Result of FASTA (omim) for
pFN21AE4191
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4191, 688 aa
1>>>pF1KE4191 688 - 688 aa - 688 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.6755+/-0.000355; mu= -5.7374+/- 0.022
mean_var=261.3198+/-54.654, 0's: 0 Z-trim(122.1): 87 B-trim: 0 in 0/58
Lambda= 0.079339
statistics sampled from 39589 (39681) to 39589 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.773), E-opt: 0.2 (0.465), width: 16
Scan time: 14.650
The best scores are: opt bits E(85289)
NP_002527 (OMIM: 311240) TBC1 domain family member ( 688) 4666 547.5 6e-155
NP_001161694 (OMIM: 616659) TBC1 domain family mem ( 615) 648 87.6 1.5e-16
NP_078958 (OMIM: 616659) TBC1 domain family member ( 648) 648 87.6 1.6e-16
XP_006719630 (OMIM: 612662) PREDICTED: TBC1 domain ( 445) 602 82.3 4.5e-15
XP_011536984 (OMIM: 612662) PREDICTED: TBC1 domain ( 445) 602 82.3 4.5e-15
XP_016875317 (OMIM: 612662) PREDICTED: TBC1 domain ( 530) 602 82.3 5.2e-15
XP_016875316 (OMIM: 612662) PREDICTED: TBC1 domain ( 547) 602 82.3 5.3e-15
XP_016875315 (OMIM: 612662) PREDICTED: TBC1 domain ( 575) 602 82.3 5.6e-15
XP_016875314 (OMIM: 612662) PREDICTED: TBC1 domain ( 575) 602 82.3 5.6e-15
XP_011536981 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 602 82.3 5.7e-15
XP_016875313 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 602 82.3 5.7e-15
XP_011536982 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 602 82.3 5.7e-15
XP_006719629 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 602 82.3 5.7e-15
NP_001139685 (OMIM: 612662) TBC1 domain family mem ( 674) 602 82.4 6.4e-15
NP_001139686 (OMIM: 612662) TBC1 domain family mem ( 682) 602 82.4 6.4e-15
XP_006719628 (OMIM: 612662) PREDICTED: TBC1 domain ( 682) 602 82.4 6.4e-15
NP_073608 (OMIM: 612662) TBC1 domain family member ( 691) 602 82.4 6.5e-15
XP_006719627 (OMIM: 612662) PREDICTED: TBC1 domain ( 699) 602 82.4 6.6e-15
XP_011522626 (OMIM: 616637) PREDICTED: TBC1 domain ( 396) 522 73.1 2.3e-12
NP_001258775 (OMIM: 616637) TBC1 domain family mem ( 278) 518 72.6 2.4e-12
NP_001258774 (OMIM: 616637) TBC1 domain family mem ( 405) 522 73.1 2.4e-12
XP_016879677 (OMIM: 616637) PREDICTED: TBC1 domain ( 462) 522 73.1 2.6e-12
XP_011522625 (OMIM: 616637) PREDICTED: TBC1 domain ( 521) 522 73.1 2.9e-12
XP_016879676 (OMIM: 616637) PREDICTED: TBC1 domain ( 543) 522 73.2 3e-12
XP_016879675 (OMIM: 616637) PREDICTED: TBC1 domain ( 599) 522 73.2 3.3e-12
XP_005257107 (OMIM: 616637) PREDICTED: TBC1 domain ( 766) 522 73.2 4e-12
XP_005257106 (OMIM: 616637) PREDICTED: TBC1 domain ( 767) 522 73.2 4e-12
NP_061893 (OMIM: 616637) TBC1 domain family member ( 767) 522 73.2 4e-12
XP_006721757 (OMIM: 616637) PREDICTED: TBC1 domain ( 767) 522 73.2 4e-12
XP_016879674 (OMIM: 616637) PREDICTED: TBC1 domain ( 639) 518 72.7 4.8e-12
XP_005257109 (OMIM: 616637) PREDICTED: TBC1 domain ( 640) 518 72.7 4.8e-12
XP_011525619 (OMIM: 616659) PREDICTED: TBC1 domain ( 501) 493 69.8 2.8e-11
NP_001258773 (OMIM: 616637) TBC1 domain family mem ( 392) 472 67.4 1.2e-10
XP_011522624 (OMIM: 616637) PREDICTED: TBC1 domain ( 753) 472 67.5 2.1e-10
XP_016880965 (OMIM: 611418) PREDICTED: small G pro ( 785) 392 58.4 1.2e-07
NP_001091979 (OMIM: 611418) small G protein signal (1006) 392 58.4 1.5e-07
XP_011522410 (OMIM: 611418) PREDICTED: small G pro (1012) 392 58.4 1.5e-07
XP_011522409 (OMIM: 611418) PREDICTED: small G pro (1042) 392 58.4 1.6e-07
XP_016880964 (OMIM: 611418) PREDICTED: small G pro (1047) 392 58.4 1.6e-07
NP_055668 (OMIM: 611418) small G protein signaling (1051) 392 58.4 1.6e-07
XP_016880963 (OMIM: 611418) PREDICTED: small G pro (1052) 392 58.4 1.6e-07
XP_011522408 (OMIM: 611418) PREDICTED: small G pro (1057) 392 58.4 1.6e-07
XP_011522407 (OMIM: 611418) PREDICTED: small G pro (1058) 392 58.4 1.6e-07
XP_011522406 (OMIM: 611418) PREDICTED: small G pro (1087) 392 58.4 1.6e-07
XP_011522405 (OMIM: 611418) PREDICTED: small G pro (1092) 392 58.4 1.6e-07
XP_011522404 (OMIM: 611418) PREDICTED: small G pro (1097) 392 58.4 1.7e-07
XP_011522403 (OMIM: 611418) PREDICTED: small G pro (1103) 392 58.4 1.7e-07
NP_001091968 (OMIM: 611417) small G protein signal (1032) 386 57.7 2.5e-07
NP_597711 (OMIM: 611417) small G protein signaling (1087) 386 57.7 2.6e-07
NP_001091967 (OMIM: 611417) small G protein signal (1093) 386 57.7 2.7e-07
>>NP_002527 (OMIM: 311240) TBC1 domain family member 25 (688 aa)
initn: 4666 init1: 4666 opt: 4666 Z-score: 2902.8 bits: 547.5 E(85289): 6e-155
Smith-Waterman score: 4666; 99.7% identity (100.0% similar) in 688 aa overlap (1-688:1-688)
10 20 30 40 50 60
pF1KE4 MATASGASDLSGSGAPPPGVGAQAAAAAEEEEREVVRVRVKKCESFLPPEFRSFAVDPQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MATASGASDLSGSGAPPPGVGAQAAAAAEEEEREVVRVRVKKCESFLPPEFRSFAVDPQI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 TSLDVLQHILIRAFDLSGKKNFGISYLGRDRLGQEVYLSLLSDWDLSTAFATASKPYLQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TSLDVLQHILIRAFDLSGKKNFGISYLGRDRLGQEVYLSLLSDWDLSTAFATASKPYLQL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 RVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILTQVGRTLSKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILTQVGRTLSKV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 QQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPEDLEFIRSTVLKDVLRTDRAHP
::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::
NP_002 LLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRSTVLKDVLRTDRAHP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 YYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 RLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 DDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGHRGWPVRQRHMLRPAGGGGST
::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::
NP_002 DDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADAGFGGHRGWPVRQRHMLRPAGGGGST
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 FEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 EPLLNSPDPLLSSFSHPDSPSSSSPPSTQEASPTGDMAVGSPLMQEVGSPKDPGKSLPPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EPLLNSPDPLLSSFSHPDSPSSSSPPSTQEASPTGDMAVGSPLMQEVGSPKDPGKSLPPV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 PPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVL
610 620 630 640 650 660
670 680
pF1KE4 RRARALFADYLQSEVWDSEEGAEATAAS
::::::::::::::::::::::::::::
NP_002 RRARALFADYLQSEVWDSEEGAEATAAS
670 680
>>NP_001161694 (OMIM: 616659) TBC1 domain family member (615 aa)
initn: 718 init1: 384 opt: 648 Z-score: 418.0 bits: 87.6 E(85289): 1.5e-16
Smith-Waterman score: 656; 33.2% identity (60.7% similar) in 389 aa overlap (197-576:246-599)
170 180 190 200 210 220
pF1KE4 QSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYH
::... :. ... ::.:.. ::. ::.
NP_001 LPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFS
220 230 240 250 260 270
230 240 250 260 270 280
pF1KE4 GGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED------
::. ::::. .:..::. :..:. ....:. :: ..: .: . .:::.
NP_001 GGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQW-KSVSPEQERRNSL
280 290 300 310 320 330
290 300 310 320 330 340
pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP
:. :: . .:: ::::.. .: :::. : : :.:.: :: . : ...: :::::: ::
NP_001 LHGYRSLIERDVSRTDRTNKFYEGPEN-PGLGLLNDILLTYCMYHFDLGYVQGMSDLLSP
340 350 360 370 380 390
350 360 370 380 390 400
pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA
:: :...: :: ::::.:. . .::. . ..: ....: :::: :: . ..:. .
NP_001 ILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDS
400 410 420 430 440 450
410 420 430 440 450 460
pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH
.: ::.::::. .:::: : :.::. :: :..:: : : ::. . :
NP_001 GSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLP-GPNLHL--LVA--CAILDM-----
460 470 480 490 500
470 480 490 500 510 520
pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR
.: : .: :.. . . :. ..: . :.. . . . .
NP_001 ------ERDTLMLSGFGSN---EILKHI----------NELTMKLSVEDVLTRAEALHRQ
510 520 530 540
530 540 550 560 570
pF1KE4 RDPLVQLPHPAA-LISSKSLSEPLLNSPDPLLSSFSHPDSPSSS--SPPSTQEASPTGDM
.::: . ... .:: .::.: : . : ::. . .:: . ...: :
NP_001 LTACPELPHNVQEILGLAPPAEP--HSPSPTASPL--PLSPTRAPPTPPPSTDTAPQPDS
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE4 AVGSPLMQEVGSPKDPGKSLPPVPPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNG
NP_001 SLEILPEEEDEGADS
610
>>NP_078958 (OMIM: 616659) TBC1 domain family member 17 (648 aa)
initn: 718 init1: 384 opt: 648 Z-score: 417.6 bits: 87.6 E(85289): 1.6e-16
Smith-Waterman score: 656; 33.2% identity (60.7% similar) in 389 aa overlap (197-576:279-632)
170 180 190 200 210 220
pF1KE4 QSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYH
::... :. ... ::.:.. ::. ::.
NP_078 LPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFS
250 260 270 280 290 300
230 240 250 260 270 280
pF1KE4 GGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED------
::. ::::. .:..::. :..:. ....:. :: ..: .: . .:::.
NP_078 GGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQW-KSVSPEQERRNSL
310 320 330 340 350 360
290 300 310 320 330 340
pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP
:. :: . .:: ::::.. .: :::. : : :.:.: :: . : ...: :::::: ::
NP_078 LHGYRSLIERDVSRTDRTNKFYEGPEN-PGLGLLNDILLTYCMYHFDLGYVQGMSDLLSP
370 380 390 400 410 420
350 360 370 380 390 400
pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA
:: :...: :: ::::.:. . .::. . ..: ....: :::: :: . ..:. .
NP_078 ILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDS
430 440 450 460 470 480
410 420 430 440 450 460
pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH
.: ::.::::. .:::: : :.::. :: :..:: : : ::. . :
NP_078 GSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLP-GPNLHL--LVA--CAILDM-----
490 500 510 520 530
470 480 490 500 510 520
pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR
.: : .: :.. . . :. ..: . :.. . . . .
NP_078 ------ERDTLMLSGFGSN---EILKHI----------NELTMKLSVEDVLTRAEALHRQ
540 550 560 570
530 540 550 560 570
pF1KE4 RDPLVQLPHPAA-LISSKSLSEPLLNSPDPLLSSFSHPDSPSSS--SPPSTQEASPTGDM
.::: . ... .:: .::.: : . : ::. . .:: . ...: :
NP_078 LTACPELPHNVQEILGLAPPAEP--HSPSPTASPL--PLSPTRAPPTPPPSTDTAPQPDS
580 590 600 610 620 630
580 590 600 610 620 630
pF1KE4 AVGSPLMQEVGSPKDPGKSLPPVPPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNG
NP_078 SLEILPEEEDEGADS
640
>>XP_006719630 (OMIM: 612662) PREDICTED: TBC1 domain fam (445 aa)
initn: 638 init1: 377 opt: 602 Z-score: 391.6 bits: 82.3 E(85289): 4.5e-15
Smith-Waterman score: 602; 38.8% identity (67.3% similar) in 245 aa overlap (196-435:68-311)
170 180 190 200 210 220
pF1KE4 TQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIY
. :.: :. .. ::.. .... :.
XP_006 IPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIF
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE4 HGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED-----
.::. .::: .:..::. .: : .:: . .:.:. :: ..: .: . .. ..
XP_006 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP
:. :: . ::: ::::.. .: : .:.: : :::.: :: . ...: :::::: ::
XP_006 LRDYRSLIEKDVNRTDRTNKFYEG-QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSP
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA
.: ::..: :: :: . : .. ::. . ..: :.. .:. ::: : : .::. .
XP_006 LLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDS
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH
:.::.::::...::::.: : ::. :: :. ::
XP_006 GYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR
XP_006 GFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTPDSDV
340 350 360 370 380 390
>>XP_011536984 (OMIM: 612662) PREDICTED: TBC1 domain fam (445 aa)
initn: 638 init1: 377 opt: 602 Z-score: 391.6 bits: 82.3 E(85289): 4.5e-15
Smith-Waterman score: 602; 38.8% identity (67.3% similar) in 245 aa overlap (196-435:68-311)
170 180 190 200 210 220
pF1KE4 TQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIY
. :.: :. .. ::.. .... :.
XP_011 IPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIF
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE4 HGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED-----
.::. .::: .:..::. .: : .:: . .:.:. :: ..: .: . .. ..
XP_011 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP
:. :: . ::: ::::.. .: : .:.: : :::.: :: . ...: :::::: ::
XP_011 LRDYRSLIEKDVNRTDRTNKFYEG-QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSP
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA
.: ::..: :: :: . : .. ::. . ..: :.. .:. ::: : : .::. .
XP_011 LLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDS
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH
:.::.::::...::::.: : ::. :: :. ::
XP_011 GYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR
XP_011 GFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTPDSDV
340 350 360 370 380 390
>>XP_016875317 (OMIM: 612662) PREDICTED: TBC1 domain fam (530 aa)
initn: 638 init1: 377 opt: 602 Z-score: 390.5 bits: 82.3 E(85289): 5.2e-15
Smith-Waterman score: 602; 38.8% identity (67.3% similar) in 245 aa overlap (196-435:153-396)
170 180 190 200 210 220
pF1KE4 TQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIY
. :.: :. .. ::.. .... :.
XP_016 IPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIF
130 140 150 160 170 180
230 240 250 260 270 280
pF1KE4 HGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED-----
.::. .::: .:..::. .: : .:: . .:.:. :: ..: .: . .. ..
XP_016 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR
190 200 210 220 230 240
290 300 310 320 330 340
pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP
:. :: . ::: ::::.. .: : .:.: : :::.: :: . ...: :::::: ::
XP_016 LRDYRSLIEKDVNRTDRTNKFYEG-QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSP
250 260 270 280 290 300
350 360 370 380 390 400
pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA
.: ::..: :: :: . : .. ::. . ..: :.. .:. ::: : : .::. .
XP_016 LLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDS
310 320 330 340 350 360
410 420 430 440 450 460
pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH
:.::.::::...::::.: : ::. :: :. ::
XP_016 GYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY
370 380 390 400 410 420
470 480 490 500 510 520
pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR
XP_016 GFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTPDSDV
430 440 450 460 470 480
>>XP_016875316 (OMIM: 612662) PREDICTED: TBC1 domain fam (547 aa)
initn: 638 init1: 377 opt: 602 Z-score: 390.3 bits: 82.3 E(85289): 5.3e-15
Smith-Waterman score: 602; 38.8% identity (67.3% similar) in 245 aa overlap (196-435:170-413)
170 180 190 200 210 220
pF1KE4 TQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIY
. :.: :. .. ::.. .... :.
XP_016 IPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIF
140 150 160 170 180 190
230 240 250 260 270 280
pF1KE4 HGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED-----
.::. .::: .:..::. .: : .:: . .:.:. :: ..: .: . .. ..
XP_016 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR
200 210 220 230 240 250
290 300 310 320 330 340
pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP
:. :: . ::: ::::.. .: : .:.: : :::.: :: . ...: :::::: ::
XP_016 LRDYRSLIEKDVNRTDRTNKFYEG-QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSP
260 270 280 290 300 310
350 360 370 380 390 400
pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA
.: ::..: :: :: . : .. ::. . ..: :.. .:. ::: : : .::. .
XP_016 LLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDS
320 330 340 350 360 370
410 420 430 440 450 460
pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH
:.::.::::...::::.: : ::. :: :. ::
XP_016 GYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY
380 390 400 410 420 430
470 480 490 500 510 520
pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR
XP_016 GFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTPDSDV
440 450 460 470 480 490
>>XP_016875315 (OMIM: 612662) PREDICTED: TBC1 domain fam (575 aa)
initn: 638 init1: 377 opt: 602 Z-score: 390.0 bits: 82.3 E(85289): 5.6e-15
Smith-Waterman score: 602; 38.8% identity (67.3% similar) in 245 aa overlap (196-435:198-441)
170 180 190 200 210 220
pF1KE4 TQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIY
. :.: :. .. ::.. .... :.
XP_016 IPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIF
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE4 HGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED-----
.::. .::: .:..::. .: : .:: . .:.:. :: ..: .: . .. ..
XP_016 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP
:. :: . ::: ::::.. .: : .:.: : :::.: :: . ...: :::::: ::
XP_016 LRDYRSLIEKDVNRTDRTNKFYEG-QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSP
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA
.: ::..: :: :: . : .. ::. . ..: :.. .:. ::: : : .::. .
XP_016 LLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDS
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH
:.::.::::...::::.: : ::. :: :. ::
XP_016 GYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY
410 420 430 440 450 460
470 480 490 500 510 520
pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR
XP_016 GFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTPDSDV
470 480 490 500 510 520
>>XP_016875314 (OMIM: 612662) PREDICTED: TBC1 domain fam (575 aa)
initn: 638 init1: 377 opt: 602 Z-score: 390.0 bits: 82.3 E(85289): 5.6e-15
Smith-Waterman score: 602; 38.8% identity (67.3% similar) in 245 aa overlap (196-435:198-441)
170 180 190 200 210 220
pF1KE4 TQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIY
. :.: :. .. ::.. .... :.
XP_016 IPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIF
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE4 HGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED-----
.::. .::: .:..::. .: : .:: . .:.:. :: ..: .: . .. ..
XP_016 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP
:. :: . ::: ::::.. .: : .:.: : :::.: :: . ...: :::::: ::
XP_016 LRDYRSLIEKDVNRTDRTNKFYEG-QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSP
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA
.: ::..: :: :: . : .. ::. . ..: :.. .:. ::: : : .::. .
XP_016 LLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDS
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH
:.::.::::...::::.: : ::. :: :. ::
XP_016 GYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY
410 420 430 440 450 460
470 480 490 500 510 520
pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR
XP_016 GFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTPDSDV
470 480 490 500 510 520
>>XP_011536981 (OMIM: 612662) PREDICTED: TBC1 domain fam (592 aa)
initn: 638 init1: 377 opt: 602 Z-score: 389.8 bits: 82.3 E(85289): 5.7e-15
Smith-Waterman score: 602; 38.8% identity (67.3% similar) in 245 aa overlap (196-435:215-458)
170 180 190 200 210 220
pF1KE4 TQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIY
. :.: :. .. ::.. .... :.
XP_011 IPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIF
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE4 HGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED-----
.::. .::: .:..::. .: : .:: . .:.:. :: ..: .: . .. ..
XP_011 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP
:. :: . ::: ::::.. .: : .:.: : :::.: :: . ...: :::::: ::
XP_011 LRDYRSLIEKDVNRTDRTNKFYEG-QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSP
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA
.: ::..: :: :: . : .. ::. . ..: :.. .:. ::: : : .::. .
XP_011 LLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDS
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH
:.::.::::...::::.: : ::. :: :. ::
XP_011 GYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR
XP_011 GFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTPDSDV
490 500 510 520 530 540
688 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 17:10:16 2016 done: Sat Nov 5 17:10:18 2016
Total Scan time: 14.650 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]