FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4181, 653 aa
1>>>pF1KE4181 653 - 653 aa - 653 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.7143+/-0.000413; mu= 9.5974+/- 0.026
mean_var=185.3900+/-37.817, 0's: 0 Z-trim(118.5): 125 B-trim: 705 in 2/52
Lambda= 0.094196
statistics sampled from 31397 (31527) to 31397 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.701), E-opt: 0.2 (0.37), width: 16
Scan time: 11.530
The best scores are: opt bits E(85289)
NP_002224 (OMIM: 176266) potassium voltage-gated c ( 653) 4351 604.2 4.9e-172
NP_002223 (OMIM: 176263) potassium voltage-gated c ( 575) 2243 317.6 7.7e-86
XP_011539701 (OMIM: 176262,616366) PREDICTED: pota ( 499) 2188 310.1 1.2e-83
XP_011539699 (OMIM: 176262,616366) PREDICTED: pota ( 499) 2188 310.1 1.2e-83
NP_004965 (OMIM: 176262,616366) potassium voltage- ( 499) 2188 310.1 1.2e-83
XP_011539700 (OMIM: 176262,616366) PREDICTED: pota ( 499) 2188 310.1 1.2e-83
XP_011539702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 2188 310.1 1.2e-83
XP_016856702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 2188 310.1 1.2e-83
XP_011539698 (OMIM: 176262,616366) PREDICTED: pota ( 499) 2188 310.1 1.2e-83
NP_114092 (OMIM: 176268) potassium voltage-gated c ( 456) 1910 272.3 2.7e-72
NP_001191198 (OMIM: 176262,616366) potassium volta ( 356) 1341 194.9 4.3e-49
NP_000208 (OMIM: 160120,176260) potassium voltage- ( 495) 1280 186.7 1.7e-46
NP_002225 (OMIM: 176267,612240) potassium voltage- ( 613) 1216 178.1 8.3e-44
XP_016874761 (OMIM: 176257) PREDICTED: potassium v ( 529) 1199 175.7 3.7e-43
XP_005253743 (OMIM: 176257) PREDICTED: potassium v ( 529) 1199 175.7 3.7e-43
XP_016874759 (OMIM: 176257) PREDICTED: potassium v ( 529) 1199 175.7 3.7e-43
XP_011519257 (OMIM: 176257) PREDICTED: potassium v ( 529) 1199 175.7 3.7e-43
NP_002226 (OMIM: 176257) potassium voltage-gated c ( 529) 1199 175.7 3.7e-43
XP_016874760 (OMIM: 176257) PREDICTED: potassium v ( 529) 1199 175.7 3.7e-43
NP_005540 (OMIM: 602420) potassium voltage-gated c ( 511) 1120 165.0 6.2e-40
NP_004761 (OMIM: 607738) potassium voltage-gated c ( 911) 721 111.0 2e-23
XP_011527101 (OMIM: 600397,616056) PREDICTED: pota ( 858) 716 110.3 3e-23
XP_006723847 (OMIM: 600397,616056) PREDICTED: pota ( 858) 716 110.3 3e-23
NP_004966 (OMIM: 600397,616056) potassium voltage- ( 858) 716 110.3 3e-23
NP_001269357 (OMIM: 603888) potassium voltage-gate ( 491) 701 108.0 8.3e-23
NP_002243 (OMIM: 603888) potassium voltage-gated c ( 491) 701 108.0 8.3e-23
XP_011531127 (OMIM: 603888) PREDICTED: potassium v ( 491) 701 108.0 8.3e-23
XP_016859548 (OMIM: 603888) PREDICTED: potassium v ( 491) 701 108.0 8.3e-23
XP_016869470 (OMIM: 607738) PREDICTED: potassium v ( 666) 647 100.8 1.7e-20
XP_016869471 (OMIM: 607738) PREDICTED: potassium v ( 666) 647 100.8 1.7e-20
XP_011539703 (OMIM: 176265) PREDICTED: potassium v ( 609) 641 100.0 2.8e-20
XP_006710688 (OMIM: 176265) PREDICTED: potassium v ( 618) 641 100.0 2.8e-20
XP_006710690 (OMIM: 176265) PREDICTED: potassium v ( 624) 641 100.0 2.8e-20
NP_001034663 (OMIM: 176265) potassium voltage-gate ( 626) 641 100.0 2.8e-20
NP_004969 (OMIM: 176265) potassium voltage-gated c ( 635) 641 100.0 2.8e-20
XP_011524220 (OMIM: 605696) PREDICTED: potassium v ( 466) 632 98.6 5.3e-20
NP_036415 (OMIM: 605696) potassium voltage-gated c ( 466) 632 98.6 5.3e-20
XP_016881194 (OMIM: 605696) PREDICTED: potassium v ( 466) 632 98.6 5.3e-20
XP_011524222 (OMIM: 605696) PREDICTED: potassium v ( 466) 632 98.6 5.3e-20
XP_016881193 (OMIM: 605696) PREDICTED: potassium v ( 509) 632 98.7 5.7e-20
XP_011518382 (OMIM: 176258,616187) PREDICTED: pota ( 535) 629 98.3 7.8e-20
NP_004967 (OMIM: 176258,616187) potassium voltage- ( 511) 626 97.8 1e-19
NP_001106212 (OMIM: 176258,616187) potassium volta ( 585) 627 98.0 1e-19
XP_006723848 (OMIM: 603788) PREDICTED: potassium v ( 513) 625 97.7 1.1e-19
XP_011527106 (OMIM: 603788) PREDICTED: potassium v ( 513) 625 97.7 1.1e-19
NP_002228 (OMIM: 603788) potassium voltage-gated c ( 513) 625 97.7 1.1e-19
XP_011527105 (OMIM: 603788) PREDICTED: potassium v ( 513) 625 97.7 1.1e-19
XP_011527102 (OMIM: 603788) PREDICTED: potassium v ( 513) 625 97.7 1.1e-19
XP_011527104 (OMIM: 603788) PREDICTED: potassium v ( 513) 625 97.7 1.1e-19
XP_011527107 (OMIM: 603788) PREDICTED: potassium v ( 513) 625 97.7 1.1e-19
>>NP_002224 (OMIM: 176266) potassium voltage-gated chann (653 aa)
initn: 4351 init1: 4351 opt: 4351 Z-score: 3209.5 bits: 604.2 E(85289): 4.9e-172
Smith-Waterman score: 4351; 100.0% identity (100.0% similar) in 653 aa overlap (1-653:1-653)
10 20 30 40 50 60
pF1KE4 MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGSGGSGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGSGGSGGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 SHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 NVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 ESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 NSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 TDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 LIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 GSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSS
550 560 570 580 590 600
610 620 630 640 650
pF1KE4 TSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV
610 620 630 640 650
>>NP_002223 (OMIM: 176263) potassium voltage-gated chann (575 aa)
initn: 1907 init1: 868 opt: 2243 Z-score: 1662.1 bits: 317.6 E(85289): 7.7e-86
Smith-Waterman score: 2252; 63.4% identity (79.9% similar) in 576 aa overlap (90-653:15-575)
60 70 80 90 100 110
pF1KE4 GSHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAH--YRQSSFPHCSDLMPSG-SEEK
: ...:: : .: :. : .:
NP_002 MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPA
10 20 30 40
120 130 140 150 160 170
pF1KE4 ILRELSEEEE----DEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYS
::: . :. : : . : . : :. . :: . ..: .
NP_002 AGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQ-----
50 60 70 80 90
180 190 200 210 220 230
pF1KE4 DCC-ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAI
::: ::::::.::::::::.::: ::::::::::..: .:::::::::::::::::::::
NP_002 DCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAI
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE4 LYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKK
:::::::::..::::::.:::.::..::::::::. ::::::::.:::: : ::. .:..
NP_002 LYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEE-RPLPRRDFQR
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE4 QIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLL
:.::::::::::.::::::::::::::::::::::::::::::..: . : . .
NP_002 QVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAG
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE4 NDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVS
:.::. . .: . :.::::.:::.::.:::::..:: :::::.: : .::::.::::.
NP_002 NSTSGSR---AGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVA
280 290 300 310 320 330
420 430 440 450 460 470
pF1KE4 ILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTL
:.::::::::.::..::.: :::::.::::.:::::::::::::::::::::::.::
NP_002 IIPYFITLGTELAERQGNG----QQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTL
340 350 360 370 380 390
480 490 500 510 520 530
pF1KE4 RASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMK
.::::::::::::::::::::::::::::::.::. :.:::::::::::::::::::::.
NP_002 KASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMH
400 410 420 430 440 450
540 550 560 570 580 590
pF1KE4 PITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPS
:.:.:::::::::::::::::::::::::::::::::::::.:::.: ... :: .: :
NP_002 PVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQY-MHVGSCQHLSS
460 470 480 490 500 510
600 610 620 630 640
pF1KE4 NLLKKFRSSTSSSLGDKSEYLEMEEG-VKESLCAKEEKCQGKGDDSETDKNN---CSNAK
. ...:.. :.: .::::. .::: ...: . :.. . : .:: : : :
NP_002 SA-EELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIK
520 530 540 550 560
650
pF1KE4 AVETDV
. :::
NP_002 KIFTDV
570
>>XP_011539701 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa)
initn: 1877 init1: 872 opt: 2188 Z-score: 1622.5 bits: 310.1 E(85289): 1.2e-83
Smith-Waterman score: 2200; 71.7% identity (85.3% similar) in 477 aa overlap (146-621:7-468)
120 130 140 150 160 170
pF1KE4 KILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCC
: .:: . ::: :. .::
XP_011 MTVATGDPADEAAALPGHPQDT----YDPEADHECC
10 20 30
180 190 200 210 220 230
pF1KE4 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY
::::::.::::::::.::::::::::::::.:: .:::::::::::::::::::::::::
XP_011 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE4 QSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWL
::::::.::::::.:::.::..::.:::::. ::::::...::: : ::::::..:.::
XP_011 QSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-RPLPENEFQRQVWL
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE4 LFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTS
::::::::.::: ::::::.::::::: ::::::: :::. . . : : .. :
XP_011 LFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-----DMHGSGVTFHTYS
160 170 180 190 200
360 370 380 390 400 410
pF1KE4 APHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPY
. . : :.::::::::.::.::::::.:: :::::.: :: :::::::::.:.::
XP_011 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPY
210 220 230 240 250 260
420 430 440 450 460 470
pF1KE4 FITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASM
::::::.::.. .. : :::::.::::.:::::::::::::::::::::::.::.:::
XP_011 FITLGTELAEKPEDAQ-QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM
270 280 290 300 310 320
480 490 500 510 520 530
pF1KE4 RELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITV
:::::::::::::::::::::::::::: ..: :::::::::::.::::::::: : :.
XP_011 RELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTI
330 340 350 360 370 380
540 550 560 570 580 590
pF1KE4 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNL-L
:::::::::::::::::::::::::::::::::::::.:::.: : ..::: .::. :
XP_011 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQ-VTSCPKIPSSPDL
390 400 410 420 430 440
600 610 620 630 640 650
pF1KE4 KKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV
:: ::... : ::.:.:..:::..:
XP_011 KKSRSASTIS---KSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV
450 460 470 480 490
>>XP_011539699 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa)
initn: 1877 init1: 872 opt: 2188 Z-score: 1622.5 bits: 310.1 E(85289): 1.2e-83
Smith-Waterman score: 2200; 71.7% identity (85.3% similar) in 477 aa overlap (146-621:7-468)
120 130 140 150 160 170
pF1KE4 KILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCC
: .:: . ::: :. .::
XP_011 MTVATGDPADEAAALPGHPQDT----YDPEADHECC
10 20 30
180 190 200 210 220 230
pF1KE4 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY
::::::.::::::::.::::::::::::::.:: .:::::::::::::::::::::::::
XP_011 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE4 QSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWL
::::::.::::::.:::.::..::.:::::. ::::::...::: : ::::::..:.::
XP_011 QSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-RPLPENEFQRQVWL
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE4 LFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTS
::::::::.::: ::::::.::::::: ::::::: :::. . . : : .. :
XP_011 LFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-----DMHGSGVTFHTYS
160 170 180 190 200
360 370 380 390 400 410
pF1KE4 APHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPY
. . : :.::::::::.::.::::::.:: :::::.: :: :::::::::.:.::
XP_011 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPY
210 220 230 240 250 260
420 430 440 450 460 470
pF1KE4 FITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASM
::::::.::.. .. : :::::.::::.:::::::::::::::::::::::.::.:::
XP_011 FITLGTELAEKPEDAQ-QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM
270 280 290 300 310 320
480 490 500 510 520 530
pF1KE4 RELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITV
:::::::::::::::::::::::::::: ..: :::::::::::.::::::::: : :.
XP_011 RELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTI
330 340 350 360 370 380
540 550 560 570 580 590
pF1KE4 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNL-L
:::::::::::::::::::::::::::::::::::::.:::.: : ..::: .::. :
XP_011 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQ-VTSCPKIPSSPDL
390 400 410 420 430 440
600 610 620 630 640 650
pF1KE4 KKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV
:: ::... : ::.:.:..:::..:
XP_011 KKSRSASTIS---KSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV
450 460 470 480 490
>>NP_004965 (OMIM: 176262,616366) potassium voltage-gate (499 aa)
initn: 1877 init1: 872 opt: 2188 Z-score: 1622.5 bits: 310.1 E(85289): 1.2e-83
Smith-Waterman score: 2200; 71.7% identity (85.3% similar) in 477 aa overlap (146-621:7-468)
120 130 140 150 160 170
pF1KE4 KILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCC
: .:: . ::: :. .::
NP_004 MTVATGDPADEAAALPGHPQDT----YDPEADHECC
10 20 30
180 190 200 210 220 230
pF1KE4 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY
::::::.::::::::.::::::::::::::.:: .:::::::::::::::::::::::::
NP_004 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE4 QSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWL
::::::.::::::.:::.::..::.:::::. ::::::...::: : ::::::..:.::
NP_004 QSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-RPLPENEFQRQVWL
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE4 LFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTS
::::::::.::: ::::::.::::::: ::::::: :::. . . : : .. :
NP_004 LFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-----DMHGSGVTFHTYS
160 170 180 190 200
360 370 380 390 400 410
pF1KE4 APHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPY
. . : :.::::::::.::.::::::.:: :::::.: :: :::::::::.:.::
NP_004 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPY
210 220 230 240 250 260
420 430 440 450 460 470
pF1KE4 FITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASM
::::::.::.. .. : :::::.::::.:::::::::::::::::::::::.::.:::
NP_004 FITLGTELAEKPEDAQ-QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM
270 280 290 300 310 320
480 490 500 510 520 530
pF1KE4 RELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITV
:::::::::::::::::::::::::::: ..: :::::::::::.::::::::: : :.
NP_004 RELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTI
330 340 350 360 370 380
540 550 560 570 580 590
pF1KE4 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNL-L
:::::::::::::::::::::::::::::::::::::.:::.: : ..::: .::. :
NP_004 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQ-VTSCPKIPSSPDL
390 400 410 420 430 440
600 610 620 630 640 650
pF1KE4 KKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV
:: ::... : ::.:.:..:::..:
NP_004 KKSRSASTIS---KSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV
450 460 470 480 490
>>XP_011539700 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa)
initn: 1877 init1: 872 opt: 2188 Z-score: 1622.5 bits: 310.1 E(85289): 1.2e-83
Smith-Waterman score: 2200; 71.7% identity (85.3% similar) in 477 aa overlap (146-621:7-468)
120 130 140 150 160 170
pF1KE4 KILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCC
: .:: . ::: :. .::
XP_011 MTVATGDPADEAAALPGHPQDT----YDPEADHECC
10 20 30
180 190 200 210 220 230
pF1KE4 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY
::::::.::::::::.::::::::::::::.:: .:::::::::::::::::::::::::
XP_011 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE4 QSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWL
::::::.::::::.:::.::..::.:::::. ::::::...::: : ::::::..:.::
XP_011 QSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-RPLPENEFQRQVWL
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE4 LFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTS
::::::::.::: ::::::.::::::: ::::::: :::. . . : : .. :
XP_011 LFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-----DMHGSGVTFHTYS
160 170 180 190 200
360 370 380 390 400 410
pF1KE4 APHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPY
. . : :.::::::::.::.::::::.:: :::::.: :: :::::::::.:.::
XP_011 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPY
210 220 230 240 250 260
420 430 440 450 460 470
pF1KE4 FITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASM
::::::.::.. .. : :::::.::::.:::::::::::::::::::::::.::.:::
XP_011 FITLGTELAEKPEDAQ-QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM
270 280 290 300 310 320
480 490 500 510 520 530
pF1KE4 RELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITV
:::::::::::::::::::::::::::: ..: :::::::::::.::::::::: : :.
XP_011 RELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTI
330 340 350 360 370 380
540 550 560 570 580 590
pF1KE4 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNL-L
:::::::::::::::::::::::::::::::::::::.:::.: : ..::: .::. :
XP_011 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQ-VTSCPKIPSSPDL
390 400 410 420 430 440
600 610 620 630 640 650
pF1KE4 KKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV
:: ::... : ::.:.:..:::..:
XP_011 KKSRSASTIS---KSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV
450 460 470 480 490
>>XP_011539702 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa)
initn: 1877 init1: 872 opt: 2188 Z-score: 1622.5 bits: 310.1 E(85289): 1.2e-83
Smith-Waterman score: 2200; 71.7% identity (85.3% similar) in 477 aa overlap (146-621:7-468)
120 130 140 150 160 170
pF1KE4 KILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCC
: .:: . ::: :. .::
XP_011 MTVATGDPADEAAALPGHPQDT----YDPEADHECC
10 20 30
180 190 200 210 220 230
pF1KE4 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY
::::::.::::::::.::::::::::::::.:: .:::::::::::::::::::::::::
XP_011 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE4 QSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWL
::::::.::::::.:::.::..::.:::::. ::::::...::: : ::::::..:.::
XP_011 QSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-RPLPENEFQRQVWL
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE4 LFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTS
::::::::.::: ::::::.::::::: ::::::: :::. . . : : .. :
XP_011 LFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-----DMHGSGVTFHTYS
160 170 180 190 200
360 370 380 390 400 410
pF1KE4 APHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPY
. . : :.::::::::.::.::::::.:: :::::.: :: :::::::::.:.::
XP_011 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPY
210 220 230 240 250 260
420 430 440 450 460 470
pF1KE4 FITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASM
::::::.::.. .. : :::::.::::.:::::::::::::::::::::::.::.:::
XP_011 FITLGTELAEKPEDAQ-QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM
270 280 290 300 310 320
480 490 500 510 520 530
pF1KE4 RELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITV
:::::::::::::::::::::::::::: ..: :::::::::::.::::::::: : :.
XP_011 RELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTI
330 340 350 360 370 380
540 550 560 570 580 590
pF1KE4 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNL-L
:::::::::::::::::::::::::::::::::::::.:::.: : ..::: .::. :
XP_011 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQ-VTSCPKIPSSPDL
390 400 410 420 430 440
600 610 620 630 640 650
pF1KE4 KKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV
:: ::... : ::.:.:..:::..:
XP_011 KKSRSASTIS---KSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV
450 460 470 480 490
>>XP_016856702 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa)
initn: 1877 init1: 872 opt: 2188 Z-score: 1622.5 bits: 310.1 E(85289): 1.2e-83
Smith-Waterman score: 2200; 71.7% identity (85.3% similar) in 477 aa overlap (146-621:7-468)
120 130 140 150 160 170
pF1KE4 KILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCC
: .:: . ::: :. .::
XP_016 MTVATGDPADEAAALPGHPQDT----YDPEADHECC
10 20 30
180 190 200 210 220 230
pF1KE4 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY
::::::.::::::::.::::::::::::::.:: .:::::::::::::::::::::::::
XP_016 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE4 QSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWL
::::::.::::::.:::.::..::.:::::. ::::::...::: : ::::::..:.::
XP_016 QSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-RPLPENEFQRQVWL
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE4 LFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTS
::::::::.::: ::::::.::::::: ::::::: :::. . . : : .. :
XP_016 LFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-----DMHGSGVTFHTYS
160 170 180 190 200
360 370 380 390 400 410
pF1KE4 APHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPY
. . : :.::::::::.::.::::::.:: :::::.: :: :::::::::.:.::
XP_016 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPY
210 220 230 240 250 260
420 430 440 450 460 470
pF1KE4 FITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASM
::::::.::.. .. : :::::.::::.:::::::::::::::::::::::.::.:::
XP_016 FITLGTELAEKPEDAQ-QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM
270 280 290 300 310 320
480 490 500 510 520 530
pF1KE4 RELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITV
:::::::::::::::::::::::::::: ..: :::::::::::.::::::::: : :.
XP_016 RELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTI
330 340 350 360 370 380
540 550 560 570 580 590
pF1KE4 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNL-L
:::::::::::::::::::::::::::::::::::::.:::.: : ..::: .::. :
XP_016 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQ-VTSCPKIPSSPDL
390 400 410 420 430 440
600 610 620 630 640 650
pF1KE4 KKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV
:: ::... : ::.:.:..:::..:
XP_016 KKSRSASTIS---KSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV
450 460 470 480 490
>>XP_011539698 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa)
initn: 1877 init1: 872 opt: 2188 Z-score: 1622.5 bits: 310.1 E(85289): 1.2e-83
Smith-Waterman score: 2200; 71.7% identity (85.3% similar) in 477 aa overlap (146-621:7-468)
120 130 140 150 160 170
pF1KE4 KILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCC
: .:: . ::: :. .::
XP_011 MTVATGDPADEAAALPGHPQDT----YDPEADHECC
10 20 30
180 190 200 210 220 230
pF1KE4 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY
::::::.::::::::.::::::::::::::.:: .:::::::::::::::::::::::::
XP_011 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE4 QSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWL
::::::.::::::.:::.::..::.:::::. ::::::...::: : ::::::..:.::
XP_011 QSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-RPLPENEFQRQVWL
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE4 LFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTS
::::::::.::: ::::::.::::::: ::::::: :::. . . : : .. :
XP_011 LFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-----DMHGSGVTFHTYS
160 170 180 190 200
360 370 380 390 400 410
pF1KE4 APHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPY
. . : :.::::::::.::.::::::.:: :::::.: :: :::::::::.:.::
XP_011 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPY
210 220 230 240 250 260
420 430 440 450 460 470
pF1KE4 FITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASM
::::::.::.. .. : :::::.::::.:::::::::::::::::::::::.::.:::
XP_011 FITLGTELAEKPEDAQ-QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM
270 280 290 300 310 320
480 490 500 510 520 530
pF1KE4 RELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITV
:::::::::::::::::::::::::::: ..: :::::::::::.::::::::: : :.
XP_011 RELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTI
330 340 350 360 370 380
540 550 560 570 580 590
pF1KE4 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNL-L
:::::::::::::::::::::::::::::::::::::.:::.: : ..::: .::. :
XP_011 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQ-VTSCPKIPSSPDL
390 400 410 420 430 440
600 610 620 630 640 650
pF1KE4 KKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV
:: ::... : ::.:.:..:::..:
XP_011 KKSRSASTIS---KSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV
450 460 470 480 490
>>NP_114092 (OMIM: 176268) potassium voltage-gated chann (456 aa)
initn: 1944 init1: 821 opt: 1910 Z-score: 1418.8 bits: 272.3 E(85289): 2.7e-72
Smith-Waterman score: 1910; 69.4% identity (86.4% similar) in 412 aa overlap (174-581:11-415)
150 160 170 180 190 200
pF1KE4 EDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLG
::::.:.::.::::::. .::..::.::::
NP_114 MEPRCPPPCGCCERLVLNVAGLRFETRARTLGRFPDTLLG
10 20 30 40
210 220 230 240 250 260
pF1KE4 DPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGE
:: .: ...: : ::::::.::::::.::::::::::.::..::.:.: ::: :: ::
NP_114 DPARRGRFYDDARREYFFDRHRPSFDAVLYYYQSGGRLRRPAHVPLDVFLEEVAFYGLGA
50 60 70 80 90 100
270 280 290 300 310 320
pF1KE4 EALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVI
:: ..::::: : : ::. : .:.:::::.::::. :: .:.:::::::.:::.
NP_114 AALARLREDEGCPVPPE-RPLPRRAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVV
110 120 130 140 150
330 340 350 360 370
pF1KE4 FCLETLPEFRDDRD---LVMALSAGGHGGLLNDTSA-PHLENSGHTIFNDPFFIVETVCI
:::::::.:::::: :. : .:: . :: .: : : . ::::::.:::.::
NP_114 FCLETLPDFRDDRDGTGLAAAAAAGPFPAPLNGSSQMPG--NPPRLPFNDPFFVVETLCI
160 170 180 190 200 210
380 390 400 410 420 430
pF1KE4 VWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMS
:::::..:: ..:::.:.::::.::.::.:.:::::..:::.::.:.: : :::::
NP_114 CWFSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQRGVG----QQAMS
220 230 240 250 260 270
440 450 460 470 480 490
pF1KE4 FAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFA
.::::.:::::::::::::::::::::::.::::::::::::::::::::.:::::::::
NP_114 LAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFA
280 290 300 310 320 330
500 510 520 530 540 550
pF1KE4 EADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVI
:.:. .:: :::..:::::::::::::::: :.:::::::::::::::::::.::::::
NP_114 EVDRVDSHFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVI
340 350 360 370 380 390
560 570 580 590 600 610
pF1KE4 VSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVK
::::.::::::::.:: ....
NP_114 VSNFSYFYHRETEGEEAGMFSHVDMQPCGPLEGKANGGLVDGEVPELPPPLWAPPGKHLV
400 410 420 430 440 450
653 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:26:51 2016 done: Sun Nov 6 01:26:53 2016
Total Scan time: 11.530 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]