Result of FASTA (omim) for
pFN21AE4306
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4306, 306 aa
1>>>pF1KE4306 306 - 306 aa - 306 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7209+/-0.000321; mu= 19.1969+/- 0.020
mean_var=62.2644+/-12.705, 0's: 0 Z-trim(116.4): 15 B-trim: 1205 in 1/51
Lambda= 0.162538
statistics sampled from 27560 (27567) to 27560 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.703), E-opt: 0.2 (0.323), width: 16
Scan time: 7.100
The best scores are: opt bits E(85289)
NP_000301 (OMIM: 256730,600722) palmitoyl-protein ( 306) 2100 500.6 1.6e-141
XP_005271065 (OMIM: 256730,600722) PREDICTED: palm ( 282) 1663 398.1 1.1e-110
NP_001136076 (OMIM: 256730,600722) palmitoyl-prote ( 203) 1108 267.8 1.3e-71
NP_005146 (OMIM: 603298) lysosomal thioesterase PP ( 302) 257 68.4 2e-11
NP_001191032 (OMIM: 603298) lysosomal thioesterase ( 302) 257 68.4 2e-11
NP_619731 (OMIM: 603298) lysosomal thioesterase PP ( 308) 257 68.4 2.1e-11
>>NP_000301 (OMIM: 256730,600722) palmitoyl-protein thio (306 aa)
initn: 2100 init1: 2100 opt: 2100 Z-score: 2661.6 bits: 500.6 E(85289): 1.6e-141
Smith-Waterman score: 2100; 100.0% identity (100.0% similar) in 306 aa overlap (1-306:1-306)
10 20 30 40 50 60
pF1KE4 MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMGDSCCNPLSMGAIKKMVEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMGDSCCNPLSMGAIKKMVEK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 KIPGIYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKDPKLQQGYNAMGFSQGGQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KIPGIYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKDPKLQQGYNAMGFSQGGQF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDFIRKTLNAGAYSKVVQERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDFIRKTLNAGAYSKVVQERL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 VQAEYWHDPIKEDVYRNHSIFLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VQAEYWHDPIKEDVYRNHSIFLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SEWFGFYRSGQAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SEWFGFYRSGQAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAH
250 260 270 280 290 300
pF1KE4 IIPFLG
::::::
NP_000 IIPFLG
>>XP_005271065 (OMIM: 256730,600722) PREDICTED: palmitoy (282 aa)
initn: 1663 init1: 1663 opt: 1663 Z-score: 2108.2 bits: 398.1 E(85289): 1.1e-110
Smith-Waterman score: 1878; 92.2% identity (92.2% similar) in 306 aa overlap (1-306:1-282)
10 20 30 40 50 60
pF1KE4 MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMGDSCCNPLSMGAIKKMVEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMGDSCCNPLSMGAIKKMVEK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 KIPGIYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKDPKLQQGYNAMGFSQGGQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KIPGIYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKDPKLQQGYNAMGFSQGGQF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDFIRKTLNAGAYSKVVQERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDFIRKTLNAGAYSKVVQERL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 VQAEYWHDPIKEDVYRNHSIFLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VQAEYWHDPIKEDVYRNHSIFLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SEWFGFYRSGQAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAH
:: ::::::::::::::::::::::::::::::::::
XP_005 SE------------------------DRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAH
250 260 270
pF1KE4 IIPFLG
::::::
XP_005 IIPFLG
280
>>NP_001136076 (OMIM: 256730,600722) palmitoyl-protein t (203 aa)
initn: 1098 init1: 1098 opt: 1108 Z-score: 1406.9 bits: 267.8 E(85289): 1.3e-71
Smith-Waterman score: 1190; 66.3% identity (66.3% similar) in 306 aa overlap (1-306:1-203)
10 20 30 40 50 60
pF1KE4 MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMGDSCCNPLSMGAIKKMVEK
::::::::::::::::::::::::::::::::::::::::::
NP_001 MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMG------------------
10 20 30 40
70 80 90 100 110 120
pF1KE4 KIPGIYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKDPKLQQGYNAMGFSQGGQF
NP_001 ------------------------------------------------------------
130 140 150 160 170 180
pF1KE4 LRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDFIRKTLNAGAYSKVVQERL
:::::::::::::::::::::::::::::::::::
NP_001 -------------------------VFGLPRCPGESSHICDFIRKTLNAGAYSKVVQERL
50 60 70
190 200 210 220 230 240
pF1KE4 VQAEYWHDPIKEDVYRNHSIFLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQAEYWHDPIKEDVYRNHSIFLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVD
80 90 100 110 120 130
250 260 270 280 290 300
pF1KE4 SEWFGFYRSGQAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEWFGFYRSGQAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAH
140 150 160 170 180 190
pF1KE4 IIPFLG
::::::
NP_001 IIPFLG
200
>>NP_005146 (OMIM: 603298) lysosomal thioesterase PPT2 i (302 aa)
initn: 245 init1: 107 opt: 257 Z-score: 326.0 bits: 68.4 E(85289): 2e-11
Smith-Waterman score: 296; 28.5% identity (56.6% similar) in 288 aa overlap (8-281:13-274)
10 20 30 40 50
pF1KE4 MASPGCLWLLAVALLPWTCASRALQHLDPPAPL-----PLVIWHGMGDSCCNPLS
:.: :::. : : ::: :... ::. :: :
NP_005 MLGLCGQRLPAAWVLL--LLPFL----PLLLLAAPAPHRASYKPVIVVHGLFDSS---YS
10 20 30 40 50
60 70 80 90 100
pF1KE4 MGAIKKMVEKKIPG--IYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKDPKLQQG
. . ..... :: . ::.: :. .. .. .:.. .: .:: : ::
NP_005 FRHLLEYINETHPGTVVTVLDLFDGRESLRP----LWEQVQGFREAVVPIMAKAP---QG
60 70 80 90 100
110 120 130 140 150 160
pF1KE4 YNAMGFSQGGQFLRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDF----IR
. . .:::: ::. . . . ..::... ..: .: ..... . .:
NP_005 VHLICYSQGGLVCRALLSVMDDHNVDSFISLSSPQMGQYG------DTDYLKWLFPTSMR
110 120 130 140 150
170 180 190 200 210 220
pF1KE4 KTLNAGAYSKVVQERLVQAEYWHDPIKEDVYRNHSIFLADINQERGINES--YKKNLMAL
..: :: :: . .::::: ..:.: : : ::: :: :: .. ..::.. .
NP_005 SNLYRICYSPWGQEFSI-CNYWHDPHHDDLYLNASSFLALINGERDHPNATVWRKNFLRV
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE4 KKFVMVKFLNDSIVDPVDSEWFGFYRSGQAKETI-PLQETSLYTQDRLGLKEMDNAGQLV
..:.. .:... : .: .:::: .:.::. ..: .: .: .::: . : .:
NP_005 GHLVLIGGPDDGVITPWQSSFFGFY---DANETVLEMEEQLVYLRDSFGLKTLLARGAIV
220 230 240 250 260 270
290 300
pF1KE4 FLATEGDHLQLSEEWFYAHIIPFLG
NP_005 RCPMAGISHTAWHSNRTLYETCIEPWLS
280 290 300
>>NP_001191032 (OMIM: 603298) lysosomal thioesterase PPT (302 aa)
initn: 245 init1: 107 opt: 257 Z-score: 326.0 bits: 68.4 E(85289): 2e-11
Smith-Waterman score: 296; 28.5% identity (56.6% similar) in 288 aa overlap (8-281:13-274)
10 20 30 40 50
pF1KE4 MASPGCLWLLAVALLPWTCASRALQHLDPPAPL-----PLVIWHGMGDSCCNPLS
:.: :::. : : ::: :... ::. :: :
NP_001 MLGLCGQRLPAAWVLL--LLPFL----PLLLLAAPAPHRASYKPVIVVHGLFDSS---YS
10 20 30 40 50
60 70 80 90 100
pF1KE4 MGAIKKMVEKKIPG--IYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKDPKLQQG
. . ..... :: . ::.: :. .. .. .:.. .: .:: : ::
NP_001 FRHLLEYINETHPGTVVTVLDLFDGRESLRP----LWEQVQGFREAVVPIMAKAP---QG
60 70 80 90 100
110 120 130 140 150 160
pF1KE4 YNAMGFSQGGQFLRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDF----IR
. . .:::: ::. . . . ..::... ..: .: ..... . .:
NP_001 VHLICYSQGGLVCRALLSVMDDHNVDSFISLSSPQMGQYG------DTDYLKWLFPTSMR
110 120 130 140 150
170 180 190 200 210 220
pF1KE4 KTLNAGAYSKVVQERLVQAEYWHDPIKEDVYRNHSIFLADINQERGINES--YKKNLMAL
..: :: :: . .::::: ..:.: : : ::: :: :: .. ..::.. .
NP_001 SNLYRICYSPWGQEFSI-CNYWHDPHHDDLYLNASSFLALINGERDHPNATVWRKNFLRV
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE4 KKFVMVKFLNDSIVDPVDSEWFGFYRSGQAKETI-PLQETSLYTQDRLGLKEMDNAGQLV
..:.. .:... : .: .:::: .:.::. ..: .: .: .::: . : .:
NP_001 GHLVLIGGPDDGVITPWQSSFFGFY---DANETVLEMEEQLVYLRDSFGLKTLLARGAIV
220 230 240 250 260 270
290 300
pF1KE4 FLATEGDHLQLSEEWFYAHIIPFLG
NP_001 RCPMAGISHTAWHSNRTLYETCIEPWLS
280 290 300
>>NP_619731 (OMIM: 603298) lysosomal thioesterase PPT2 i (308 aa)
initn: 245 init1: 107 opt: 257 Z-score: 325.9 bits: 68.4 E(85289): 2.1e-11
Smith-Waterman score: 296; 28.5% identity (56.6% similar) in 288 aa overlap (8-281:19-280)
10 20 30 40
pF1KE4 MASPGCLWLLAVALLPWTCASRALQHLDPPAPL-----PLVIWHGMGDS
:.: :::. : : ::: :... ::. ::
NP_619 MKSCGSMLGLCGQRLPAAWVLL--LLPFL----PLLLLAAPAPHRASYKPVIVVHGLFDS
10 20 30 40 50
50 60 70 80 90 100
pF1KE4 CCNPLSMGAIKKMVEKKIPG--IYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKD
:. . ..... :: . ::.: :. .. .. .:.. .: .::
NP_619 S---YSFRHLLEYINETHPGTVVTVLDLFDGRESLRP----LWEQVQGFREAVVPIMAKA
60 70 80 90 100
110 120 130 140 150 160
pF1KE4 PKLQQGYNAMGFSQGGQFLRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDF
: :: . . .:::: ::. . . . ..::... ..: .: ..... .
NP_619 P---QGVHLICYSQGGLVCRALLSVMDDHNVDSFISLSSPQMGQYG------DTDYLKWL
110 120 130 140 150
170 180 190 200 210
pF1KE4 ----IRKTLNAGAYSKVVQERLVQAEYWHDPIKEDVYRNHSIFLADINQERGINES--YK
.:..: :: :: . .::::: ..:.: : : ::: :: :: .. ..
NP_619 FPTSMRSNLYRICYSPWGQEFSI-CNYWHDPHHDDLYLNASSFLALINGERDHPNATVWR
160 170 180 190 200 210
220 230 240 250 260 270
pF1KE4 KNLMALKKFVMVKFLNDSIVDPVDSEWFGFYRSGQAKETI-PLQETSLYTQDRLGLKEMD
::.. . ..:.. .:... : .: .:::: .:.::. ..: .: .: .::: .
NP_619 KNFLRVGHLVLIGGPDDGVITPWQSSFFGFY---DANETVLEMEEQLVYLRDSFGLKTLL
220 230 240 250 260 270
280 290 300
pF1KE4 NAGQLVFLATEGDHLQLSEEWFYAHIIPFLG
: .:
NP_619 ARGAIVRCPMAGISHTAWHSNRTLYETCIEPWLS
280 290 300
306 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 23:28:04 2016 done: Sat Nov 5 23:28:05 2016
Total Scan time: 7.100 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]