Result of FASTA (ccds) for
pFN21AE4372
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4372, 390 aa
1>>>pF1KE4372 390 - 390 aa - 390 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4151+/-0.000858; mu= 16.2895+/- 0.051
mean_var=66.1853+/-13.386, 0's: 0 Z-trim(105.9): 20 B-trim: 0 in 0/50
Lambda= 0.157650
statistics sampled from 8646 (8660) to 8646 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.644), E-opt: 0.2 (0.266), width: 16
Scan time: 2.700
The best scores are: opt bits E(32554)
CCDS14192.1 PDHA1 gene_id:5160|Hs108|chrX ( 390) 2624 605.7 2.3e-173
CCDS55381.1 PDHA1 gene_id:5160|Hs108|chrX ( 397) 2600 600.3 1e-171
CCDS55380.1 PDHA1 gene_id:5160|Hs108|chrX ( 428) 2511 580.0 1.3e-165
CCDS3644.1 PDHA2 gene_id:5161|Hs108|chr4 ( 388) 2263 523.6 1.2e-148
CCDS55382.1 PDHA1 gene_id:5160|Hs108|chrX ( 359) 1285 301.1 1e-81
CCDS12581.1 BCKDHA gene_id:593|Hs108|chr19 ( 445) 424 105.4 1.1e-22
>>CCDS14192.1 PDHA1 gene_id:5160|Hs108|chrX (390 aa)
initn: 2624 init1: 2624 opt: 2624 Z-score: 3226.0 bits: 605.7 E(32554): 2.3e-173
Smith-Waterman score: 2624; 100.0% identity (100.0% similar) in 390 aa overlap (1-390:1-390)
10 20 30 40 50 60
pF1KE4 MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 HGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 HGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
310 320 330 340 350 360
370 380 390
pF1KE4 LEELGYHIYSSDPPFEVRGANQWIKFKSVS
::::::::::::::::::::::::::::::
CCDS14 LEELGYHIYSSDPPFEVRGANQWIKFKSVS
370 380 390
>>CCDS55381.1 PDHA1 gene_id:5160|Hs108|chrX (397 aa)
initn: 1992 init1: 1992 opt: 2600 Z-score: 3196.4 bits: 600.3 E(32554): 1e-171
Smith-Waterman score: 2600; 98.2% identity (98.2% similar) in 397 aa overlap (1-390:1-397)
10 20 30 40 50 60
pF1KE4 MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
10 20 30 40 50 60
70 80 90 100 110
pF1KE4 GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQ-------EACCVGLEAGINPTDH
::::::::::::::::::::::::::::::::::::: ::::::::::::::::
CCDS55 GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQFLLPLTQEACCVGLEAGINPTDH
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 LITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 LITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 GAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 GAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 ERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 ERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHS
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE4 MSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 MSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFA
310 320 330 340 350 360
360 370 380 390
pF1KE4 TADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS
:::::::::::::::::::::::::::::::::::::
CCDS55 TADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS
370 380 390
>>CCDS55380.1 PDHA1 gene_id:5160|Hs108|chrX (428 aa)
initn: 2511 init1: 2511 opt: 2511 Z-score: 3086.5 bits: 580.0 E(32554): 1.3e-165
Smith-Waterman score: 2511; 99.5% identity (99.7% similar) in 373 aa overlap (18-390:56-428)
10 20 30 40
pF1KE4 MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLE
. ::::::::::::::::::::::::::::
CCDS55 LPSLVSISRLKQSSHLGLPKCWDYSHSLKTRQASRVLVASRNFANDATFEIKKCDLHRLE
30 40 50 60 70 80
50 60 70 80 90 100
pF1KE4 EGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 EGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAG
90 100 110 120 130 140
110 120 130 140 150 160
pF1KE4 INPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 INPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIV
150 160 170 180 190 200
170 180 190 200 210 220
pF1KE4 GAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 GAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRY
210 220 230 240 250 260
230 240 250 260 270 280
pF1KE4 GMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 GMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTY
270 280 290 300 310 320
290 300 310 320 330 340
pF1KE4 RYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 RYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIE
330 340 350 360 370 380
350 360 370 380 390
pF1KE4 DAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS
:::::::::::::::::::::::::::::::::::::::::::
CCDS55 DAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS
390 400 410 420
>>CCDS3644.1 PDHA2 gene_id:5161|Hs108|chr4 (388 aa)
initn: 2256 init1: 2256 opt: 2263 Z-score: 2782.3 bits: 523.6 E(32554): 1.2e-148
Smith-Waterman score: 2263; 85.8% identity (94.1% similar) in 388 aa overlap (4-390:1-388)
10 20 30 40 50
pF1KE4 MRKMLAA-VSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRE
:::: .:::: ..:: : :::::::: .::::::::::::. :::::::::::::
CCDS36 MLAAFISRVLRRVAQKSARRVLVASRNSSNDATFEIKKCDLYLLEEGPPVTTVLTRA
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 DGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYR
.:::::::: ::::::::::::::::.::::::::::::::::::::::::.::.::.::
CCDS36 EGLKYYRMMLTVRRMELKADQLYKQKFIRGFCHLCDGQEACCVGLEAGINPSDHVITSYR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 AHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIAL
::: .::::::: ::::::::.::::::::::::::.::::::::::::: ::::::::
CCDS36 AHGVCYTRGLSVRSILAELTGRRGGCAKGKGGSMHMYTKNFYGGNGIVGAQGPLGAGIAL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 ACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAS
::::.:.::.::::::::::::::: ::.::::::::::.:::::: ::::::.::::::
CCDS36 ACKYKGNDEICLTLYGDGAANQGQIAEAFNMAALWKLPCVFICENNLYGMGTSTERAAAS
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 TDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGV
::::::.:::::.:::::.:::::::.::: ::::::::::::::::::::::::::::
CCDS36 PDYYKRGNFIPGLKVDGMDVLCVREATKFAANYCRSGKGPILMELQTYRYHGHSMSDPGV
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE4 SYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEP
:::::::::::::: :::..:.::::::.::.::::::: .::::::.:::::::.::::
CCDS36 SYRTREEIQEVRSKRDPIIILQDRMVNSKLATVEELKEIGAEVRKEIDDAAQFATTDPEP
300 310 320 330 340 350
360 370 380 390
pF1KE4 PLEELGYHIYSSDPPFEVRGANQWIKFKSVS
:::::.:::::: ::::::: ::::::::
CCDS36 HLEELGHHIYSSDSSFEVRGANPWIKFKSVS
360 370 380
>>CCDS55382.1 PDHA1 gene_id:5160|Hs108|chrX (359 aa)
initn: 1280 init1: 1280 opt: 1285 Z-score: 1580.7 bits: 301.1 E(32554): 1e-81
Smith-Waterman score: 2340; 92.1% identity (92.1% similar) in 390 aa overlap (1-390:1-359)
10 20 30 40 50 60
pF1KE4 MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 HGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 HGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQ----------
130 140 150 160 170
190 200 210 220 230 240
pF1KE4 CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
:::::::::::::::::::::::::::::::::::::::
CCDS55 ---------------------GQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
180 190 200
250 260 270 280 290 300
pF1KE4 DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE4 YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
270 280 290 300 310 320
370 380 390
pF1KE4 LEELGYHIYSSDPPFEVRGANQWIKFKSVS
::::::::::::::::::::::::::::::
CCDS55 LEELGYHIYSSDPPFEVRGANQWIKFKSVS
330 340 350
>>CCDS12581.1 BCKDHA gene_id:593|Hs108|chr19 (445 aa)
initn: 215 init1: 163 opt: 424 Z-score: 520.9 bits: 105.4 E(32554): 1.1e-22
Smith-Waterman score: 424; 27.6% identity (56.5% similar) in 322 aa overlap (56-373:97-417)
30 40 50 60 70 80
pF1KE4 ASRNFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQK
: .: :: :. : . :. . .:
CCDS12 FIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLLNTMDRILYESQRQG
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE4 IIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGC
: .: :.:. :: :... :: .. :: : . : .. ..:. : .
CCDS12 RI-SFYMTNYGEEGTHVGSAAALDNTDLVFGQYREAGVLMYRDYPLELFMAQCYGNISDL
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE4 AKGKGGSMHMYAK--NFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQ
.::. .:. : .: .. ...:.: ..: : : : . ..: . .:.:::..:.
CCDS12 GKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEGD
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE4 IFEAYNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDF--IPGLRVDGMDILC
..:.:: . : ::.:.:: :...: . . . :: : ..:::: :..
CCDS12 AHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFA
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE4 VREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLK
: .::. : . . :.:.: .::: :: :: . .::. .:.. ... :: :.
CCDS12 VYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLR
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE4 DRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGAN
..... . :. : . :... .: . : :.: . : .:. :
CCDS12 HYLLSQGWWDEEQEKAWRKQSRRKVMEAFEQAERKPKPNPNLLFSDVYQEMPAQLRKQQE
370 380 390 400 410 420
390
pF1KE4 QWIKFKSVS
CCDS12 SLARHLQTYGEHYPLDHFDK
430 440
390 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 23:06:21 2016 done: Sat Nov 5 23:06:22 2016
Total Scan time: 2.700 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]