMIM: 601922) angiopoietin-2 isoform c p (444 aa)
initn: 462 init1: 285 opt: 606 Z-score: 551.7 bits: 111.1 E(85289): 5.4e-24
Smith-Waterman score: 606; 33.5% identity (63.7% similar) in 358 aa overlap (60-399:100-441)
30 40 50 60 70 80
pF1KE4 SKSPRFASWDEMNVLAHGLLQLGQGLREHAERTRSQLSALERRLSACGSACQGTEGSTDL
. :: .:. ::. ::. : . ....
NP_001 PLEYDDSVQRLQVLENIMENNTQWLMKVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEI
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE4 PLAPE--SRVDPEVL-----HSLQTQ-LKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQ
. : .. .:: : .: : .: .....: : :..:. .:. . .:
NP_001 NKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVL---VSKQNSIIEELEKKIVTAT
130 140 150 160 170 180
150 160 170 180 190
pF1KE4 SQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHN--VSRLHRLP-RDCQELFQVGERQ
. ..:.... :.. . . . : : . . :.. :.. ... ::: :.:. :.
NP_001 VNNSVLQKQQ--HDLMETV--NNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTT
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE4 SGLFEIQ-PQGSPPFLVNCKMTSDGG-WTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFW
.:.. . :... . . : : . :: ::.::::.::::::.: :. ::.:::.: ::.:
NP_001 NGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYW
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE4 LGLEKVHSITGDRNSRLAVQLRDWDGN-AELLQFSVHLGGEDTAYSLQLTA--PVAGQLG
:: : : ..:... : ..:.::.:: : : .:..:. : ..: . .::...
NP_001 LGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKIS
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE4 ATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLNGQYFRSIPQQRQK
. . : . ::: : :.: . .:.. :.::::: .:. :::::.:. :: ::.
NP_001 SISQPGN----DFSTKDGDND-KCICKCSQMLTGGWWFDACGPSNLNGMYY---PQ-RQN
370 380 390 400 410
380 390 400
pF1KE4 LKK--GIFWKTWRGRYYPLQATTMLIQPMAAEAAS
.: :: : :.: : :.::::.:.:
NP_001 TNKFNGIKWYYWKGSGYSLKATTMMIRPADF
420 430 440
>>NP_001138 (OMIM: 601922) angiopoietin-2 isoform a prec (496 aa)
initn: 462 init1: 285 opt: 606 Z-score: 551.0 bits: 111.2 E(85289): 5.9e-24
Smith-Waterman score: 606; 33.5% identity (63.7% similar) in 358 aa overlap (60-399:152-493)
30 40 50 60 70 80
pF1KE4 SKSPRFASWDEMNVLAHGLLQLGQGLREHAERTRSQLSALERRLSACGSACQGTEGSTDL
. :: .:. ::. ::. : . ....
NP_001 AVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEI
130 140 150 160 170 180
90 100 110 120 130 140
pF1KE4 PLAPE--SRVDPEVL-----HSLQTQ-LKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQ
. : .. .:: : .: : .: .....: : :..:. .:. . .:
NP_001 NKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVL---VSKQNSIIEELEKKIVTAT
190 200 210 220 230
150 160 170 180 190
pF1KE4 SQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHN--VSRLHRLP-RDCQELFQVGERQ
. ..:.... :.. . . . : : . . :.. :.. ... ::: :.:. :.
NP_001 VNNSVLQKQQ--HDLMETV--NNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTT
240 250 260 270 280 290
200 210 220 230 240 250
pF1KE4 SGLFEIQ-PQGSPPFLVNCKMTSDGG-WTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFW
.:.. . :... . . : : . :: ::.::::.::::::.: :. ::.:::.: ::.:
NP_001 NGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYW
300 310 320 330 340 350
260 270 280 290 300 310
pF1KE4 LGLEKVHSITGDRNSRLAVQLRDWDGN-AELLQFSVHLGGEDTAYSLQLTA--PVAGQLG
:: : : ..:... : ..:.::.:: : : .:..:. : ..: . .::...
NP_001 LGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKIS
360 370 380 390 400 410
320 330 340 350 360 370
pF1KE4 ATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLNGQYFRSIPQQRQK
. . : . ::: : :.: . .:.. :.::::: .:. :::::.:. :: ::.
NP_001 SISQPGN----DFSTKDGDND-KCICKCSQMLTGGWWFDACGPSNLNGMYY---PQ-RQN
420 430 440 450 460
380 390 400
pF1KE4 LKK--GIFWKTWRGRYYPLQATTMLIQPMAAEAAS
.: :: : :.: : :.::::.:.:
NP_001 TNKFNGIKWYYWKGSGYSLKATTMMIRPADF
470 480 490
>>XP_005245634 (OMIM: 603874) PREDICTED: angiopoietin-re (491 aa)
initn: 514 init1: 261 opt: 591 Z-score: 537.8 bits: 108.7 E(85289): 3.3e-23
Smith-Waterman score: 595; 34.3% identity (65.7% similar) in 300 aa overlap (117-400:198-490)
90 100 110 120 130 140
pF1KE4 TDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLFHKVAQQQRHLEKQHLRI--QHLQS--
.: .. ..:. :. ... ::. .
XP_005 MATRYRELEVKYASLTDLVNNQSVMITLLEEQCLRIFSRQDTHVSPPLVQVVPQHIPNSQ
170 180 190 200 210 220
150 160 170 180 190
pF1KE4 QF--GLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHN------VSRLHRLP-RDCQELFQ
:. ::: ...... . : : .: ..:... :. ... : .:::. .
XP_005 QYTPGLLGGNEIQRDPGYP--RDLMPPPDLATSPTKSPFKIPPVTFINEGPFKDCQQAKE
230 240 250 260 270 280
200 210 220 230 240 250
pF1KE4 VGERQSGLFEIQPQGSP-PFLVNCKMTSD-GGWTVIQRRHDGSVDFNRPWEAYKAGFGDP
.:. ::.. :.:..: :. . :. . : :::::::.: ::::.: : :: :: :::.
XP_005 AGHSVSGIYMIKPENSNGPMQLWCENSLDPGGWTVIQKRTDGSVNFFRNWENYKKGFGNI
290 300 310 320 330 340
260 270 280 290 300 310
pF1KE4 HGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFS-VHLGGEDTAYSLQLTAPVAG
::.:::::... .... : .: ..:.::. . ..: .: :. : :.: . :
XP_005 DGEYWLGLENIYMLSNQDNYKLLIELEDWSDKKVYAEYSSFRLEPESEFYRLRL-GTYQG
350 360 370 380 390 400
320 330 340 350 360 370
pF1KE4 QLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLNGQYFRSIPQQ
. : . . .: . :.: :.:.:. :::. .::::...:.:::::: ..:. .
XP_005 NAGDSMMWHNGKQ--FTTLDRDKDMYAG-NCAHFHKGGWWYNACAHSNLNGVWYRG-GHY
410 420 430 440 450 460
380 390 400
pF1KE4 RQKLKKGIFWKTWRGRYYPLQATTMLIQPMAAEAAS
:.: . :::: .:: : :.:. :.:.:.
XP_005 RSKHQDGIFWAEYRGGSYSLRAVQMMIKPID
470 480 490
406 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 22:58:04 2016 done: Sat Nov 5 22:58:05 2016
Total Scan time: 8.540 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]