Result of FASTA (omim) for
pFN21AE4221
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4221, 767 aa
1>>>pF1KE4221 767 - 767 aa - 767 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.9258+/-0.00037; mu= 7.9822+/- 0.023
mean_var=152.5625+/-31.196, 0's: 0 Z-trim(118.4): 197 B-trim: 435 in 1/56
Lambda= 0.103837
statistics sampled from 30971 (31237) to 30971 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.72), E-opt: 0.2 (0.366), width: 16
Scan time: 13.660
The best scores are: opt bits E(85289)
NP_061893 (OMIM: 616637) TBC1 domain family member ( 767) 5254 799.4 0
XP_005257106 (OMIM: 616637) PREDICTED: TBC1 domain ( 767) 5254 799.4 0
XP_006721757 (OMIM: 616637) PREDICTED: TBC1 domain ( 767) 5254 799.4 0
XP_005257107 (OMIM: 616637) PREDICTED: TBC1 domain ( 766) 5235 796.6 0
XP_005257109 (OMIM: 616637) PREDICTED: TBC1 domain ( 640) 4321 659.6 1.1e-188
XP_016879674 (OMIM: 616637) PREDICTED: TBC1 domain ( 639) 4302 656.8 8.2e-188
XP_006721758 (OMIM: 616637) PREDICTED: TBC1 domain ( 634) 3885 594.3 5.2e-169
XP_016879675 (OMIM: 616637) PREDICTED: TBC1 domain ( 599) 3549 544.0 7e-154
XP_016879677 (OMIM: 616637) PREDICTED: TBC1 domain ( 462) 3203 492.1 2.3e-138
XP_011522624 (OMIM: 616637) PREDICTED: TBC1 domain ( 753) 2834 436.9 1.5e-121
XP_011522625 (OMIM: 616637) PREDICTED: TBC1 domain ( 521) 2808 432.9 1.6e-120
XP_016879676 (OMIM: 616637) PREDICTED: TBC1 domain ( 543) 2808 432.9 1.7e-120
NP_001258774 (OMIM: 616637) TBC1 domain family mem ( 405) 2796 431.1 4.6e-120
XP_011522626 (OMIM: 616637) PREDICTED: TBC1 domain ( 396) 2742 423.0 1.2e-117
NP_001258773 (OMIM: 616637) TBC1 domain family mem ( 392) 2331 361.4 4.2e-99
NP_001258775 (OMIM: 616637) TBC1 domain family mem ( 278) 1863 291.2 4e-78
XP_011536984 (OMIM: 612662) PREDICTED: TBC1 domain ( 445) 690 115.6 4.7e-25
XP_006719630 (OMIM: 612662) PREDICTED: TBC1 domain ( 445) 690 115.6 4.7e-25
XP_016875317 (OMIM: 612662) PREDICTED: TBC1 domain ( 530) 690 115.6 5.4e-25
XP_016875316 (OMIM: 612662) PREDICTED: TBC1 domain ( 547) 690 115.6 5.5e-25
XP_016875315 (OMIM: 612662) PREDICTED: TBC1 domain ( 575) 690 115.7 5.7e-25
XP_016875314 (OMIM: 612662) PREDICTED: TBC1 domain ( 575) 690 115.7 5.7e-25
XP_011536981 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 690 115.7 5.9e-25
XP_016875313 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 690 115.7 5.9e-25
XP_006719629 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 690 115.7 5.9e-25
XP_011536982 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 690 115.7 5.9e-25
NP_001139685 (OMIM: 612662) TBC1 domain family mem ( 674) 690 115.7 6.5e-25
XP_006719628 (OMIM: 612662) PREDICTED: TBC1 domain ( 682) 690 115.7 6.6e-25
NP_001139686 (OMIM: 612662) TBC1 domain family mem ( 682) 690 115.7 6.6e-25
NP_073608 (OMIM: 612662) TBC1 domain family member ( 691) 690 115.7 6.7e-25
NP_001161694 (OMIM: 616659) TBC1 domain family mem ( 615) 689 115.5 6.7e-25
XP_006719627 (OMIM: 612662) PREDICTED: TBC1 domain ( 699) 690 115.7 6.7e-25
NP_078958 (OMIM: 616659) TBC1 domain family member ( 648) 689 115.5 7e-25
NP_002527 (OMIM: 311240) TBC1 domain family member ( 688) 521 90.4 2.8e-17
XP_011525619 (OMIM: 616659) PREDICTED: TBC1 domain ( 501) 449 79.5 3.8e-14
NP_001035037 (OMIM: 611417) small G protein signal (1148) 428 76.6 6.6e-13
NP_001091979 (OMIM: 611418) small G protein signal (1006) 402 72.7 8.8e-12
NP_055668 (OMIM: 611418) small G protein signaling (1051) 402 72.7 9.2e-12
XP_016880963 (OMIM: 611418) PREDICTED: small G pro (1052) 402 72.7 9.2e-12
XP_011522404 (OMIM: 611418) PREDICTED: small G pro (1097) 402 72.7 9.5e-12
XP_016880964 (OMIM: 611418) PREDICTED: small G pro (1047) 397 71.9 1.5e-11
XP_011522405 (OMIM: 611418) PREDICTED: small G pro (1092) 397 71.9 1.6e-11
XP_016880965 (OMIM: 611418) PREDICTED: small G pro ( 785) 361 66.5 5.1e-10
XP_011522410 (OMIM: 611418) PREDICTED: small G pro (1012) 361 66.5 6.3e-10
XP_011522409 (OMIM: 611418) PREDICTED: small G pro (1042) 361 66.5 6.4e-10
XP_011522408 (OMIM: 611418) PREDICTED: small G pro (1057) 361 66.5 6.5e-10
XP_011522407 (OMIM: 611418) PREDICTED: small G pro (1058) 361 66.5 6.5e-10
XP_011522406 (OMIM: 611418) PREDICTED: small G pro (1087) 361 66.5 6.7e-10
XP_011522403 (OMIM: 611418) PREDICTED: small G pro (1103) 361 66.5 6.7e-10
XP_011536983 (OMIM: 612662) PREDICTED: TBC1 domain ( 456) 295 56.4 3.1e-07
>>NP_061893 (OMIM: 616637) TBC1 domain family member 16 (767 aa)
initn: 5254 init1: 5254 opt: 5254 Z-score: 4262.4 bits: 799.4 E(85289): 0
Smith-Waterman score: 5254; 100.0% identity (100.0% similar) in 767 aa overlap (1-767:1-767)
10 20 30 40 50 60
pF1KE4 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM
670 680 690 700 710 720
730 740 750 760
pF1KE4 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR
:::::::::::::::::::::::::::::::::::::::::::::::
NP_061 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR
730 740 750 760
>>XP_005257106 (OMIM: 616637) PREDICTED: TBC1 domain fam (767 aa)
initn: 5254 init1: 5254 opt: 5254 Z-score: 4262.4 bits: 799.4 E(85289): 0
Smith-Waterman score: 5254; 100.0% identity (100.0% similar) in 767 aa overlap (1-767:1-767)
10 20 30 40 50 60
pF1KE4 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM
670 680 690 700 710 720
730 740 750 760
pF1KE4 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR
:::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR
730 740 750 760
>>XP_006721757 (OMIM: 616637) PREDICTED: TBC1 domain fam (767 aa)
initn: 5254 init1: 5254 opt: 5254 Z-score: 4262.4 bits: 799.4 E(85289): 0
Smith-Waterman score: 5254; 100.0% identity (100.0% similar) in 767 aa overlap (1-767:1-767)
10 20 30 40 50 60
pF1KE4 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM
670 680 690 700 710 720
730 740 750 760
pF1KE4 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR
:::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR
730 740 750 760
>>XP_005257107 (OMIM: 616637) PREDICTED: TBC1 domain fam (766 aa)
initn: 2801 init1: 2801 opt: 5235 Z-score: 4247.1 bits: 796.6 E(85289): 0
Smith-Waterman score: 5235; 99.9% identity (99.9% similar) in 767 aa overlap (1-767:1-766)
10 20 30 40 50 60
pF1KE4 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA
::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDQ-VAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA
370 380 390 400 410
430 440 450 460 470 480
pF1KE4 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE4 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE4 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE4 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE4 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM
660 670 680 690 700 710
730 740 750 760
pF1KE4 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR
:::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR
720 730 740 750 760
>>XP_005257109 (OMIM: 616637) PREDICTED: TBC1 domain fam (640 aa)
initn: 4321 init1: 4321 opt: 4321 Z-score: 3508.2 bits: 659.6 E(85289): 1.1e-188
Smith-Waterman score: 4321; 100.0% identity (100.0% similar) in 636 aa overlap (1-636:1-636)
10 20 30 40 50 60
pF1KE4 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ
::::::::::::::::::::::::::::::::::::
XP_005 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQGADV
610 620 630 640
670 680 690 700 710 720
pF1KE4 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM
>>XP_016879674 (OMIM: 616637) PREDICTED: TBC1 domain fam (639 aa)
initn: 2453 init1: 2453 opt: 4302 Z-score: 3492.9 bits: 656.8 E(85289): 8.2e-188
Smith-Waterman score: 4302; 99.8% identity (99.8% similar) in 636 aa overlap (1-636:1-635)
10 20 30 40 50 60
pF1KE4 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA
::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDQ-VAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA
370 380 390 400 410
430 440 450 460 470 480
pF1KE4 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE4 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE4 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE4 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ
::::::::::::::::::::::::::::::::::::
XP_016 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQGADV
600 610 620 630
670 680 690 700 710 720
pF1KE4 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM
>>XP_006721758 (OMIM: 616637) PREDICTED: TBC1 domain fam (634 aa)
initn: 3885 init1: 3885 opt: 3885 Z-score: 3155.3 bits: 594.3 E(85289): 5.2e-169
Smith-Waterman score: 3885; 100.0% identity (100.0% similar) in 576 aa overlap (1-576:1-576)
10 20 30 40 50 60
pF1KE4 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED
::::::::::::::::::::::::::::::::::::
XP_006 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLEEWTWETAPKCALRVGSLPGHGAA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ
XP_006 ASVLPRPGTTLCLTLDHTTASGTVRSGRNWQRQV
610 620 630
>>XP_016879675 (OMIM: 616637) PREDICTED: TBC1 domain fam (599 aa)
initn: 3549 init1: 3549 opt: 3549 Z-score: 2883.6 bits: 544.0 E(85289): 7e-154
Smith-Waterman score: 3549; 98.8% identity (99.2% similar) in 518 aa overlap (250-767:82-599)
220 230 240 250 260 270
pF1KE4 VSRDSSFDSDSDTFSSPFCLSPISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQ
::: .. :::::::::::::::::::::
XP_016 GLHGQMPLVTFCSLVPKMRCRLCRESRLSPRGSGAERAVSSPPSSSDAGLRFPDSNGLLQ
60 70 80 90 100 110
280 290 300 310 320 330
pF1KE4 TPRWDEPQRVCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPRWDEPQRVCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHH
120 130 140 150 160 170
340 350 360 370 380 390
pF1KE4 GGLDKLSDVFQQWKYCTEMQLKDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGLDKLSDVFQQWKYCTEMQLKDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVS
180 190 200 210 220 230
400 410 420 430 440 450
pF1KE4 AWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKR
240 250 260 270 280 290
460 470 480 490 500 510
pF1KE4 KEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLN
300 310 320 330 340 350
520 530 540 550 560 570
pF1KE4 YAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYL
360 370 380 390 400 410
580 590 600 610 620 630
pF1KE4 RELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDY
420 430 440 450 460 470
640 650 660 670 680 690
pF1KE4 FHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRI
480 490 500 510 520 530
700 710 720 730 740 750
pF1KE4 PCSLHDLCKLCGSGMWDSGSMPAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PCSLHDLCKLCGSGMWDSGSMPAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTP
540 550 560 570 580 590
760
pF1KE4 QDGFGFRR
::::::::
XP_016 QDGFGFRR
>>XP_016879677 (OMIM: 616637) PREDICTED: TBC1 domain fam (462 aa)
initn: 3203 init1: 3203 opt: 3203 Z-score: 2605.2 bits: 492.1 E(85289): 2.3e-138
Smith-Waterman score: 3203; 100.0% identity (100.0% similar) in 462 aa overlap (306-767:1-462)
280 290 300 310 320 330
pF1KE4 GLLQTPRWDEPQRVCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVF
::::::::::::::::::::::::::::::
XP_016 MRSLRLFFSDEACTSGQLVVASRESQYKVF
10 20 30
340 350 360 370 380 390
pF1KE4 HFHHGGLDKLSDVFQQWKYCTEMQLKDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFHHGGLDKLSDVFQQWKYCTEMQLKDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKR
40 50 60 70 80 90
400 410 420 430 440 450
pF1KE4 LGVSAWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGVSAWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALR
100 110 120 130 140 150
460 470 480 490 500 510
pF1KE4 LQKRKEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQKRKEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRR
160 170 180 190 200 210
520 530 540 550 560 570
pF1KE4 ILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQ
220 230 240 250 260 270
580 590 600 610 620 630
pF1KE4 LLYLRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLYLRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHY
280 290 300 310 320 330
640 650 660 670 680 690
pF1KE4 QTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRL
340 350 360 370 380 390
700 710 720 730 740 750
pF1KE4 LPRIPCSLHDLCKLCGSGMWDSGSMPAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPRIPCSLHDLCKLCGSGMWDSGSMPAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKG
400 410 420 430 440 450
760
pF1KE4 PKTPQDGFGFRR
::::::::::::
XP_016 PKTPQDGFGFRR
460
>>XP_011522624 (OMIM: 616637) PREDICTED: TBC1 domain fam (753 aa)
initn: 2834 init1: 2834 opt: 2834 Z-score: 2303.3 bits: 436.9 E(85289): 1.5e-121
Smith-Waterman score: 5125; 98.2% identity (98.2% similar) in 767 aa overlap (1-767:1-753)
10 20 30 40 50 60
pF1KE4 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRK-
370 380 390 400 410
430 440 450 460 470 480
pF1KE4 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 -------------VWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
420 430 440 450 460
490 500 510 520 530 540
pF1KE4 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE4 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE4 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE4 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM
650 660 670 680 690 700
730 740 750 760
pF1KE4 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR
:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR
710 720 730 740 750
767 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:29:06 2016 done: Sun Nov 6 01:29:08 2016
Total Scan time: 13.660 Total Display time: 0.160
Function used was FASTA [36.3.4 Apr, 2011]