Result of FASTA (omim) for
pFN21AE4270
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4270, 1125 aa
1>>>pF1KE4270 1125 - 1125 aa - 1125 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 13.0734+/-0.000456; mu= -14.1307+/- 0.028
mean_var=450.8347+/-92.811, 0's: 0 Z-trim(122.5): 57 B-trim: 1907 in 1/59
Lambda= 0.060404
statistics sampled from 40705 (40772) to 40705 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.764), E-opt: 0.2 (0.478), width: 16
Scan time: 16.420
The best scores are: opt bits E(85289)
NP_001287780 (OMIM: 609424) roquin-1 isoform c [Ho (1125) 7669 683.7 1.6e-195
NP_001287781 (OMIM: 609424) roquin-1 isoform d [Ho (1124) 7652 682.2 4.6e-195
NP_742068 (OMIM: 609424) roquin-1 isoform b [Homo (1133) 7106 634.6 9.7e-181
NP_001287779 (OMIM: 609424) roquin-1 isoform a [Ho (1134) 6804 608.3 8.1e-173
XP_011507533 (OMIM: 609424) PREDICTED: roquin-1 is (1076) 6779 606.1 3.5e-172
XP_005244978 (OMIM: 609424) PREDICTED: roquin-1 is (1113) 3745 341.7 1.4e-92
NP_061323 (OMIM: 615231) roquin-2 isoform 2 [Homo (1064) 2710 251.5 1.9e-65
NP_001094058 (OMIM: 615231) roquin-2 isoform 1 [Ho (1191) 2710 251.6 2.1e-65
>>NP_001287780 (OMIM: 609424) roquin-1 isoform c [Homo s (1125 aa)
initn: 7669 init1: 7669 opt: 7669 Z-score: 3631.0 bits: 683.7 E(85289): 1.6e-195
Smith-Waterman score: 7669; 100.0% identity (100.0% similar) in 1125 aa overlap (1-1125:1-1125)
10 20 30 40 50 60
pF1KE4 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE4 AEREQLRLELQQLNHQISQQTQLRGLEREANTLAGQSQPPPPPPPKWPGMISSEQLSLEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEREQLRLELQQLNHQISQQTQLRGLEREANTLAGQSQPPPPPPPKWPGMISSEQLSLEL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE4 HQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLTLTFSSDVPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLTLTFSSDVPN
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120
pF1KE4 GSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP
1090 1100 1110 1120
>>NP_001287781 (OMIM: 609424) roquin-1 isoform d [Homo s (1124 aa)
initn: 7350 init1: 7350 opt: 7652 Z-score: 3623.0 bits: 682.2 E(85289): 4.6e-195
Smith-Waterman score: 7652; 99.9% identity (99.9% similar) in 1125 aa overlap (1-1125:1-1124)
10 20 30 40 50 60
pF1KE4 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE4 AEREQLRLELQQLNHQISQQTQLRGLEREANTLAGQSQPPPPPPPKWPGMISSEQLSLEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEREQLRLELQQLNHQISQQTQLRGLEREANTLAGQSQPPPPPPPKWPGMISSEQLSLEL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE4 HQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLTLTFSSDVPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
NP_001 HQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLTLTFS-DVPN
1030 1040 1050 1060 1070
1090 1100 1110 1120
pF1KE4 GSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP
1080 1090 1100 1110 1120
>>NP_742068 (OMIM: 609424) roquin-1 isoform b [Homo sapi (1133 aa)
initn: 7117 init1: 6766 opt: 7106 Z-score: 3365.8 bits: 634.6 E(85289): 9.7e-181
Smith-Waterman score: 7624; 99.1% identity (99.1% similar) in 1134 aa overlap (1-1125:1-1133)
10 20 30 40 50 60
pF1KE4 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS
910 920 930 940 950 960
970 980 990 1000 1010
pF1KE4 AEREQLRLELQQLNHQISQQTQLRGLE---------REANTLAGQSQPPPPPPPKWPGMI
::::::::::::::::::::::::::: ::::::::::::::::::::::::
NP_742 AEREQLRLELQQLNHQISQQTQLRGLEAVSNRLVLQREANTLAGQSQPPPPPPPKWPGMI
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE4 SSEQLSLELHQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 SSEQLSLELHQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLT
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120
pF1KE4 LTFSSDVPNGSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP
:::: :::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 LTFS-DVPNGSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP
1090 1100 1110 1120 1130
>>NP_001287779 (OMIM: 609424) roquin-1 isoform a [Homo s (1134 aa)
initn: 6812 init1: 6766 opt: 6804 Z-score: 3223.6 bits: 608.3 E(85289): 8.1e-173
Smith-Waterman score: 7641; 99.2% identity (99.2% similar) in 1134 aa overlap (1-1125:1-1134)
10 20 30 40 50 60
pF1KE4 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS
910 920 930 940 950 960
970 980 990 1000 1010
pF1KE4 AEREQLRLELQQLNHQISQQTQLRGLE---------REANTLAGQSQPPPPPPPKWPGMI
::::::::::::::::::::::::::: ::::::::::::::::::::::::
NP_001 AEREQLRLELQQLNHQISQQTQLRGLEAVSNRLVLQREANTLAGQSQPPPPPPPKWPGMI
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE4 SSEQLSLELHQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSEQLSLELHQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLT
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120
pF1KE4 LTFSSDVPNGSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTFSSDVPNGSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP
1090 1100 1110 1120 1130
>>XP_011507533 (OMIM: 609424) PREDICTED: roquin-1 isofor (1076 aa)
initn: 6763 init1: 6763 opt: 6779 Z-score: 3212.1 bits: 606.1 E(85289): 3.5e-172
Smith-Waterman score: 7222; 95.6% identity (95.6% similar) in 1125 aa overlap (1-1125:1-1076)
10 20 30 40 50 60
pF1KE4 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE4 AEREQLRLELQQLNHQISQQTQLRGLEREANTLAGQSQPPPPPPPKWPGMISSEQLSLEL
:::::::::::::::::::::::::::
XP_011 AEREQLRLELQQLNHQISQQTQLRGLE---------------------------------
970 980
1030 1040 1050 1060 1070 1080
pF1KE4 HQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLTLTFSSDVPN
::::::::::::::::::::::::::::::::::::::::::::
XP_011 ----------------ENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLTLTFSSDVPN
990 1000 1010 1020 1030
1090 1100 1110 1120
pF1KE4 GSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP
1040 1050 1060 1070
>>XP_005244978 (OMIM: 609424) PREDICTED: roquin-1 isofor (1113 aa)
initn: 4541 init1: 3601 opt: 3745 Z-score: 1783.0 bits: 341.7 E(85289): 1.4e-92
Smith-Waterman score: 7448; 97.4% identity (97.4% similar) in 1134 aa overlap (1-1125:1-1113)
10 20 30 40 50 60
pF1KE4 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDL-
490 500 510 520 530
550 560 570 580 590 600
pF1KE4 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA
::::::::::::::::::::::::::::::::::::::::
XP_005 --------------------GPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA
540 550 560 570
610 620 630 640 650 660
pF1KE4 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE4 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE4 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP
700 710 720 730 740 750
790 800 810 820 830 840
pF1KE4 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM
760 770 780 790 800 810
850 860 870 880 890 900
pF1KE4 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA
820 830 840 850 860 870
910 920 930 940 950 960
pF1KE4 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS
880 890 900 910 920 930
970 980 990 1000 1010
pF1KE4 AEREQLRLELQQLNHQISQQTQLRGLE---------REANTLAGQSQPPPPPPPKWPGMI
::::::::::::::::::::::::::: ::::::::::::::::::::::::
XP_005 AEREQLRLELQQLNHQISQQTQLRGLEAVSNRLVLQREANTLAGQSQPPPPPPPKWPGMI
940 950 960 970 980 990
1020 1030 1040 1050 1060 1070
pF1KE4 SSEQLSLELHQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSEQLSLELHQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLT
1000 1010 1020 1030 1040 1050
1080 1090 1100 1110 1120
pF1KE4 LTFSSDVPNGSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTFSSDVPNGSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP
1060 1070 1080 1090 1100 1110
>>NP_061323 (OMIM: 615231) roquin-2 isoform 2 [Homo sapi (1064 aa)
initn: 2936 init1: 1939 opt: 2710 Z-score: 1295.8 bits: 251.5 E(85289): 1.9e-65
Smith-Waterman score: 3434; 53.8% identity (73.2% similar) in 1092 aa overlap (1-1046:1-1055)
10 20 30 40 50 60
pF1KE4 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD
::::: :::.::::::: . :::...:::::::.::::: :::::::::::::::.::::
NP_061 MPVQAAQWTEFLSCPICYNEFDENVHKPISLGCSHTVCKTCLNKLHRKACPFDQTAINTD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG
:..:::: :::::::::::..: : : :.. ..:::: ::::::.:::::::::...::.
NP_061 IDVLPVNFALLQLVGAQVPDHQSIKL-SNLGENKHYEVAKKCVEDLALYLKPLSGGKGVA
70 80 90 100 110
130 140 150 160 170 180
pF1KE4 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS
: .::.:::::::::::::.:::::::::.::::::::::::::::::::::::::::
NP_061 --SLNQSALSRPMQRKLVTLVNCQLVEEEGRVRAMRAARSLGERTVTELILQHQNPQQLS
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE4 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 ANLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP
::::::::::::::::::::::::::::::::::.:::::::::.:::.:::::::::.:
NP_061 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRSYEALRREHDAQIVHIAMEAGLRISP
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL
.::::::::: .:::::::::::::.: :::.:::::::.::::::::::::::::::::
NP_061 EQWSSLLYGDLAHKSHMQSIIDKLQSPESFAKSVQELTIVLQRTGDPANLNRLRPHLELL
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR
:::::.::: ::::::::..:::.::::::::.:::.:.:: . :: .::::: :::
NP_061 ANIDPNPDAVSPTWEQLENAMVAVKTVVHGLVDFIQNYSRKGHETPQPQPNSKYKTSMCR
360 370 380 390 400 410
430 440 450 460 470
pF1KE4 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRL---VPRRPLSASLGQLNEVGLPSAAIL
:..:.::::::..::::::::::::.: ::.. : :: ..: : : .. ..
NP_061 DLRQQGGCPRGTNCTFAHSQEELEKYRLRNKKINATVRTFPLLNKVGVNNTVTTTAGNVI
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE4 PDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSY---DSSLKPGKIDHLSSSAPG
:... .. :. ::: .. :.:.::: :.:: . .. : ::. ...: :
NP_061 SVIGSTETTGKIVPST-NGISNAENSVSQLISRSTDSTLRALETVKKVGKVGANGQNAAG
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE4 SPPD-LLESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQL--YPAQQTDV
: . :. : ::. . ::... . : . : ... :: .. ..
NP_061 PSADSVTENKIGSPPKTPVSNVAATSAGPSNVGTELNSVPQKSSPFLTRVPVYPPHSENI
540 550 560 570 580 590
600 610 620 630
pF1KE4 -YYQDPRGAAPPFEPAPYQQGMYYTPPPQ-------CVSRFVR----PPPSAPEPAPPYL
:.:::: : :: : : :: ::: :: :::: : : : . ::
NP_061 QYFQDPRTQIP-FEVPQYPQTGYYPPPPTVPAGVAPCVPRFVRSNNVPESSLPPASMPYA
600 610 620 630 640 650
640 650 660 670 680 690
pF1KE4 DHYPPYL-QERVVNSQYGTQPQQ----YPPI----YPSHYDGRRVYPAPSYTREEIFRES
::: . ..:. .: : : : ::. : ::.::.. : : :..:.: .
NP_061 DHYSTFSPRDRMNSSPYQPPPPQPYGPVPPVPSGMYAPVYDSRRIWRPPMYQRDDIIRSN
660 670 680 690 700 710
700 710 720 730 740
pF1KE4 PIP-IEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQP--
.: ... ..: : ::::.....:: :: .: :: : . .: : .:
NP_061 SLPPMDVMHSSV--YQTSLRERYNSLDGYYSVACQP----PS----EPRTTVPLPREPCG
720 730 740 750 760
750 760 770 780 790 800
pF1KE4 H--PSLDELHRRRKEIMAQLEERK---VISPPPFAP-SPTLP-PTFHPEEFLDEDLKVAG
: : .: ::. . :: . .: : : : : ::: : : : . : . .:.:
NP_061 HLKTSCEEQIRRKPDQWAQYHTQKAPLVSSTLPVATQSPTPPSPLFSVDFRADFSESVSG
770 780 790 800 810 820
810 820 830 840 850
pF1KE4 -KYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEMMNVESKGM--RDQRLDLQR
:.. . :.:::::: :::: :.. :..::::.: ... .:...: . : . .. ::
NP_061 TKFEEDHLSHYSPWSCGTIGSCINAIDSEPKDVIANSNAVLMDLDSGDVKRRVHLFETQR
830 840 850 860 870 880
860 870 880 890 900 910
pF1KE4 RAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMAPQGAPTKSINISDYSPY
:. : .: .:::.: : .:..:::::.:.: :. . :.:: : ::. :: :..::: ::
NP_061 RTKE--EDPIIPFSDGPIISKWGAISRSSRTGYHTTDPVQATASQGSATKPISVSDYVPY
890 900 910 920 930 940
920 930 940 950 960 970
pF1KE4 --GTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPSAEREQLRLELQQLNH
.. . : : :. .. :..:. ::.:. ......: : :. . : :::::
NP_061 VNAVDSRW--SSYG--NEATSSAHYVERDRFIVTDLSGHRKH--SSTGDLLSLELQQ---
950 960 970 980 990
980 990 1000 1010 1020 1030
pF1KE4 QISQQTQLRGLEREANTLAGQSQPPPPPPPKWPGMISSEQLSLELHQVEREI-GKRTREL
.....: :.::::.:: :. :: .. ...:.:.: . : :. . ....:
NP_061 --AKSNSLL-LQREANALAMQQ--------KWNSLDEGRHLTLNLLSKEIELRNGEVKKL
1000 1010 1020 1030 1040
1040 1050 1060 1070 1080 1090
pF1KE4 SMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLTLTFSSDVPNGSALTQENISLLSN
.. .: . . :
NP_061 NLSASCLMYLFSAAASWLYHY
1050 1060
>>NP_001094058 (OMIM: 615231) roquin-2 isoform 1 [Homo s (1191 aa)
initn: 2936 init1: 1939 opt: 2710 Z-score: 1295.1 bits: 251.6 E(85289): 2.1e-65
Smith-Waterman score: 3444; 52.7% identity (72.3% similar) in 1138 aa overlap (1-1084:1-1099)
10 20 30 40 50 60
pF1KE4 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD
::::: :::.::::::: . :::...:::::::.::::: :::::::::::::::.::::
NP_001 MPVQAAQWTEFLSCPICYNEFDENVHKPISLGCSHTVCKTCLNKLHRKACPFDQTAINTD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG
:..:::: :::::::::::..: : : :.. ..:::: ::::::.:::::::::...::.
NP_001 IDVLPVNFALLQLVGAQVPDHQSIKL-SNLGENKHYEVAKKCVEDLALYLKPLSGGKGVA
70 80 90 100 110
130 140 150 160 170 180
pF1KE4 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS
: .::.:::::::::::::.:::::::::.::::::::::::::::::::::::::::
NP_001 --SLNQSALSRPMQRKLVTLVNCQLVEEEGRVRAMRAARSLGERTVTELILQHQNPQQLS
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE4 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP
::::::::::::::::::::::::::::::::::.:::::::::.:::.:::::::::.:
NP_001 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRSYEALRREHDAQIVHIAMEAGLRISP
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL
.::::::::: .:::::::::::::.: :::.:::::::.::::::::::::::::::::
NP_001 EQWSSLLYGDLAHKSHMQSIIDKLQSPESFAKSVQELTIVLQRTGDPANLNRLRPHLELL
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR
:::::.::: ::::::::..:::.::::::::.:::.:.:: . :: .::::: :::
NP_001 ANIDPNPDAVSPTWEQLENAMVAVKTVVHGLVDFIQNYSRKGHETPQPQPNSKYKTSMCR
360 370 380 390 400 410
430 440 450 460 470
pF1KE4 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRL---VPRRPLSASLGQLNEVGLPSAAIL
:..:.::::::..::::::::::::.: ::.. : :: ..: : : .. ..
NP_001 DLRQQGGCPRGTNCTFAHSQEELEKYRLRNKKINATVRTFPLLNKVGVNNTVTTTAGNVI
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE4 PDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSY---DSSLKPGKIDHLSSSAPG
:... .. :. ::: .. :.:.::: :.:: . .. : ::. ...: :
NP_001 SVIGSTETTGKIVPST-NGISNAENSVSQLISRSTDSTLRALETVKKVGKVGANGQNAAG
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE4 SPPD-LLESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQL--YPAQQTDV
: . :. : ::. . ::... . : . : ... :: .. ..
NP_001 PSADSVTENKIGSPPKTPVSNVAATSAGPSNVGTELNSVPQKSSPFLTRVPVYPPHSENI
540 550 560 570 580 590
600 610 620 630
pF1KE4 -YYQDPRGAAPPFEPAPYQQGMYYTPPPQ-------CVSRFVR----PPPSAPEPAPPYL
:.:::: : :: : : :: ::: :: :::: : : : . ::
NP_001 QYFQDPRTQIP-FEVPQYPQTGYYPPPPTVPAGVAPCVPRFVRSNNVPESSLPPASMPYA
600 610 620 630 640 650
640 650 660 670 680 690
pF1KE4 DHYPPYL-QERVVNSQYGTQPQQ----YPPI----YPSHYDGRRVYPAPSYTREEIFRES
::: . ..:. .: : : : ::. : ::.::.. : : :..:.: .
NP_001 DHYSTFSPRDRMNSSPYQPPPPQPYGPVPPVPSGMYAPVYDSRRIWRPPMYQRDDIIRSN
660 670 680 690 700 710
700 710 720 730 740
pF1KE4 PIP-IEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQP--
.: ... ..: : ::::.....:: :: .: :: : . .: : .:
NP_001 SLPPMDVMHSSV--YQTSLRERYNSLDGYYSVACQP----PS----EPRTTVPLPREPCG
720 730 740 750 760
750 760 770 780 790 800
pF1KE4 H--PSLDELHRRRKEIMAQLEERK---VISPPPFAP-SPTLP-PTFHPEEFLDEDLKVAG
: : .: ::. . :: . .: : : : : ::: : : : . : . .:.:
NP_001 HLKTSCEEQIRRKPDQWAQYHTQKAPLVSSTLPVATQSPTPPSPLFSVDFRADFSESVSG
770 780 790 800 810 820
810 820 830 840 850
pF1KE4 -KYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEMMNVESKGM--RDQRLDLQR
:.. . :.:::::: :::: :.. :..::::.: ... .:...: . : . .. ::
NP_001 TKFEEDHLSHYSPWSCGTIGSCINAIDSEPKDVIANSNAVLMDLDSGDVKRRVHLFETQR
830 840 850 860 870 880
860 870 880 890 900 910
pF1KE4 RAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMAPQGAPTKSINISDYSPY
:. : .: .:::.: : .:..:::::.:.: :. . :.:: : ::. :: :..::: ::
NP_001 RTKE--EDPIIPFSDGPIISKWGAISRSSRTGYHTTDPVQATASQGSATKPISVSDYVPY
890 900 910 920 930 940
920 930 940 950 960 970
pF1KE4 --GTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPSAEREQLRLELQQLNH
.. . : : :. .. :..:. ::.:. ......: : :. . : :::::
NP_001 VNAVDSRW--SSYG--NEATSSAHYVERDRFIVTDLSGHRK--HSSTGDLLSLELQQ---
950 960 970 980 990
980 990 1000 1010 1020 1030
pF1KE4 QISQQTQLRGLEREANTLAGQSQPPPPPPPKWPGMISSEQLSLELHQVEREIGKRTREL-
.....: :.::::.:: :. :: .. ...:.:.: . .:: :. ::
NP_001 --AKSNSLL-LQREANALAMQQ--------KWNSLDEGRHLTLNL--LSKEIELRNGELQ
1000 1010 1020 1030 1040
1040 1050 1060 1070 1080
pF1KE4 ------SMENQCSLDMKSKLNTSKQAE-NGQPEPQNKVPAEDLTLTFSSD-VPNGSALTQ
. ... . :.. .:.. : .:: :: ... .: .. ..: . :: :.
NP_001 SDYTEDATDTKPDRDIELELSALDTDEPDGQSEPIEEILDIQLGISSQNDQLLNGMAVEN
1050 1060 1070 1080 1090 1100
1090 1100 1110 1120
pF1KE4 ENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP
NP_001 GHPVQQHQKEPPKQKKQSLGEDHVILEEQKTILPVTSCFSQPLPVSISNASCLPITTSVS
1110 1120 1130 1140 1150 1160
1125 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 17:20:07 2016 done: Mon Nov 7 17:20:09 2016
Total Scan time: 16.420 Total Display time: 0.360
Function used was FASTA [36.3.4 Apr, 2011]