Result of FASTA (omim) for
pFN21AE4315
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4315, 323 aa
1>>>pF1KE4315 323 - 323 aa - 323 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1755+/-0.000394; mu= 17.0125+/- 0.024
mean_var=73.7454+/-14.960, 0's: 0 Z-trim(113.2): 51 B-trim: 0 in 0/49
Lambda= 0.149351
statistics sampled from 22385 (22435) to 22385 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.263), width: 16
Scan time: 6.060
The best scores are: opt bits E(85289)
NP_001809 (OMIM: 600451,614279) aldo-keto reductas ( 323) 2170 476.9 2.5e-134
NP_001344 (OMIM: 600449) aldo-keto reductase famil ( 323) 1848 407.5 1.9e-113
NP_003730 (OMIM: 603966) aldo-keto reductase famil ( 323) 1847 407.3 2.2e-113
NP_001240837 (OMIM: 603966) aldo-keto reductase fa ( 323) 1843 406.4 4e-113
NP_995317 (OMIM: 600450,614279) aldo-keto reductas ( 323) 1818 401.0 1.7e-111
NP_001345 (OMIM: 600450,614279) aldo-keto reductas ( 323) 1818 401.0 1.7e-111
NP_005980 (OMIM: 235555,604741) 3-oxo-5-beta-stero ( 326) 1285 286.2 6.3e-77
NP_001177836 (OMIM: 235555,604741) 3-oxo-5-beta-st ( 290) 1132 253.2 4.8e-67
NP_001619 (OMIM: 103880) aldose reductase isoform ( 316) 1066 239.0 9.8e-63
XP_016871280 (OMIM: 600449) PREDICTED: aldo-keto r ( 297) 1032 231.7 1.5e-60
NP_001307956 (OMIM: 600450,614279) aldo-keto reduc ( 297) 1032 231.7 1.5e-60
NP_064695 (OMIM: 604707) aldo-keto reductase famil ( 316) 1011 227.2 3.6e-59
XP_011514543 (OMIM: 616336) PREDICTED: aldo-keto r ( 316) 965 217.2 3.5e-56
NP_001074007 (OMIM: 616336) aldo-keto reductase fa ( 344) 936 211.0 2.8e-54
XP_016867713 (OMIM: 616336) PREDICTED: aldo-keto r ( 344) 936 211.0 2.8e-54
NP_001189342 (OMIM: 103830) alcohol dehydrogenase ( 325) 905 204.3 2.8e-52
NP_006057 (OMIM: 103830) alcohol dehydrogenase [NA ( 325) 905 204.3 2.8e-52
NP_697021 (OMIM: 103830) alcohol dehydrogenase [NA ( 325) 905 204.3 2.8e-52
NP_001189343 (OMIM: 103830) alcohol dehydrogenase ( 325) 905 204.3 2.8e-52
NP_001240838 (OMIM: 603966) aldo-keto reductase fa ( 138) 699 159.7 3.3e-39
NP_001128713 (OMIM: 600450,614279) aldo-keto reduc ( 139) 653 149.7 3.2e-36
XP_011514718 (OMIM: 604707) PREDICTED: aldo-keto r ( 277) 651 149.5 7.4e-36
NP_001333071 (OMIM: 103880) aldose reductase isofo ( 172) 621 142.9 4.5e-34
XP_005250291 (OMIM: 103880) PREDICTED: aldose redu ( 172) 621 142.9 4.5e-34
XP_011538793 (OMIM: 103830) PREDICTED: alcohol deh ( 214) 590 136.3 5.4e-32
XP_011538794 (OMIM: 103830) PREDICTED: alcohol deh ( 214) 590 136.3 5.4e-32
NP_001177835 (OMIM: 235555,604741) 3-oxo-5-beta-st ( 285) 513 119.8 6.7e-27
XP_011514719 (OMIM: 604707) PREDICTED: aldo-keto r ( 175) 429 101.6 1.3e-21
NP_036199 (OMIM: 608477) aflatoxin B1 aldehyde red ( 331) 171 46.2 0.00011
XP_011539348 (OMIM: 608477) PREDICTED: aflatoxin B ( 375) 171 46.2 0.00013
NP_003680 (OMIM: 603418) aflatoxin B1 aldehyde red ( 359) 157 43.2 0.00099
>>NP_001809 (OMIM: 600451,614279) aldo-keto reductase fa (323 aa)
initn: 2170 init1: 2170 opt: 2170 Z-score: 2532.7 bits: 476.9 E(85289): 2.5e-134
Smith-Waterman score: 2170; 99.7% identity (99.7% similar) in 323 aa overlap (1-323:1-323)
10 20 30 40 50 60
pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP
::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
NP_001 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
250 260 270 280 290 300
310 320
pF1KE4 RNYRYVVMDFLMDHPDYPFSDEY
:::::::::::::::::::::::
NP_001 RNYRYVVMDFLMDHPDYPFSDEY
310 320
>>NP_001344 (OMIM: 600449) aldo-keto reductase family 1 (323 aa)
initn: 1848 init1: 1848 opt: 1848 Z-score: 2157.7 bits: 407.5 E(85289): 1.9e-113
Smith-Waterman score: 1848; 83.0% identity (95.0% similar) in 323 aa overlap (1-323:1-323)
10 20 30 40 50 60
pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
:: ::: :.::::::::::::::::: :::...:.:.:::::::::::::::.:::::::
NP_001 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
:::::::::::::::::::::::::::. .:..:.:::: :::.::::::::::.:::.
NP_001 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP
..:::: .:::::::..:::::: ::::..:::::::::::::::::: ::::::::::
NP_001 SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
::::::::::::::::.:: :::::::::::::::.::::..:.. ::::::::::::::
NP_001 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
::::::::::::::::::::::::::::::::::::::.:.::::::::::.::..::::
NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
250 260 270 280 290 300
310 320
pF1KE4 RNYRYVVMDFLMDHPDYPFSDEY
:: ::...:.. :.:::::::
NP_001 RNVRYLTLDIFAGPPNYPFSDEY
310 320
>>NP_003730 (OMIM: 603966) aldo-keto reductase family 1 (323 aa)
initn: 1847 init1: 1847 opt: 1847 Z-score: 2156.6 bits: 407.3 E(85289): 2.2e-113
Smith-Waterman score: 1847; 84.2% identity (93.5% similar) in 323 aa overlap (1-323:1-323)
10 20 30 40 50 60
pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
:: :.: :.::::::::::::::::::::::..:.:::::::::::::::::.:::::::
NP_003 MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
:::::::::::::::::::::::::: :: .:..:.::::.:::: :::::::::.: ::
NP_003 VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP
.::::: : ::::::::: ::: .:::.::::::::::::::::::: ::::::::::
NP_003 SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
::::::::::::::::.:.::::::::::::::::.::::.:: : ::::::::::::::
NP_003 GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
::::::::::::::::::::::::::::::::::::::.:.::::::::.::::..:::.
NP_003 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
250 260 270 280 290 300
310 320
pF1KE4 RNYRYVVMDFLMDHPDYPFSDEY
:: .: : . .::.::.::::
NP_003 RNLHYFNSDSFASHPNYPYSDEY
310 320
>>NP_001240837 (OMIM: 603966) aldo-keto reductase family (323 aa)
initn: 1843 init1: 1843 opt: 1843 Z-score: 2151.9 bits: 406.4 E(85289): 4e-113
Smith-Waterman score: 1843; 83.9% identity (93.5% similar) in 323 aa overlap (1-323:1-323)
10 20 30 40 50 60
pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
:: :.: ..::::::::::::::::::::::..:.:::::::::::::::::.:::::::
NP_001 MDSKHQCLKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
:::::::::::::::::::::::::: :: .:..:.::::.:::: :::::::::.: ::
NP_001 VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP
.::::: : ::::::::: ::: .:::.::::::::::::::::::: ::::::::::
NP_001 SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
::::::::::::::::.:.::::::::::::::::.::::.:: : ::::::::::::::
NP_001 GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
::::::::::::::::::::::::::::::::::::::.:.::::::::.::::..:::.
NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
250 260 270 280 290 300
310 320
pF1KE4 RNYRYVVMDFLMDHPDYPFSDEY
:: .: : . .::.::.::::
NP_001 RNLHYFNSDSFASHPNYPYSDEY
310 320
>>NP_995317 (OMIM: 600450,614279) aldo-keto reductase fa (323 aa)
initn: 1818 init1: 1818 opt: 1818 Z-score: 2122.8 bits: 401.0 E(85289): 1.7e-111
Smith-Waterman score: 1818; 81.7% identity (94.7% similar) in 323 aa overlap (1-323:1-323)
10 20 30 40 50 60
pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
:: ::: :.::::::::::::::::: :::...:.:..::::::::.:::::..::::::
NP_995 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
:::::::::::::::::::::::::: . .:..:.:::: :::.::::::::::.:::.
NP_995 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP
..:::: .:::::::..:::::: ::::.:::::::::::::::::::.: ::::::::
NP_995 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
::::::::::::::::.:: :::::::::::::::.::::..:.. ::::::::::::::
NP_995 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
::::::::::::::::::::::::::::::::::::::.:.::::::::::.::..::::
NP_995 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
250 260 270 280 290 300
310 320
pF1KE4 RNYRYVVMDFLMDHPDYPFSDEY
:: ::...:.. :.:::::::
NP_995 RNVRYLTLDIFAGPPNYPFSDEY
310 320
>>NP_001345 (OMIM: 600450,614279) aldo-keto reductase fa (323 aa)
initn: 1818 init1: 1818 opt: 1818 Z-score: 2122.8 bits: 401.0 E(85289): 1.7e-111
Smith-Waterman score: 1818; 81.7% identity (94.7% similar) in 323 aa overlap (1-323:1-323)
10 20 30 40 50 60
pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
:: ::: :.::::::::::::::::: :::...:.:..::::::::.:::::..::::::
NP_001 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
:::::::::::::::::::::::::: . .:..:.:::: :::.::::::::::.:::.
NP_001 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP
..:::: .:::::::..:::::: ::::.:::::::::::::::::::.: ::::::::
NP_001 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
::::::::::::::::.:: :::::::::::::::.::::..:.. ::::::::::::::
NP_001 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
::::::::::::::::::::::::::::::::::::::.:.::::::::::.::..::::
NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
250 260 270 280 290 300
310 320
pF1KE4 RNYRYVVMDFLMDHPDYPFSDEY
:: ::...:.. :.:::::::
NP_001 RNVRYLTLDIFAGPPNYPFSDEY
310 320
>>NP_005980 (OMIM: 235555,604741) 3-oxo-5-beta-steroid 4 (326 aa)
initn: 1259 init1: 1200 opt: 1285 Z-score: 1502.1 bits: 286.2 E(85289): 6.3e-77
Smith-Waterman score: 1285; 56.7% identity (84.6% similar) in 319 aa overlap (6-323:8-326)
10 20 30 40 50
pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPE-VPRNRAVEVTKLAIEAGFRHIDSAYLYNN
.:. :.::. .:..:.:::. :. .:.. . .:.::..:.::::.::.:.:
NP_005 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 EEQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLH
:..:: ::: :::.:.:.:::::: .::: : :.::.:.:: .:. :::::::::...
NP_005 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 FPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMIL
:::.:::. :.::::: .. .: ::::.:: ::::::.::.:::::: ::::.::
NP_005 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 NKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLE
::::::.::: ::::::::..: ::: ::...:::..:.: :::.:. .::. .:: ::.
NP_005 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 DPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLD
: .: .:.:....: : :.::...::::::. ::.: .::.::.:.:.:.:: :.:: ..
NP_005 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE
250 260 270 280 290 300
300 310 320
pF1KE4 GLNRNYRYVVMDFLMDHPDYPFSDEY
.::.: :.: . . :::.::: :::
NP_005 ALNKNVRFVELLMWRDHPEYPFHDEY
310 320
>>NP_001177836 (OMIM: 235555,604741) 3-oxo-5-beta-steroi (290 aa)
initn: 1106 init1: 1047 opt: 1132 Z-score: 1324.6 bits: 253.2 E(85289): 4.8e-67
Smith-Waterman score: 1132; 57.7% identity (85.3% similar) in 279 aa overlap (6-283:8-286)
10 20 30 40 50
pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPE-VPRNRAVEVTKLAIEAGFRHIDSAYLYNN
.:. :.::. .:..:.:::. :. .:.. . .:.::..:.::::.::.:.:
NP_001 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 EEQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLH
:..:: ::: :::.:.:.:::::: .::: : :.::.:.:: .:. :::::::::...
NP_001 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 FPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMIL
:::.:::. :.::::: .. .: ::::.:: ::::::.::.:::::: ::::.::
NP_001 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 NKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLE
::::::.::: ::::::::..: ::: ::...:::..:.: :::.:. .::. .:: ::.
NP_001 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 DPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLD
: .: .:.:....: : :.::...::::::. ::.: .::.::.::
NP_001 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQVARSS
250 260 270 280 290
300 310 320
pF1KE4 GLNRNYRYVVMDFLMDHPDYPFSDEY
>>NP_001619 (OMIM: 103880) aldose reductase isoform 1 [H (316 aa)
initn: 986 init1: 726 opt: 1066 Z-score: 1247.3 bits: 239.0 E(85289): 9.8e-63
Smith-Waterman score: 1066; 48.3% identity (79.5% similar) in 317 aa overlap (7-323:4-316)
10 20 30 40 50 60
pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
:. ::.: ::.::.::. : : ....:..:.::..:.:::: :..:.::..
NP_001 MASRLLLNNGAKMPILGLGTWKSP--P-GQVTEAVKVAIDVGYRHIDCAHVYQNENE
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
::.::. :. . ::::..: .::::::. . .:. : ...:. :.:::.::::.:.:
NP_001 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPT
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE4 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP
..:::. .: ::.:.:. . ... :: .::. : ::.:.::.::::. :.:::::::
NP_001 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE4 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
::::::. ::.::::::.: ::...:.:: ::..:.: ::. . :. :..: :::::
NP_001 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSP-DRPWAKPEDPSLLEDPR
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
. :.: ::..: : . .:. .::..::. :: . .:: ::..::.:.:.:.:: .: . :
NP_001 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN
240 250 260 270 280 290
310 320
pF1KE4 RNYRYVVMDFLMDHPDYPFSDEY
::.: .. .: :::: .:.
NP_001 RNWRVCALLSCTSHKDYPFHEEF
300 310
>>XP_016871280 (OMIM: 600449) PREDICTED: aldo-keto reduc (297 aa)
initn: 1020 init1: 1020 opt: 1032 Z-score: 1208.0 bits: 231.7 E(85289): 1.5e-60
Smith-Waterman score: 1638; 76.8% identity (87.9% similar) in 323 aa overlap (1-323:1-297)
10 20 30 40 50 60
pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
:: ::: :.::::::::::::::::: :::...:.:.:::::::::::::::.:::::::
XP_016 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
:::::::::::::::::::::::::::. .:..:.:::: :::.::::::::::.:::.
XP_016 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP
..: ..:::::::::::::::::: ::::::::::
XP_016 SVK--------------------------AVEKCKDAGLAKSIGVSNFNRRQLEMILNKP
130 140 150
190 200 210 220 230 240
pF1KE4 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
::::::::::::::::.:: :::::::::::::::.::::..:.. ::::::::::::::
XP_016 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
::::::::::::::::::::::::::::::::::::::.:.::::::::::.::..::::
XP_016 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
220 230 240 250 260 270
310 320
pF1KE4 RNYRYVVMDFLMDHPDYPFSDEY
:: ::...:.. :.:::::::
XP_016 RNVRYLTLDIFAGPPNYPFSDEY
280 290
323 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 23:14:08 2016 done: Sat Nov 5 23:14:09 2016
Total Scan time: 6.060 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]