Result of FASTA (omim) for
pFN21AE4158
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4158, 532 aa
1>>>pF1KE4158 532 - 532 aa - 532 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.0116+/-0.00041; mu= 15.6180+/- 0.026
mean_var=115.0831+/-23.421, 0's: 0 Z-trim(113.3): 141 B-trim: 0 in 0/54
Lambda= 0.119555
statistics sampled from 22425 (22574) to 22425 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.623), E-opt: 0.2 (0.265), width: 16
Scan time: 9.810
The best scores are: opt bits E(85289)
NP_036306 (OMIM: 609073) F-box/WD repeat-containin ( 532) 3614 635.0 1.7e-181
NP_699179 (OMIM: 609073) F-box/WD repeat-containin ( 598) 3344 588.5 1.9e-167
XP_016874665 (OMIM: 609073) PREDICTED: F-box/WD re ( 599) 3344 588.5 1.9e-167
XP_016874664 (OMIM: 609073) PREDICTED: F-box/WD re ( 517) 3339 587.6 3.1e-167
XP_005253924 (OMIM: 609073) PREDICTED: F-box/WD re ( 417) 2498 442.4 1.2e-123
XP_005253925 (OMIM: 609073) PREDICTED: F-box/WD re ( 417) 2498 442.4 1.2e-123
XP_016874667 (OMIM: 609073) PREDICTED: F-box/WD re ( 328) 2144 381.3 2.5e-105
XP_016874666 (OMIM: 609073) PREDICTED: F-box/WD re ( 423) 2097 373.3 8.3e-103
XP_011530390 (OMIM: 606278) PREDICTED: F-box/WD re ( 540) 213 48.4 6.6e-05
NP_001013433 (OMIM: 606278) F-box/WD repeat-contai ( 589) 213 48.4 7e-05
NP_060785 (OMIM: 606278) F-box/WD repeat-containin ( 627) 213 48.5 7.3e-05
XP_011530388 (OMIM: 606278) PREDICTED: F-box/WD re ( 679) 213 48.5 7.8e-05
XP_011530389 (OMIM: 606278) PREDICTED: F-box/WD re ( 679) 213 48.5 7.8e-05
XP_011530385 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 213 48.5 8e-05
XP_011530386 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 213 48.5 8e-05
NP_361014 (OMIM: 606278) F-box/WD repeat-containin ( 707) 213 48.5 8e-05
XP_016863851 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 213 48.5 8e-05
XP_011530387 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 213 48.5 8e-05
NP_004805 (OMIM: 607797) U5 small nuclear ribonucl ( 357) 169 40.6 0.0094
>>NP_036306 (OMIM: 609073) F-box/WD repeat-containing pr (532 aa)
initn: 3614 init1: 3614 opt: 3614 Z-score: 3379.5 bits: 635.0 E(85289): 1.7e-181
Smith-Waterman score: 3614; 99.8% identity (100.0% similar) in 532 aa overlap (1-532:1-532)
10 20 30 40 50 60
pF1KE4 MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPENEMNDVPFFDIQLPYELAIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPENEMNDVPFFDIQLPYELAIN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 IFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 KEHMLQTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPF
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 KEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 LESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 LSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 LMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 LMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 KLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 KLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDW
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 KIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 KIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSF
430 440 450 460 470 480
490 500 510 520 530
pF1KE4 TTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 TTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV
490 500 510 520 530
>>NP_699179 (OMIM: 609073) F-box/WD repeat-containing pr (598 aa)
initn: 3341 init1: 3341 opt: 3344 Z-score: 3127.1 bits: 588.5 E(85289): 1.9e-167
Smith-Waterman score: 3344; 94.5% identity (97.0% similar) in 526 aa overlap (10-532:73-598)
10 20 30
pF1KE4 MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRAR--
: . :. .....: :. ..:. .
NP_699 SGRGEQASGDPALAQRLLEGAGRPPAARATRAEGQDVASRSRSPLAREGAGGGEQLVDQL
50 60 70 80 90 100
40 50 60 70 80 90
pF1KE4 -RPENEMNDVPFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQ
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 IRDLNEMNDVPFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQ
110 120 130 140 150 160
100 110 120 130 140 150
pF1KE4 EGHLPDSSISDYSCWKLIFQECRAKEHMLQTNWKNRKGAVSELEHVPDTVLCDVHSHDGV
:::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
NP_699 EGHLPDSSISDYSCWKLIFQECRAKEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGV
170 180 190 200 210 220
160 170 180 190 200 210
pF1KE4 VIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 VIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLN
230 240 250 260 270 280
220 230 240 250 260 270
pF1KE4 IWDLRTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 IWDLRTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVP
290 300 310 320 330 340
280 290 300 310 320 330
pF1KE4 KLVQYLEIVPETRRYPVAVAAAGDLMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 KLVQYLEIVPETRRYPVAVAAAGDLMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGV
350 360 370 380 390 400
340 350 360 370 380 390
pF1KE4 QGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 QGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDL
410 420 430 440 450 460
400 410 420 430 440 450
pF1KE4 RSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 RSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISF
470 480 490 500 510 520
460 470 480 490 500 510
pF1KE4 SSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 SSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAM
530 540 550 560 570 580
520 530
pF1KE4 ATHYYDLALAFPYNHV
::::::::::::::::
NP_699 ATHYYDLALAFPYNHV
590
>--
initn: 282 init1: 276 opt: 276 Z-score: 267.3 bits: 59.3 E(85289): 3.8e-08
Smith-Waterman score: 276; 100.0% identity (100.0% similar) in 40 aa overlap (1-40:1-40)
10 20 30 40 50 60
pF1KE4 MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPENEMNDVPFFDIQLPYELAIN
::::::::::::::::::::::::::::::::::::::::
NP_699 MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPEVGSGRGEQASGDPALAQRLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRA
NP_699 EGAGRPPAARATRAEGQDVASRSRSPLAREGAGGGEQLVDQLIRDLNEMNDVPFFDIQLP
70 80 90 100 110 120
>>XP_016874665 (OMIM: 609073) PREDICTED: F-box/WD repeat (599 aa)
initn: 3344 init1: 3344 opt: 3344 Z-score: 3127.1 bits: 588.5 E(85289): 1.9e-167
Smith-Waterman score: 3344; 99.8% identity (100.0% similar) in 493 aa overlap (40-532:107-599)
10 20 30 40 50 60
pF1KE4 RRRWQEELAQAQAPKKRRRPEAAERRARRPENEMNDVPFFDIQLPYELAINIFQYLDRKE
::::::::::::::::::::::::::::::
XP_016 CKLGHVSTFQPITDSNCSDSNPLPIPEDEGENEMNDVPFFDIQLPYELAINIFQYLDRKE
80 90 100 110 120 130
70 80 90 100 110 120
pF1KE4 LGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRAKEHMLQTNW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
XP_016 LGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRAKEHMLRTNW
140 150 160 170 180 190
130 140 150 160 170 180
pF1KE4 KNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDE
200 210 220 230 240 250
190 200 210 220 230 240
pF1KE4 PGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVA
260 270 280 290 300 310
250 260 270 280 290 300
pF1KE4 TASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAED
320 330 340 350 360 370
310 320 330 340 350 360
pF1KE4 SARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDF
380 390 400 410 420 430
370 380 390 400 410 420
pF1KE4 TCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEG
440 450 460 470 480 490
430 440 450 460 470 480
pF1KE4 LVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGL
500 510 520 530 540 550
490 500 510 520 530
pF1KE4 IRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV
:::::::::::::::::::::::::::::::::::::::::::
XP_016 IRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV
560 570 580 590
>--
initn: 303 init1: 276 opt: 288 Z-score: 278.4 bits: 61.4 E(85289): 9e-09
Smith-Waterman score: 288; 65.7% identity (80.0% similar) in 70 aa overlap (1-70:1-67)
10 20 30 40 50 60
pF1KE4 MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPENEMNDVPFFDIQLPYELAIN
:::::::::::::::::::::::::::::::::::::::: . :. . :: :..
XP_016 MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPE---TGFPLGEKWLPATLVFY
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 IFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRA
... ..::
XP_016 LLSNSRERELQVMNLNSHCCKLGHVSTFQPITDSNCSDSNPLPIPEDEGENEMNDVPFFD
60 70 80 90 100 110
>>XP_016874664 (OMIM: 609073) PREDICTED: F-box/WD repeat (517 aa)
initn: 3339 init1: 3339 opt: 3339 Z-score: 3123.3 bits: 587.6 E(85289): 3.1e-167
Smith-Waterman score: 3339; 99.6% identity (100.0% similar) in 493 aa overlap (40-532:25-517)
10 20 30 40 50 60
pF1KE4 RRRWQEELAQAQAPKKRRRPEAAERRARRPENEMNDVPFFDIQLPYELAINIFQYLDRKE
.:::::::::::::::::::::::::::::
XP_016 MCPPFSQSLIQIVQTRIHCPFLKMKNEMNDVPFFDIQLPYELAINIFQYLDRKE
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 LGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRAKEHMLQTNW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
XP_016 LGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRAKEHMLRTNW
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE4 KNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDE
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE4 PGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVA
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 TASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAED
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 SARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDF
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 TCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEG
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE4 LVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGL
420 430 440 450 460 470
490 500 510 520 530
pF1KE4 IRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV
:::::::::::::::::::::::::::::::::::::::::::
XP_016 IRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV
480 490 500 510
>>XP_005253924 (OMIM: 609073) PREDICTED: F-box/WD repeat (417 aa)
initn: 2498 init1: 2498 opt: 2498 Z-score: 2340.6 bits: 442.4 E(85289): 1.2e-123
Smith-Waterman score: 2498; 100.0% identity (100.0% similar) in 372 aa overlap (161-532:46-417)
140 150 160 170 180 190
pF1KE4 NRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEP
::::::::::::::::::::::::::::::
XP_005 RIAASLTILAGSSSSKSAEPRNTCYEPTGRYTSGDVRVWDTRTWDYVAPFLESEDEEDEP
20 30 40 50 60 70
200 210 220 230 240 250
pF1KE4 GMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVAT
80 90 100 110 120 130
260 270 280 290 300 310
pF1KE4 ASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAEDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAEDS
140 150 160 170 180 190
320 330 340 350 360 370
pF1KE4 ARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFT
200 210 220 230 240 250
380 390 400 410 420 430
pF1KE4 CVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGL
260 270 280 290 300 310
440 450 460 470 480 490
pF1KE4 VSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLI
320 330 340 350 360 370
500 510 520 530
pF1KE4 RAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV
::::::::::::::::::::::::::::::::::::::::::
XP_005 RAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV
380 390 400 410
>>XP_005253925 (OMIM: 609073) PREDICTED: F-box/WD repeat (417 aa)
initn: 2498 init1: 2498 opt: 2498 Z-score: 2340.6 bits: 442.4 E(85289): 1.2e-123
Smith-Waterman score: 2498; 100.0% identity (100.0% similar) in 372 aa overlap (161-532:46-417)
140 150 160 170 180 190
pF1KE4 NRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEP
::::::::::::::::::::::::::::::
XP_005 RIAASLTILAGSSSSKSAEPRNTCYEPTGRYTSGDVRVWDTRTWDYVAPFLESEDEEDEP
20 30 40 50 60 70
200 210 220 230 240 250
pF1KE4 GMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVAT
80 90 100 110 120 130
260 270 280 290 300 310
pF1KE4 ASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAEDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAEDS
140 150 160 170 180 190
320 330 340 350 360 370
pF1KE4 ARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFT
200 210 220 230 240 250
380 390 400 410 420 430
pF1KE4 CVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGL
260 270 280 290 300 310
440 450 460 470 480 490
pF1KE4 VSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLI
320 330 340 350 360 370
500 510 520 530
pF1KE4 RAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV
::::::::::::::::::::::::::::::::::::::::::
XP_005 RAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV
380 390 400 410
>>XP_016874667 (OMIM: 609073) PREDICTED: F-box/WD repeat (328 aa)
initn: 2144 init1: 2144 opt: 2144 Z-score: 2011.9 bits: 381.3 E(85289): 2.5e-105
Smith-Waterman score: 2144; 100.0% identity (100.0% similar) in 320 aa overlap (213-532:9-328)
190 200 210 220 230 240
pF1KE4 SEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALS
::::::::::::::::::::::::::::::
XP_016 MCGLNEQRGFLNIWDLRTGKYPVHRFEHDARIQALALS
10 20 30
250 260 270 280 290 300
pF1KE4 QDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLM
40 50 60 70 80 90
310 320 330 340 350 360
pF1KE4 YLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKL
100 110 120 130 140 150
370 380 390 400 410 420
pF1KE4 GNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKI
160 170 180 190 200 210
430 440 450 460 470 480
pF1KE4 VSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTT
220 230 240 250 260 270
490 500 510 520 530
pF1KE4 HRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV
280 290 300 310 320
>>XP_016874666 (OMIM: 609073) PREDICTED: F-box/WD repeat (423 aa)
initn: 2097 init1: 2097 opt: 2097 Z-score: 1966.7 bits: 373.3 E(85289): 8.3e-103
Smith-Waterman score: 2097; 99.7% identity (100.0% similar) in 308 aa overlap (40-347:107-414)
10 20 30 40 50 60
pF1KE4 RRRWQEELAQAQAPKKRRRPEAAERRARRPENEMNDVPFFDIQLPYELAINIFQYLDRKE
::::::::::::::::::::::::::::::
XP_016 CKLGHVSTFQPITDSNCSDSNPLPIPEDEGENEMNDVPFFDIQLPYELAINIFQYLDRKE
80 90 100 110 120 130
70 80 90 100 110 120
pF1KE4 LGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRAKEHMLQTNW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
XP_016 LGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRAKEHMLRTNW
140 150 160 170 180 190
130 140 150 160 170 180
pF1KE4 KNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDE
200 210 220 230 240 250
190 200 210 220 230 240
pF1KE4 PGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVA
260 270 280 290 300 310
250 260 270 280 290 300
pF1KE4 TASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAED
320 330 340 350 360 370
310 320 330 340 350 360
pF1KE4 SARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDF
::::::::::::::::::::::::::::::::::::::
XP_016 SARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKGEDPRPPQW
380 390 400 410 420
370 380 390 400 410 420
pF1KE4 TCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEG
>--
initn: 303 init1: 276 opt: 288 Z-score: 280.4 bits: 61.2 E(85289): 7e-09
Smith-Waterman score: 288; 65.7% identity (80.0% similar) in 70 aa overlap (1-70:1-67)
10 20 30 40 50 60
pF1KE4 MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPENEMNDVPFFDIQLPYELAIN
:::::::::::::::::::::::::::::::::::::::: . :. . :: :..
XP_016 MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPE---TGFPLGEKWLPATLVFY
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 IFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRA
... ..::
XP_016 LLSNSRERELQVMNLNSHCCKLGHVSTFQPITDSNCSDSNPLPIPEDEGENEMNDVPFFD
60 70 80 90 100 110
>>XP_011530390 (OMIM: 606278) PREDICTED: F-box/WD repeat (540 aa)
initn: 441 init1: 154 opt: 213 Z-score: 209.1 bits: 48.4 E(85289): 6.6e-05
Smith-Waterman score: 327; 22.2% identity (54.4% similar) in 436 aa overlap (53-464:117-518)
30 40 50 60 70 80
pF1KE4 PKKRRRPEAAERRARRPENEMNDVPFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKV
:: :::. ....:. :.: . ::. . :..
XP_011 DELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRI
90 100 110 120 130 140
90 100 110 120 130
pF1KE4 IAEDEVLWYRLCQQEG-----HLPDSSISD----YSCWKLIFQECRAKEHMLQTNWKNRK
.:::..:: . :..:: :. .. .: :: . ..: ..::: :.
XP_011 LAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAY----IRQHRIDTNW--RR
150 160 170 180 190 200
140 150 160 170 180 190
pF1KE4 GAVSE---LEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEP
: .. :. : :. .. . ...: .. ..::.. : . ..
XP_011 GELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLV---------
210 220 230 240 250
200 210 220 230 240
pF1KE4 GMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHR-FEHDARIQALALSQDDATVA
: .: .. ... ... : :..:. .::. .: . : . .. . : . .. .
XP_011 GHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGEC-IHTLYGHTSTVRCMHLHEKRVVSG
260 270 280 290 300 310
250 260 270 280 290 300
pF1KE4 TASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAED
. .: : . . . .. . . ::: . :: .:..: :.: . .
XP_011 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQY-----DGRR---VVSGAYDFMVKVWDPE
320 330 340 350 360
310 320 330 340 350 360
pF1KE4 SARTL--LYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLR
. : : .: : :. .. .:. : ..: :...:.: . : .
XP_011 TETCLHTLQGHTNRVYSLQFDGIHVVSGSLD-------TSIRVWDVETGNCIHTLTGHQS
370 380 390 400 410
370 380 390 400 410 420
pF1KE4 DFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSA---HQLRVSAVQMDDWKIVS
. ..:.: :..:::: :. :.: :...:. .:.. :: :. .:.. ...
XP_011 LTSGMELKD---NILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVIT
420 430 440 450 460 470
430 440 450 460 470
pF1KE4 GGEEGLVSVWDYRMNQKLWEVY------SGHPVQHISFSSHSLITANVPYQTVMRNADLD
....: :..:: . .. . .. :: : .: :. .:. :
XP_011 SSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLV
480 490 500 510 520 530
480 490 500 510 520 530
pF1KE4 SFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV
XP_011 LDFDVDMK
540
>>NP_001013433 (OMIM: 606278) F-box/WD repeat-containing (589 aa)
initn: 441 init1: 154 opt: 213 Z-score: 208.6 bits: 48.4 E(85289): 7e-05
Smith-Waterman score: 327; 22.2% identity (54.4% similar) in 436 aa overlap (53-464:166-567)
30 40 50 60 70 80
pF1KE4 PKKRRRPEAAERRARRPENEMNDVPFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKV
:: :::. ....:. :.: . ::. . :..
NP_001 DELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRI
140 150 160 170 180 190
90 100 110 120 130
pF1KE4 IAEDEVLWYRLCQQEG-----HLPDSSISD----YSCWKLIFQECRAKEHMLQTNWKNRK
.:::..:: . :..:: :. .. .: :: . ..: ..::: :.
NP_001 LAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAY----IRQHRIDTNW--RR
200 210 220 230 240
140 150 160 170 180 190
pF1KE4 GAVSE---LEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEP
: .. :. : :. .. . ...: .. ..::.. : . ..
NP_001 GELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLV---------
250 260 270 280 290 300
200 210 220 230 240
pF1KE4 GMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHR-FEHDARIQALALSQDDATVA
: .: .. ... ... : :..:. .::. .: . : . .. . : . .. .
NP_001 GHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGEC-IHTLYGHTSTVRCMHLHEKRVVSG
310 320 330 340 350
250 260 270 280 290 300
pF1KE4 TASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAED
. .: : . . . .. . . ::: . :: .:..: :.: . .
NP_001 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQY-----DGRR---VVSGAYDFMVKVWDPE
360 370 380 390 400 410
310 320 330 340 350 360
pF1KE4 SARTL--LYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLR
. : : .: : :. .. .:. : ..: :...:.: . : .
NP_001 TETCLHTLQGHTNRVYSLQFDGIHVVSGSLD-------TSIRVWDVETGNCIHTLTGHQS
420 430 440 450 460
370 380 390 400 410 420
pF1KE4 DFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSA---HQLRVSAVQMDDWKIVS
. ..:.: :..:::: :. :.: :...:. .:.. :: :. .:.. ...
NP_001 LTSGMELKD---NILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVIT
470 480 490 500 510 520
430 440 450 460 470
pF1KE4 GGEEGLVSVWDYRMNQKLWEVY------SGHPVQHISFSSHSLITANVPYQTVMRNADLD
....: :..:: . .. . .. :: : .: :. .:. :
NP_001 SSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLV
530 540 550 560 570 580
480 490 500 510 520 530
pF1KE4 SFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV
NP_001 LDFDVDMK
532 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:48:32 2016 done: Sun Nov 6 01:48:33 2016
Total Scan time: 9.810 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]