Result of FASTA (omim) for
pFN21AE4126
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4126, 517 aa
1>>>pF1KE4126 517 - 517 aa - 517 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.4588+/-0.000328; mu= 16.9891+/- 0.021
mean_var=219.7080+/-46.858, 0's: 0 Z-trim(122.5): 199 B-trim: 2102 in 2/53
Lambda= 0.086527
statistics sampled from 40516 (40799) to 40516 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.793), E-opt: 0.2 (0.478), width: 16
Scan time: 12.280
The best scores are: opt bits E(85289)
NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468) 362 57.9 7.7e-08
XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467) 360 57.6 9.2e-08
XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 555) 344 55.8 4e-07
NP_060677 (OMIM: 616755) E3 ubiquitin-protein liga ( 475) 342 55.4 4.4e-07
XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 391) 335 54.4 7.2e-07
XP_016873951 (OMIM: 608487) PREDICTED: tripartite ( 300) 328 53.4 1.1e-06
XP_005253241 (OMIM: 608487) PREDICTED: tripartite ( 326) 328 53.4 1.2e-06
NP_149084 (OMIM: 608487) tripartite motif-containi ( 326) 328 53.4 1.2e-06
NP_149083 (OMIM: 608487) tripartite motif-containi ( 347) 328 53.5 1.2e-06
NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 328 53.7 1.5e-06
XP_016873952 (OMIM: 608487) PREDICTED: tripartite ( 265) 324 52.8 1.5e-06
XP_006718421 (OMIM: 608487) PREDICTED: tripartite ( 265) 324 52.8 1.5e-06
NP_149023 (OMIM: 608487) tripartite motif-containi ( 493) 328 53.7 1.5e-06
XP_005253240 (OMIM: 608487) PREDICTED: tripartite ( 493) 328 53.7 1.5e-06
NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 328 53.7 1.5e-06
XP_016873950 (OMIM: 608487) PREDICTED: tripartite ( 310) 324 52.9 1.6e-06
XP_011518728 (OMIM: 608487) PREDICTED: tripartite ( 310) 324 52.9 1.6e-06
XP_011518729 (OMIM: 608487) PREDICTED: tripartite ( 271) 322 52.6 1.8e-06
XP_016873949 (OMIM: 608487) PREDICTED: tripartite ( 314) 322 52.6 2e-06
XP_016856908 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 315 51.7 3.3e-06
XP_016856907 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 315 51.7 3.3e-06
NP_001128327 (OMIM: 606123) E3 ubiquitin-protein l ( 343) 315 51.8 3.8e-06
XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 315 52.0 4.6e-06
NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 315 52.0 4.6e-06
XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 315 52.0 4.6e-06
NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 315 52.0 4.6e-06
XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 315 52.0 4.6e-06
NP_976038 (OMIM: 609315) tripartite motif-containi ( 511) 314 52.0 5.2e-06
NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 313 51.8 5.6e-06
NP_006065 (OMIM: 606559) E3 ubiquitin-protein liga ( 498) 306 50.9 1e-05
NP_001186502 (OMIM: 606559) E3 ubiquitin-protein l ( 494) 304 50.7 1.2e-05
XP_011512566 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 424) 302 50.3 1.3e-05
NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 303 50.6 1.3e-05
NP_439893 (OMIM: 605701) tripartite motif-containi ( 395) 300 50.0 1.5e-05
NP_006769 (OMIM: 605701) tripartite motif-containi ( 481) 300 50.2 1.7e-05
XP_011512567 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 421) 296 49.6 2.2e-05
NP_008959 (OMIM: 609316) E3 ubiquitin-protein liga ( 425) 296 49.6 2.2e-05
XP_011512568 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 261) 287 48.2 3.7e-05
NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 288 48.7 4.8e-05
NP_569074 (OMIM: 605684) tripartite motif-containi ( 270) 283 47.7 5.3e-05
NP_005073 (OMIM: 600453) E3 ubiquitin/ISG15 ligase ( 630) 288 48.8 5.5e-05
XP_016866752 (OMIM: 600830) PREDICTED: tripartite ( 462) 285 48.3 6e-05
XP_011513161 (OMIM: 600830) PREDICTED: tripartite ( 462) 285 48.3 6e-05
XP_005249435 (OMIM: 600830) PREDICTED: tripartite ( 539) 285 48.4 6.5e-05
NP_003440 (OMIM: 600830) tripartite motif-containi ( 539) 285 48.4 6.5e-05
NP_001229712 (OMIM: 600830) tripartite motif-conta ( 539) 285 48.4 6.5e-05
XP_005249434 (OMIM: 600830) PREDICTED: tripartite ( 539) 285 48.4 6.5e-05
XP_005249433 (OMIM: 600830) PREDICTED: tripartite ( 539) 285 48.4 6.5e-05
XP_005249431 (OMIM: 600830) PREDICTED: tripartite ( 539) 285 48.4 6.5e-05
XP_005249432 (OMIM: 600830) PREDICTED: tripartite ( 539) 285 48.4 6.5e-05
>>NP_660215 (OMIM: 607868) E3 ubiquitin-protein ligase T (468 aa)
initn: 343 init1: 159 opt: 362 Z-score: 261.7 bits: 57.9 E(85289): 7.7e-08
Smith-Waterman score: 508; 30.6% identity (52.2% similar) in 529 aa overlap (6-512:10-468)
10 20 30 40 50
pF1KE4 MAAQLLEEKLTCAICLGLYQDPVTLPCGHNFCGACIRDWWDR-CGK-ACPECREPF
:.:. :::::: . ::: :::::: ::: : . : :::::::
NP_660 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 PDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGRCVC
:. .:: : :. . :. :: : :.: : . :: : .:: :: : : .:
NP_660 PQ-RNLRPNRPLAKMAEM-----ARRLHP---PSPVPQGVCPAHREPLAAFCGDELRLLC
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 SVCTVR-ECRLHE-RALLDA-ERLKREAQLRASLEVTQQQATQAEGQLLELRKQSSQIQN
..: : :. : : :: : :: :.:. ::: ..: .: : .. :...
NP_660 AACERSGEHWAHRVRPLQDAAEDLK--AKLEKSLEHLRKQMQDA----LLFQAQADE---
120 130 140 150 160
180 190 200 210 220
pF1KE4 SACIL-ASWVSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEEQ-----RLRVHLE
.:.: . : .. ...: .: :: . . . : : : .::. :::
NP_660 -TCVLWQKMVESQRQNVLGEFE-----RLRRLLAEEEQQLLQRLEEEELEVLPRLREGAA
170 180 190 200 210
230 240 250 260 270 280
pF1KE4 AVARHGCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDLKQLLSRLCG
..... .. ::. ... . : ::: :.:. : :.
NP_660 HLGQQSAHLAELIAELEGRCQLPALGLLQ--------------------DIKDALRRVQD
220 230 240 250
290 300 310 320 330 340
pF1KE4 LLLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYR-NLTFDPVSANRHF
. :. : ...:.: . ::. : ::: .: ..:.:: .:: ..
NP_660 VKLQ----------PPEVVPMELR-TVCRVPGLVETLRR-----FRGDVTLDPDTANPEL
260 270 280 290 300
350 360 370 380 390 400
pF1KE4 YLSRQDQQVKH--CRQSRGPGGPGSFELWQVQCAQS-FQAGHHYWEVRASDH-SVTLGVS
::.. ..:.. ::. : .: :. .: : .:.:::::...:. : .:::
NP_660 ILSEDRRSVQRGDLRQAL-PDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVC
310 320 330 340 350
410 420 430 440 450
pF1KE4 YPQLPRCRLGPHTDNIGRGPCSWGLCVQEDSLQAWHNGEAQRLPGVSG--RLLGMDLDLA
.. : . : ... : : : : ...:. . : . : .:. ::
NP_660 RENVNRKEKG----ELSAGNGFWILVF----LGSYYNSSERALAPLRDPPRRVGIFLDYE
360 370 380 390 400 410
460 470 480 490 500 510
pF1KE4 SGCLTFYSLEPQTQPLYTFHAL-FNQPLTPVFWLLEGRT--LTLCHQPGAVFP-LGPQEE
.: :.::: . :. : . :. : :.: : . .:.:. :. :.::
NP_660 AGHLSFYSATDGSL-LFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ
420 430 440 450 460
pF1KE4 VLS
>>XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquitin-pr (467 aa)
initn: 343 init1: 159 opt: 360 Z-score: 260.4 bits: 57.6 E(85289): 9.2e-08
Smith-Waterman score: 518; 30.7% identity (52.3% similar) in 528 aa overlap (6-512:10-467)
10 20 30 40 50
pF1KE4 MAAQLLEEKLTCAICLGLYQDPVTLPCGHNFCGACIRDWWDR-CGK-ACPECREPF
:.:. :::::: . ::: :::::: ::: : . : :::::::
XP_016 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 PDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGRCVC
:. .:: : :. . :. :: : :.: : . :: : .:: :: : : .:
XP_016 PQ-RNLRPNRPLAKMAEM-----ARRLHP---PSPVPQGVCPAHREPLAAFCGDELRLLC
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 SVCTVR-ECRLHE-RALLDA-ERLKREAQLRASLEVTQQQATQAEGQLLELRKQSSQIQN
..: : :. : : :: : :: :.:. ::: ..: .: : .. :...
XP_016 AACERSGEHWAHRVRPLQDAAEDLK--AKLEKSLEHLRKQMQDA----LLFQAQADE---
120 130 140 150 160
180 190 200 210 220
pF1KE4 SACILASWVSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEEQ-----RLRVHLEA
.:.: . : .. ...: .: :: . . . : : : .::. :::
XP_016 -TCVLWQMVESQRQNVLGEFE-----RLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAH
170 180 190 200 210
230 240 250 260 270 280
pF1KE4 VARHGCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDLKQLLSRLCGL
..... .. ::. ... . : ::: :.:. : :. .
XP_016 LGQQSAHLAELIAELEGRCQLPALGLLQ--------------------DIKDALRRVQDV
220 230 240 250
290 300 310 320 330 340
pF1KE4 LLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYR-NLTFDPVSANRHFY
:. : ...:.: . ::. : ::: .: ..:.:: .:: ..
XP_016 KLQ----------PPEVVPMELR-TVCRVPGLVETLRR-----FRGDVTLDPDTANPELI
260 270 280 290 300
350 360 370 380 390 400
pF1KE4 LSRQDQQVKH--CRQSRGPGGPGSFELWQVQCAQS-FQAGHHYWEVRASDH-SVTLGVSY
::.. ..:.. ::. : .: :. .: : .:.:::::...:. : .:::
XP_016 LSEDRRSVQRGDLRQAL-PDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR
310 320 330 340 350
410 420 430 440 450
pF1KE4 PQLPRCRLGPHTDNIGRGPCSWGLCVQEDSLQAWHNGEAQRLPGVSG--RLLGMDLDLAS
.. : . : ... : : : : ...:. . : . : .:. :: .
XP_016 ENVNRKEKG----ELSAGNGFWILVF----LGSYYNSSERALAPLRDPPRRVGIFLDYEA
360 370 380 390 400 410
460 470 480 490 500 510
pF1KE4 GCLTFYSLEPQTQPLYTFHAL-FNQPLTPVFWLLEGRT--LTLCHQPGAVFP-LGPQEEV
: :.::: . :. : . :. : :.: : . .:.:. :. :.::
XP_016 GHLSFYSATDGSL-LFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ
420 430 440 450 460
pF1KE4 LS
>>XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquitin-pr (555 aa)
initn: 275 init1: 165 opt: 344 Z-score: 248.8 bits: 55.8 E(85289): 4e-07
Smith-Waterman score: 393; 25.7% identity (51.8% similar) in 510 aa overlap (1-489:80-533)
10 20 30
pF1KE4 MAAQLLEEKLTCAICLGLYQDPVTLPCGHN
.... :...: :.:::..:::::.: : :
XP_016 HGGGEAAAATGSSDSAGSGLRGCAGPKRWLLSSRGLKDELLCSICLSIYQDPVSLGCEHY
50 60 70 80 90 100
40 50 60 70 80
pF1KE4 FCGACIRDWWDRC----GKACPECREPFPDGAELRRNVALSGVLEVVRAGPARDPGPDPG
:: :: . : : .. :::::. : . : : .. :....: . : :
XP_016 FCRRCITEHWVRQEAQGARDCPECRRTFAEPA-LAPSLKLANIVERYSSFPL-----DAI
110 120 130 140 150 160
90 100 110 120 130 140
pF1KE4 PGPDPAAR-CPRHGRPLELFCRTEGRCVCSVCTVRECRLHER----ALLDA-ERLKREAQ
. ::: : : . ..::: :. .: : : :::. .. :: ..:.::
XP_016 LNARRAARPCQAHDK-VKLFCLTDRALLCFFCD--EPALHEQHQVTGIDDAFDELQRE--
170 180 190 200 210
150 160 170 180 190 200
pF1KE4 LRASLEVTQQQATQAEGQLLELRKQSSQIQNSACILASWVSGKFSSLLQALEIQHTTALR
:. .:.. :.. . : :..: .. ..:. : . .. : : . :. .. . :.
XP_016 LKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLE
220 230 240 250 260 270
210 220 230 240 250 260
pF1KE4 SIEVAKTQALAQARDEEQRLRVHLEAVARHGCRIRELLEQVDEQTFLQESQLLQPPGPLG
.:. ...:.. ... :: .:. : . . ..: : ..:..:::
XP_016 ELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFL-------------
280 290 300 310 320
270 280 290 300 310 320
pF1KE4 PLTPLQWDEDQQLGDLKQLLSRLCGLLLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVC
. . .: :: : . : . :. . ::: .
XP_016 -------------AGVASLSERLKGKIHETN------LTYEDFPTSKYTGPLQYT-----
330 340 350 360
330 340 350 360 370
pF1KE4 PLRRKLWQNYR----NLTFDPVSANRHFYLSRQDQQVKHCRQSRGP--GGPGSFELW-QV
. ..:.:. . ::.:: .:.... :: . : . : .: :.. .:
XP_016 -IWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSV
370 380 390 400 410 420
380 390 400 410 420 430
pF1KE4 QCAQSFQAGHHYWEVRASDHSV-TLGVSYPQLPRCRLGPHTDNIGRGPCSWGLC-VQEDS
...:..: ::::: ..... ..:... : .: : : :..:.
XP_016 LGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASR------KGSIQIQPSRGFYCIVMHDG
430 440 450 460 470
440 450 460 470 480
pF1KE4 LQAWHNGEAQRLPGVSGRL--LGMDLDLASGCLTFYSLEPQTQPLYTFHALFNQPLTPVF
: : .: .: .:. :: .: : ::. . .. ::::. : : :
XP_016 NQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSW-LYTFREKFPGKLCSYF
480 490 500 510 520 530
490 500 510
pF1KE4 WLLEGRTLTLCHQPGAVFPLGPQEEVLS
XP_016 SPGQSHANGKNVQPLRINTVRI
540 550
>>NP_060677 (OMIM: 616755) E3 ubiquitin-protein ligase T (475 aa)
initn: 273 init1: 163 opt: 342 Z-score: 248.2 bits: 55.4 E(85289): 4.4e-07
Smith-Waterman score: 391; 25.9% identity (51.5% similar) in 505 aa overlap (6-489:5-453)
10 20 30 40 50
pF1KE4 MAAQLLEEKLTCAICLGLYQDPVTLPCGHNFCGACIRDWWDRC----GKACPECREPFPD
:...: :.:::..:::::.: : : :: :: . : : .. :::::. : .
NP_060 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAE
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 GAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAAR-CPRHGRPLELFCRTEGRCVCS
: : .. :....: . : : . ::: : : . ..::: :. .:
NP_060 PA-LAPSLKLANIVERYSSFPL-----DAILNARRAARPCQAHDK-VKLFCLTDRALLCF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 VCTVRECRLHER----ALLDA-ERLKREAQLRASLEVTQQQATQAEGQLLELRKQSSQIQ
: : :::. .. :: ..:.:: :. .:.. :.. . : :..: .. .
NP_060 FCD--EPALHEQHQVTGIDDAFDELQRE--LKDQLQALQDSEREHTEALQLLKRQLAETK
120 130 140 150 160
180 190 200 210 220 230
pF1KE4 NSACILASWVSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEEQRLRVHLEAVARH
.:. : . .. : : . :. .. . :. .:. ...:.. ... :: .:. : .
NP_060 SSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEG
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE4 GCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDLKQLLSRLCGLLLEE
. ..: : ..:..::: . . .: :: : . :
NP_060 AQILQERLAETDRHTFL--------------------------AGVASLSERLKGKIHET
230 240 250 260
300 310 320 330 340
pF1KE4 GSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYR----NLTFDPVSANRHFYL
. :. . ::: . . ..:.:. . ::.:: .:.... :
NP_060 N------LTYEDFPTSKYTGPLQYT------IWKSLFQDIHPVPAALTLDPGTAHQRLIL
270 280 290 300 310
350 360 370 380 390 400
pF1KE4 SRQDQQVKHCRQSRGP--GGPGSFELW-QVQCAQSFQAGHHYWEVRASDHSV-TLGVSYP
: . : . : .: :.. .: ...:..: ::::: ..... ..:...
NP_060 SDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHE
320 330 340 350 360 370
410 420 430 440 450
pF1KE4 QLPRCRLGPHTDNIGRGPCSWGLC-VQEDSLQAWHNGEAQRLPGVSGRL--LGMDLDLAS
: .: : : :..:. : : .: .: .:. :: .
NP_060 AASR------KGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQ
380 390 400 410 420
460 470 480 490 500 510
pF1KE4 GCLTFYSLEPQTQPLYTFHALFNQPLTPVFWLLEGRTLTLCHQPGAVFPLGPQEEVLS
: : ::. . .. ::::. : : :
NP_060 GLLIFYNADDMSW-LYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI
430 440 450 460 470
>>XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquitin-pr (391 aa)
initn: 370 init1: 159 opt: 335 Z-score: 244.3 bits: 54.4 E(85289): 7.2e-07
Smith-Waterman score: 349; 28.3% identity (45.3% similar) in 523 aa overlap (6-512:10-391)
10 20 30 40 50
pF1KE4 MAAQLLEEKLTCAICLGLYQDPVTLPCGHNFCGACIRDWWDR-CGK-ACPECREPF
:.:. :::::: . ::: :::::: ::: : . : :::::::
XP_011 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 PDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGRCVC
:. .:: : :. . :. :: : :.: : . :: : .:: :: : : .:
XP_011 PQ-RNLRPNRPLAKMAEM-----ARRLHP---PSPVPQGVCPAHREPLAAFCGDELRLLC
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 SVCTVR-ECRLHE-RALLDA-ERLKREAQLRASLEVTQQQATQAEGQLLELRKQSSQIQN
..: : :. : : :: : :: :.:. ::: ..: .: : .. :...
XP_011 AACERSGEHWAHRVRPLQDAAEDLK--AKLEKSLEHLRKQMQDA----LLFQAQADE---
120 130 140 150 160
180 190 200 210 220 230
pF1KE4 SACILASWVSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEEQRLRVHLEAVARHG
.:.: : . : ::: .. .:
XP_011 -TCVL--WQDIK-------------DALRRVQDVK-------------------------
170 180
240 250 260 270 280 290
pF1KE4 CRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDLKQLLSRLCGLLLEEG
:::: ..:.. : .:
XP_011 ---------------------LQPP----EVVPME-------------LRTVCR------
190
300 310 320 330 340 350
pF1KE4 SHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYR-NLTFDPVSANRHFYLSRQD
::. : ::: .: ..:.:: .:: .. ::..
XP_011 -----------------------VPGLVETLRR-----FRGDVTLDPDTANPELILSEDR
200 210 220
360 370 380 390 400
pF1KE4 QQVKH--CRQSRGPGGPGSFELWQVQCAQS-FQAGHHYWEVRASDH-SVTLGVSYPQLPR
..:.. ::. : .: :. .: : .:.:::::...:. : .::: .. :
XP_011 RSVQRGDLRQAL-PDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCRENVNR
230 240 250 260 270 280
410 420 430 440 450 460
pF1KE4 CRLGPHTDNIGRGPCSWGLCVQEDSLQAWHNGEAQRLPGVSG--RLLGMDLDLASGCLTF
. : ... : : : : ...:. . : . : .:. :: .: :.:
XP_011 KEKG----ELSAGNGFWILVF----LGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSF
290 300 310 320 330 340
470 480 490 500 510
pF1KE4 YSLEPQTQPLYTFHAL-FNQPLTPVFWLLEGRT--LTLCHQPGAVFP-LGPQEEVLS
:: . :. : . :. : :.: : . .:.:. :. :.::
XP_011 YSATDGSL-LFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ
350 360 370 380 390
>>XP_016873951 (OMIM: 608487) PREDICTED: tripartite moti (300 aa)
initn: 242 init1: 138 opt: 328 Z-score: 240.7 bits: 53.4 E(85289): 1.1e-06
Smith-Waterman score: 339; 30.0% identity (56.8% similar) in 280 aa overlap (1-256:1-265)
10 20 30 40 50
pF1KE4 MAAQLL---EEKLTCAICLGLYQDPVTLPCGHNFCGACI-----RDWWDRCGKACPECRE
::. .: .:..:: ::: : .:..: :::.:: ::. .. :. ..:: ::
XP_016 MASGILVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 PF-PDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGR
. :.. . :.:: ...: .: : . . .: :::. : :::. .:.
XP_016 SYQPENIRPNRHVA--NIVEKLREVKLSPEG-------QKVDHCARHGEKLLLFCQEDGK
70 80 90 100 110
120 130 140 150 160
pF1KE4 CVCSVCT-VRECRLHERALLDAERLKREAQ--LRASLEVTQQQATQAEGQLLELRKQS--
.: .: .: : :. : .:.. :: : :.:.::. .:. .:: ..:...
XP_016 VICWLCERSQEHRGHHTFL--TEEVAREYQVKLQAALEMLRQKQQEAEELEADIREEKAS
120 130 140 150 160
170 180 190 200 210
pF1KE4 --SQIQ-NSACILASW------VSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEE
.::: ... .::.. .. . :. :: :: .. :.:. ..:. . :.
XP_016 WKTQIQYDKTNVLADFEQLRDILDWEESNELQNLEKEEEDILKSLTNSETEMVQQT----
170 180 190 200 210 220
220 230 240 250 260 270
pF1KE4 QRLRVHLEAVA-RHGCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDL
: :: . . : . :::. :: :. :. :
XP_016 QSLRELISDLEHRLQGSVMELLQGVDGVIKRTENVTLKKPETFPKNQRRVFRAPDLKGML
230 240 250 260 270 280
280 290 300 310 320 330
pF1KE4 KQLLSRLCGLLLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYRNLTFD
XP_016 EVFRELTDVRRYWED
290 300
>>XP_005253241 (OMIM: 608487) PREDICTED: tripartite moti (326 aa)
initn: 242 init1: 138 opt: 328 Z-score: 240.4 bits: 53.4 E(85289): 1.2e-06
Smith-Waterman score: 339; 30.0% identity (56.8% similar) in 280 aa overlap (1-256:1-265)
10 20 30 40 50
pF1KE4 MAAQLL---EEKLTCAICLGLYQDPVTLPCGHNFCGACI-----RDWWDRCGKACPECRE
::. .: .:..:: ::: : .:..: :::.:: ::. .. :. ..:: ::
XP_005 MASGILVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 PF-PDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGR
. :.. . :.:: ...: .: : . . .: :::. : :::. .:.
XP_005 SYQPENIRPNRHVA--NIVEKLREVKLSPEG-------QKVDHCARHGEKLLLFCQEDGK
70 80 90 100 110
120 130 140 150 160
pF1KE4 CVCSVCT-VRECRLHERALLDAERLKREAQ--LRASLEVTQQQATQAEGQLLELRKQS--
.: .: .: : :. : .:.. :: : :.:.::. .:. .:: ..:...
XP_005 VICWLCERSQEHRGHHTFL--TEEVAREYQVKLQAALEMLRQKQQEAEELEADIREEKAS
120 130 140 150 160
170 180 190 200 210
pF1KE4 --SQIQ-NSACILASW------VSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEE
.::: ... .::.. .. . :. :: :: .. :.:. ..:. . :.
XP_005 WKTQIQYDKTNVLADFEQLRDILDWEESNELQNLEKEEEDILKSLTNSETEMVQQT----
170 180 190 200 210 220
220 230 240 250 260 270
pF1KE4 QRLRVHLEAVA-RHGCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDL
: :: . . : . :::. :: :. :. :
XP_005 QSLRELISDLEHRLQGSVMELLQGVDGVIKRTENVTLKKPETFPKNQRRVFRAPDLKGML
230 240 250 260 270 280
280 290 300 310 320 330
pF1KE4 KQLLSRLCGLLLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYRNLTFD
XP_005 EVFRELTDVRRYWGWSAMARSRFTATSTSQIQAILLPQPPK
290 300 310 320
>>NP_149084 (OMIM: 608487) tripartite motif-containing p (326 aa)
initn: 242 init1: 138 opt: 328 Z-score: 240.4 bits: 53.4 E(85289): 1.2e-06
Smith-Waterman score: 339; 30.0% identity (56.8% similar) in 280 aa overlap (1-256:1-265)
10 20 30 40 50
pF1KE4 MAAQLL---EEKLTCAICLGLYQDPVTLPCGHNFCGACI-----RDWWDRCGKACPECRE
::. .: .:..:: ::: : .:..: :::.:: ::. .. :. ..:: ::
NP_149 MASGILVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 PF-PDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGR
. :.. . :.:: ...: .: : . . .: :::. : :::. .:.
NP_149 SYQPENIRPNRHVA--NIVEKLREVKLSPEG-------QKVDHCARHGEKLLLFCQEDGK
70 80 90 100 110
120 130 140 150 160
pF1KE4 CVCSVCT-VRECRLHERALLDAERLKREAQ--LRASLEVTQQQATQAEGQLLELRKQS--
.: .: .: : :. : .:.. :: : :.:.::. .:. .:: ..:...
NP_149 VICWLCERSQEHRGHHTFL--TEEVAREYQVKLQAALEMLRQKQQEAEELEADIREEKAS
120 130 140 150 160
170 180 190 200 210
pF1KE4 --SQIQ-NSACILASW------VSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEE
.::: ... .::.. .. . :. :: :: .. :.:. ..:. . :.
NP_149 WKTQIQYDKTNVLADFEQLRDILDWEESNELQNLEKEEEDILKSLTNSETEMVQQT----
170 180 190 200 210 220
220 230 240 250 260 270
pF1KE4 QRLRVHLEAVA-RHGCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDL
: :: . . : . :::. :: :. :. :
NP_149 QSLRELISDLEHRLQGSVMELLQGVDGVIKRTENVTLKKPETFPKNQRRVFRAPDLKGML
230 240 250 260 270 280
280 290 300 310 320 330
pF1KE4 KQLLSRLCGLLLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYRNLTFD
NP_149 EVFRELTDVRRYWGWSAMARSRFTATSTSQIQAILLPQPPK
290 300 310 320
>>NP_149083 (OMIM: 608487) tripartite motif-containing p (347 aa)
initn: 242 init1: 138 opt: 328 Z-score: 240.1 bits: 53.5 E(85289): 1.2e-06
Smith-Waterman score: 339; 30.0% identity (56.8% similar) in 280 aa overlap (1-256:1-265)
10 20 30 40 50
pF1KE4 MAAQLL---EEKLTCAICLGLYQDPVTLPCGHNFCGACI-----RDWWDRCGKACPECRE
::. .: .:..:: ::: : .:..: :::.:: ::. .. :. ..:: ::
NP_149 MASGILVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 PF-PDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGR
. :.. . :.:: ...: .: : . . .: :::. : :::. .:.
NP_149 SYQPENIRPNRHVA--NIVEKLREVKLSPEG-------QKVDHCARHGEKLLLFCQEDGK
70 80 90 100 110
120 130 140 150 160
pF1KE4 CVCSVCT-VRECRLHERALLDAERLKREAQ--LRASLEVTQQQATQAEGQLLELRKQS--
.: .: .: : :. : .:.. :: : :.:.::. .:. .:: ..:...
NP_149 VICWLCERSQEHRGHHTFL--TEEVAREYQVKLQAALEMLRQKQQEAEELEADIREEKAS
120 130 140 150 160
170 180 190 200 210
pF1KE4 --SQIQ-NSACILASW------VSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEE
.::: ... .::.. .. . :. :: :: .. :.:. ..:. . :.
NP_149 WKTQIQYDKTNVLADFEQLRDILDWEESNELQNLEKEEEDILKSLTNSETEMVQQT----
170 180 190 200 210 220
220 230 240 250 260 270
pF1KE4 QRLRVHLEAVA-RHGCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDL
: :: . . : . :::. :: :. :. :
NP_149 QSLRELISDLEHRLQGSVMELLQGVDGVIKRTENVTLKKPETFPKNQRRVFRAPDLKGML
230 240 250 260 270 280
280 290 300 310 320 330
pF1KE4 KQLLSRLCGLLLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYRNLTFD
NP_149 EVFRELTDVRRYWGKEKSHYHKPPCGLSLLLSLSFRILCSLLGSCFKIYDSPSKTHITYP
290 300 310 320 330 340
>>NP_477514 (OMIM: 607564) tripartite motif-containing p (488 aa)
initn: 349 init1: 140 opt: 328 Z-score: 238.6 bits: 53.7 E(85289): 1.5e-06
Smith-Waterman score: 413; 25.5% identity (52.0% similar) in 521 aa overlap (6-489:9-472)
10 20 30 40 50
pF1KE4 MAAQLLEEKLTCAICLGLYQDPVTLPCGHNFCGACI-----RDWWDRCG-KACPECR
..:..:: ::: : .:... :::.:: ::: .. . : ..:: :.
NP_477 MTSPVLVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 EPFPDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPD-PAARCPRHGRPLELFCRTEG
. : .:: : :..... .: ::: . :. : ::. :.:::. .:
NP_477 TSYQPG-NLRPNRHLANIVRRLREVVL-------GPGKQLKAVLCADHGEKLQLFCQEDG
70 80 90 100 110
120 130 140 150 160
pF1KE4 RCVCSVCT-VRECRLHERALLDAERLKREAQLRASLEVTQQQATQAEGQLLELRKQSSQI
. .: .: .: : :. :.. . . ... ::. ... .:: .:.....
NP_477 KVICWLCERSQEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSW
120 130 140 150 160 170
170 180 190 200 210
pF1KE4 QNSACILASWVSGKFSSL-----------LQALEIQHTTALRSIEVAKTQALAQARDEEQ
.:. .. .:..: :. :: .. .:: :: :... . :. :
NP_477 KNQMEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQT----Q
180 190 200 210 220
220 230 240 250 260 270
pF1KE4 RLRVHLEAVARHGCR--IRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDL
:: . . :. :. :::..:.. : .: :. : : : . . ::
NP_477 SLRELISDLERR-CQGSTMELLQDVSDVTERSEFWTLRKPEAL----PTKLRSMFRAPDL
230 240 250 260 270 280
280 290 300 310 320 330
pF1KE4 KQLLSRLCGLLLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYRNLTFD
:..: :.: : . :. : ..:..
NP_477 KRML-RVCRELTDVQSY---------------------------------WV---DVTLN
290 300
340 350 360 370 380 390
pF1KE4 PVSANRHFYLSRQDQQVKHCRQSRGPGGPGSFELWQVQCA----QSFQAGHHYWEVRASD
: .:: .. :... .::. . .::. .: . .:. : :..:.::::: ..
NP_477 PHTANLNLVLAKNRRQVRFVGAKV--SGPSCLEK-HYDCSVLGSQHFSSGKHYWEVDVAK
310 320 330 340 350 360
400 410 420 430 440
pF1KE4 HSV-TLGVSYPQL-PRCRLGPHTDN---IGR-GPCS--WGLCVQEDS-LQAWHNGEAQRL
... ::: .: : .. ..: .: : : : . .:.. .:.... . :
NP_477 KTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSSPSLL
370 380 390 400 410 420
450 460 470 480 490 500
pF1KE4 PG--VSGRLLGMDLDLASGCLTFYSLEPQTQPLYTFHAL-FNQPLTPVFWLLEGRTLTLC
. : : .:. :: .: ..::.. . :.::: : : : :
NP_477 LSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVIPMTL
430 440 450 460 470 480
510
pF1KE4 HQPGAVFPLGPQEEVLS
NP_477 RRPSS
517 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 03:38:33 2016 done: Sun Nov 6 03:38:35 2016
Total Scan time: 12.280 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]