Result of FASTA (omim) for
pFN21AE4137
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4137, 452 aa
1>>>pF1KE4137 452 - 452 aa - 452 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.0608+/-0.000344; mu= 3.6693+/- 0.022
mean_var=250.2084+/-50.892, 0's: 0 Z-trim(123.0): 109 B-trim: 378 in 1/59
Lambda= 0.081082
statistics sampled from 41832 (41965) to 41832 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.79), E-opt: 0.2 (0.492), width: 16
Scan time: 10.760
The best scores are: opt bits E(85289)
XP_011515918 (OMIM: 606469) PREDICTED: tripartite ( 452) 3042 368.4 2.2e-101
NP_908974 (OMIM: 606469) tripartite motif-containi ( 452) 3042 368.4 2.2e-101
XP_011515917 (OMIM: 606469) PREDICTED: tripartite ( 540) 2796 339.7 1.1e-92
NP_149047 (OMIM: 606469) tripartite motif-containi ( 540) 2796 339.7 1.1e-92
XP_011515916 (OMIM: 606469) PREDICTED: tripartite ( 548) 2796 339.7 1.1e-92
XP_011515915 (OMIM: 606469) PREDICTED: tripartite ( 548) 2796 339.7 1.1e-92
NP_908973 (OMIM: 606469) tripartite motif-containi ( 548) 2796 339.7 1.1e-92
XP_005251373 (OMIM: 606469) PREDICTED: tripartite ( 547) 2778 337.6 4.9e-92
XP_016869397 (OMIM: 606469) PREDICTED: tripartite ( 479) 2318 283.8 7e-76
XP_011515919 (OMIM: 606469) PREDICTED: tripartite ( 426) 1951 240.8 5.4e-63
XP_016869398 (OMIM: 606469) PREDICTED: tripartite ( 426) 1951 240.8 5.4e-63
NP_912730 (OMIM: 606474) tripartite motif-containi ( 358) 1539 192.5 1.5e-48
XP_016858048 (OMIM: 606131) PREDICTED: E3 ubiquiti ( 379) 1450 182.1 2.2e-45
NP_115977 (OMIM: 606131) E3 ubiquitin-protein liga ( 353) 1449 182.0 2.2e-45
NP_908975 (OMIM: 606469) tripartite motif-containi ( 241) 1391 175.1 1.9e-43
NP_115935 (OMIM: 606474) tripartite motif-containi ( 400) 955 124.3 6.1e-28
XP_016865112 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 529) 382 57.3 1.1e-07
NP_001287681 (OMIM: 609317) E3 ubiquitin-protein l ( 573) 382 57.4 1.2e-07
NP_001287688 (OMIM: 609317) E3 ubiquitin-protein l ( 716) 382 57.4 1.4e-07
NP_061170 (OMIM: 609317) E3 ubiquitin-protein liga ( 728) 382 57.5 1.4e-07
XP_016865111 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 733) 382 57.5 1.4e-07
XP_016865110 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 745) 382 57.5 1.4e-07
NP_001180208 (OMIM: 189960,300000,300552) E3 ubiqu ( 489) 365 55.3 4.2e-07
XP_016885031 (OMIM: 189960,300000,300552) PREDICTE ( 489) 365 55.3 4.2e-07
XP_016885029 (OMIM: 189960,300000,300552) PREDICTE ( 552) 365 55.4 4.6e-07
NP_000372 (OMIM: 189960,300000,300552) E3 ubiquiti ( 667) 365 55.4 5.3e-07
NP_001180206 (OMIM: 189960,300000,300552) E3 ubiqu ( 667) 365 55.4 5.3e-07
NP_150632 (OMIM: 189960,300000,300552) E3 ubiquiti ( 667) 365 55.4 5.3e-07
NP_001092094 (OMIM: 189960,300000,300552) E3 ubiqu ( 667) 365 55.4 5.3e-07
XP_016885025 (OMIM: 189960,300000,300552) PREDICTE ( 667) 365 55.4 5.3e-07
NP_001269308 (OMIM: 600986) tripartite motif-conta ( 551) 358 54.5 8.1e-07
NP_001269307 (OMIM: 600986) tripartite motif-conta ( 633) 358 54.6 9e-07
NP_001243528 (OMIM: 600986) tripartite motif-conta ( 736) 358 54.7 1e-06
NP_001243530 (OMIM: 600986) tripartite motif-conta ( 746) 358 54.7 1e-06
XP_016857882 (OMIM: 600986) PREDICTED: tripartite ( 746) 358 54.7 1e-06
NP_079334 (OMIM: 600986) tripartite motif-containi ( 759) 358 54.7 1e-06
XP_011508304 (OMIM: 600986) PREDICTED: tripartite ( 788) 358 54.7 1.1e-06
XP_016884728 (OMIM: 300204,300928) PREDICTED: prob ( 685) 340 52.5 4.1e-06
NP_438112 (OMIM: 300204,300928) probable E3 ubiqui ( 705) 340 52.5 4.2e-06
XP_005262119 (OMIM: 300204,300928) PREDICTED: prob ( 715) 340 52.5 4.2e-06
NP_036348 (OMIM: 300204,300928) probable E3 ubiqui ( 735) 340 52.5 4.3e-06
NP_001180210 (OMIM: 189960,300000,300552) E3 ubiqu ( 228) 279 45.0 0.00026
NP_001180209 (OMIM: 189960,300000,300552) E3 ubiqu ( 451) 285 45.9 0.00026
XP_016885026 (OMIM: 189960,300000,300552) PREDICTE ( 629) 285 46.1 0.00033
XP_016885028 (OMIM: 189960,300000,300552) PREDICTE ( 629) 285 46.1 0.00033
XP_016885027 (OMIM: 189960,300000,300552) PREDICTE ( 629) 285 46.1 0.00033
NP_150631 (OMIM: 189960,300000,300552) E3 ubiquiti ( 629) 285 46.1 0.00033
XP_016885024 (OMIM: 189960,300000,300552) PREDICTE ( 680) 279 45.4 0.00057
NP_001287818 (OMIM: 610584) tripartite motif-conta ( 721) 277 45.2 0.0007
XP_011542494 (OMIM: 610584) PREDICTED: tripartite ( 781) 277 45.2 0.00075
>>XP_011515918 (OMIM: 606469) PREDICTED: tripartite moti (452 aa)
initn: 3042 init1: 3042 opt: 3042 Z-score: 1941.3 bits: 368.4 E(85289): 2.2e-101
Smith-Waterman score: 3042; 100.0% identity (100.0% similar) in 452 aa overlap (1-452:1-452)
10 20 30 40 50 60
pF1KE4 MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 YLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 QPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 NVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQIGFEAPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQIGFEAPPL
370 380 390 400 410 420
430 440 450
pF1KE4 QGQAAAPASGSGADSEPARHIFSFSWLNSLNE
::::::::::::::::::::::::::::::::
XP_011 QGQAAAPASGSGADSEPARHIFSFSWLNSLNE
430 440 450
>>NP_908974 (OMIM: 606469) tripartite motif-containing p (452 aa)
initn: 3042 init1: 3042 opt: 3042 Z-score: 1941.3 bits: 368.4 E(85289): 2.2e-101
Smith-Waterman score: 3042; 100.0% identity (100.0% similar) in 452 aa overlap (1-452:1-452)
10 20 30 40 50 60
pF1KE4 MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_908 MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 YLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_908 YLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 QPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_908 QPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_908 GSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_908 LEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_908 EHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 NVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQIGFEAPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_908 NVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQIGFEAPPL
370 380 390 400 410 420
430 440 450
pF1KE4 QGQAAAPASGSGADSEPARHIFSFSWLNSLNE
::::::::::::::::::::::::::::::::
NP_908 QGQAAAPASGSGADSEPARHIFSFSWLNSLNE
430 440 450
>>XP_011515917 (OMIM: 606469) PREDICTED: tripartite moti (540 aa)
initn: 2770 init1: 2770 opt: 2796 Z-score: 1784.8 bits: 339.7 E(85289): 1.1e-92
Smith-Waterman score: 2796; 94.4% identity (96.0% similar) in 446 aa overlap (1-446:1-445)
10 20 30 40 50 60
pF1KE4 MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 YLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 QPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 NVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQIGFEAPPL
:::::::::::::::::::::::::::::::::::::::::::::::::::: : .:
XP_011 NVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQ-GEVVPTG
370 380 390 400 410
430 440 450
pF1KE4 QGQAAAPASGSGADSEPARHIFSFSWLNSLNE
. :.. . : .: : .: ::
XP_011 SEQTTESETPVPAAAETADPLFYPSWYKGQTRKATTNPPCTPGSEGLGQIGPPGSEDSNV
420 430 440 450 460 470
>>NP_149047 (OMIM: 606469) tripartite motif-containing p (540 aa)
initn: 2770 init1: 2770 opt: 2796 Z-score: 1784.8 bits: 339.7 E(85289): 1.1e-92
Smith-Waterman score: 2796; 94.4% identity (96.0% similar) in 446 aa overlap (1-446:1-445)
10 20 30 40 50 60
pF1KE4 MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 YLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 YLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 QPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 QPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 GSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 LEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 EHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 NVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQIGFEAPPL
:::::::::::::::::::::::::::::::::::::::::::::::::::: : .:
NP_149 NVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQ-GEVVPTG
370 380 390 400 410
430 440 450
pF1KE4 QGQAAAPASGSGADSEPARHIFSFSWLNSLNE
. :.. . : .: : .: ::
NP_149 SEQTTESETPVPAAAETADPLFYPSWYKGQTRKATTNPPCTPGSEGLGQIGPPGSEDSNV
420 430 440 450 460 470
>>XP_011515916 (OMIM: 606469) PREDICTED: tripartite moti (548 aa)
initn: 2770 init1: 2770 opt: 2796 Z-score: 1784.7 bits: 339.7 E(85289): 1.1e-92
Smith-Waterman score: 2796; 94.4% identity (96.0% similar) in 446 aa overlap (1-446:1-445)
10 20 30 40 50 60
pF1KE4 MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 YLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 QPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 NVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQIGFEAPPL
:::::::::::::::::::::::::::::::::::::::::::::::::::: : .:
XP_011 NVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQ-GEVVPTG
370 380 390 400 410
430 440 450
pF1KE4 QGQAAAPASGSGADSEPARHIFSFSWLNSLNE
. :.. . : .: : .: ::
XP_011 SEQTTESETPVPAAAETADPLFYPSWYKGQTRKATTNPPCTPGSEGLGQIGPPGSEDSNV
420 430 440 450 460 470
>--
initn: 305 init1: 290 opt: 302 Z-score: 208.0 bits: 48.0 E(85289): 7.6e-05
Smith-Waterman score: 302; 64.4% identity (71.3% similar) in 87 aa overlap (367-452:472-548)
340 350 360 370 380 390
pF1KE4 EGGEGEKEGEGEVGGEAVEVEEVENVQTEFPG-EDENPEKASELSQVELQAAPGALPVSS
:: :: : .:: .: :: ::.
XP_011 YPSWYKGQTRKATTNPPCTPGSEGLGQIGPPGSEDSNVRKA----EVAAAAASERAAVSG
450 460 470 480 490
400 410 420 430 440 450
pF1KE4 PEPPPALPPAADAPVTQIGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE
: .: : ..:::::::::::::::::::::::::::::::::::::::::
XP_011 KET------SAPAATSQIGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE
500 510 520 530 540
>>XP_011515915 (OMIM: 606469) PREDICTED: tripartite moti (548 aa)
initn: 2770 init1: 2770 opt: 2796 Z-score: 1784.7 bits: 339.7 E(85289): 1.1e-92
Smith-Waterman score: 2796; 94.4% identity (96.0% similar) in 446 aa overlap (1-446:1-445)
10 20 30 40 50 60
pF1KE4 MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 YLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 QPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 NVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQIGFEAPPL
:::::::::::::::::::::::::::::::::::::::::::::::::::: : .:
XP_011 NVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQ-GEVVPTG
370 380 390 400 410
430 440 450
pF1KE4 QGQAAAPASGSGADSEPARHIFSFSWLNSLNE
. :.. . : .: : .: ::
XP_011 SEQTTESETPVPAAAETADPLFYPSWYKGQTRKATTNPPCTPGSEGLGQIGPPGSEDSNV
420 430 440 450 460 470
>--
initn: 305 init1: 290 opt: 302 Z-score: 208.0 bits: 48.0 E(85289): 7.6e-05
Smith-Waterman score: 302; 64.4% identity (71.3% similar) in 87 aa overlap (367-452:472-548)
340 350 360 370 380 390
pF1KE4 EGGEGEKEGEGEVGGEAVEVEEVENVQTEFPG-EDENPEKASELSQVELQAAPGALPVSS
:: :: : .:: .: :: ::.
XP_011 YPSWYKGQTRKATTNPPCTPGSEGLGQIGPPGSEDSNVRKA----EVAAAAASERAAVSG
450 460 470 480 490
400 410 420 430 440 450
pF1KE4 PEPPPALPPAADAPVTQIGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE
: .: : ..:::::::::::::::::::::::::::::::::::::::::
XP_011 KET------SAPAATSQIGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE
500 510 520 530 540
>>NP_908973 (OMIM: 606469) tripartite motif-containing p (548 aa)
initn: 2770 init1: 2770 opt: 2796 Z-score: 1784.7 bits: 339.7 E(85289): 1.1e-92
Smith-Waterman score: 2796; 94.4% identity (96.0% similar) in 446 aa overlap (1-446:1-445)
10 20 30 40 50 60
pF1KE4 MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_908 MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 YLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_908 YLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 QPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_908 QPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_908 GSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_908 LEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_908 EHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 NVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQIGFEAPPL
:::::::::::::::::::::::::::::::::::::::::::::::::::: : .:
NP_908 NVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQ-GEVVPTG
370 380 390 400 410
430 440 450
pF1KE4 QGQAAAPASGSGADSEPARHIFSFSWLNSLNE
. :.. . : .: : .: ::
NP_908 SEQTTESETPVPAAAETADPLFYPSWYKGQTRKATTNPPCTPGSEGLGQIGPPGSEDSNV
420 430 440 450 460 470
>--
initn: 305 init1: 290 opt: 302 Z-score: 208.0 bits: 48.0 E(85289): 7.6e-05
Smith-Waterman score: 302; 64.4% identity (71.3% similar) in 87 aa overlap (367-452:472-548)
340 350 360 370 380 390
pF1KE4 EGGEGEKEGEGEVGGEAVEVEEVENVQTEFPG-EDENPEKASELSQVELQAAPGALPVSS
:: :: : .:: .: :: ::.
NP_908 YPSWYKGQTRKATTNPPCTPGSEGLGQIGPPGSEDSNVRKA----EVAAAAASERAAVSG
450 460 470 480 490
400 410 420 430 440 450
pF1KE4 PEPPPALPPAADAPVTQIGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE
: .: : ..:::::::::::::::::::::::::::::::::::::::::
NP_908 KET------SAPAATSQIGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE
500 510 520 530 540
>>XP_005251373 (OMIM: 606469) PREDICTED: tripartite moti (547 aa)
initn: 2556 init1: 2252 opt: 2778 Z-score: 1773.3 bits: 337.6 E(85289): 4.9e-92
Smith-Waterman score: 2778; 94.2% identity (95.7% similar) in 446 aa overlap (1-446:1-444)
10 20 30 40 50 60
pF1KE4 MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 YLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 QPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVE
:::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
XP_005 EHGYENMNHFTVNLNREEKIIREIDFYR-DEDEEEEEGGEGEKEGEGEVGGEAVEVEEVE
310 320 330 340 350
370 380 390 400 410 420
pF1KE4 NVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQIGFEAPPL
:::::::::::::::::::::::::::::::::::::::::::::::::::: : .:
XP_005 NVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQ-GEVVPTG
360 370 380 390 400 410
430 440 450
pF1KE4 QGQAAAPASGSGADSEPARHIFSFSWLNSLNE
. :.. . : .: : .: ::
XP_005 SEQTTESETPVPAAAETADPLFYPSWYKGQTRKATTNPPCTPGSEGLGQIGPPGSEDSNV
420 430 440 450 460 470
>--
initn: 305 init1: 290 opt: 302 Z-score: 208.0 bits: 48.0 E(85289): 7.6e-05
Smith-Waterman score: 302; 64.4% identity (71.3% similar) in 87 aa overlap (367-452:471-547)
340 350 360 370 380 390
pF1KE4 EGGEGEKEGEGEVGGEAVEVEEVENVQTEFPG-EDENPEKASELSQVELQAAPGALPVSS
:: :: : .:: .: :: ::.
XP_005 YPSWYKGQTRKATTNPPCTPGSEGLGQIGPPGSEDSNVRKA----EVAAAAASERAAVSG
450 460 470 480 490
400 410 420 430 440 450
pF1KE4 PEPPPALPPAADAPVTQIGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE
: .: : ..:::::::::::::::::::::::::::::::::::::::::
XP_005 KET------SAPAATSQIGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE
500 510 520 530 540
>>XP_016869397 (OMIM: 606469) PREDICTED: tripartite moti (479 aa)
initn: 2292 init1: 2292 opt: 2318 Z-score: 1483.3 bits: 283.8 E(85289): 7e-76
Smith-Waterman score: 2318; 93.4% identity (95.2% similar) in 377 aa overlap (70-446:1-376)
40 50 60 70 80 90
pF1KE4 LPCQHNLCRKCASDIFQASNPYLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNL
::::::::::::::::::::::::::::::
XP_016 MASGGRFRCPSCRHEVVLDRHGVYGLQRNL
10 20 30
100 110 120 130 140 150
pF1KE4 LVENIIDIYKQESTRPEKKSDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVENIIDIYKQESTRPEKKSDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVA
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE4 PLTHVFQRQKSELSDGIAILVGSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLTHVFQRQKSELSDGIAILVGSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLY
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE4 GILEERKNEMTQVITRTQEEKLEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GILEERKNEMTQVITRTQEEKLEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQ
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE4 NAKTLLKKISEASKAFQMEKIEHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAKTLLKKISEASKAFQMEKIEHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGG
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE4 EGEKEGEGEVGGEAVEVEEVENVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGEKEGEGEVGGEAVEVEEVENVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPP
280 290 300 310 320 330
400 410 420 430 440 450
pF1KE4 PALPPAADAPVTQIGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE
::::::::::::: : .: . :.. . : .: : .: ::
XP_016 PALPPAADAPVTQ-GEVVPTGSEQTTESETPVPAAAETADPLFYPSWYKGQTRKATTNPP
340 350 360 370 380
XP_016 CTPGSEGLGQIGPPGSEDSNVRKAEVAAAAASERAAVSGKETSAPAATSQIGFEAPPLQG
390 400 410 420 430 440
>--
initn: 305 init1: 290 opt: 302 Z-score: 208.8 bits: 47.9 E(85289): 6.9e-05
Smith-Waterman score: 302; 64.4% identity (71.3% similar) in 87 aa overlap (367-452:403-479)
340 350 360 370 380 390
pF1KE4 EGGEGEKEGEGEVGGEAVEVEEVENVQTEFPG-EDENPEKASELSQVELQAAPGALPVSS
:: :: : .:: .: :: ::.
XP_016 YPSWYKGQTRKATTNPPCTPGSEGLGQIGPPGSEDSNVRKA----EVAAAAASERAAVSG
380 390 400 410 420
400 410 420 430 440 450
pF1KE4 PEPPPALPPAADAPVTQIGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE
: .: : ..:::::::::::::::::::::::::::::::::::::::::
XP_016 KET------SAPAATSQIGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE
430 440 450 460 470
>>XP_011515919 (OMIM: 606469) PREDICTED: tripartite moti (426 aa)
initn: 1925 init1: 1925 opt: 1951 Z-score: 1251.9 bits: 240.8 E(85289): 5.4e-63
Smith-Waterman score: 1951; 92.3% identity (94.4% similar) in 324 aa overlap (123-446:1-323)
100 110 120 130 140 150
pF1KE4 YGLQRNLLVENIIDIYKQESTRPEKKSDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGA
::::::::::::::::::::::::::::::
XP_011 MCEEHEEERINIYCLNCEVPTCSLCKVFGA
10 20 30
160 170 180 190 200 210
pF1KE4 HKDCQVAPLTHVFQRQKSELSDGIAILVGSNDRVQGVISQLEDTCKTIEECCRKQKQELC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HKDCQVAPLTHVFQRQKSELSDGIAILVGSNDRVQGVISQLEDTCKTIEECCRKQKQELC
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE4 EKFDYLYGILEERKNEMTQVITRTQEEKLEHVRALIKKYSDHLENVSKLVESGIQFMDEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKFDYLYGILEERKNEMTQVITRTQEEKLEHVRALIKKYSDHLENVSKLVESGIQFMDEP
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE4 EMAVFLQNAKTLLKKISEASKAFQMEKIEHGYENMNHFTVNLNREEKIIREIDFYREDED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMAVFLQNAKTLLKKISEASKAFQMEKIEHGYENMNHFTVNLNREEKIIREIDFYREDED
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE4 EEEEEGGEGEKEGEGEVGGEAVEVEEVENVQTEFPGEDENPEKASELSQVELQAAPGALP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEEEEGGEGEKEGEGEVGGEAVEVEEVENVQTEFPGEDENPEKASELSQVELQAAPGALP
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE4 VSSPEPPPALPPAADAPVTQIGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE
:::::::::::::::::::: : .: . :.. . : .: : .: ::
XP_011 VSSPEPPPALPPAADAPVTQ-GEVVPTGSEQTTESETPVPAAAETADPLFYPSWYKGQTR
280 290 300 310 320
XP_011 KATTNPPCTPGSEGLGQIGPPGSEDSNVRKAEVAAAAASERAAVSGKETSAPAATSQIGF
330 340 350 360 370 380
>--
initn: 305 init1: 290 opt: 302 Z-score: 209.5 bits: 47.9 E(85289): 6.3e-05
Smith-Waterman score: 302; 64.4% identity (71.3% similar) in 87 aa overlap (367-452:350-426)
340 350 360 370 380 390
pF1KE4 EGGEGEKEGEGEVGGEAVEVEEVENVQTEFPG-EDENPEKASELSQVELQAAPGALPVSS
:: :: : .:: .: :: ::.
XP_011 YPSWYKGQTRKATTNPPCTPGSEGLGQIGPPGSEDSNVRKA----EVAAAAASERAAVSG
320 330 340 350 360 370
400 410 420 430 440 450
pF1KE4 PEPPPALPPAADAPVTQIGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE
: .: : ..:::::::::::::::::::::::::::::::::::::::::
XP_011 KET------SAPAATSQIGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE
380 390 400 410 420
452 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 14:40:42 2016 done: Mon Nov 7 14:40:43 2016
Total Scan time: 10.760 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]