Result of FASTA (omim) for
pFN21AE4314
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4314, 323 aa
1>>>pF1KE4314 323 - 323 aa - 323 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1137+/-0.000377; mu= 16.9663+/- 0.023
mean_var=65.2406+/-13.340, 0's: 0 Z-trim(112.7): 59 B-trim: 0 in 0/50
Lambda= 0.158787
statistics sampled from 21647 (21706) to 21647 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.632), E-opt: 0.2 (0.254), width: 16
Scan time: 7.460
The best scores are: opt bits E(85289)
NP_001345 (OMIM: 600450,614279) aldo-keto reductas ( 323) 2171 506.2 3.8e-143
NP_995317 (OMIM: 600450,614279) aldo-keto reductas ( 323) 2171 506.2 3.8e-143
NP_001344 (OMIM: 600449) aldo-keto reductase famil ( 323) 2123 495.2 7.8e-140
NP_003730 (OMIM: 603966) aldo-keto reductase famil ( 323) 1907 445.7 6.1e-125
NP_001240837 (OMIM: 603966) aldo-keto reductase fa ( 323) 1903 444.8 1.2e-124
NP_001809 (OMIM: 600451,614279) aldo-keto reductas ( 323) 1813 424.1 1.9e-118
NP_005980 (OMIM: 235555,604741) 3-oxo-5-beta-stero ( 326) 1313 309.6 5.6e-84
NP_001307956 (OMIM: 600450,614279) aldo-keto reduc ( 297) 1188 280.9 2.2e-75
XP_016871280 (OMIM: 600449) PREDICTED: aldo-keto r ( 297) 1165 275.7 8.4e-74
NP_001177836 (OMIM: 235555,604741) 3-oxo-5-beta-st ( 290) 1163 275.2 1.1e-73
NP_001619 (OMIM: 103880) aldose reductase isoform ( 316) 1064 252.6 8.2e-67
NP_064695 (OMIM: 604707) aldo-keto reductase famil ( 316) 1020 242.5 8.8e-64
XP_011514543 (OMIM: 616336) PREDICTED: aldo-keto r ( 316) 977 232.6 8.2e-61
NP_001074007 (OMIM: 616336) aldo-keto reductase fa ( 344) 952 226.9 4.6e-59
XP_016867713 (OMIM: 616336) PREDICTED: aldo-keto r ( 344) 952 226.9 4.6e-59
NP_001189342 (OMIM: 103830) alcohol dehydrogenase ( 325) 918 219.1 9.8e-57
NP_001189343 (OMIM: 103830) alcohol dehydrogenase ( 325) 918 219.1 9.8e-57
NP_006057 (OMIM: 103830) alcohol dehydrogenase [NA ( 325) 918 219.1 9.8e-57
NP_697021 (OMIM: 103830) alcohol dehydrogenase [NA ( 325) 918 219.1 9.8e-57
NP_001128713 (OMIM: 600450,614279) aldo-keto reduc ( 139) 813 194.8 8.5e-50
NP_001240838 (OMIM: 603966) aldo-keto reductase fa ( 138) 718 173.1 3e-43
XP_011514718 (OMIM: 604707) PREDICTED: aldo-keto r ( 277) 675 163.4 4.9e-40
XP_005250291 (OMIM: 103880) PREDICTED: aldose redu ( 172) 604 147.0 2.6e-35
NP_001333071 (OMIM: 103880) aldose reductase isofo ( 172) 604 147.0 2.6e-35
NP_001177835 (OMIM: 235555,604741) 3-oxo-5-beta-st ( 285) 587 143.3 5.9e-34
XP_011538793 (OMIM: 103830) PREDICTED: alcohol deh ( 214) 555 135.9 7.5e-32
XP_011538794 (OMIM: 103830) PREDICTED: alcohol deh ( 214) 555 135.9 7.5e-32
XP_011514719 (OMIM: 604707) PREDICTED: aldo-keto r ( 175) 425 106.0 5.9e-23
NP_036199 (OMIM: 608477) aflatoxin B1 aldehyde red ( 331) 176 49.1 1.5e-05
XP_011539348 (OMIM: 608477) PREDICTED: aflatoxin B ( 375) 176 49.2 1.6e-05
NP_003680 (OMIM: 603418) aflatoxin B1 aldehyde red ( 359) 167 47.1 6.5e-05
XP_016856203 (OMIM: 608477) PREDICTED: aflatoxin B ( 304) 141 41.1 0.0035
NP_001307908 (OMIM: 603418) aflatoxin B1 aldehyde ( 324) 141 41.1 0.0037
NP_001186791 (OMIM: 601142) voltage-gated potassiu ( 415) 142 41.4 0.0039
XP_016858110 (OMIM: 601142) PREDICTED: voltage-gat ( 435) 142 41.4 0.004
XP_016862660 (OMIM: 601141) PREDICTED: voltage-gat ( 337) 138 40.4 0.0062
XP_011511417 (OMIM: 601141) PREDICTED: voltage-gat ( 337) 138 40.4 0.0062
NP_751891 (OMIM: 601141) voltage-gated potassium c ( 401) 138 40.5 0.0071
NP_003462 (OMIM: 601141) voltage-gated potassium c ( 408) 138 40.5 0.0072
NP_751892 (OMIM: 601141) voltage-gated potassium c ( 419) 138 40.5 0.0074
>>NP_001345 (OMIM: 600450,614279) aldo-keto reductase fa (323 aa)
initn: 2171 init1: 2171 opt: 2171 Z-score: 2690.9 bits: 506.2 E(85289): 3.8e-143
Smith-Waterman score: 2171; 100.0% identity (100.0% similar) in 323 aa overlap (1-323:1-323)
10 20 30 40 50 60
pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
250 260 270 280 290 300
310 320
pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY
:::::::::::::::::::::::
NP_001 RNVRYLTLDIFAGPPNYPFSDEY
310 320
>>NP_995317 (OMIM: 600450,614279) aldo-keto reductase fa (323 aa)
initn: 2171 init1: 2171 opt: 2171 Z-score: 2690.9 bits: 506.2 E(85289): 3.8e-143
Smith-Waterman score: 2171; 100.0% identity (100.0% similar) in 323 aa overlap (1-323:1-323)
10 20 30 40 50 60
pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_995 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_995 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_995 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_995 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_995 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
250 260 270 280 290 300
310 320
pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY
:::::::::::::::::::::::
NP_995 RNVRYLTLDIFAGPPNYPFSDEY
310 320
>>NP_001344 (OMIM: 600449) aldo-keto reductase family 1 (323 aa)
initn: 2123 init1: 2123 opt: 2123 Z-score: 2631.5 bits: 495.2 E(85289): 7.8e-140
Smith-Waterman score: 2123; 97.8% identity (99.4% similar) in 323 aa overlap (1-323:1-323)
10 20 30 40 50 60
pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
:::::::::::::::::::::::::::::::::::::.::::::::.::::::.::::::
NP_001 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_001 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
::::::::::::::::::::::::::::::.::::::::::::::::::.: ::::::::
NP_001 SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
250 260 270 280 290 300
310 320
pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY
:::::::::::::::::::::::
NP_001 RNVRYLTLDIFAGPPNYPFSDEY
310 320
>>NP_003730 (OMIM: 603966) aldo-keto reductase family 1 (323 aa)
initn: 1907 init1: 1907 opt: 1907 Z-score: 2364.1 bits: 445.7 E(85289): 6.1e-125
Smith-Waterman score: 1907; 87.0% identity (95.7% similar) in 323 aa overlap (1-323:1-323)
10 20 30 40 50 60
pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
::::.::::::::::::::::::::: :::.:::::..::::::::.::::::.::::::
NP_003 MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
:::::::::::::::::::::::::::. ::::::::::: :::. ::::::::::: :.
NP_003 VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
:.:::::. : :::::..:: ::::.:::::::::::::::::::::::.: ::::::::
NP_003 SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
::::::::::::::::::. :::::::::::::::::::::.:.. ::::::::::::::
NP_003 GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
:::::::::::::::::::::::::::::::::::::::::::::::::.:.:::::::.
NP_003 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
250 260 270 280 290 300
310 320
pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY
::..:.. : ::. ::::.::::
NP_003 RNLHYFNSDSFASHPNYPYSDEY
310 320
>>NP_001240837 (OMIM: 603966) aldo-keto reductase family (323 aa)
initn: 1903 init1: 1903 opt: 1903 Z-score: 2359.1 bits: 444.8 E(85289): 1.2e-124
Smith-Waterman score: 1903; 86.7% identity (95.7% similar) in 323 aa overlap (1-323:1-323)
10 20 30 40 50 60
pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
::::.::.:::::::::::::::::: :::.:::::..::::::::.::::::.::::::
NP_001 MDSKHQCLKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
:::::::::::::::::::::::::::. ::::::::::: :::. ::::::::::: :.
NP_001 VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
:.:::::. : :::::..:: ::::.:::::::::::::::::::::::.: ::::::::
NP_001 SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
::::::::::::::::::. :::::::::::::::::::::.:.. ::::::::::::::
NP_001 GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
:::::::::::::::::::::::::::::::::::::::::::::::::.:.:::::::.
NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
250 260 270 280 290 300
310 320
pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY
::..:.. : ::. ::::.::::
NP_001 RNLHYFNSDSFASHPNYPYSDEY
310 320
>>NP_001809 (OMIM: 600451,614279) aldo-keto reductase fa (323 aa)
initn: 1813 init1: 1813 opt: 1813 Z-score: 2247.7 bits: 424.1 E(85289): 1.9e-118
Smith-Waterman score: 1813; 81.7% identity (94.4% similar) in 323 aa overlap (1-323:1-323)
10 20 30 40 50 60
pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
:: ::: :.::::::::::::::::: :::...:.:..::::::::.:::::..::::::
NP_001 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
:::::::::::::::::::::::::: . .:..:.:::: :::.::::::::::.:::.
NP_001 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
..:::: .:::::::..:::::: ::::.::::::::::::::::::: : ::::::::
NP_001 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
::::::::::::::::.:: :::::::::::::::.::::..:.. ::::::::::::::
NP_001 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
::::::::::::::::::::::::::::::::::::::.:.::::::::::.::..::::
NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
250 260 270 280 290 300
310 320
pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY
:: ::...:.. :.:::::::
NP_001 RNYRYVVMDFLMDHPDYPFSDEY
310 320
>>NP_005980 (OMIM: 235555,604741) 3-oxo-5-beta-steroid 4 (326 aa)
initn: 1302 init1: 1253 opt: 1313 Z-score: 1628.6 bits: 309.6 E(85289): 5.6e-84
Smith-Waterman score: 1313; 58.4% identity (85.2% similar) in 317 aa overlap (8-323:10-326)
10 20 30 40 50
pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYA-PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN
. :.::. .:..:.:::. : .::. .::.::..:..:::.:..:.:
NP_005 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 EEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIH
:..:: ::: :::.:.:.:::::: .:::...: ::.:::.:::.:. :::::::::.:.
NP_005 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 FPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMIL
:.. :::.:. :.::::: :. .::::::::: ::::::.::.::::::.: ::.::
NP_005 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 NKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLE
::::::.::: :::::::::.: ::: ::...:::..::: ::. :. ::. .:: ::.
NP_005 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 DPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAID
: .: .:.:....: : :.::...::::::. ::.: .::..: :.:.:.:: :::: :.
NP_005 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE
250 260 270 280 290 300
300 310 320
pF1KE4 GLNRNVRYLTLDIFAGPPNYPFSDEY
.::.:::.. : .. :.::: :::
NP_005 ALNKNVRFVELLMWRDHPEYPFHDEY
310 320
>>NP_001307956 (OMIM: 600450,614279) aldo-keto reductase (297 aa)
initn: 1175 init1: 1175 opt: 1188 Z-score: 1474.4 bits: 280.9 E(85289): 2.2e-75
Smith-Waterman score: 1925; 92.0% identity (92.0% similar) in 323 aa overlap (1-323:1-297)
10 20 30 40 50 60
pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
::: :::::::::::::::::::::::::::::::
NP_001 SVK--------------------------AMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
130 140 150
190 200 210 220 230 240
pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
220 230 240 250 260 270
310 320
pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY
:::::::::::::::::::::::
NP_001 RNVRYLTLDIFAGPPNYPFSDEY
280 290
>>XP_016871280 (OMIM: 600449) PREDICTED: aldo-keto reduc (297 aa)
initn: 1152 init1: 1152 opt: 1165 Z-score: 1446.0 bits: 275.7 E(85289): 8.4e-74
Smith-Waterman score: 1877; 89.8% identity (91.3% similar) in 323 aa overlap (1-323:1-297)
10 20 30 40 50 60
pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
:::::::::::::::::::::::::::::::::::::.::::::::.::::::.::::::
XP_016 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
XP_016 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
::: :.::::::::::::::::::.: ::::::::
XP_016 SVK--------------------------AVEKCKDAGLAKSIGVSNFNRRQLEMILNKP
130 140 150
190 200 210 220 230 240
pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
220 230 240 250 260 270
310 320
pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY
:::::::::::::::::::::::
XP_016 RNVRYLTLDIFAGPPNYPFSDEY
280 290
>>NP_001177836 (OMIM: 235555,604741) 3-oxo-5-beta-steroi (290 aa)
initn: 1152 init1: 1103 opt: 1163 Z-score: 1443.6 bits: 275.2 E(85289): 1.1e-73
Smith-Waterman score: 1163; 59.2% identity (85.9% similar) in 277 aa overlap (8-283:10-286)
10 20 30 40 50
pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYA-PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN
. :.::. .:..:.:::. : .::. .::.::..:..:::.:..:.:
NP_001 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 EEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIH
:..:: ::: :::.:.:.:::::: .:::...: ::.:::.:::.:. :::::::::.:.
NP_001 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 FPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMIL
:.. :::.:. :.::::: :. .::::::::: ::::::.::.::::::.: ::.::
NP_001 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 NKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLE
::::::.::: :::::::::.: ::: ::...:::..::: ::. :. ::. .:: ::.
NP_001 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 DPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAID
: .: .:.:....: : :.::...::::::. ::.: .::..: ::
NP_001 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQVARSS
250 260 270 280 290
300 310 320
pF1KE4 GLNRNVRYLTLDIFAGPPNYPFSDEY
323 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 23:14:41 2016 done: Sat Nov 5 23:14:42 2016
Total Scan time: 7.460 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]