Result of FASTA (omim) for
pFN21AE4143
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4143, 569 aa
1>>>pF1KE4143 569 - 569 aa - 569 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.2269+/-0.000436; mu= -8.3419+/- 0.027
mean_var=348.7885+/-73.644, 0's: 0 Z-trim(121.2): 88 B-trim: 626 in 2/54
Lambda= 0.068674
statistics sampled from 37419 (37512) to 37419 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.758), E-opt: 0.2 (0.44), width: 16
Scan time: 12.740
The best scores are: opt bits E(85289)
NP_079092 (OMIM: 611869) rab GTPase-binding effect ( 569) 3596 370.4 8.9e-102
NP_001077054 (OMIM: 603616) rab GTPase-binding eff ( 829) 593 73.0 4.4e-12
XP_016880784 (OMIM: 603616) PREDICTED: rab GTPase- ( 552) 397 53.4 2.2e-06
XP_016880783 (OMIM: 603616) PREDICTED: rab GTPase- ( 574) 397 53.4 2.3e-06
NP_001278510 (OMIM: 603616) rab GTPase-binding eff ( 819) 397 53.5 3e-06
NP_004694 (OMIM: 603616) rab GTPase-binding effect ( 862) 397 53.6 3.1e-06
XP_011522362 (OMIM: 603616) PREDICTED: rab GTPase- ( 884) 397 53.6 3.2e-06
NP_001278511 (OMIM: 603616) rab GTPase-binding eff ( 190) 305 43.9 0.00054
>>NP_079092 (OMIM: 611869) rab GTPase-binding effector p (569 aa)
initn: 3596 init1: 3596 opt: 3596 Z-score: 1948.2 bits: 370.4 E(85289): 8.9e-102
Smith-Waterman score: 3596; 99.8% identity (100.0% similar) in 569 aa overlap (1-569:1-569)
10 20 30 40 50 60
pF1KE4 MAAAAPVAADDDERRRRPGSALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAV
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
NP_079 MAAAAPVAADDDERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 AEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 AEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 ELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 ELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 QRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 QRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 GGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 GGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 QLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 QLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 LQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 LCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEAS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 LCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLE
490 500 510 520 530 540
550 560
pF1KE4 RIRQAETLEQVRSIMDEAPLTDVRDIKDT
:::::::::::::::::::::::::::::
NP_079 RIRQAETLEQVRSIMDEAPLTDVRDIKDT
550 560
>>NP_001077054 (OMIM: 603616) rab GTPase-binding effecto (829 aa)
initn: 782 init1: 359 opt: 593 Z-score: 338.0 bits: 73.0 E(85289): 4.4e-12
Smith-Waterman score: 686; 30.2% identity (62.0% similar) in 553 aa overlap (76-569:291-829)
50 60 70 80 90 100
pF1KE4 ELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALK
:: .... .. .: : :. ::
NP_001 EVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVL---TSEQLRQVEELK
270 280 290 300 310
110 120 130 140 150 160
pF1KE4 ---QERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKE
:: ..::. ..:... . ... .. :. : :.. . :.. .: . .
NP_001 KKDQEDDEQQRLNKRKDHKKADVEEEIK--IPVVCALTQEESSAQLSNE-EEHLDSTRGS
320 330 340 350 360 370
170 180 190 200 210
pF1KE4 IEELKAKLL---------RAEELIQEIQRRPRHAPSL--HGSTELLPLSRD-PSPPLEPL
.. : : :: ...... :: . . :: :: . :. . . :
NP_001 VHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNL
380 390 400 410 420 430
220 230 240 250 260
pF1KE4 EELSGDGGP--AAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVS
.: .: :: .:.. ..: : .::..:... .: ... .. ....:::::::::.:
NP_001 DE--SDFGPLVGADSVSENFD-TASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLS
440 450 460 470 480 490
270 280 290 300
pF1KE4 TGTLVPEGIYLPPPGYQLVPDTQWEQLQTE--------GR----------QLQ-------
. : :. :. : ::.:: .:.:. :: : :: :::
NP_001 SVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEA
500 510 520 530 540 550
310 320 330 340
pF1KE4 --KD---------------LESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLR
.: ::.. ....::.. ...:.:: ..:...:. ..: :: ::.
NP_001 ETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLE
560 570 580 590 600 610
350 360 370 380 390 400
pF1KE4 TLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGE
:: .:::.. :: ::: :. ... . .:. ::...:..:.... . : :.:
NP_001 ELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQ-----QAE
620 630 640 650 660
410 420 430 440 450 460
pF1KE4 EESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQ
. ::... :..:. :.. : .: :.:. ::. :.: .. : . .::
NP_001 DFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEET
670 680 690 700 710 720
470 480 490 500 510 520
pF1KE4 LRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQR
:... :. . ::. ::..:.::.. :...: . .:. :.. :. :::.::..::::::
NP_001 LQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQR
730 740 750 760 770 780
530 540 550 560
pF1KE4 DFVRLSQALQVRLERIRQAETLEQVRSIMDEAPLTDVRDIKDT
:::.:::.:::.:::::::..::..:.:.... :::. .. .:
NP_001 DFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET
790 800 810 820
>--
initn: 471 init1: 228 opt: 439 Z-score: 255.5 bits: 57.7 E(85289): 1.7e-07
Smith-Waterman score: 439; 47.5% identity (77.2% similar) in 162 aa overlap (21-181:52-213)
10 20 30 40 50
pF1KE4 MAAAAPVAADDDERRRRPGSALEDSRSQEGANGEAESGELSRLRAELAGA
: :.. ....: .: . .:..::..: :
NP_001 EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEA
30 40 50 60 70 80
60 70 80 90 100
pF1KE4 LAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQI-TALKQERQ
::::..::.: :::.:: ::. :.:: .::::::::..:... .:: :. :.:::
NP_001 QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERT
90 100 110 120 130 140
110 120 130 140 150 160
pF1KE4 QQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAK
: : : :::.. :.. ::.. ..::..:.::.::.:::: .:.:::::: :: :
NP_001 QWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDK
150 160 170 180 190 200
170 180 190 200 210 220
pF1KE4 LLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCD
: .::. :.:..
NP_001 LTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHE
210 220 230 240 250 260
>>XP_016880784 (OMIM: 603616) PREDICTED: rab GTPase-bind (552 aa)
initn: 591 init1: 267 opt: 397 Z-score: 235.5 bits: 53.4 E(85289): 2.2e-06
Smith-Waterman score: 606; 31.2% identity (61.1% similar) in 475 aa overlap (175-569:86-552)
150 160 170 180 190 200
pF1KE4 AHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSL--HGSTELLPLSRD
..... :: . . :: :: . :. .
XP_016 EHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYN
60 70 80 90 100 110
210 220 230 240 250
pF1KE4 -PSPPLEPLEELSGDGGP--AAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPE
. :.: .: :: .:.. ..: : .::..:... .: ... .. ....::
XP_016 YKAKSAGNLDE--SDFGPLVGADSVSENFD-TASLGSLQMPSGFMLTKDQERAIKAMTPE
120 130 140 150 160 170
260 270 280 290 300
pF1KE4 QEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTE--------GR----------Q
:::::::.:. : :. :. : ::.:: .:.:. :: : :: :
XP_016 QEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQ
180 190 200 210 220 230
310 320 330
pF1KE4 LQ---------KD---------------LESVSRERDELQEGLRRSNEDCAKQMQVLLAQ
:: .: ::.. ....::.. ...:.:: ..:...:. .
XP_016 LQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLR
240 250 260 270 280 290
340 350 360 370 380 390
pF1KE4 VQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAP
.: :: ::. :: .:::.. :: ::: :. ... . .:. ::...:..:.... .
XP_016 AQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKH----SL
300 310 320 330 340
400 410 420 430 440 450
pF1KE4 QGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEET
. : : :.:. ::... :..:. :.. : .: :.:. ::. :.: .. :
XP_016 HVSLQ-QAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQ
350 360 370 380 390 400
460 470 480 490
pF1KE4 VARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQ----------------------
. .:: :... :. . ::. ::..:.::.. :.
XP_016 CLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKI
410 420 430 440 450 460
500 510 520 530 540
pF1KE4 -----------SKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQ
.:: . .:. :.. :. :::.::..:::::::::.:::.:::.::::::
XP_016 SLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQ
470 480 490 500 510 520
550 560
pF1KE4 AETLEQVRSIMDEAPLTDVRDIKDT
:..::..:.:.... :::. .. .:
XP_016 ADSLERIRAILNDTKLTDINQLPET
530 540 550
>>XP_016880783 (OMIM: 603616) PREDICTED: rab GTPase-bind (574 aa)
initn: 622 init1: 267 opt: 397 Z-score: 235.3 bits: 53.4 E(85289): 2.3e-06
Smith-Waterman score: 612; 29.2% identity (59.2% similar) in 552 aa overlap (101-569:39-574)
80 90 100 110 120 130
pF1KE4 AVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLS
. :: ::... : . ::: ..:
XP_016 CMKEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEKTPF--KIKITDR
10 20 30 40 50 60
140 150 160 170 180
pF1KE4 RAYP--LDSLEKQMEKAHEDSEKLRE-IVLPMEKEIEELKAKLLRAEELIQEIQRRPRHA
.:: .. ....... . ..: ..:: . . ...... :: . .
XP_016 SSYPEVTTNILEHLDSTRGSVHSLDAGLLLPSGDPFSK------SDNDMFKDGLRRAQST
70 80 90 100 110 120
190 200 210 220 230 240
pF1KE4 PSL--HGSTELLPLSRD-PSPPLEPLEELSGDGGP--AAEAFAHNCDDSASISSFSLGGG
:: :: . :. . . :.: .: :: .:.. ..: : .::..:... .:
XP_016 DSLGTSGSLQSKALGYNYKAKSAGNLDE--SDFGPLVGADSVSENFD-TASLGSLQMPSG
130 140 150 160 170
250 260 270 280 290
pF1KE4 VGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTE----
... .. ....:::::::::.:. : :. :. : ::.:: .:.:. :: :
XP_016 FMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA
180 190 200 210 220 230
300 310 320
pF1KE4 ----GR----------QLQ---------KD---------------LESVSRERDELQEGL
:: ::: .: ::.. ....::.. .
XP_016 GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI
240 250 260 270 280 290
330 340 350 360 370 380
pF1KE4 RRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRL
..:.:: ..:...:. ..: :: ::. :: .:::.. :: ::: :. ... . .:. ::
XP_016 KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRL
300 310 320 330 340 350
390 400 410 420 430 440
pF1KE4 NEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAE
...:..:.... . : :.:. ::... :..:. :.. : .: :
XP_016 QKDNDSLQGKHSLHVSLQ-----QAEDFILPDTTEALRELVLKYREDIINVRTAADHVEE
360 370 380 390 400 410
450 460 470 480 490
pF1KE4 RLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQ-----
.:. ::. :.: .. : . .:: :... :. . ::. ::..:.::.. :.
XP_016 KLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLES
420 430 440 450 460 470
500 510 520
pF1KE4 ----------------------------SKAQLPDLLSEQRAKVLRLQAELETSEQVQRD
.:: . .:. :.. :. :::.::..:::::::
XP_016 TLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRD
480 490 500 510 520 530
530 540 550 560
pF1KE4 FVRLSQALQVRLERIRQAETLEQVRSIMDEAPLTDVRDIKDT
::.:::.:::.:::::::..::..:.:.... :::. .. .:
XP_016 FVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET
540 550 560 570
>>NP_001278510 (OMIM: 603616) rab GTPase-binding effecto (819 aa)
initn: 691 init1: 267 opt: 397 Z-score: 233.1 bits: 53.5 E(85289): 3e-06
Smith-Waterman score: 443; 46.7% identity (77.0% similar) in 165 aa overlap (18-181:6-170)
10 20 30 40 50 60
pF1KE4 MAAAAPVAADDDERRRRPGSALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAV
:.: ... ....: .: . .:..::..: : ::::..::.
NP_001 MAQPGPASQPDEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAI
10 20 30 40
70 80 90 100 110
pF1KE4 AEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQI-TALKQERQQQQQDCEEKE
: :::.:: ::. :.:: .::::::::..:... .:: :. :.::: : : : :
NP_001 ATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAE
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE4 RELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQE
::.. :.. ::.. ..::..:.::.::.:::: .:.:::::: :: :: .::. :.:
NP_001 REIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKE
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE4 IQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSL
..
NP_001 LEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQ
170 180 190 200 210 220
>--
initn: 691 init1: 267 opt: 405 Z-score: 237.4 bits: 54.3 E(85289): 1.7e-06
Smith-Waterman score: 615; 28.7% identity (58.5% similar) in 586 aa overlap (76-569:248-819)
50 60 70 80 90 100
pF1KE4 ELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALK
:: .... .. .: : :. ::
NP_001 EVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVL---TSEQLRQVEELK
220 230 240 250 260 270
110 120 130 140 150 160
pF1KE4 ---QERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKE
:: ..::. ..:... . ... .. :. : :.. . :.. .: . .
NP_001 KKDQEDDEQQRLNKRKDHKKADVEEEIK--IPVVCALTQEESSAQLSNE-EEHLDSTRGS
280 290 300 310 320 330
170 180 190 200 210
pF1KE4 IEELKAKLL---------RAEELIQEIQRRPRHAPSL--HGSTELLPLSRD-PSPPLEPL
.. : : :: ...... :: . . :: :: . :. . . :
NP_001 VHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNL
340 350 360 370 380 390
220 230 240 250 260
pF1KE4 EELSGDGGP--AAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVS
.: .: :: .:.. ..: : .::..:... .: ... .. ....:::::::::.:
NP_001 DE--SDFGPLVGADSVSENFD-TASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLS
400 410 420 430 440
270 280 290 300
pF1KE4 TGTLVPEGIYLPPPGYQLVPDTQWEQLQTE--------GR----------QLQ-------
. : :. :. : ::.:: .:.:. :: : :: :::
NP_001 SVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEA
450 460 470 480 490 500
310 320 330 340
pF1KE4 --KD---------------LESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLR
.: ::.. ....::.. ...:.:: ..:...:. ..: :: ::.
NP_001 ETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLE
510 520 530 540 550 560
350 360 370 380 390 400
pF1KE4 TLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGE
:: .:::.. :: ::: :. ... . .:. ::...:..:.... . : :.:
NP_001 ELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQ-----QAE
570 580 590 600 610 620
410 420 430 440 450 460
pF1KE4 EESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQ
. ::... :..:. :.. : .: :.:. ::. :.: .. : . .::
NP_001 DFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEET
630 640 650 660 670 680
470 480 490
pF1KE4 LRVQREETEVLEASLCSLRTEMERVQQEQ-------------------------------
:... :. . ::. ::..:.::.. :.
NP_001 LQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKE
690 700 710 720 730 740
500 510 520 530 540 550
pF1KE4 --SKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRS
.:: . .:. :.. :. :::.::..:::::::::.:::.:::.:::::::..::..:.
NP_001 TAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRA
750 760 770 780 790 800
560
pF1KE4 IMDEAPLTDVRDIKDT
:.... :::. .. .:
NP_001 ILNDTKLTDINQLPET
810
>>NP_004694 (OMIM: 603616) rab GTPase-binding effector p (862 aa)
initn: 684 init1: 267 opt: 397 Z-score: 232.8 bits: 53.6 E(85289): 3.1e-06
Smith-Waterman score: 439; 47.5% identity (77.2% similar) in 162 aa overlap (21-181:52-213)
10 20 30 40 50
pF1KE4 MAAAAPVAADDDERRRRPGSALEDSRSQEGANGEAESGELSRLRAELAGA
: :.. ....: .: . .:..::..: :
NP_004 EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEA
30 40 50 60 70 80
60 70 80 90 100
pF1KE4 LAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQI-TALKQERQ
::::..::.: :::.:: ::. :.:: .::::::::..:... .:: :. :.:::
NP_004 QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERT
90 100 110 120 130 140
110 120 130 140 150 160
pF1KE4 QQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAK
: : : :::.. :.. ::.. ..::..:.::.::.:::: .:.:::::: :: :
NP_004 QWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDK
150 160 170 180 190 200
170 180 190 200 210 220
pF1KE4 LLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCD
: .::. :.:..
NP_004 LTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHE
210 220 230 240 250 260
>--
initn: 690 init1: 267 opt: 405 Z-score: 237.1 bits: 54.4 E(85289): 1.8e-06
Smith-Waterman score: 615; 28.7% identity (58.5% similar) in 586 aa overlap (76-569:291-862)
50 60 70 80 90 100
pF1KE4 ELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALK
:: .... .. .: : :. ::
NP_004 EVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVL---TSEQLRQVEELK
270 280 290 300 310
110 120 130 140 150 160
pF1KE4 ---QERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKE
:: ..::. ..:... . ... .. :. : :.. . :.. .: . .
NP_004 KKDQEDDEQQRLNKRKDHKKADVEEEIK--IPVVCALTQEESSAQLSNE-EEHLDSTRGS
320 330 340 350 360 370
170 180 190 200 210
pF1KE4 IEELKAKLL---------RAEELIQEIQRRPRHAPSL--HGSTELLPLSRD-PSPPLEPL
.. : : :: ...... :: . . :: :: . :. . . :
NP_004 VHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNL
380 390 400 410 420 430
220 230 240 250 260
pF1KE4 EELSGDGGP--AAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVS
.: .: :: .:.. ..: : .::..:... .: ... .. ....:::::::::.:
NP_004 DE--SDFGPLVGADSVSENFD-TASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLS
440 450 460 470 480 490
270 280 290 300
pF1KE4 TGTLVPEGIYLPPPGYQLVPDTQWEQLQTE--------GR----------QLQ-------
. : :. :. : ::.:: .:.:. :: : :: :::
NP_004 SVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEA
500 510 520 530 540 550
310 320 330 340
pF1KE4 --KD---------------LESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLR
.: ::.. ....::.. ...:.:: ..:...:. ..: :: ::.
NP_004 ETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLE
560 570 580 590 600 610
350 360 370 380 390 400
pF1KE4 TLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGE
:: .:::.. :: ::: :. ... . .:. ::...:..:.... . : :.:
NP_004 ELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQ-----QAE
620 630 640 650 660
410 420 430 440 450 460
pF1KE4 EESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQ
. ::... :..:. :.. : .: :.:. ::. :.: .. : . .::
NP_004 DFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEET
670 680 690 700 710 720
470 480 490
pF1KE4 LRVQREETEVLEASLCSLRTEMERVQQEQ-------------------------------
:... :. . ::. ::..:.::.. :.
NP_004 LQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKE
730 740 750 760 770 780
500 510 520 530 540 550
pF1KE4 --SKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRS
.:: . .:. :.. :. :::.::..:::::::::.:::.:::.:::::::..::..:.
NP_004 TAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRA
790 800 810 820 830 840
560
pF1KE4 IMDEAPLTDVRDIKDT
:.... :::. .. .:
NP_004 ILNDTKLTDINQLPET
850 860
>>XP_011522362 (OMIM: 603616) PREDICTED: rab GTPase-bind (884 aa)
initn: 684 init1: 267 opt: 397 Z-score: 232.7 bits: 53.6 E(85289): 3.2e-06
Smith-Waterman score: 439; 47.5% identity (77.2% similar) in 162 aa overlap (21-181:52-213)
10 20 30 40 50
pF1KE4 MAAAAPVAADDDERRRRPGSALEDSRSQEGANGEAESGELSRLRAELAGA
: :.. ....: .: . .:..::..: :
XP_011 EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEA
30 40 50 60 70 80
60 70 80 90 100
pF1KE4 LAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQI-TALKQERQ
::::..::.: :::.:: ::. :.:: .::::::::..:... .:: :. :.:::
XP_011 QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERT
90 100 110 120 130 140
110 120 130 140 150 160
pF1KE4 QQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAK
: : : :::.. :.. ::.. ..::..:.::.::.:::: .:.:::::: :: :
XP_011 QWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDK
150 160 170 180 190 200
170 180 190 200 210 220
pF1KE4 LLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCD
: .::. :.:..
XP_011 LTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHE
210 220 230 240 250 260
>--
initn: 690 init1: 267 opt: 405 Z-score: 236.9 bits: 54.4 E(85289): 1.9e-06
Smith-Waterman score: 612; 29.2% identity (59.2% similar) in 552 aa overlap (101-569:349-884)
80 90 100 110 120 130
pF1KE4 AVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLS
. :: ::... : . ::: ..:
XP_011 KDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEKTPF--KIKITDR
320 330 340 350 360 370
140 150 160 170 180
pF1KE4 RAYP--LDSLEKQMEKAHEDSEKLRE-IVLPMEKEIEELKAKLLRAEELIQEIQRRPRHA
.:: .. ....... . ..: ..:: . . ...... :: . .
XP_011 SSYPEVTTNILEHLDSTRGSVHSLDAGLLLPSGDPFSK------SDNDMFKDGLRRAQST
380 390 400 410 420 430
190 200 210 220 230 240
pF1KE4 PSL--HGSTELLPLSRD-PSPPLEPLEELSGDGGP--AAEAFAHNCDDSASISSFSLGGG
:: :: . :. . . :.: .: :: .:.. ..: : .::..:... .:
XP_011 DSLGTSGSLQSKALGYNYKAKSAGNLDE--SDFGPLVGADSVSENFD-TASLGSLQMPSG
440 450 460 470 480
250 260 270 280 290
pF1KE4 VGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTE----
... .. ....:::::::::.:. : :. :. : ::.:: .:.:. :: :
XP_011 FMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA
490 500 510 520 530 540
300 310 320
pF1KE4 ----GR----------QLQ---------KD---------------LESVSRERDELQEGL
:: ::: .: ::.. ....::.. .
XP_011 GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI
550 560 570 580 590 600
330 340 350 360 370 380
pF1KE4 RRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRL
..:.:: ..:...:. ..: :: ::. :: .:::.. :: ::: :. ... . .:. ::
XP_011 KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRL
610 620 630 640 650 660
390 400 410 420 430 440
pF1KE4 NEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAE
...:..:.... . : :.:. ::... :..:. :.. : .: :
XP_011 QKDNDSLQGKHSLHVSLQ-----QAEDFILPDTTEALRELVLKYREDIINVRTAADHVEE
670 680 690 700 710 720
450 460 470 480 490
pF1KE4 RLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQ-----
.:. ::. :.: .. : . .:: :... :. . ::. ::..:.::.. :.
XP_011 KLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLES
730 740 750 760 770 780
500 510 520
pF1KE4 ----------------------------SKAQLPDLLSEQRAKVLRLQAELETSEQVQRD
.:: . .:. :.. :. :::.::..:::::::
XP_011 TLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRD
790 800 810 820 830 840
530 540 550 560
pF1KE4 FVRLSQALQVRLERIRQAETLEQVRSIMDEAPLTDVRDIKDT
::.:::.:::.:::::::..::..:.:.... :::. .. .:
XP_011 FVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET
850 860 870 880
>>NP_001278511 (OMIM: 603616) rab GTPase-binding effecto (190 aa)
initn: 274 init1: 200 opt: 305 Z-score: 192.6 bits: 43.9 E(85289): 0.00054
Smith-Waterman score: 305; 41.7% identity (72.7% similar) in 139 aa overlap (21-158:52-190)
10 20 30 40 50
pF1KE4 MAAAAPVAADDDERRRRPGSALEDSRSQEGANGEAESGELSRLRAELAGA
: :.. ....: .: . .:..::..: :
NP_001 EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEA
30 40 50 60 70 80
60 70 80 90 100
pF1KE4 LAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQI-TALKQERQ
::::..::.: :::.:: ::. :.:: .::::::::..:... .:: :. :.:::
NP_001 QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERT
90 100 110 120 130 140
110 120 130 140 150 160
pF1KE4 QQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAK
: : : :::.. :.. ::.. ..::..:.: .. :. .: :
NP_001 QWAQYRESAEREIADLRRRLSEGQEEENLENEMKKDPIQDTILHLVVSP
150 160 170 180 190
170 180 190 200 210 220
pF1KE4 LLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCD
569 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:49:11 2016 done: Sun Nov 6 01:49:13 2016
Total Scan time: 12.740 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]