Result of FASTA (omim) for
pFN21AE4136
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4136, 547 aa
1>>>pF1KE4136 547 - 547 aa - 547 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3149+/-0.000371; mu= 14.2688+/- 0.023
mean_var=93.4801+/-19.618, 0's: 0 Z-trim(115.0): 304 B-trim: 608 in 1/55
Lambda= 0.132652
statistics sampled from 24787 (25107) to 24787 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.666), E-opt: 0.2 (0.294), width: 16
Scan time: 10.880
The best scores are: opt bits E(85289)
NP_659404 (OMIM: 300937) rho GTPase-activating pro ( 547) 3583 696.1 7e-200
NP_001269536 (OMIM: 300937) rho GTPase-activating ( 535) 3368 655.0 1.7e-187
NP_001317580 (OMIM: 300937) rho GTPase-activating ( 411) 2684 524.0 3.4e-148
XP_011529582 (OMIM: 300937) PREDICTED: rho GTPase- ( 411) 2684 524.0 3.4e-148
NP_006116 (OMIM: 300118) rho GTPase-activating pro ( 765) 908 184.3 1.2e-45
NP_038267 (OMIM: 300118) rho GTPase-activating pro ( 771) 908 184.3 1.2e-45
NP_001274171 (OMIM: 300118) rho GTPase-activating ( 794) 908 184.3 1.2e-45
NP_038286 (OMIM: 300118) rho GTPase-activating pro ( 974) 908 184.3 1.5e-45
XP_011531508 (OMIM: 610587) PREDICTED: rho GTPase- ( 620) 296 67.1 1.8e-10
XP_011531510 (OMIM: 610587) PREDICTED: rho GTPase- ( 620) 296 67.1 1.8e-10
XP_011531509 (OMIM: 610587) PREDICTED: rho GTPase- ( 620) 296 67.1 1.8e-10
NP_001159748 (OMIM: 610587) rho GTPase-activating ( 639) 296 67.1 1.9e-10
NP_001007232 (OMIM: 610587) rho GTPase-activating ( 646) 296 67.1 1.9e-10
XP_016860912 (OMIM: 610587) PREDICTED: rho GTPase- ( 650) 296 67.1 1.9e-10
NP_055697 (OMIM: 610587) rho GTPase-activating pro ( 638) 289 65.8 4.7e-10
XP_005264732 (OMIM: 610587) PREDICTED: rho GTPase- ( 645) 289 65.8 4.7e-10
XP_016860913 (OMIM: 610587) PREDICTED: rho GTPase- ( 649) 289 65.8 4.8e-10
NP_001159749 (OMIM: 610587) rho GTPase-activating ( 606) 283 64.6 1e-09
XP_011531511 (OMIM: 610587) PREDICTED: rho GTPase- ( 528) 281 64.2 1.2e-09
XP_005264733 (OMIM: 610587) PREDICTED: rho GTPase- ( 607) 281 64.2 1.3e-09
XP_016860914 (OMIM: 610587) PREDICTED: rho GTPase- ( 611) 281 64.2 1.3e-09
XP_011517909 (OMIM: 609870) PREDICTED: rho GTPase- (1491) 284 65.0 1.9e-09
XP_011517908 (OMIM: 609870) PREDICTED: rho GTPase- (1924) 284 65.1 2.3e-09
XP_005252601 (OMIM: 609870) PREDICTED: rho GTPase- (1948) 284 65.1 2.3e-09
XP_016871949 (OMIM: 609870) PREDICTED: rho GTPase- (1948) 284 65.1 2.3e-09
XP_016871950 (OMIM: 609870) PREDICTED: rho GTPase- (1948) 284 65.1 2.3e-09
XP_005252599 (OMIM: 609870) PREDICTED: rho GTPase- (1958) 284 65.1 2.3e-09
XP_016871948 (OMIM: 609870) PREDICTED: rho GTPase- (1958) 284 65.1 2.3e-09
NP_065875 (OMIM: 609870) rho GTPase-activating pro (1958) 284 65.1 2.3e-09
XP_011517907 (OMIM: 609870) PREDICTED: rho GTPase- (1982) 284 65.1 2.4e-09
XP_011517906 (OMIM: 609870) PREDICTED: rho GTPase- (1992) 284 65.1 2.4e-09
XP_011517905 (OMIM: 609870) PREDICTED: rho GTPase- (1992) 284 65.1 2.4e-09
XP_011517904 (OMIM: 609870) PREDICTED: rho GTPase- (1992) 284 65.1 2.4e-09
NP_001157743 (OMIM: 114500,604258) rho GTPase-acti (1017) 278 63.8 3e-09
XP_016868441 (OMIM: 114500,604258) PREDICTED: rho (1017) 278 63.8 3e-09
NP_006085 (OMIM: 114500,604258) rho GTPase-activat (1091) 278 63.8 3.2e-09
NP_001303597 (OMIM: 114500,604258) rho GTPase-acti (1125) 278 63.8 3.2e-09
XP_005273431 (OMIM: 114500,604258) PREDICTED: rho (1528) 278 63.9 4.2e-09
NP_872584 (OMIM: 114500,604258) rho GTPase-activat (1528) 278 63.9 4.2e-09
XP_016868440 (OMIM: 114500,604258) PREDICTED: rho (1528) 278 63.9 4.2e-09
NP_055540 (OMIM: 300689) stAR-related lipid transf (1023) 267 61.7 1.3e-08
XP_011529371 (OMIM: 300689) PREDICTED: stAR-relate (1023) 267 61.7 1.3e-08
NP_001135976 (OMIM: 300689) stAR-related lipid tra (1023) 267 61.7 1.3e-08
XP_011529372 (OMIM: 300689) PREDICTED: stAR-relate (1027) 267 61.7 1.3e-08
XP_005262372 (OMIM: 300689) PREDICTED: stAR-relate (1027) 267 61.7 1.3e-08
NP_001135975 (OMIM: 300689) stAR-related lipid tra (1103) 267 61.7 1.4e-08
XP_005262371 (OMIM: 300689) PREDICTED: stAR-relate (1107) 267 61.7 1.4e-08
NP_001243776 (OMIM: 600365) active breakpoint clus ( 310) 251 58.3 4e-08
XP_011509785 (OMIM: 610578) PREDICTED: rho GTPase- ( 397) 247 57.6 8.3e-08
XP_016859989 (OMIM: 610578) PREDICTED: rho GTPase- ( 432) 247 57.7 8.9e-08
>>NP_659404 (OMIM: 300937) rho GTPase-activating protein (547 aa)
initn: 3583 init1: 3583 opt: 3583 Z-score: 3709.4 bits: 696.1 E(85289): 7e-200
Smith-Waterman score: 3583; 100.0% identity (100.0% similar) in 547 aa overlap (1-547:1-547)
10 20 30 40 50 60
pF1KE4 MGGCIPFLKAARALCPRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 MGGCIPFLKAARALCPRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELER
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LKLQETAYHELVARHFLSEFKPDRALPIDRPNTLDKWFLILRGQQRAVSHKTFGISLEEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 LKLQETAYHELVARHFLSEFKPDRALPIDRPNTLDKWFLILRGQQRAVSHKTFGISLEEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LVNEFTRRKHLELTATMQVEEATGQAAGRRRGNVVRRVFGRIRRFFSRRRNEPTLPREFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 LVNEFTRRKHLELTATMQVEEATGQAAGRRRGNVVRRVFGRIRRFFSRRRNEPTLPREFT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 RRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 RRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 ACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 ACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 MKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 MKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCED
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 SIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 SIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMID
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 NWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 NWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 EARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 EARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKT
490 500 510 520 530 540
pF1KE4 GVSYFFP
:::::::
NP_659 GVSYFFP
>>NP_001269536 (OMIM: 300937) rho GTPase-activating prot (535 aa)
initn: 3368 init1: 3368 opt: 3368 Z-score: 3487.2 bits: 655.0 E(85289): 1.7e-187
Smith-Waterman score: 3368; 100.0% identity (100.0% similar) in 516 aa overlap (32-547:20-535)
10 20 30 40 50 60
pF1KE4 GGCIPFLKAARALCPRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELERL
::::::::::::::::::::::::::::::
NP_001 MAWILDCLFASAFEPRPRRVSVLGGAPGHNPDRRTKMVSIHSLSELERL
10 20 30 40
70 80 90 100 110 120
pF1KE4 KLQETAYHELVARHFLSEFKPDRALPIDRPNTLDKWFLILRGQQRAVSHKTFGISLEEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLQETAYHELVARHFLSEFKPDRALPIDRPNTLDKWFLILRGQQRAVSHKTFGISLEEVL
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE4 VNEFTRRKHLELTATMQVEEATGQAAGRRRGNVVRRVFGRIRRFFSRRRNEPTLPREFTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNEFTRRKHLELTATMQVEEATGQAAGRRRGNVVRRVFGRIRRFFSRRRNEPTLPREFTR
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 RGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEA
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE4 CCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDM
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE4 KDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDS
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 IGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDN
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE4 WDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSAE
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE4 ARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKTG
470 480 490 500 510 520
pF1KE4 VSYFFP
::::::
NP_001 VSYFFP
530
>>NP_001317580 (OMIM: 300937) rho GTPase-activating prot (411 aa)
initn: 2684 init1: 2684 opt: 2684 Z-score: 2781.5 bits: 524.0 E(85289): 3.4e-148
Smith-Waterman score: 2684; 100.0% identity (100.0% similar) in 411 aa overlap (137-547:1-411)
110 120 130 140 150 160
pF1KE4 AVSHKTFGISLEEVLVNEFTRRKHLELTATMQVEEATGQAAGRRRGNVVRRVFGRIRRFF
::::::::::::::::::::::::::::::
NP_001 MQVEEATGQAAGRRRGNVVRRVFGRIRRFF
10 20 30
170 180 190 200 210 220
pF1KE4 SRRRNEPTLPREFTRRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRRRNEPTLPREFTRRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKM
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE4 SLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQN
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE4 VHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLER
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE4 LLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGID
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE4 HYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKM
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE4 EEDALLSDPVETSAEARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEDALLSDPVETSAEARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQD
340 350 360 370 380 390
530 540
pF1KE4 RPLLRVPREKEAKTGVSYFFP
:::::::::::::::::::::
NP_001 RPLLRVPREKEAKTGVSYFFP
400 410
>>XP_011529582 (OMIM: 300937) PREDICTED: rho GTPase-acti (411 aa)
initn: 2684 init1: 2684 opt: 2684 Z-score: 2781.5 bits: 524.0 E(85289): 3.4e-148
Smith-Waterman score: 2684; 100.0% identity (100.0% similar) in 411 aa overlap (137-547:1-411)
110 120 130 140 150 160
pF1KE4 AVSHKTFGISLEEVLVNEFTRRKHLELTATMQVEEATGQAAGRRRGNVVRRVFGRIRRFF
::::::::::::::::::::::::::::::
XP_011 MQVEEATGQAAGRRRGNVVRRVFGRIRRFF
10 20 30
170 180 190 200 210 220
pF1KE4 SRRRNEPTLPREFTRRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRRRNEPTLPREFTRRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKM
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE4 SLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQN
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE4 VHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLER
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE4 LLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGID
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE4 HYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKM
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE4 EEDALLSDPVETSAEARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEDALLSDPVETSAEARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQD
340 350 360 370 380 390
530 540
pF1KE4 RPLLRVPREKEAKTGVSYFFP
:::::::::::::::::::::
XP_011 RPLLRVPREKEAKTGVSYFFP
400 410
>>NP_006116 (OMIM: 300118) rho GTPase-activating protein (765 aa)
initn: 934 init1: 691 opt: 908 Z-score: 940.5 bits: 184.3 E(85289): 1.2e-45
Smith-Waterman score: 974; 37.8% identity (66.9% similar) in 489 aa overlap (46-509:210-695)
20 30 40 50 60 70
pF1KE4 PRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELERLKLQETAYHELVARH
: . : :.::::::: .:::.:...:
NP_006 QSPPDSRGHPYVVWKSEGDFTWNSMSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDC
180 190 200 210 220 230
80 90 100 110 120
pF1KE4 FLSEFKPDRALPID---RPNTLDKWFLIL---RGQQRAVSHKTFGISLEEVLVNEFTRRK
:: . ..: : : ..: : . : ..... ..::. : .:..:. . .
NP_006 DLSC---QITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKL
240 250 260 270 280 290
130 140 150 160 170 180
pF1KE4 HLELTATMQVEEATGQAA----GRRRGNVVRRVFGRIRRFFSRRRNE---PTLPREFTRR
. .: : . . :. : .: : . :. :: :. :. :
NP_006 KQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRA
300 310 320 330 340 350
190 200 210 220 230 240
pF1KE4 GRRGAVSVDSLAELEDG-ALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEA
::::.::::...:.:. . ::..:::: . ... . .:.::::: .:.:..:..
NP_006 RRRGAMSVDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDS
360 370 380 390 400 410
250 260 270 280 290 300
pF1KE4 CCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDM
::: .:::::..:::: . : .::::::::::.:.:: :.....:::::::::::.:::
NP_006 CCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDM
420 430 440 450 460 470
310 320 330 340 350 360
pF1KE4 KDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDS
: :: .:: .:. : :.:..::..::::.::.:::. :::.:::. : .... .:.
NP_006 PDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDN
480 490 500 510 520 530
370 380 390 400 410 420
pF1KE4 IGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRE-SRKTKLGIDHYVASVNVVRAMID
:. ::: : ::.::: ::: .:: ::.: : . .: : ... .. .: . ::. ::.
NP_006 ISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIE
540 550 560 570 580 590
430 440 450 460 470 480
pF1KE4 NWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSA
:...::.::: .: .: . ...:...:.. ::. . .: . . : .. ..:.
NP_006 NYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRHSST
600 610 620 630 640 650
490 500 510 520 530
pF1KE4 EARAAVLAQSKPSDEGS---SE-------EPAVPSGTARSHDDEEGAGNPPIPEQDRPLL
.. : .. .: :..: :: : :.:.:. .
NP_006 DSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRE
660 670 680 690 700 710
540
pF1KE4 RVPREKEAKTGVSYFFP
NP_006 SSPGPRLGKGNWSLASRRWPKQATLLLLHVAWCGALRTFSSSLPYLMFL
720 730 740 750 760
>>NP_038267 (OMIM: 300118) rho GTPase-activating protein (771 aa)
initn: 934 init1: 691 opt: 908 Z-score: 940.5 bits: 184.3 E(85289): 1.2e-45
Smith-Waterman score: 974; 37.8% identity (66.9% similar) in 489 aa overlap (46-509:7-492)
20 30 40 50 60 70
pF1KE4 PRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELERLKLQETAYHELVARH
: . : :.::::::: .:::.:...:
NP_038 MSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDC
10 20 30
80 90 100 110 120
pF1KE4 FLSEFKPDRALPID---RPNTLDKWFLIL---RGQQRAVSHKTFGISLEEVLVNEFTRRK
:: . ..: : : ..: : . : ..... ..::. : .:..:. . .
NP_038 DLSC---QITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 HLELTATMQVEEATGQAA----GRRRGNVVRRVFGRIRRFFSRRRNE---PTLPREFTRR
. .: : . . :. : .: : . :. :: :. :. :
NP_038 KQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRA
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE4 GRRGAVSVDSLAELEDG-ALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEA
::::.::::...:.:. . ::..:::: . ... . .:.::::: .:.:..:..
NP_038 RRRGAMSVDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDS
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE4 CCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDM
::: .:::::..:::: . : .::::::::::.:.:: :.....:::::::::::.:::
NP_038 CCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDM
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE4 KDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDS
: :: .:: .:. : :.:..::..::::.::.:::. :::.:::. : .... .:.
NP_038 PDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDN
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE4 IGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRE-SRKTKLGIDHYVASVNVVRAMID
:. ::: : ::.::: ::: .:: ::.: : . .: : ... .. .: . ::. ::.
NP_038 ISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIE
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE4 NWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSA
:...::.::: .: .: . ...:...:.. ::. . .: . . : .. ..:.
NP_038 NYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRHSST
400 410 420 430 440 450
490 500 510 520 530
pF1KE4 EARAAVLAQSKPSDEGS---SE-------EPAVPSGTARSHDDEEGAGNPPIPEQDRPLL
.. : .. .: :..: :: : :.:.:. .
NP_038 DSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRE
460 470 480 490 500 510
540
pF1KE4 RVPREKEAKTGVSYFFP
NP_038 SSPGPRLGKDLSEEPFDIWGTWHSTLKSGSKDPGMTGSSGDIFESSSLRAGPCSLSQGNL
520 530 540 550 560 570
>>NP_001274171 (OMIM: 300118) rho GTPase-activating prot (794 aa)
initn: 934 init1: 691 opt: 908 Z-score: 940.3 bits: 184.3 E(85289): 1.2e-45
Smith-Waterman score: 974; 37.8% identity (66.9% similar) in 489 aa overlap (46-509:30-515)
20 30 40 50 60 70
pF1KE4 PRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELERLKLQETAYHELVARH
: . : :.::::::: .:::.:...:
NP_001 MGHPVYRGEKPQLHYAGDFTWNSMSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDC
10 20 30 40 50
80 90 100 110 120
pF1KE4 FLSEFKPDRALPID---RPNTLDKWFLIL---RGQQRAVSHKTFGISLEEVLVNEFTRRK
:: . ..: : : ..: : . : ..... ..::. : .:..:. . .
NP_001 DLSC---QITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE4 HLELTATMQVEEATGQAA----GRRRGNVVRRVFGRIRRFFSRRRNE---PTLPREFTRR
. .: : . . :. : .: : . :. :: :. :. :
NP_001 KQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRA
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE4 GRRGAVSVDSLAELEDG-ALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEA
::::.::::...:.:. . ::..:::: . ... . .:.::::: .:.:..:..
NP_001 RRRGAMSVDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDS
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 CCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDM
::: .:::::..:::: . : .::::::::::.:.:: :.....:::::::::::.:::
NP_001 CCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDM
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 KDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDS
: :: .:: .:. : :.:..::..::::.::.:::. :::.:::. : .... .:.
NP_001 PDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDN
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 IGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRE-SRKTKLGIDHYVASVNVVRAMID
:. ::: : ::.::: ::: .:: ::.: : . .: : ... .. .: . ::. ::.
NP_001 ISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIE
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE4 NWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSA
:...::.::: .: .: . ...:...:.. ::. . .: . . : .. ..:.
NP_001 NYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRHSST
420 430 440 450 460 470
490 500 510 520 530
pF1KE4 EARAAVLAQSKPSDEGS---SE-------EPAVPSGTARSHDDEEGAGNPPIPEQDRPLL
.. : .. .: :..: :: : :.:.:. .
NP_001 DSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRE
480 490 500 510 520 530
540
pF1KE4 RVPREKEAKTGVSYFFP
NP_001 SSPGPRLGKDLSEEPFDIWGTWHSTLKSGSKDPGMTGSSGDIFESSSLRAGPCSLSQGNL
540 550 560 570 580 590
>>NP_038286 (OMIM: 300118) rho GTPase-activating protein (974 aa)
initn: 934 init1: 691 opt: 908 Z-score: 939.0 bits: 184.3 E(85289): 1.5e-45
Smith-Waterman score: 974; 37.8% identity (66.9% similar) in 489 aa overlap (46-509:210-695)
20 30 40 50 60 70
pF1KE4 PRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELERLKLQETAYHELVARH
: . : :.::::::: .:::.:...:
NP_038 QSPPDSRGHPYVVWKSEGDFTWNSMSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDC
180 190 200 210 220 230
80 90 100 110 120
pF1KE4 FLSEFKPDRALPID---RPNTLDKWFLIL---RGQQRAVSHKTFGISLEEVLVNEFTRRK
:: . ..: : : ..: : . : ..... ..::. : .:..:. . .
NP_038 DLSC---QITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKL
240 250 260 270 280 290
130 140 150 160 170 180
pF1KE4 HLELTATMQVEEATGQAA----GRRRGNVVRRVFGRIRRFFSRRRNE---PTLPREFTRR
. .: : . . :. : .: : . :. :: :. :. :
NP_038 KQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRA
300 310 320 330 340 350
190 200 210 220 230 240
pF1KE4 GRRGAVSVDSLAELEDG-ALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEA
::::.::::...:.:. . ::..:::: . ... . .:.::::: .:.:..:..
NP_038 RRRGAMSVDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDS
360 370 380 390 400 410
250 260 270 280 290 300
pF1KE4 CCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDM
::: .:::::..:::: . : .::::::::::.:.:: :.....:::::::::::.:::
NP_038 CCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDM
420 430 440 450 460 470
310 320 330 340 350 360
pF1KE4 KDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDS
: :: .:: .:. : :.:..::..::::.::.:::. :::.:::. : .... .:.
NP_038 PDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDN
480 490 500 510 520 530
370 380 390 400 410 420
pF1KE4 IGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRE-SRKTKLGIDHYVASVNVVRAMID
:. ::: : ::.::: ::: .:: ::.: : . .: : ... .. .: . ::. ::.
NP_038 ISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIE
540 550 560 570 580 590
430 440 450 460 470 480
pF1KE4 NWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSA
:...::.::: .: .: . ...:...:.. ::. . .: . . : .. ..:.
NP_038 NYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRHSST
600 610 620 630 640 650
490 500 510 520 530
pF1KE4 EARAAVLAQSKPSDEGS---SE-------EPAVPSGTARSHDDEEGAGNPPIPEQDRPLL
.. : .. .: :..: :: : :.:.:. .
NP_038 DSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRE
660 670 680 690 700 710
540
pF1KE4 RVPREKEAKTGVSYFFP
NP_038 SSPGPRLGKDLSEEPFDIWGTWHSTLKSGSKDPGMTGSSGDIFESSSLRAGPCSLSQGNL
720 730 740 750 760 770
>>XP_011531508 (OMIM: 610587) PREDICTED: rho GTPase-acti (620 aa)
initn: 260 init1: 234 opt: 296 Z-score: 308.9 bits: 67.1 E(85289): 1.8e-10
Smith-Waterman score: 303; 26.9% identity (51.5% similar) in 361 aa overlap (181-536:97-403)
160 170 180 190 200
pF1KE4 RGNVVRRVFGRIRRFFSRRRNEPTLPREFTRRGRRGAVSV-DSLAELEDGALLLQTLQLS
: :. . : . .: ::.:. . .:. . .
XP_011 PGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGT
70 80 90 100 110 120
210 220 230 240 250 260
pF1KE4 KISFPIGQRLLGS-KRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQ
. .:::: . .....: . .: .:: : .:: .:: . ::: : . . :.:
XP_011 PCGAVFGQRLDETVAYEQKFGP--HLVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQ
130 140 150 160 170 180
270 280 290 300 310 320
pF1KE4 LREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSA
::. :: : .: . .:: ::.::: ..::. . ..: . : .::: . : :. .:
XP_011 LRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKA
190 200 210 220 230 240
330 340 350 360 370 380
pF1KE4 LQLLVY---LMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGS
: :. ..: . . : . . ::.: :: .. :.:. ::: :.:
XP_011 QQELMKQLSILPRDNYSLLSYICRFLHEIQLNC--AV---------NKMSVDNLATVIG-
250 260 270 280 290
390 400 410 420 430 440
pF1KE4 ALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSP
::..:. ... :... :.::: ..
XP_011 --------------------------VNLIRSKVEDPAVIMRGTPQIQRVMTM-------
300 310
450 460 470 480 490 500
pF1KE4 EALDFIRRRNLRKIQSARIKMEEDALLSDPVETSAEARAAVLAQSKPSDEGSSEEPAVPS
.:: ... .: : . : .:: . . ::..: . . : :. . :
XP_011 ----MIRDHEVLFPKSKDIPLSPPAQKNDP-KKAPVARSSV-GWDATEDLRISRTDSFSS
320 330 340 350 360 370
510 520 530 540
pF1KE4 GTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKTGVSYFFP
:. : : .:. : . .:::::
XP_011 MTSDS-DTTSPTGQQPSDAFPEDSSKVPREKPGDWKMQSRKRTQTLPNRKCFLTSAFQGA
380 390 400 410 420 430
XP_011 NSSKMEIFKNEFWSPSSEAKAGEGHRRTMSQDLRQLSDSQRTSTYDNVPSLPGSPGEEAS
440 450 460 470 480 490
>>XP_011531510 (OMIM: 610587) PREDICTED: rho GTPase-acti (620 aa)
initn: 260 init1: 234 opt: 296 Z-score: 308.9 bits: 67.1 E(85289): 1.8e-10
Smith-Waterman score: 303; 26.9% identity (51.5% similar) in 361 aa overlap (181-536:97-403)
160 170 180 190 200
pF1KE4 RGNVVRRVFGRIRRFFSRRRNEPTLPREFTRRGRRGAVSV-DSLAELEDGALLLQTLQLS
: :. . : . .: ::.:. . .:. . .
XP_011 PGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGT
70 80 90 100 110 120
210 220 230 240 250 260
pF1KE4 KISFPIGQRLLGS-KRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQ
. .:::: . .....: . .: .:: : .:: .:: . ::: : . . :.:
XP_011 PCGAVFGQRLDETVAYEQKFGP--HLVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQ
130 140 150 160 170 180
270 280 290 300 310 320
pF1KE4 LREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSA
::. :: : .: . .:: ::.::: ..::. . ..: . : .::: . : :. .:
XP_011 LRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKA
190 200 210 220 230 240
330 340 350 360 370 380
pF1KE4 LQLLVY---LMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGS
: :. ..: . . : . . ::.: :: .. :.:. ::: :.:
XP_011 QQELMKQLSILPRDNYSLLSYICRFLHEIQLNC--AV---------NKMSVDNLATVIG-
250 260 270 280 290
390 400 410 420 430 440
pF1KE4 ALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSP
::..:. ... :... :.::: ..
XP_011 --------------------------VNLIRSKVEDPAVIMRGTPQIQRVMTM-------
300 310
450 460 470 480 490 500
pF1KE4 EALDFIRRRNLRKIQSARIKMEEDALLSDPVETSAEARAAVLAQSKPSDEGSSEEPAVPS
.:: ... .: : . : .:: . . ::..: . . : :. . :
XP_011 ----MIRDHEVLFPKSKDIPLSPPAQKNDP-KKAPVARSSV-GWDATEDLRISRTDSFSS
320 330 340 350 360 370
510 520 530 540
pF1KE4 GTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKTGVSYFFP
:. : : .:. : . .:::::
XP_011 MTSDS-DTTSPTGQQPSDAFPEDSSKVPREKPGDWKMQSRKRTQTLPNRKCFLTSAFQGA
380 390 400 410 420 430
XP_011 NSSKMEIFKNEFWSPSSEAKAGEGHRRTMSQDLRQLSDSQRTSTYDNVPSLPGSPGEEAS
440 450 460 470 480 490
547 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 02:29:05 2016 done: Sun Nov 6 02:29:07 2016
Total Scan time: 10.880 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]