Result of FASTA (omim) for
pFN21AE4208
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4208, 728 aa
1>>>pF1KE4208 728 - 728 aa - 728 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.8892+/-0.000441; mu= 13.1043+/- 0.028
mean_var=151.8294+/-32.128, 0's: 0 Z-trim(113.8): 182 B-trim: 0 in 0/58
Lambda= 0.104087
statistics sampled from 23140 (23345) to 23140 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.628), E-opt: 0.2 (0.274), width: 16
Scan time: 11.990
The best scores are: opt bits E(85289)
NP_061170 (OMIM: 609317) E3 ubiquitin-protein liga ( 728) 4941 754.9 2.6e-217
NP_001287688 (OMIM: 609317) E3 ubiquitin-protein l ( 716) 4809 735.1 2.3e-211
XP_016865111 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 733) 4267 653.7 7.5e-187
XP_016865110 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 745) 4267 653.7 7.6e-187
NP_001287681 (OMIM: 609317) E3 ubiquitin-protein l ( 573) 3881 595.6 1.8e-169
XP_016865112 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 529) 2793 432.2 2.6e-120
NP_001243528 (OMIM: 600986) tripartite motif-conta ( 736) 1779 280.1 2.2e-74
XP_016857882 (OMIM: 600986) PREDICTED: tripartite ( 746) 1779 280.1 2.2e-74
NP_001243530 (OMIM: 600986) tripartite motif-conta ( 746) 1779 280.1 2.2e-74
NP_079334 (OMIM: 600986) tripartite motif-containi ( 759) 1779 280.1 2.3e-74
XP_011508304 (OMIM: 600986) PREDICTED: tripartite ( 788) 1779 280.1 2.3e-74
NP_001269307 (OMIM: 600986) tripartite motif-conta ( 633) 1708 269.4 3.2e-71
NP_001269308 (OMIM: 600986) tripartite motif-conta ( 551) 1365 217.8 9.4e-56
NP_001243529 (OMIM: 600986) tripartite motif-conta ( 717) 838 138.8 7.5e-32
XP_016876437 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 688) 644 109.6 4.3e-23
XP_016876435 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 706) 644 109.6 4.4e-23
XP_016876432 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 791) 633 108.0 1.5e-22
XP_011534691 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 802) 633 108.0 1.5e-22
XP_016876436 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 692) 610 104.5 1.5e-21
NP_055978 (OMIM: 606555) E3 ubiquitin-protein liga ( 710) 610 104.5 1.5e-21
XP_016876434 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 710) 610 104.5 1.5e-21
NP_443210 (OMIM: 606555) E3 ubiquitin-protein liga ( 550) 599 102.8 4e-21
XP_005267359 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 714) 599 102.9 4.8e-21
XP_016876433 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 732) 599 102.9 4.9e-21
XP_005267358 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 777) 599 102.9 5.1e-21
XP_006720081 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 795) 599 102.9 5.2e-21
NP_001180206 (OMIM: 189960,300000,300552) E3 ubiqu ( 667) 570 98.5 9.3e-20
NP_000372 (OMIM: 189960,300000,300552) E3 ubiquiti ( 667) 570 98.5 9.3e-20
NP_001092094 (OMIM: 189960,300000,300552) E3 ubiqu ( 667) 570 98.5 9.3e-20
XP_016885025 (OMIM: 189960,300000,300552) PREDICTE ( 667) 570 98.5 9.3e-20
NP_150632 (OMIM: 189960,300000,300552) E3 ubiquiti ( 667) 570 98.5 9.3e-20
XP_016885031 (OMIM: 189960,300000,300552) PREDICTE ( 489) 565 97.6 1.3e-19
NP_001180208 (OMIM: 189960,300000,300552) E3 ubiqu ( 489) 565 97.6 1.3e-19
XP_016885029 (OMIM: 189960,300000,300552) PREDICTE ( 552) 565 97.7 1.4e-19
XP_016884728 (OMIM: 300204,300928) PREDICTED: prob ( 685) 558 96.7 3.3e-19
NP_438112 (OMIM: 300204,300928) probable E3 ubiqui ( 705) 558 96.7 3.4e-19
XP_005262119 (OMIM: 300204,300928) PREDICTED: prob ( 715) 558 96.7 3.4e-19
NP_036348 (OMIM: 300204,300928) probable E3 ubiqui ( 735) 558 96.7 3.5e-19
XP_016876439 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 593) 531 92.6 5e-18
XP_016876438 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 611) 531 92.6 5.1e-18
XP_011542494 (OMIM: 610584) PREDICTED: tripartite ( 781) 434 78.1 1.5e-13
NP_001287818 (OMIM: 610584) tripartite motif-conta ( 721) 429 77.3 2.3e-13
NP_001004342 (OMIM: 610584) tripartite motif-conta ( 783) 429 77.4 2.5e-13
XP_016856812 (OMIM: 610584) PREDICTED: tripartite ( 854) 429 77.4 2.6e-13
NP_001274121 (OMIM: 609829) FSD1-like protein isof ( 497) 409 74.2 1.4e-12
XP_011517381 (OMIM: 609829) PREDICTED: FSD1-like p ( 542) 409 74.2 1.5e-12
XP_016870671 (OMIM: 609829) PREDICTED: FSD1-like p ( 529) 405 73.6 2.3e-12
XP_016870672 (OMIM: 609829) PREDICTED: FSD1-like p ( 498) 403 73.3 2.7e-12
XP_011517380 (OMIM: 609829) PREDICTED: FSD1-like p ( 543) 403 73.3 2.8e-12
NP_001138785 (OMIM: 609829) FSD1-like protein isof ( 530) 399 72.7 4.2e-12
>>NP_061170 (OMIM: 609317) E3 ubiquitin-protein ligase T (728 aa)
initn: 4941 init1: 4941 opt: 4941 Z-score: 4022.6 bits: 754.9 E(85289): 2.6e-217
Smith-Waterman score: 4941; 99.9% identity (100.0% similar) in 728 aa overlap (1-728:1-728)
10 20 30 40 50 60
pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPGWKRNSLTPRTTVFPCPGCEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPGWKRNSLTPRTTVFPCPGCEH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 DVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 ECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 HANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 HANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 THFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 THFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 QSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 QSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 EINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 EINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLEN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 SSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 SSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 AGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 AGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 LRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 LRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 PMPTSIGIFLDCDKGKVNFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAK
:::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::
NP_061 PMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAK
670 680 690 700 710 720
pF1KE4 YLEYQEDM
::::::::
NP_061 YLEYQEDM
>>NP_001287688 (OMIM: 609317) E3 ubiquitin-protein ligas (716 aa)
initn: 4809 init1: 4809 opt: 4809 Z-score: 3915.5 bits: 735.1 E(85289): 2.3e-211
Smith-Waterman score: 4809; 99.9% identity (100.0% similar) in 707 aa overlap (22-728:10-716)
10 20 30 40 50 60
pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL
:::::::::::::::::::::::::::::::::::::::
NP_001 MEGDGSDSPVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL
10 20 30 40
70 80 90 100 110 120
pF1KE4 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPGWKRNSLTPRTTVFPCPGCEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPGWKRNSLTPRTTVFPCPGCEH
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE4 DVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCN
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 ECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGN
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE4 HANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAI
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE4 THFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 THFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETD
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 QSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVP
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE4 EINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLEN
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE4 SSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESR
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE4 AGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEW
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE4 LRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVL
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE4 PMPTSIGIFLDCDKGKVNFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAK
:::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::
NP_001 PMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAK
650 660 670 680 690 700
pF1KE4 YLEYQEDM
::::::::
NP_001 YLEYQEDM
710
>>XP_016865111 (OMIM: 609317) PREDICTED: E3 ubiquitin-pr (733 aa)
initn: 4267 init1: 4267 opt: 4267 Z-score: 3475.5 bits: 653.7 E(85289): 7.5e-187
Smith-Waterman score: 4765; 97.5% identity (97.7% similar) in 724 aa overlap (22-728:10-733)
10 20 30 40 50 60
pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL
:::::::::::::::::::::::::::::::::::::::
XP_016 MEGDGSDSPVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL
10 20 30 40
70 80 90 100
pF1KE4 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRP-----------------GWKR
::::::::::::::::::::::::::::::::::::::: ::::
XP_016 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPASQRRSVGWRGHKKLLNGWKR
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE4 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE4 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE4 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE4 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE4 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE4 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSW
410 420 430 440 450 460
470 480 490 500 510 520
pF1KE4 NEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGY
470 480 490 500 510 520
530 540 550 560 570 580
pF1KE4 NNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPY
530 540 550 560 570 580
590 600 610 620 630 640
pF1KE4 SYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKF
590 600 610 620 630 640
650 660 670 680 690 700
pF1KE4 FIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVNFYDMDQMKCLYERQVDCSHTLYPAF
::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::
XP_016 FIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAF
650 660 670 680 690 700
710 720
pF1KE4 ALMGSGGIQLEEPITAKYLEYQEDM
:::::::::::::::::::::::::
XP_016 ALMGSGGIQLEEPITAKYLEYQEDM
710 720 730
>>XP_016865110 (OMIM: 609317) PREDICTED: E3 ubiquitin-pr (745 aa)
initn: 4267 init1: 4267 opt: 4267 Z-score: 3475.4 bits: 653.7 E(85289): 7.6e-187
Smith-Waterman score: 4897; 97.6% identity (97.7% similar) in 745 aa overlap (1-728:1-745)
10 20 30 40 50 60
pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL
10 20 30 40 50 60
70 80 90 100
pF1KE4 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRP-----------------GWKR
::::::::::::::::::::::::::::::::::::::: ::::
XP_016 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPASQRRSVGWRGHKKLLNGWKR
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE4 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE4 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE4 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE4 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE4 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE4 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSW
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE4 NEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGY
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE4 NNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPY
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE4 SYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKF
610 620 630 640 650 660
650 660 670 680 690 700
pF1KE4 FIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVNFYDMDQMKCLYERQVDCSHTLYPAF
::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::
XP_016 FIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAF
670 680 690 700 710 720
710 720
pF1KE4 ALMGSGGIQLEEPITAKYLEYQEDM
:::::::::::::::::::::::::
XP_016 ALMGSGGIQLEEPITAKYLEYQEDM
730 740
>>NP_001287681 (OMIM: 609317) E3 ubiquitin-protein ligas (573 aa)
initn: 3881 init1: 3881 opt: 3881 Z-score: 3163.6 bits: 595.6 E(85289): 1.8e-169
Smith-Waterman score: 3881; 99.8% identity (100.0% similar) in 573 aa overlap (156-728:1-573)
130 140 150 160 170 180
pF1KE4 ERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCNECFKI
::::::::::::::::::::::::::::::
NP_001 MCDLCKPPPQESTKSCMDCSASYCNECFKI
10 20 30
190 200 210 220 230 240
pF1KE4 HHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGNHANHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGNHANHR
40 50 60 70 80 90
250 260 270 280 290 300
pF1KE4 VTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAITHFEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAITHFEK
100 110 120 130 140 150
310 320 330 340 350 360
pF1KE4 LFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETDQSCFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETDQSCFV
160 170 180 190 200 210
370 380 390 400 410 420
pF1KE4 QTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVPEINEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVPEINEE
220 230 240 250 260 270
430 440 450 460 470 480
pF1KE4 QSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLENSSTYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLENSSTYA
280 290 300 310 320 330
490 500 510 520 530 540
pF1KE4 FRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESRAGFNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESRAGFNL
340 350 360 370 380 390
550 560 570 580 590 600
pF1KE4 LLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEWLRSPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEWLRSPR
400 410 420 430 440 450
610 620 630 640 650 660
pF1KE4 DAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVLPMPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVLPMPTS
460 470 480 490 500 510
670 680 690 700 710 720
pF1KE4 IGIFLDCDKGKVNFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQ
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQ
520 530 540 550 560 570
pF1KE4 EDM
:::
NP_001 EDM
>>XP_016865112 (OMIM: 609317) PREDICTED: E3 ubiquitin-pr (529 aa)
initn: 2793 init1: 2793 opt: 2793 Z-score: 2281.1 bits: 432.2 E(85289): 2.6e-120
Smith-Waterman score: 3423; 96.8% identity (96.8% similar) in 528 aa overlap (1-511:1-528)
10 20 30 40 50 60
pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL
10 20 30 40 50 60
70 80 90 100
pF1KE4 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRP-----------------GWKR
::::::::::::::::::::::::::::::::::::::: ::::
XP_016 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPASQRRSVGWRGHKKLLNGWKR
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE4 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE4 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE4 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE4 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE4 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE4 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSW
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE4 NEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGY
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPG
490 500 510 520
530 540 550 560 570 580
pF1KE4 NNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPY
>>NP_001243528 (OMIM: 600986) tripartite motif-containin (736 aa)
initn: 1457 init1: 626 opt: 1779 Z-score: 1456.3 bits: 280.1 E(85289): 2.2e-74
Smith-Waterman score: 2102; 42.8% identity (75.3% similar) in 726 aa overlap (24-720:1-722)
10 20 30 40 50 60
pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL
.::.:.::.::.:.:.. .::.::: :..:. :..:.
NP_001 MKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
10 20 30
70 80 90 100
pF1KE4 LLTLDDSFNDVGSDNSNQ-----SSPRLRLPS------PSMDKIDRINR------PGWKR
: .... :.: :.. :.: : : :. :..::. . :: ::
NP_001 L--GQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKR
40 50 60 70 80 90
110 120 130 140 150 160
pF1KE4 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP
..: :.. .::::.:. ::.:::::. :::::.::: .::::::.. .. ::.:.:::::
NP_001 GALHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPP
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE4 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY
: :.::.: .: :..::::::. ::::: ::::: . :: .:::: ::::.:. :... :
NP_001 PLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHK-EEVTHY
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE4 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL
:. :.: ::.::.. .:..:..: . :::..::.::.:.. :..:... :..:: ::.
NP_001 CKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEE
220 230 240 250 260 270
290 300 310 320 330 340
pF1KE4 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL
...:: .:..::::. . : ::::...:.:.::. .. :: ....:..:...::
NP_001 AVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLL
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE4 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ
...::::::::::::::: ::::.::::: :: .:::.:..:::::..::. ......
NP_001 DGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGRE
340 350 360 370 380 390
410 420 430 440 450
pF1KE4 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWH-HPEKDKADSYVLEYRKIN---RDD
.:: ::.:. ..: :. ... .:.. .. :. :.. : :..:.:. . .
NP_001 MKLLTELNFLRVP-EAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPG
400 410 420 430 440 450
460 470 480 490 500 510
pF1KE4 EMSWNEIE-VCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFD
:.. : : ::: .... ...:.:..:::. . . . :... ::::::::. :..:
NP_001 PTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLD
460 470 480 490 500 510
520 530 540 550 560 570
pF1KE4 EKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAF
. : . :.: .. . :.: :. :::::.:. .: . :.: ..::...:.:. .::
NP_001 SRWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWAC
520 530 540 550 560 570
580 590 600 610 620 630
pF1KE4 RVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTI
:.: ::::::::. .:::: ... :..::::. :::::::.::: ..: ::...::
NP_001 AVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTI
580 590 600 610 620 630
640 650 660 670 680 690
pF1KE4 GMQKFFIPKSPTSSNEPENR-------VLPMPTSIGIFLDCDKGKVNFYDMDQMKCLYER
:: :... .. .:. .: ..:.: .:: :: ..:.:.: : ... : :
NP_001 GMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLEC
640 650 660 670 680 690
700 710 720
pF1KE4 QVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM
.::: . ::: ..:.:..::.::. .:
NP_001 PLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD
700 710 720 730
>>XP_016857882 (OMIM: 600986) PREDICTED: tripartite moti (746 aa)
initn: 1457 init1: 626 opt: 1779 Z-score: 1456.3 bits: 280.1 E(85289): 2.2e-74
Smith-Waterman score: 2110; 42.8% identity (75.4% similar) in 729 aa overlap (21-720:8-732)
10 20 30 40 50 60
pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL
:...::.:.::.::.:.:.. .::.::: :..:. :..:.
XP_016 MAAKRGTKTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
10 20 30 40
70 80 90 100
pF1KE4 LLTLDDSFNDVGSDNSNQ-----SSPRLRLPS------PSMDKIDRINR------PGWKR
: .... :.: :.. :.: : : :. :..::. . :: ::
XP_016 L--GQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKR
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE4 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP
..: :.. .::::.:. ::.:::::. :::::.::: .::::::.. .. ::.:.:::::
XP_016 GALHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPP
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE4 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY
: :.::.: .: :..::::::. ::::: ::::: . :: .:::: ::::.:. :... :
XP_016 PLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHK-EEVTHY
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE4 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL
:. :.: ::.::.. .:..:..: . :::..::.::.:.. :..:... :..:: ::.
XP_016 CKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEE
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE4 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL
...:: .:..::::. . : ::::...:.:.::. .. :: ....:..:...::
XP_016 AVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLL
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE4 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ
...::::::::::::::: ::::.::::: :: .:::.:..:::::..::. ......
XP_016 DGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGRE
350 360 370 380 390 400
410 420 430 440 450
pF1KE4 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWH-HPEKDKADSYVLEYRKIN---RDD
.:: ::.:. ..: :. ... .:.. .. :. :.. : :..:.:. . .
XP_016 MKLLTELNFLRVP-EAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPG
410 420 430 440 450 460
460 470 480 490 500 510
pF1KE4 EMSWNEIE-VCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFD
:.. : : ::: .... ...:.:..:::. . . . :... ::::::::. :..:
XP_016 PTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLD
470 480 490 500 510 520
520 530 540 550 560 570
pF1KE4 EKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAF
. : . :.: .. . :.: :. :::::.:. .: . :.: ..::...:.:. .::
XP_016 SRWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWAC
530 540 550 560 570 580
580 590 600 610 620 630
pF1KE4 RVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTI
:.: ::::::::. .:::: ... :..::::. :::::::.::: ..: ::...::
XP_016 AVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTI
590 600 610 620 630 640
640 650 660 670 680 690
pF1KE4 GMQKFFIPKSPTSSNEPENR-------VLPMPTSIGIFLDCDKGKVNFYDMDQMKCLYER
:: :... .. .:. .: ..:.: .:: :: ..:.:.: : ... : :
XP_016 GMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLEC
650 660 670 680 690 700
700 710 720
pF1KE4 QVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM
.::: . ::: ..:.:..::.::. .:
XP_016 PLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD
710 720 730 740
>>NP_001243530 (OMIM: 600986) tripartite motif-containin (746 aa)
initn: 1457 init1: 626 opt: 1779 Z-score: 1456.3 bits: 280.1 E(85289): 2.2e-74
Smith-Waterman score: 2109; 42.7% identity (75.3% similar) in 730 aa overlap (20-720:7-732)
10 20 30 40 50 60
pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL
: ...::.:.::.::.:.:.. .::.::: :..:. :..:.
NP_001 MGAKGNGLTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
10 20 30 40
70 80 90 100
pF1KE4 LLTLDDSFNDVGSDNSNQ-----SSPRLRLPS------PSMDKIDRINR------PGWKR
: .... :.: :.. :.: : : :. :..::. . :: ::
NP_001 LG--QQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKR
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE4 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP
..: :.. .::::.:. ::.:::::. :::::.::: .::::::.. .. ::.:.:::::
NP_001 GALHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPP
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE4 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY
: :.::.: .: :..::::::. ::::: ::::: . :: .:::: ::::.:. :... :
NP_001 PLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHK-EEVTHY
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE4 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL
:. :.: ::.::.. .:..:..: . :::..::.::.:.. :..:... :..:: ::.
NP_001 CKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEE
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE4 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL
...:: .:..::::. . : ::::...:.:.::. .. :: ....:..:...::
NP_001 AVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLL
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE4 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ
...::::::::::::::: ::::.::::: :: .:::.:..:::::..::. ......
NP_001 DGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGRE
350 360 370 380 390 400
410 420 430 440 450
pF1KE4 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWH-HPEKDKADSYVLEYRKIN---RDD
.:: ::.:. ..: :. ... .:.. .. :. :.. : :..:.:. . .
NP_001 MKLLTELNFLRVP-EAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPG
410 420 430 440 450 460
460 470 480 490 500 510
pF1KE4 EMSWNEIE-VCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFD
:.. : : ::: .... ...:.:..:::. . . . :... ::::::::. :..:
NP_001 PTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLD
470 480 490 500 510 520
520 530 540 550 560 570
pF1KE4 EKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAF
. : . :.: .. . :.: :. :::::.:. .: . :.: ..::...:.:. .::
NP_001 SRWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWAC
530 540 550 560 570 580
580 590 600 610 620 630
pF1KE4 RVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTI
:.: ::::::::. .:::: ... :..::::. :::::::.::: ..: ::...::
NP_001 AVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTI
590 600 610 620 630 640
640 650 660 670 680 690
pF1KE4 GMQKFFIPKSPTSSNEPENR-------VLPMPTSIGIFLDCDKGKVNFYDMDQMKCLYER
:: :... .. .:. .: ..:.: .:: :: ..:.:.: : ... : :
NP_001 GMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLEC
650 660 670 680 690 700
700 710 720
pF1KE4 QVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM
.::: . ::: ..:.:..::.::. .:
NP_001 PLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD
710 720 730 740
>>NP_079334 (OMIM: 600986) tripartite motif-containing p (759 aa)
initn: 1474 init1: 626 opt: 1779 Z-score: 1456.2 bits: 280.1 E(85289): 2.3e-74
Smith-Waterman score: 2140; 42.3% identity (75.3% similar) in 749 aa overlap (1-720:1-745)
10 20 30 40 50 60
pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL
:.:. .:. : ::. ... ....::.:.::.::.:.:.. .::.::: :..:. :..:.
NP_079 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
10 20 30 40 50 60
70 80 90 100
pF1KE4 LLTLDDSFNDVGSDNSNQ-----SSPRLRLPS------PSMDKIDRINR------PGWKR
: .... :.: :.. :.: : : :. :..::. . :: ::
NP_079 LG--QQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKR
70 80 90 100 110
110 120 130 140 150 160
pF1KE4 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP
..: :.. .::::.:. ::.:::::. :::::.::: .::::::.. .. ::.:.:::::
NP_079 GALHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPP
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY
: :.::.: .: :..::::::. ::::: ::::: . :: .:::: ::::.:. :... :
NP_079 PLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHK-EEVTHY
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL
:. :.: ::.::.. .:..:..: . :::..::.::.:.. :..:... :..:: ::.
NP_079 CKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEE
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL
...:: .:..::::. . : ::::...:.:.::. .. :: ....:..:...::
NP_079 AVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLL
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ
...::::::::::::::: ::::.::::: :: .:::.:..:::::..::. ......
NP_079 DGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGRE
360 370 380 390 400 410
410 420 430 440 450
pF1KE4 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWH-HPEKDKADSYVLEYRKIN---RDD
.:: ::.:. ..: :. ... .:.. .. :. :.. : :..:.:. . .
NP_079 MKLLTELNFLRVP-EAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPG
420 430 440 450 460 470
460 470 480 490 500 510
pF1KE4 EMSWNEIE-VCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFD
:.. : : ::: .... ...:.:..:::. . . . :... ::::::::. :..:
NP_079 PTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLD
480 490 500 510 520 530
520 530 540 550 560 570
pF1KE4 EKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAF
. : . :.: .. . :.: :. :::::.:. .: . :.: ..::...:.:. .::
NP_079 SRWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWAC
540 550 560 570 580 590
580 590 600 610 620 630
pF1KE4 RVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTI
:.: ::::::::. .:::: ... :..::::. :::::::.::: ..: ::...::
NP_079 AVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTI
600 610 620 630 640 650
640 650 660 670 680 690
pF1KE4 GMQKFFIPKSPTSSNEPENR-------VLPMPTSIGIFLDCDKGKVNFYDMDQMKCLYER
:: :... .. .:. .: ..:.: .:: :: ..:.:.: : ... : :
NP_079 GMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLEC
660 670 680 690 700 710
700 710 720
pF1KE4 QVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM
.::: . ::: ..:.:..::.::. .:
NP_079 PLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD
720 730 740 750
728 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 16:40:56 2016 done: Mon Nov 7 16:40:58 2016
Total Scan time: 11.990 Total Display time: 0.220
Function used was FASTA [36.3.4 Apr, 2011]