Result of FASTA (ccds) for
pFN21AE4365
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4365, 383 aa
1>>>pF1KE4365 383 - 383 aa - 383 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1296+/-0.00125; mu= 15.0249+/- 0.075
mean_var=214.5187+/-40.073, 0's: 0 Z-trim(110.3): 229 B-trim: 7 in 1/52
Lambda= 0.087567
statistics sampled from 11277 (11522) to 11277 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.714), E-opt: 0.2 (0.354), width: 16
Scan time: 2.740
The best scores are: opt bits E(32554)
CCDS9963.1 DLK1 gene_id:8788|Hs108|chr14 ( 383) 2777 363.8 1.4e-100
CCDS81852.1 DLK1 gene_id:8788|Hs108|chr14 ( 310) 1767 236.1 3.3e-62
CCDS4897.1 DLK2 gene_id:65989|Hs108|chr6 ( 383) 904 127.2 2.5e-29
CCDS75461.1 DLK2 gene_id:65989|Hs108|chr6 ( 377) 850 120.4 2.8e-27
CCDS5313.1 DLL1 gene_id:28514|Hs108|chr6 ( 723) 832 118.5 1.9e-26
CCDS45232.1 DLL4 gene_id:54567|Hs108|chr15 ( 685) 800 114.4 3e-25
CCDS13112.1 JAG1 gene_id:182|Hs108|chr20 (1218) 750 108.5 3.3e-23
CCDS9999.1 JAG2 gene_id:3714|Hs108|chr14 (1200) 742 107.5 6.6e-23
CCDS9998.1 JAG2 gene_id:3714|Hs108|chr14 (1238) 733 106.4 1.5e-22
CCDS908.1 NOTCH2 gene_id:4853|Hs108|chr1 (2471) 627 93.4 2.3e-18
CCDS43905.1 NOTCH1 gene_id:4851|Hs108|chr9 (2555) 622 92.8 3.6e-18
CCDS12326.1 NOTCH3 gene_id:4854|Hs108|chr19 (2321) 592 89.0 4.7e-17
CCDS34420.1 NOTCH4 gene_id:4855|Hs108|chr6 (2003) 543 82.7 3.2e-15
CCDS12537.1 DLL3 gene_id:10683|Hs108|chr19 ( 587) 530 80.2 5.2e-15
CCDS12538.1 DLL3 gene_id:10683|Hs108|chr19 ( 618) 530 80.3 5.3e-15
CCDS47445.1 EYS gene_id:346007|Hs108|chr6 (3144) 505 78.2 1.1e-13
CCDS78156.1 EYS gene_id:346007|Hs108|chr6 (3165) 505 78.2 1.1e-13
CCDS58052.1 CRB1 gene_id:23418|Hs108|chr1 ( 870) 495 76.1 1.4e-13
CCDS1390.1 CRB1 gene_id:23418|Hs108|chr1 (1406) 495 76.4 1.8e-13
CCDS53454.1 CRB1 gene_id:23418|Hs108|chr1 (1294) 485 75.1 4.1e-13
CCDS72880.1 NOTCH2NL gene_id:388677|Hs108|chr1 ( 236) 474 72.5 4.3e-13
CCDS64311.1 SLIT3 gene_id:6586|Hs108|chr5 (1530) 469 73.2 1.8e-12
CCDS58053.1 CRB1 gene_id:23418|Hs108|chr1 (1382) 465 72.6 2.4e-12
CCDS4369.1 SLIT3 gene_id:6586|Hs108|chr5 (1523) 460 72.0 4e-12
CCDS75111.1 SLIT2 gene_id:9353|Hs108|chr4 (1521) 459 71.9 4.3e-12
CCDS75110.1 SLIT2 gene_id:9353|Hs108|chr4 (1525) 459 71.9 4.3e-12
CCDS3426.1 SLIT2 gene_id:9353|Hs108|chr4 (1529) 459 71.9 4.3e-12
CCDS7453.1 SLIT1 gene_id:6585|Hs108|chr10 (1534) 455 71.4 6.1e-12
CCDS33390.1 DNER gene_id:92737|Hs108|chr2 ( 737) 443 69.4 1.2e-11
>>CCDS9963.1 DLK1 gene_id:8788|Hs108|chr14 (383 aa)
initn: 2777 init1: 2777 opt: 2777 Z-score: 1919.0 bits: 363.8 E(32554): 1.4e-100
Smith-Waterman score: 2777; 99.5% identity (99.7% similar) in 383 aa overlap (1-383:1-383)
10 20 30 40 50 60
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS99 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS
:::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::
CCDS99 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRTCVSLDDGLYECSCAPGYS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS99 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS99 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 GLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
CCDS99 GLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS99 EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA
310 320 330 340 350 360
370 380
pF1KE4 VNIIFPEKIDMTTFSKEAGDEEI
:::::::::::::::::::::::
CCDS99 VNIIFPEKIDMTTFSKEAGDEEI
370 380
>>CCDS81852.1 DLK1 gene_id:8788|Hs108|chr14 (310 aa)
initn: 1763 init1: 1763 opt: 1767 Z-score: 1230.3 bits: 236.1 E(32554): 3.3e-62
Smith-Waterman score: 2134; 80.7% identity (80.7% similar) in 383 aa overlap (1-383:1-310)
10 20 30 40 50 60
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS81 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS
:::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::
CCDS81 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRTCVSLDDGLYECSCAPGYS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS81 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT
::::::::::::::::::::::::::::::::::::::::::::::::
CCDS81 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQ------------
190 200 210 220
250 260 270 280 290 300
pF1KE4 GLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT
CCDS81 ------------------------------------------------------------
310 320 330 340 350 360
pF1KE4 EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS81 -GQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA
230 240 250 260 270 280
370 380
pF1KE4 VNIIFPEKIDMTTFSKEAGDEEI
:::::::::::::::::::::::
CCDS81 VNIIFPEKIDMTTFSKEAGDEEI
290 300 310
>>CCDS4897.1 DLK2 gene_id:65989|Hs108|chr6 (383 aa)
initn: 513 init1: 492 opt: 904 Z-score: 640.2 bits: 127.2 E(32554): 2.5e-29
Smith-Waterman score: 904; 37.6% identity (63.3% similar) in 319 aa overlap (7-322:10-325)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQC
:. .: .: : :. . . .: :. .: : :. :::.:::.: :..:
CCDS48 MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 VTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECSCA
: ::: :: : .: :::: .:: :..::.: . :.. .:: :.: :. : :.: :
CCDS48 VRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 PGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTP
::. :.::..: ::: ::::..:: : ::.: : . .: : :: : ::. ...:
CCDS48 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 NPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCK
:: : ..: : . : : :: :: . :. . .::: ::: :. : .... ...:::
CCDS48 RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH-DFDCLCP
190 200 210 220 230
240 250 260 270 280 290
pF1KE4 PEFTGLTCVKKRAL-SPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKK
. : :: . .: .. : : : ..:.. : .. .:..:.::. ..
CCDS48 SGYGGKTCELVLPVPDPPTTVDTPLGPTSAV-VVPATGPAP-HSAGAGLLRISVKEVVRR
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE4 TPL-LTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYN
: : . . ....:.::. .::.::
CCDS48 QEAGLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQE
300 310 320 330 340 350
>>CCDS75461.1 DLK2 gene_id:65989|Hs108|chr6 (377 aa)
initn: 730 init1: 492 opt: 850 Z-score: 603.4 bits: 120.4 E(32554): 2.8e-27
Smith-Waterman score: 850; 36.7% identity (61.8% similar) in 319 aa overlap (7-322:10-319)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQC
:. .: .: : :. . . .: :. .: : :. :::.:::.: :..:
CCDS75 MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 VTSPGCLHGLCGEPGQCICTDGW-DGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCA
: ::: :: : .: :::: .:: : ..: ...:: :.: :. : :.: :
CCDS75 VRMPGCQHGTCHQPWQCICHSGWADEHICT------TQSPCQNGGQCMYDGGGEYHCVCL
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 PGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTP
::. :.::..: ::: ::::..:: : ::.: : . .: : :: : ::. ...:
CCDS75 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 NPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCK
:: : ..: : . : : :: :: . :. . .::: ::: :. : .... ...:::
CCDS75 RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH-DFDCLCP
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 PEFTGLTCVKKRAL-SPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKK
. : :: . .: .. : : : ..:.. : .. .:..:.::. ..
CCDS75 SGYGGKTCELVLPVPDPPTTVDTPLGPTSAV-VVPATGPAP-HSAGAGLLRISVKEVVRR
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE4 TPL-LTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYN
: : . . ....:.::. .::.::
CCDS75 QEAGLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQE
300 310 320 330 340 350
>>CCDS5313.1 DLL1 gene_id:28514|Hs108|chr6 (723 aa)
initn: 742 init1: 345 opt: 832 Z-score: 588.3 bits: 118.5 E(32554): 1.9e-26
Smith-Waterman score: 832; 43.4% identity (67.0% similar) in 221 aa overlap (26-244:226-440)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCD
:.:.:. :.:::. . :.:. :::: ::
CCDS53 DDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCD
200 210 220 230 240 250
60 70 80 90 100 110
pF1KE4 QCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECS
.:. :::::: : .: :: : .:: : .:..:. :. :: :..::.. .: : ::
CCDS53 ECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCS
260 270 280 290 300 310
120 130 140 150 160 170
pF1KE4 CAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC
: :::.: :. : . :::..::.:.: : . :: ::::: :..::. : .:
CCDS53 CRPGYTGATCELGIDEC--DPSPCKNGGSCTDLE---NSYSCTCPPGFYGKICELSAMTC
320 330 340 350 360 370
180 190 200 210 220 230
pF1KE4 TPNPCENDGVCTDI-GGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYEC
. .:: : : :.: : . ::::.:. .: . . :.::::.::. :.. . .: :
CCDS53 ADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD-AYLC
380 390 400 410 420
240 250 260 270 280 290
pF1KE4 LCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELN
:. :.: :
CCDS53 RCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAP
430 440 450 460 470 480
>>CCDS45232.1 DLL4 gene_id:54567|Hs108|chr15 (685 aa)
initn: 794 init1: 329 opt: 800 Z-score: 566.7 bits: 114.4 E(32554): 3e-25
Smith-Waterman score: 801; 36.3% identity (60.1% similar) in 311 aa overlap (26-331:222-518)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCD
:. .:. :::.: : :.::::: ::.
CCDS45 NDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCN
200 210 220 230 240 250
60 70 80 90 100 110
pF1KE4 QCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECS
.:. :: :: :. : :: : .:: : .::.:. :. .:: :..:: . . : :.
CCDS45 ECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCT
260 270 280 290 300 310
120 130 140 150 160 170
pF1KE4 CAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC
: :::.: ::. . . : ...::..::.: :.: . : ::::::. : :: . ::
CCDS45 CRPGYTGVDCELELSEC--DSNPCRNGGSCKDQED-GYH--CLCPPGYYGLHCEHSTLSC
320 330 340 350 360
180 190 200 210 220 230
pF1KE4 TPNPCENDGVCTD--IGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYE
. .:: : : : . :... :.:: .: ..: . : :.:.:: ::: ::.. :
CCDS45 ADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGP-SRM
370 380 390 400 410 420
240 250 260 270 280 290
pF1KE4 CLCKPEFTGLTCVKKRALSPQQVTRLPNGYG-LAYRLTPGVH-ELPVQQPEHRILKVSMK
: :.: ::: : : .. .: : ..: . : :. :. .: .
CCDS45 CRCRPGFTGTYC----ELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSI
430 440 450 460 470 480
300 310 320 330 340 350
pF1KE4 ELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLL
. ..: . ..: :.: :.. ..: :.: ..::
CCDS45 DACASSPCF--NRATCYTDLST-DTFVCNCPYGFVG-SRCEFPVGLPPSFPWVAVSLGVG
490 500 510 520 530
360 370 380
pF1KE4 LQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI
CCDS45 LAVLLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVD
540 550 560 570 580 590
>>CCDS13112.1 JAG1 gene_id:182|Hs108|chr20 (1218 aa)
initn: 972 init1: 297 opt: 750 Z-score: 530.2 bits: 108.5 E(32554): 3.3e-23
Smith-Waterman score: 750; 39.2% identity (64.4% similar) in 222 aa overlap (24-244:232-447)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPL
: : .:.:..: :. . :::: ::::
CCDS13 PRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLY
210 220 230 240 250 260
60 70 80 90 100 110
pF1KE4 CDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYE
::.:. :::.::.:.:: ::.: .: :.:::.:. :.. :: :.::: . :.
CCDS13 CDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQ
270 280 290 300 310 320
120 130 140 150 160 170
pF1KE4 CSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVAN
::: :::: .:. . :. ..::.. :.: . . : : ::..: : .
CCDS13 CSCPEGYSGPNCEIAEHACL--SDPCHNRGSCKET---SLGFECECSPGWTGPTCSTNID
330 340 350 360 370
180 190 200 210 220 230
pF1KE4 SCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYE
.:.:: : . :.: :. . :.: :: . :::. ...: ..:: :. .: .. .::
CCDS13 DCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSC-KNLIASYY
380 390 400 410 420 430
240 250 260 270 280 290
pF1KE4 CLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKEL
: : : . : .:
CCDS13 CDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNP
440 450 460 470 480 490
>--
initn: 736 init1: 265 opt: 521 Z-score: 373.8 bits: 79.6 E(32554): 1.7e-14
Smith-Waterman score: 624; 37.7% identity (64.0% similar) in 228 aa overlap (30-244:599-817)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDN----VCRCQPGWQGPLC-
:.:. : :.... .: :. :. : :
CCDS13 TTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPH-GKCKSQSGGKFTCDCNKGFTGTYCH
570 580 590 600 610 620
60 70 80 90 100
pF1KE4 ---DQCVTSPGCLHG-LCGE---PGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLD
..: ..: : .: : . .:::.:::.: :. .. ::. :: :.::: .:
CCDS13 ENINDCESNP-CRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLV
630 640 650 660 670 680
110 120 130 140 150 160
pF1KE4 DGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFC
. .: :.: :..:: :...:. : . . :..:::: : :: : .:.:: :. :. :
CCDS13 NDFY-CDCKNGWKGKTCHSRDSQC--DEATCNNGGTCYD-EGDAF--KCMCPGGWEGTTC
690 700 710 720 730 740
170 180 190 200 210 220
pF1KE4 EIVANS-CTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH
.:. :: : ::::.: :.:. : .: : : :. :.. ...:. :: :.:::..
CCDS13 NIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDG
750 760 770 780 790 800
230 240 250 260 270 280
pF1KE4 TQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILK
. :.: : : :.: :
CCDS13 DNW-YRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVS
810 820 830 840 850
>>CCDS9999.1 JAG2 gene_id:3714|Hs108|chr14 (1200 aa)
initn: 1053 init1: 302 opt: 742 Z-score: 524.8 bits: 107.5 E(32554): 6.6e-23
Smith-Waterman score: 748; 37.2% identity (57.7% similar) in 298 aa overlap (18-311:237-518)
10 20 30 40
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQP
:. : : .:: .: : . :::.
CCDS99 CNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSY
210 220 230 240 250 260
50 60 70 80 90 100
pF1KE4 GWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSA-PCANNGTCVSL
:::: .::.:: :::.:: : :: :: : .: : :::.:. :.: ::.:.:::..
CCDS99 GWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINA
270 280 290 300 310 320
110 120 130 140 150 160
pF1KE4 DDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNF
. :.:.: ::::..:.: . :. : :: .::.: . : : :: :.::
CCDS99 EPDQYRCTCPDGYSGRNCEKAEHACTSN--PCANGGSCHE---VPSGFECHCPSGWSGPT
330 340 350 360 370 380
170 180 190 200 210 220
pF1KE4 CEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH
: . . :. ::: :.:.: :.: :: .. ::. :..: . ::.:::: .
CCDS99 CALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDC-RGQCQHGGTC-KD
390 400 410 420 430
230 240 250 260 270 280
pF1KE4 TQVSYECLCKPEFTGLTCVKKR---ALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHR
.:.:.: : : : .: : :: . .: :: :. : : :
CCDS99 LVNGYQCVCPRGFGGRHCELERDECASSPCH-----SG-GLCEDLADGFHCHCPQGFSGP
440 450 460 470 480 490
290 300 310 320 330 340
pF1KE4 ILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHML
. .:.. .: . .: .. : :... :
CCDS99 LCEVDV-DLCEPSP--CRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDG
500 510 520 530 540 550
>--
initn: 604 init1: 256 opt: 477 Z-score: 343.8 bits: 74.0 E(32554): 7.8e-13
Smith-Waterman score: 591; 36.4% identity (55.6% similar) in 239 aa overlap (21-244:593-824)
10 20 30 40
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQ----NGFCEDDN---VC
:: : . : : .: : :. :
CCDS99 AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC
570 580 590 600 610 620
50 60 70 80 90
pF1KE4 RCQPGWQGPLCD----QCVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDVRACSSAP
: ::.: ::: .:. .: .: : . : : ::: :. : :..
CCDS99 FCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT
630 640 650 660 670 680
100 110 120 130 140 150
pF1KE4 CANNGTCVSLDDGLYECSCAPGYSGKDCQ-KKDGPCVINGSPCQHGGTCVDDEGRASHAS
:.:.::: . : ..:.: ::..:. : :.. :. : :: .::::: : .. :
CCDS99 CSNGGTCYDSGD-TFRCACPPGWKGSTCAVAKNSSCLPN--PCVNGGTCV---GSGASFS
690 700 710 720 730
160 170 180 190 200 210
pF1KE4 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS
:.: :. : : .:.:.: :: : :.:.: . :::.: :: : . .: ::
CCDS99 CICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSS
740 750 760 770 780 790
220 230 240 250 260 270
pF1KE4 PCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHEL
:: :.::... . .:.: : : .: :
CCDS99 PCAYGATCVDEIN-GYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCR
800 810 820 830 840 850
>>CCDS9998.1 JAG2 gene_id:3714|Hs108|chr14 (1238 aa)
initn: 1253 init1: 302 opt: 733 Z-score: 518.5 bits: 106.4 E(32554): 1.5e-22
Smith-Waterman score: 733; 39.9% identity (61.8% similar) in 228 aa overlap (18-244:237-458)
10 20 30 40
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQP
:. : : .:: .: : . :::.
CCDS99 CNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSY
210 220 230 240 250 260
50 60 70 80 90 100
pF1KE4 GWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSA-PCANNGTCVSL
:::: .::.:: :::.:: : :: :: : .: : :::.:. :.: ::.:.:::..
CCDS99 GWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINA
270 280 290 300 310 320
110 120 130 140 150 160
pF1KE4 DDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNF
. :.:.: ::::..:.: . :. : :: .::.: . : : :: :.::
CCDS99 EPDQYRCTCPDGYSGRNCEKAEHACTSN--PCANGGSCHE---VPSGFECHCPSGWSGPT
330 340 350 360 370 380
170 180 190 200 210 220
pF1KE4 CEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH
: . . :. ::: :.:.: :.: :: .. ::. ...: ..:: :. .: ..
CCDS99 CALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSC-KN
390 400 410 420 430 440
230 240 250 260 270 280
pF1KE4 TQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILK
.: : : : . :..:
CCDS99 LIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERD
450 460 470 480 490 500
>>CCDS908.1 NOTCH2 gene_id:4853|Hs108|chr1 (2471 aa)
initn: 1105 init1: 309 opt: 627 Z-score: 443.2 bits: 93.4 E(32554): 2.3e-18
Smith-Waterman score: 633; 39.4% identity (59.3% similar) in 236 aa overlap (25-244:341-567)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAEC-FPACNPQNGFCEDDNV---CRCQPGWQ
.: : .:.: .. : : . : : :
CCDS90 NGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTP-GSTCIDRVASFSCMCPEGKA
320 330 340 350 360
60 70 80 90
pF1KE4 GPLC---DQCVTSPGCLHG-LCG-EP--GQ--CICTDGWDGELCDRDVRACS---SAPCA
: :: : :...: : .: :: .: :: : : .:. : : .:: :. : ::
CCDS90 GLLCHLDDACISNP-CHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCE
370 380 390 400 410 420
100 110 120 130 140 150
pF1KE4 NNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLC
. : ::. : : ..: : ::.: :. . : ...:::. .::.: : .:::
CCDS90 HAGKCVNTD-GAFHCECLKGYAGPRCEMDINEC--HSDPCQNDATCLDKIG---GFTCLC
430 440 450 460 470 480
160 170 180 190 200 210
pF1KE4 PPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQ
:::.: ::. : : ::: :.: :.: . :.: :: :: .:. . .:.:.::
CCDS90 MPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCL
490 500 510 520 530 540
220 230 240 250 260 270
pF1KE4 NGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQ
::. :..: . .::: : :::. :
CCDS90 NGAKCIDHPN-GYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMG
550 560 570 580 590 600
>--
initn: 1105 init1: 309 opt: 627 Z-score: 443.2 bits: 93.4 E(32554): 2.3e-18
Smith-Waterman score: 627; 38.5% identity (61.9% similar) in 231 aa overlap (25-244:876-1098)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDN---VCRCQPGWQG
::. ..:.:.. . .:.: ::..:
CCDS90 AVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSG
850 860 870 880 890 900
60 70 80 90 100
pF1KE4 PLC----DQCVTSPGCLHGLCGEPG----QCICTDGWDGELCDRDVRACSSAPCANNGTC
: :.:...: : .: : .:.: :. :. :. :. : : :: :.:::
CCDS90 MDCEEDIDDCLANP-CQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTC
910 920 930 940 950 960
110 120 130 140 150 160
pF1KE4 VSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFS
. .. : :.: :..: :... . :. : : .:::::: : : ::::: ::.
CCDS90 SDYVNS-YTCKCQAGFDGVHCENNINECT--ESSCFNGGTCVD--GINSF-SCLCPVGFT
970 980 990 1000 1010
170 180 190 200 210 220
pF1KE4 GNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTC
:.:: : :. .:: :.:.:.: : .:: :: :. :.:. :. :. :::.: :::
CCDS90 GSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTC
1020 1030 1040 1050 1060 1070
230 240 250 260 270 280
pF1KE4 LQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHR
.:. : .::: ..: :
CCDS90 VQKKAES-QCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQC
1080 1090 1100 1110 1120 1130
>--
initn: 262 init1: 262 opt: 589 Z-score: 417.3 bits: 88.6 E(32554): 6.4e-17
Smith-Waterman score: 589; 34.9% identity (59.2% similar) in 238 aa overlap (25-252:610-836)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCED---DNVCRCQPGWQG
::. . ..: : : : :::: .:
CCDS90 HHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSG
580 590 600 610 620 630
60 70 80 90 100
pF1KE4 PLC----DQCVTSPGCLHGLCGEP---GQCICTDGWDGELCDRDVRACSSAPCANNGTCV
: :.:...: :.::.: . .:.:. :. :. :. :. :.: :: ...::.
CCDS90 VNCEINFDDCASNP-CIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCI
640 650 660 670 680 690
110 120 130 140 150 160
pF1KE4 SLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSG
. .: ..: : : .: .. . :. : :: ::. :. : : .::: :. :
CCDS90 NGVNG-FRCICPEGPHHPSCYSQVNECLSN--PCIHGN-CT---GGLSGYKCLCDAGWVG
700 710 720 730 740 750
170 180 190 200 210 220
pF1KE4 NFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCL
::. : : :::.: :.: .. . .:: : :: .:. . .:::.:: : :::.
CCDS90 INCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCF
760 770 780 790 800 810
230 240 250 260 270 280
pF1KE4 QHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRI
. . .: : : .:: .: . .:.:
CCDS90 DDIS-GYTCHCVLPYTGKNC--QTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQ
820 830 840 850 860
>--
initn: 491 init1: 263 opt: 587 Z-score: 415.9 bits: 88.4 E(32554): 7.6e-17
Smith-Waterman score: 587; 34.7% identity (58.5% similar) in 277 aa overlap (6-261:7-272)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLL-LAFGHSTYGAECFPACNP--QNGFC----EDDNVCRCQPGWQGP
::: .:: : : . ... .: . .: ..:.: . . :.: :. :
CCDS90 MPALRPALLWALLALWLCCAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGE
10 20 30 40 50 60
60 70 80 90
pF1KE4 LCDQCVTSPGCLHGLCGEPGQCI-----------CTDGWDGELCDRDV-RAC-SSAPCAN
:.. .: : .. : . : :. :..:. :: :. .. . : : :: :
CCDS90 YCQH--RDP-CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLN
70 80 90 100 110
100 110 120 130 140 150
pF1KE4 NGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCP
.::: :. :::.: :..::.:: :. :. . :: .:.::. :.. :: :
CCDS90 GGTCHMLSRDTYECTCQVGFTGKECQWTDA-CL--SHPCANGSTCTT---VANQFSCKCL
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE4 PGFSGNFCEIVANSCT-PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQ
::.:. :: .: : :. :.. :.: .. :...:.:: :: . :. . :: :::
CCDS90 TGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCV
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE4 NGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQ
::::: : . ..:: : : : : :: .. :.. : ::
CCDS90 NGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNH--RCQNGGVCVDGVNTYNCRCPPQ
240 250 260 270 280
280 290 300 310 320 330
pF1KE4 QPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLR
CCDS90 WTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTP
290 300 310 320 330 340
383 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 02:02:44 2016 done: Sun Nov 6 02:02:44 2016
Total Scan time: 2.740 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]