Result of FASTA (omim) for
pFN21AE4237
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4237, 1047 aa
1>>>pF1KE4237 1047 - 1047 aa - 1047 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.4700+/-0.000473; mu= -0.9706+/- 0.030
mean_var=357.1152+/-75.612, 0's: 0 Z-trim(118.4): 149 B-trim: 0 in 0/58
Lambda= 0.067869
statistics sampled from 31188 (31366) to 31188 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.685), E-opt: 0.2 (0.368), width: 16
Scan time: 12.410
The best scores are: opt bits E(85289)
NP_002881 (OMIM: 139150,605462,608354,608355) ras (1047) 6958 696.6 1.9e-199
XP_011541827 (OMIM: 139150,605462,608354,608355) P (1018) 5793 582.5 4e-165
NP_072179 (OMIM: 139150,605462,608354,608355) ras ( 870) 5769 580.1 1.8e-164
XP_011541829 (OMIM: 139150,605462,608354,608355) P ( 539) 3608 368.3 6.5e-101
XP_016858344 (OMIM: 606136) PREDICTED: ras GTPase- (1138) 649 78.9 1.8e-13
NP_733793 (OMIM: 606136) ras GTPase-activating pro (1280) 649 78.9 2e-13
XP_016858341 (OMIM: 606136) PREDICTED: ras GTPase- (1409) 649 79.0 2.1e-13
XP_016858340 (OMIM: 606136) PREDICTED: ras GTPase- (1412) 649 79.0 2.1e-13
NP_004832 (OMIM: 606136) ras GTPase-activating pro (1139) 642 78.2 2.9e-13
XP_005245679 (OMIM: 606136) PREDICTED: ras GTPase- (1142) 642 78.2 2.9e-13
XP_016858343 (OMIM: 606136) PREDICTED: ras GTPase- (1145) 642 78.2 2.9e-13
XP_016858342 (OMIM: 606136) PREDICTED: ras GTPase- (1234) 642 78.2 3.1e-13
XP_011508469 (OMIM: 606136) PREDICTED: ras GTPase- (1287) 642 78.3 3.2e-13
XP_011508468 (OMIM: 606136) PREDICTED: ras GTPase- (1290) 642 78.3 3.2e-13
XP_016858339 (OMIM: 606136) PREDICTED: ras GTPase- (1416) 642 78.3 3.4e-13
XP_016858338 (OMIM: 606136) PREDICTED: ras GTPase- (1419) 642 78.3 3.4e-13
XP_016869789 (OMIM: 609205) PREDICTED: disabled ho (1065) 635 77.5 4.5e-13
XP_011516573 (OMIM: 609205) PREDICTED: disabled ho (1065) 635 77.5 4.5e-13
XP_011516572 (OMIM: 609205) PREDICTED: disabled ho (1065) 635 77.5 4.5e-13
NP_619723 (OMIM: 609205) disabled homolog 2-intera (1065) 635 77.5 4.5e-13
XP_005251781 (OMIM: 609205) PREDICTED: disabled ho (1128) 635 77.5 4.7e-13
XP_011516569 (OMIM: 609205) PREDICTED: disabled ho (1131) 635 77.5 4.7e-13
NP_115941 (OMIM: 609205) disabled homolog 2-intera (1132) 635 77.5 4.7e-13
XP_016869788 (OMIM: 609205) PREDICTED: disabled ho (1141) 635 77.5 4.7e-13
XP_011516568 (OMIM: 609205) PREDICTED: disabled ho (1153) 635 77.5 4.7e-13
XP_011516567 (OMIM: 609205) PREDICTED: disabled ho (1160) 635 77.5 4.8e-13
XP_005251778 (OMIM: 609205) PREDICTED: disabled ho (1161) 635 77.5 4.8e-13
XP_016869787 (OMIM: 609205) PREDICTED: disabled ho (1164) 635 77.5 4.8e-13
XP_011516566 (OMIM: 609205) PREDICTED: disabled ho (1182) 635 77.5 4.8e-13
XP_005251776 (OMIM: 609205) PREDICTED: disabled ho (1189) 635 77.5 4.8e-13
NP_075055 (OMIM: 616561) RAS protein activator lik (1011) 559 70.0 7.5e-11
XP_011526489 (OMIM: 616561) PREDICTED: RAS protein ( 949) 533 67.5 4.2e-10
XP_011526488 (OMIM: 616561) PREDICTED: RAS protein (1008) 533 67.5 4.4e-10
XP_011526487 (OMIM: 616561) PREDICTED: RAS protein (1014) 533 67.5 4.4e-10
NP_006763 (OMIM: 603384,612621) ras/Rap GTPase-act (1343) 433 57.8 4.8e-07
XP_011533144 (OMIM: 605182) PREDICTED: ras GTPase- ( 802) 418 56.1 9.1e-07
XP_011533143 (OMIM: 605182) PREDICTED: ras GTPase- ( 802) 418 56.1 9.1e-07
NP_001307751 (OMIM: 605182) ras GTPase-activating ( 802) 418 56.1 9.1e-07
NP_031394 (OMIM: 605182) ras GTPase-activating pro ( 834) 418 56.1 9.4e-07
NP_000258 (OMIM: 162200,162210,193520,601321,60778 (2818) 412 56.1 3.3e-06
XP_016880178 (OMIM: 162200,162210,193520,601321,60 (2828) 412 56.1 3.4e-06
XP_005258041 (OMIM: 162200,162210,193520,601321,60 (2836) 412 56.1 3.4e-06
XP_006721988 (OMIM: 162200,162210,193520,601321,60 (2846) 412 56.1 3.4e-06
NP_001290175 (OMIM: 601589) ras GTPase-activating ( 853) 386 53.0 8.4e-06
XP_016862459 (OMIM: 601589) PREDICTED: ras GTPase- ( 707) 377 52.1 1.3e-05
NP_006497 (OMIM: 601589) ras GTPase-activating pro ( 849) 377 52.1 1.5e-05
NP_001290174 (OMIM: 601589) ras GTPase-activating ( 850) 377 52.1 1.5e-05
XP_011511361 (OMIM: 601589) PREDICTED: ras GTPase- ( 853) 377 52.1 1.5e-05
XP_016862458 (OMIM: 601589) PREDICTED: ras GTPase- ( 871) 377 52.1 1.6e-05
XP_016862457 (OMIM: 601589) PREDICTED: ras GTPase- ( 872) 377 52.1 1.6e-05
>>NP_002881 (OMIM: 139150,605462,608354,608355) ras GTPa (1047 aa)
initn: 6958 init1: 6958 opt: 6958 Z-score: 3701.8 bits: 696.6 E(85289): 1.9e-199
Smith-Waterman score: 6958; 100.0% identity (100.0% similar) in 1047 aa overlap (1-1047:1-1047)
10 20 30 40 50 60
pF1KE4 MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 TSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 VNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFV
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE4 KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ
970 980 990 1000 1010 1020
1030 1040
pF1KE4 HVLKKLLAITELLQQKQNQYTKTNDVR
:::::::::::::::::::::::::::
NP_002 HVLKKLLAITELLQQKQNQYTKTNDVR
1030 1040
>>XP_011541827 (OMIM: 139150,605462,608354,608355) PREDI (1018 aa)
initn: 5793 init1: 5793 opt: 5793 Z-score: 3085.4 bits: 582.5 E(85289): 4e-165
Smith-Waterman score: 6692; 97.2% identity (97.2% similar) in 1047 aa overlap (1-1047:1-1018)
10 20 30 40 50 60
pF1KE4 MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 TSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 VNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFV
:::::::::::::::::::::::::::: :::
XP_011 VNTNLTHLLNILSELVEKIFMASEILPP-----------------------------GFV
850 860 870
910 920 930 940 950 960
pF1KE4 FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KE4 KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ
940 950 960 970 980 990
1030 1040
pF1KE4 HVLKKLLAITELLQQKQNQYTKTNDVR
:::::::::::::::::::::::::::
XP_011 HVLKKLLAITELLQQKQNQYTKTNDVR
1000 1010
>>NP_072179 (OMIM: 139150,605462,608354,608355) ras GTPa (870 aa)
initn: 5769 init1: 5769 opt: 5769 Z-score: 3073.6 bits: 580.1 E(85289): 1.8e-164
Smith-Waterman score: 5769; 100.0% identity (100.0% similar) in 867 aa overlap (181-1047:4-870)
160 170 180 190 200 210
pF1KE4 GTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESD
::::::::::::::::::::::::::::::
NP_072 MKGWYHGKLDRTIAEERLRQAGKSGSYLIRESD
10 20 30
220 230 240 250 260 270
pF1KE4 RRPGSFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_072 RRPGSFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLY
40 50 60 70 80 90
280 290 300 310 320 330
pF1KE4 PVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_072 PVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGL
100 110 120 130 140 150
340 350 360 370 380 390
pF1KE4 IVEDLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_072 IVEDLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYF
160 170 180 190 200 210
400 410 420 430 440 450
pF1KE4 RTNENIQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_072 RTNENIQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQVL
220 230 240 250 260 270
460 470 480 490 500 510
pF1KE4 NDTVDGKEIYNTIRRKTKDAFYKNIVKKGYLLKKGKGKRWKNLYFILEGSDAQLIYFESE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_072 NDTVDGKEIYNTIRRKTKDAFYKNIVKKGYLLKKGKGKRWKNLYFILEGSDAQLIYFESE
280 290 300 310 320 330
520 530 540 550 560 570
pF1KE4 KRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_072 KRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMK
340 350 360 370 380 390
580 590 600 610 620 630
pF1KE4 GLQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_072 GLQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHA
400 410 420 430 440 450
640 650 660 670 680 690
pF1KE4 REGQNPVWSEEFVFDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_072 REGQNPVWSEEFVFDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWF
460 470 480 490 500 510
700 710 720 730 740 750
pF1KE4 LLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_072 LLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRT
520 530 540 550 560 570
760 770 780 790 800 810
pF1KE4 LLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_072 LLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFV
580 590 600 610 620 630
820 830 840 850 860 870
pF1KE4 HHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_072 HHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTL
640 650 660 670 680 690
880 890 900 910 920 930
pF1KE4 RYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_072 RYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTL
700 710 720 730 740 750
940 950 960 970 980 990
pF1KE4 ILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_072 ILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTD
760 770 780 790 800 810
1000 1010 1020 1030 1040
pF1KE4 LSRDLAALHEICVAHSDELRTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDVR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_072 LSRDLAALHEICVAHSDELRTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDVR
820 830 840 850 860 870
>>XP_011541829 (OMIM: 139150,605462,608354,608355) PREDI (539 aa)
initn: 3608 init1: 3608 opt: 3608 Z-score: 1932.7 bits: 368.3 E(85289): 6.5e-101
Smith-Waterman score: 3608; 100.0% identity (100.0% similar) in 536 aa overlap (1-536:1-536)
10 20 30 40 50 60
pF1KE4 MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 TSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGSFR
490 500 510 520 530
550 560 570 580 590 600
pF1KE4 FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI
>>XP_016858344 (OMIM: 606136) PREDICTED: ras GTPase-acti (1138 aa)
initn: 366 init1: 239 opt: 649 Z-score: 362.8 bits: 78.9 E(85289): 1.8e-13
Smith-Waterman score: 669; 27.9% identity (60.5% similar) in 534 aa overlap (526-1044:115-629)
500 510 520 530 540 550
pF1KE4 ILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIF
:: .:.:..:. ::... :.
XP_016 PKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKC----
90 100 110 120 130 140
560 570 580 590 600 610
pF1KE4 YFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKL-PVKHFTNP
:. .. . . ::..:. : .:. .: : : . : : : ::. : : :..
XP_016 -FSCNSASERDKWMENLR-----RTVQPNKDNCR-RAENVLRLWIIEAKDLAPKKKY---
150 160 170 180 190
620 630 640 650 660
pF1KE4 YCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLPPDINRFEITL----SNKTKKSKDPD
.:.. :... :.: .. ...: :.:.: : .::: .. . . . .: ::.:.
XP_016 FCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPP-LHSITVHIYKDVEKKKKKDKNNY
200 210 220 230 240
670 680 690 700 710 720
pF1KE4 ILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG-SLRVRARYSMEKIMPEEEYSEFKE
. .. . . . ...:. .:. : :: : :.:...:.. :.: :.:.:: :
XP_016 VGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAE
250 260 270 280 290 300
730 740 750 760 770 780
pF1KE4 LILQKELHVVYALSHVCG-QDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTL
.. .. . .: : . ... :: :..:. . .: : :.. : .:
XP_016 FVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVL
310 320 330 340 350 360
790 800 810 820 830 840
pF1KE4 -FRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLT
:: .:.:. .:.:.: .. :..: :: . : ..:: ..::..::: ..: .. . .
XP_016 IFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSN
370 380 390 400 410 420
850 860 870 880 890 900
pF1KE4 HLLNILSELVE-KIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLI
:.. ::. ::. . ..: :. ... ... .. . . :..:. .:::..
XP_016 --LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDIS--ERLISASLFLRFL
430 440 450 460 470 480
910 920 930 940 950 960
pF1KE4 CPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKH
::::..: .::.... :. ..::: :.:: .:::::...:: :: :: .: :.. .
XP_016 CPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWG
490 500 510 520 530 540
970 980 990 1000 1010 1020
pF1KE4 RMIMFLDELGNVPELPDTTEHS-RTDLSRDLAALHEICVAHSDEL-RTLSNERGAQQHVL
: :: :..: . .: . ::.:.:..:: . ..: .. . : .::
XP_016 GMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVL
550 560 570 580 590 600
1030 1040
pF1KE4 K---KLLAITELLQQKQNQYTKTNDVR
: :. .::. ..:. :
XP_016 ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNT
610 620 630 640 650 660
>>NP_733793 (OMIM: 606136) ras GTPase-activating protein (1280 aa)
initn: 366 init1: 239 opt: 649 Z-score: 362.1 bits: 78.9 E(85289): 2e-13
Smith-Waterman score: 669; 27.9% identity (60.5% similar) in 534 aa overlap (526-1044:260-774)
500 510 520 530 540 550
pF1KE4 ILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIF
:: .:.:..:. ::... :.
NP_733 PKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKC----
230 240 250 260 270 280
560 570 580 590 600 610
pF1KE4 YFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKL-PVKHFTNP
:. .. . . ::..:. : .:. .: : : . : : : ::. : : :..
NP_733 -FSCNSASERDKWMENLR-----RTVQPNKDNCR-RAENVLRLWIIEAKDLAPKKKY---
290 300 310 320 330
620 630 640 650 660
pF1KE4 YCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLPPDINRFEITL----SNKTKKSKDPD
.:.. :... :.: .. ...: :.:.: : .::: .. . . . .: ::.:.
NP_733 FCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPP-LHSITVHIYKDVEKKKKKDKNNY
340 350 360 370 380 390
670 680 690 700 710 720
pF1KE4 ILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG-SLRVRARYSMEKIMPEEEYSEFKE
. .. . . . ...:. .:. : :: : :.:...:.. :.: :.:.:: :
NP_733 VGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAE
400 410 420 430 440 450
730 740 750 760 770 780
pF1KE4 LILQKELHVVYALSHVCG-QDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTL
.. .. . .: : . ... :: :..:. . .: : :.. : .:
NP_733 FVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVL
460 470 480 490 500 510
790 800 810 820 830 840
pF1KE4 -FRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLT
:: .:.:. .:.:.: .. :..: :: . : ..:: ..::..::: ..: .. . .
NP_733 IFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSN
520 530 540 550 560 570
850 860 870 880 890 900
pF1KE4 HLLNILSELVE-KIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLI
:.. ::. ::. . ..: :. ... ... .. . . :..:. .:::..
NP_733 --LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDIS--ERLISASLFLRFL
580 590 600 610 620 630
910 920 930 940 950 960
pF1KE4 CPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKH
::::..: .::.... :. ..::: :.:: .:::::...:: :: :: .: :.. .
NP_733 CPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWG
640 650 660 670 680 690
970 980 990 1000 1010 1020
pF1KE4 RMIMFLDELGNVPELPDTTEHS-RTDLSRDLAALHEICVAHSDEL-RTLSNERGAQQHVL
: :: :..: . .: . ::.:.:..:: . ..: .. . : .::
NP_733 GMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVL
700 710 720 730 740 750
1030 1040
pF1KE4 K---KLLAITELLQQKQNQYTKTNDVR
: :. .::. ..:. :
NP_733 ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNT
760 770 780 790 800 810
>>XP_016858341 (OMIM: 606136) PREDICTED: ras GTPase-acti (1409 aa)
initn: 366 init1: 239 opt: 649 Z-score: 361.6 bits: 79.0 E(85289): 2.1e-13
Smith-Waterman score: 669; 27.9% identity (60.5% similar) in 534 aa overlap (526-1044:389-903)
500 510 520 530 540 550
pF1KE4 ILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIF
:: .:.:..:. ::... :.
XP_016 PKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKC----
360 370 380 390 400 410
560 570 580 590 600 610
pF1KE4 YFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKL-PVKHFTNP
:. .. . . ::..:. : .:. .: : : . : : : ::. : : :..
XP_016 -FSCNSASERDKWMENLR-----RTVQPNKDNCR-RAENVLRLWIIEAKDLAPKKKY---
420 430 440 450 460
620 630 640 650 660
pF1KE4 YCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLPPDINRFEITL----SNKTKKSKDPD
.:.. :... :.: .. ...: :.:.: : .::: .. . . . .: ::.:.
XP_016 FCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPP-LHSITVHIYKDVEKKKKKDKNNY
470 480 490 500 510 520
670 680 690 700 710 720
pF1KE4 ILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG-SLRVRARYSMEKIMPEEEYSEFKE
. .. . . . ...:. .:. : :: : :.:...:.. :.: :.:.:: :
XP_016 VGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAE
530 540 550 560 570 580
730 740 750 760 770 780
pF1KE4 LILQKELHVVYALSHVCG-QDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTL
.. .. . .: : . ... :: :..:. . .: : :.. : .:
XP_016 FVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVL
590 600 610 620 630 640
790 800 810 820 830 840
pF1KE4 -FRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLT
:: .:.:. .:.:.: .. :..: :: . : ..:: ..::..::: ..: .. . .
XP_016 IFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSN
650 660 670 680 690 700
850 860 870 880 890 900
pF1KE4 HLLNILSELVE-KIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLI
:.. ::. ::. . ..: :. ... ... .. . . :..:. .:::..
XP_016 --LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDIS--ERLISASLFLRFL
710 720 730 740 750
910 920 930 940 950 960
pF1KE4 CPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKH
::::..: .::.... :. ..::: :.:: .:::::...:: :: :: .: :.. .
XP_016 CPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWG
760 770 780 790 800 810
970 980 990 1000 1010 1020
pF1KE4 RMIMFLDELGNVPELPDTTEHS-RTDLSRDLAALHEICVAHSDEL-RTLSNERGAQQHVL
: :: :..: . .: . ::.:.:..:: . ..: .. . : .::
XP_016 GMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVL
820 830 840 850 860 870
1030 1040
pF1KE4 K---KLLAITELLQQKQNQYTKTNDVR
: :. .::. ..:. :
XP_016 ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNT
880 890 900 910 920 930
>>XP_016858340 (OMIM: 606136) PREDICTED: ras GTPase-acti (1412 aa)
initn: 366 init1: 239 opt: 649 Z-score: 361.6 bits: 79.0 E(85289): 2.1e-13
Smith-Waterman score: 669; 27.9% identity (60.5% similar) in 534 aa overlap (526-1044:389-903)
500 510 520 530 540 550
pF1KE4 ILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIF
:: .:.:..:. ::... :.
XP_016 PKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKC----
360 370 380 390 400 410
560 570 580 590 600 610
pF1KE4 YFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKL-PVKHFTNP
:. .. . . ::..:. : .:. .: : : . : : : ::. : : :..
XP_016 -FSCNSASERDKWMENLR-----RTVQPNKDNCR-RAENVLRLWIIEAKDLAPKKKY---
420 430 440 450 460
620 630 640 650 660
pF1KE4 YCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLPPDINRFEITL----SNKTKKSKDPD
.:.. :... :.: .. ...: :.:.: : .::: .. . . . .: ::.:.
XP_016 FCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPP-LHSITVHIYKDVEKKKKKDKNNY
470 480 490 500 510 520
670 680 690 700 710 720
pF1KE4 ILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG-SLRVRARYSMEKIMPEEEYSEFKE
. .. . . . ...:. .:. : :: : :.:...:.. :.: :.:.:: :
XP_016 VGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAE
530 540 550 560 570 580
730 740 750 760 770 780
pF1KE4 LILQKELHVVYALSHVCG-QDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTL
.. .. . .: : . ... :: :..:. . .: : :.. : .:
XP_016 FVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVL
590 600 610 620 630 640
790 800 810 820 830 840
pF1KE4 -FRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLT
:: .:.:. .:.:.: .. :..: :: . : ..:: ..::..::: ..: .. . .
XP_016 IFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSN
650 660 670 680 690 700
850 860 870 880 890 900
pF1KE4 HLLNILSELVE-KIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLI
:.. ::. ::. . ..: :. ... ... .. . . :..:. .:::..
XP_016 --LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDIS--ERLISASLFLRFL
710 720 730 740 750
910 920 930 940 950 960
pF1KE4 CPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKH
::::..: .::.... :. ..::: :.:: .:::::...:: :: :: .: :.. .
XP_016 CPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWG
760 770 780 790 800 810
970 980 990 1000 1010 1020
pF1KE4 RMIMFLDELGNVPELPDTTEHS-RTDLSRDLAALHEICVAHSDEL-RTLSNERGAQQHVL
: :: :..: . .: . ::.:.:..:: . ..: .. . : .::
XP_016 GMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVL
820 830 840 850 860 870
1030 1040
pF1KE4 K---KLLAITELLQQKQNQYTKTNDVR
: :. .::. ..:. :
XP_016 ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNT
880 890 900 910 920 930
>>NP_004832 (OMIM: 606136) ras GTPase-activating protein (1139 aa)
initn: 366 init1: 239 opt: 642 Z-score: 359.0 bits: 78.2 E(85289): 2.9e-13
Smith-Waterman score: 665; 27.9% identity (60.3% similar) in 541 aa overlap (526-1044:112-633)
500 510 520 530 540 550
pF1KE4 ILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIF
:: .:.:..:. ::... :.
NP_004 PKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKC----
90 100 110 120 130
560 570 580 590 600 610
pF1KE4 YFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKL-PVKHFTNP
:. .. . . ::..:. : .:. .: : : . : : : ::. : : :..
NP_004 -FSCNSASERDKWMENLR-----RTVQPNKDNCR-RAENVLRLWIIEAKDLAPKKKY---
140 150 160 170 180
620 630 640 650 660
pF1KE4 YCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLPPDINRFEITL----SNKTKKSKDPD
.:.. :... :.: .. ...: :.:.: : .::: .. . . . .: ::.:.
NP_004 FCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPP-LHSITVHIYKDVEKKKKKDKNNY
190 200 210 220 230 240
670 680 690 700 710 720
pF1KE4 ILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG-SLRVRARYSMEKIMPEEEYSEFKE
. .. . . . ...:. .:. : :: : :.:...:.. :.: :.:.:: :
NP_004 VGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAE
250 260 270 280 290 300
730 740 750 760 770 780
pF1KE4 LILQKELHVVYALSHVCG-QDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTL
.. .. . .: : . ... :: :..:. . .: : :.. : .:
NP_004 FVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVL
310 320 330 340 350 360
790 800 810 820 830 840
pF1KE4 -FRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLT
:: .:.:. .:.:.: .. :..: :: . : ..:: ..::..::: ..: .. . .
NP_004 IFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSN
370 380 390 400 410 420
850 860 870 880 890 900
pF1KE4 HLLNILSELVE-KIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLI
:.. ::. ::. . ..: :. ... ... .. . . :..:. .:::..
NP_004 --LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDIS--ERLISASLFLRFL
430 440 450 460 470 480
910 920 930 940 950 960
pF1KE4 CPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKH
::::..: .::.... :. ..::: :.:: .:::::...:: :: :: .: :.. .
NP_004 CPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWG
490 500 510 520 530 540
970 980 990 1000 1010
pF1KE4 RMIMFLDELGNVPELPDTTEHS-RTDLSRDLAALHEI---CVAHSDE-----LRTLSNER
: :: :..: . .: . ::.:.:..:: . :.. :. :.. .
NP_004 GMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKL
550 560 570 580 590 600
1020 1030 1040
pF1KE4 GAQQHVLK---KLLAITELLQQKQNQYTKTNDVR
: .:: : :. .::. ..:. :
NP_004 GPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLK
610 620 630 640 650 660
NP_004 SPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEH
670 680 690 700 710 720
>>XP_005245679 (OMIM: 606136) PREDICTED: ras GTPase-acti (1142 aa)
initn: 366 init1: 239 opt: 642 Z-score: 359.0 bits: 78.2 E(85289): 2.9e-13
Smith-Waterman score: 665; 27.9% identity (60.3% similar) in 541 aa overlap (526-1044:112-633)
500 510 520 530 540 550
pF1KE4 ILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIF
:: .:.:..:. ::... :.
XP_005 PKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKC----
90 100 110 120 130
560 570 580 590 600 610
pF1KE4 YFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKL-PVKHFTNP
:. .. . . ::..:. : .:. .: : : . : : : ::. : : :..
XP_005 -FSCNSASERDKWMENLR-----RTVQPNKDNCR-RAENVLRLWIIEAKDLAPKKKY---
140 150 160 170 180
620 630 640 650 660
pF1KE4 YCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLPPDINRFEITL----SNKTKKSKDPD
.:.. :... :.: .. ...: :.:.: : .::: .. . . . .: ::.:.
XP_005 FCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPP-LHSITVHIYKDVEKKKKKDKNNY
190 200 210 220 230 240
670 680 690 700 710 720
pF1KE4 ILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG-SLRVRARYSMEKIMPEEEYSEFKE
. .. . . . ...:. .:. : :: : :.:...:.. :.: :.:.:: :
XP_005 VGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAE
250 260 270 280 290 300
730 740 750 760 770 780
pF1KE4 LILQKELHVVYALSHVCG-QDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTL
.. .. . .: : . ... :: :..:. . .: : :.. : .:
XP_005 FVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVL
310 320 330 340 350 360
790 800 810 820 830 840
pF1KE4 -FRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLT
:: .:.:. .:.:.: .. :..: :: . : ..:: ..::..::: ..: .. . .
XP_005 IFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSN
370 380 390 400 410 420
850 860 870 880 890 900
pF1KE4 HLLNILSELVE-KIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLI
:.. ::. ::. . ..: :. ... ... .. . . :..:. .:::..
XP_005 --LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDIS--ERLISASLFLRFL
430 440 450 460 470 480
910 920 930 940 950 960
pF1KE4 CPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKH
::::..: .::.... :. ..::: :.:: .:::::...:: :: :: .: :.. .
XP_005 CPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWG
490 500 510 520 530 540
970 980 990 1000 1010
pF1KE4 RMIMFLDELGNVPELPDTTEHS-RTDLSRDLAALHEI---CVAHSDE-----LRTLSNER
: :: :..: . .: . ::.:.:..:: . :.. :. :.. .
XP_005 GMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKL
550 560 570 580 590 600
1020 1030 1040
pF1KE4 GAQQHVLK---KLLAITELLQQKQNQYTKTNDVR
: .:: : :. .::. ..:. :
XP_005 GPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLK
610 620 630 640 650 660
XP_005 SPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEH
670 680 690 700 710 720
1047 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 06:56:53 2016 done: Tue Nov 8 06:56:54 2016
Total Scan time: 12.410 Total Display time: 0.220
Function used was FASTA [36.3.4 Apr, 2011]