Result of FASTA (omim) for
pFN21AE4124
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4124, 512 aa
1>>>pF1KE4124 512 - 512 aa - 512 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.1229+/-0.000379; mu= 9.8926+/- 0.023
mean_var=208.0794+/-45.941, 0's: 0 Z-trim(119.5): 448 B-trim: 477 in 2/56
Lambda= 0.088912
statistics sampled from 32901 (33590) to 32901 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.743), E-opt: 0.2 (0.394), width: 16
Scan time: 11.680
The best scores are: opt bits E(85289)
NP_001135931 (OMIM: 603383,615054) ankyrin repeat ( 467) 3187 422.0 1.9e-117
NP_001135932 (OMIM: 603383,615054) ankyrin repeat ( 429) 2531 337.8 3.9e-92
NP_543147 (OMIM: 603383,615054) ankyrin repeat and ( 452) 2465 329.3 1.4e-89
NP_057200 (OMIM: 605761) ankyrin repeat and SOCS b ( 426) 726 106.2 1.9e-22
NP_543139 (OMIM: 615056) ankyrin repeat and SOCS b ( 453) 607 91.0 8e-18
XP_016867792 (OMIM: 605761) PREDICTED: ankyrin rep ( 368) 555 84.2 7.1e-16
NP_665879 (OMIM: 605761) ankyrin repeat and SOCS b ( 349) 501 77.3 8.4e-14
NP_079511 (OMIM: 607128) tankyrase-2 [Homo sapiens (1166) 372 61.4 1.7e-08
XP_016872185 (OMIM: 607128) PREDICTED: tankyrase-2 (1169) 372 61.4 1.7e-08
XP_011542149 (OMIM: 603303) PREDICTED: tankyrase-1 (1223) 371 61.3 1.9e-08
XP_011542148 (OMIM: 603303) PREDICTED: tankyrase-1 (1301) 371 61.3 2e-08
XP_006716326 (OMIM: 603303) PREDICTED: tankyrase-1 (1316) 371 61.3 2e-08
XP_011542147 (OMIM: 603303) PREDICTED: tankyrase-1 (1316) 371 61.3 2e-08
NP_003738 (OMIM: 603303) tankyrase-1 [Homo sapiens (1327) 371 61.3 2e-08
XP_016872190 (OMIM: 607128) PREDICTED: tankyrase-2 ( 506) 340 56.8 1.7e-07
XP_011538515 (OMIM: 607128) PREDICTED: tankyrase-2 (1187) 340 57.3 3e-07
XP_005270242 (OMIM: 607128) PREDICTED: tankyrase-2 (1190) 340 57.3 3e-07
NP_065210 (OMIM: 182900,612641) ankyrin-1 isoform (1719) 314 54.1 3.8e-06
XP_011542807 (OMIM: 182900,612641) PREDICTED: anky (1751) 314 54.1 3.9e-06
XP_011542806 (OMIM: 182900,612641) PREDICTED: anky (1752) 314 54.1 3.9e-06
XP_016868818 (OMIM: 182900,612641) PREDICTED: anky (1759) 314 54.1 3.9e-06
XP_011542805 (OMIM: 182900,612641) PREDICTED: anky (1791) 314 54.1 3.9e-06
XP_016868817 (OMIM: 182900,612641) PREDICTED: anky (1792) 314 54.1 3.9e-06
XP_016868816 (OMIM: 182900,612641) PREDICTED: anky (1807) 314 54.2 3.9e-06
NP_065208 (OMIM: 182900,612641) ankyrin-1 isoform (1856) 314 54.2 4e-06
NP_000028 (OMIM: 182900,612641) ankyrin-1 isoform (1880) 314 54.2 4e-06
NP_065209 (OMIM: 182900,612641) ankyrin-1 isoform (1881) 314 54.2 4e-06
XP_011542804 (OMIM: 182900,612641) PREDICTED: anky (1889) 314 54.2 4.1e-06
XP_016868815 (OMIM: 182900,612641) PREDICTED: anky (1892) 314 54.2 4.1e-06
NP_001135918 (OMIM: 182900,612641) ankyrin-1 isofo (1897) 314 54.2 4.1e-06
XP_016868814 (OMIM: 182900,612641) PREDICTED: anky (1908) 314 54.2 4.1e-06
XP_011542803 (OMIM: 182900,612641) PREDICTED: anky (1913) 314 54.2 4.1e-06
XP_011542802 (OMIM: 182900,612641) PREDICTED: anky (1914) 314 54.2 4.1e-06
XP_005273533 (OMIM: 182900,612641) PREDICTED: anky (1921) 314 54.2 4.1e-06
XP_016868813 (OMIM: 182900,612641) PREDICTED: anky (1922) 314 54.2 4.1e-06
XP_016868812 (OMIM: 182900,612641) PREDICTED: anky (1936) 314 54.2 4.1e-06
XP_016868811 (OMIM: 182900,612641) PREDICTED: anky (1937) 314 54.2 4.1e-06
XP_016868810 (OMIM: 182900,612641) PREDICTED: anky (1940) 314 54.2 4.1e-06
XP_011542798 (OMIM: 182900,612641) PREDICTED: anky (1944) 314 54.2 4.1e-06
XP_016868809 (OMIM: 182900,612641) PREDICTED: anky (1946) 314 54.2 4.1e-06
XP_011542797 (OMIM: 182900,612641) PREDICTED: anky (1953) 314 54.2 4.1e-06
XP_011542796 (OMIM: 182900,612641) PREDICTED: anky (1954) 314 54.2 4.1e-06
XP_016868808 (OMIM: 182900,612641) PREDICTED: anky (1961) 314 54.2 4.1e-06
XP_011542793 (OMIM: 182900,612641) PREDICTED: anky (1968) 314 54.2 4.2e-06
XP_011542792 (OMIM: 182900,612641) PREDICTED: anky (1969) 314 54.2 4.2e-06
NP_001162003 (OMIM: 300890) ankyrin repeat and SOC ( 262) 285 49.4 1.5e-05
NP_076992 (OMIM: 300890) ankyrin repeat and SOCS b ( 262) 285 49.4 1.5e-05
NP_001026909 (OMIM: 300890) ankyrin repeat and SOC ( 294) 285 49.5 1.6e-05
XP_005274503 (OMIM: 300890) PREDICTED: ankyrin rep ( 294) 285 49.5 1.6e-05
XP_016871638 (OMIM: 600465,615493) PREDICTED: anky (1720) 297 51.9 1.7e-05
>>NP_001135931 (OMIM: 603383,615054) ankyrin repeat and (467 aa)
initn: 3187 init1: 3187 opt: 3187 Z-score: 2229.4 bits: 422.0 E(85289): 1.9e-117
Smith-Waterman score: 3187; 100.0% identity (100.0% similar) in 467 aa overlap (46-512:1-467)
20 30 40 50 60 70
pF1KE4 CLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGEPLDDRHPLCARLVEK
::::::::::::::::::::::::::::::
NP_001 MLMSWSPEECKGQGEPLDDRHPLCARLVEK
10 20 30
80 90 100 110 120 130
pF1KE4 PSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTS
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE4 DPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRT
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE4 ALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGR
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE4 SEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATT
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE4 ARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTP
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE4 LHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVV
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE4 QLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPL
400 410 420 430 440 450
500 510
pF1KE4 PPRLLRYLQLDFEGVLY
:::::::::::::::::
NP_001 PPRLLRYLQLDFEGVLY
460
>>NP_001135932 (OMIM: 603383,615054) ankyrin repeat and (429 aa)
initn: 2527 init1: 2527 opt: 2531 Z-score: 1775.1 bits: 337.8 E(85289): 3.9e-92
Smith-Waterman score: 2855; 91.9% identity (91.9% similar) in 467 aa overlap (46-512:1-429)
20 30 40 50 60 70
pF1KE4 CLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGEPLDDRHPLCARLVEK
::::::::::::::::::::::::::::::
NP_001 MLMSWSPEECKGQGEPLDDRHPLCARLVEK
10 20 30
80 90 100 110 120 130
pF1KE4 PSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTS
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE4 DPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRT
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE4 ALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGR
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE4 SEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATT
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE4 ARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTP
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE4 LHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVV
::::::::::::::::::::::::::::::::::::::
NP_001 LHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPK----------------------
340 350 360
440 450 460 470 480 490
pF1KE4 QLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPL
::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----------------KHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPL
370 380 390 400 410
500 510
pF1KE4 PPRLLRYLQLDFEGVLY
:::::::::::::::::
NP_001 PPRLLRYLQLDFEGVLY
420
>>NP_543147 (OMIM: 603383,615054) ankyrin repeat and SOC (452 aa)
initn: 2445 init1: 2445 opt: 2465 Z-score: 1729.1 bits: 329.3 E(85289): 1.4e-89
Smith-Waterman score: 2482; 82.1% identity (88.7% similar) in 468 aa overlap (48-512:1-452)
20 30 40 50 60 70
pF1KE4 SVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGEPLD--DRHPLCARLVEK
: :. . :. : : : :. .
NP_543 MPWGKNSSPHWGHHLGCLPSAPAC-RIWRP
10 20
80 90 100 110 120 130
pF1KE4 PSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTS
:: . : . :.:.. . .:. .:. .::.. ..... ::. : ....
NP_543 HSRPAWEPPR--PSPLLCQD-----MALQNALYTGDLARLQELFPPHSTA---DLLLESR
30 40 50 60 70
140 150 160 170 180 190
pF1KE4 DPE-RWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGR
: :: . . :. :::::::::::::::::::::::::::::::::::::::::::
NP_543 AAEPRWSSHQ---RG--LWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGR
80 90 100 110 120 130
200 210 220 230 240 250
pF1KE4 TALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 TALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDG
140 150 160 170 180 190
260 270 280 290 300 310
pF1KE4 RSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 RSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEAT
200 210 220 230 240 250
320 330 340 350 360 370
pF1KE4 TARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 TARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHT
260 270 280 290 300 310
380 390 400 410 420 430
pF1KE4 PLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 PLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSV
320 330 340 350 360 370
440 450 460 470 480 490
pF1KE4 VQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 VQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLP
380 390 400 410 420 430
500 510
pF1KE4 LPPRLLRYLQLDFEGVLY
::::::::::::::::::
NP_543 LPPRLLRYLQLDFEGVLY
440 450
>>NP_057200 (OMIM: 605761) ankyrin repeat and SOCS box p (426 aa)
initn: 563 init1: 265 opt: 726 Z-score: 523.8 bits: 106.2 E(85289): 1.9e-22
Smith-Waterman score: 731; 33.1% identity (61.8% similar) in 432 aa overlap (85-512:10-426)
60 70 80 90 100 110
pF1KE4 CKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGC
::: . .: :. : .:. ..: :
NP_057 MDGTTAPVTKSGAAKLVKRN-------FLEALKSNDFGK
10 20 30
120 130 140 150 160 170
pF1KE4 VSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELT--TPLHVAASRG
.. :: . . . :.::.. : ... . : .:. . . : ::... :
NP_057 LKAILIQRQIDV--DTVFEVED----ENMVLASYKQGYWLPSYKLKSSWATGLHLSVLFG
40 50 60 70 80
180 190 200 210 220 230
pF1KE4 HTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHL
:.: : .:: . : . :.:.: :: :: ... ::..: :: : . .:. ::.
NP_057 HVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHF
90 100 110 120 130 140
240 250 260 270 280 290
pF1KE4 CRGPGTLECAELLLRFGARVDGRSE-EEEETPLHVAARLGHVELADLLLRRGACPDARNA
: :... ::. :. :: :. ... ..::::::.::..: ::. . ...:: :. ::
NP_057 CTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNA
150 160 170 180 190 200
300 310 320 330 340 350
pF1KE4 EGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGH
. ::: : . . : .: . : .: .::. :...: :.: . ::: :
NP_057 HMETPL-AIAAYWALRFKEQEYSTEHHL-VCRMLLDYKAEVNARDDDFKSPLHKAAWNCD
210 220 230 240 250 260
360 370 380 390 400 410
pF1KE4 AAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGAL
......: :. :: :: .: . .. .:. .. : .:: . ::::::.:..: .
NP_057 HVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQF
270 280 290 300 310 320
420 430 440 450 460 470
pF1KE4 PKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALV-RQPRSL
::.. .::..:::..:.: .. . . . :.:. :: :::.. .::.:
NP_057 HKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSPRTL
330 340 350 360 370 380
480 490 500 510
pF1KE4 QHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY
.::::::.: :.. .:.: : :: : .:: :. ::..:
NP_057 MHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGIIY
390 400 410 420
>>NP_543139 (OMIM: 615056) ankyrin repeat and SOCS box p (453 aa)
initn: 867 init1: 410 opt: 607 Z-score: 441.0 bits: 91.0 E(85289): 8e-18
Smith-Waterman score: 847; 38.9% identity (62.5% similar) in 419 aa overlap (94-511:54-452)
70 80 90 100 110 120
pF1KE4 DRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSS
:. ::. ::...:.. :. .. :
NP_543 EWEDRRRAAAQQCRSRRCPSSPRARLTRPHRSCRDPAVH--QALFSGNLQQVQALFQDEE
30 40 50 60 70 80
130 140 150 160 170 180
pF1KE4 TGLAPDSVFDT-SDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLR
: . . .: :. : . .: :: . . :.:: .:..::.:. : :.:
NP_543 ---AANMIVETVSNQLAWSAEQ------GFWVLTPKTKQTAPLAIATARGYTDCARHLIR
90 100 110 120 130
190 200 210 220 230 240
pF1KE4 RRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECA
. :. :. :::.::::::: .. ::..::. :: :. ..: ::::: : .:.::
NP_543 QGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCA
140 150 160 170 180 190
250 260 270 280 290 300
pF1KE4 ELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACD
.:::. :: :. . : .:::::::: : . . : :..:: :...: : : .::
NP_543 KLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTAC-
200 210 220 230 240 250
310 320 330 340 350 360
pF1KE4 VRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCG
. ... .. : :: ::::: :: . .. ::: :: : ....:::: :
NP_543 ----AGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYG
260 270 280 290 300
370 380 390 400 410 420
pF1KE4 VSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCP
. :.. . .::::. ::::. . :: . :::..:: : : ..:.. .. :
NP_543 ARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRP----EMLKHCANFP
310 320 330 340 350 360
430 440 450 460 470 480
pF1KE4 RTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHL
:..:::.:.: : : : : :: ..:. :::: . .: :::.::::.: :.:..:
NP_543 RALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARL
370 380 390 400 410 420
490 500 510
pF1KE4 EGSLPQALPRLPLPPRLLRYLQLDFEGVLY
. :. :::::: : :: : :: .
NP_543 GSRCRQGATRLPLPPLLRDYLLLRVEGCIQ
430 440 450
>>XP_016867792 (OMIM: 605761) PREDICTED: ankyrin repeat (368 aa)
initn: 529 init1: 231 opt: 555 Z-score: 406.0 bits: 84.2 E(85289): 7.1e-16
Smith-Waterman score: 560; 32.2% identity (61.5% similar) in 351 aa overlap (85-432:10-345)
60 70 80 90 100 110
pF1KE4 CKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGC
::: . .: :. : .:. ..: :
XP_016 MDGTTAPVTKSGAAKLVKRN-------FLEALKSNDFGK
10 20 30
120 130 140 150 160 170
pF1KE4 VSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELT--TPLHVAASRG
.. :: . . . :.::.. : ... . : .:. . . : ::... :
XP_016 LKAILIQRQIDV--DTVFEVED----ENMVLASYKQGYWLPSYKLKSSWATGLHLSVLFG
40 50 60 70 80
180 190 200 210 220 230
pF1KE4 HTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHL
:.: : .:: . : . :.:.: :: :: ... ::..: :: : . .:. ::.
XP_016 HVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHF
90 100 110 120 130 140
240 250 260 270 280 290
pF1KE4 CRGPGTLECAELLLRFGARVDGRSE-EEEETPLHVAARLGHVELADLLLRRGACPDARNA
: :... ::. :. :: :. ... ..::::::.::..: ::. . ...:: :. ::
XP_016 CTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNA
150 160 170 180 190 200
300 310 320 330 340 350
pF1KE4 EGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGH
. ::: : . . : .: . : .: .::. :...: :.: . ::: :
XP_016 HMETPLAIAA-YWALRFKEQEYSTEHHL-VCRMLLDYKAEVNARDDDFKSPLHKAAWNCD
210 220 230 240 250 260
360 370 380 390 400 410
pF1KE4 AAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGAL
......: :. :: :: .: . .. .:. .. : .:: . ::::::.:..: .
XP_016 HVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQF
270 280 290 300 310 320
420 430 440 450 460 470
pF1KE4 PKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQ
::.. .::..:::..:.:
XP_016 HKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEGIRK
330 340 350 360
>>NP_665879 (OMIM: 605761) ankyrin repeat and SOCS box p (349 aa)
initn: 488 init1: 218 opt: 501 Z-score: 368.8 bits: 77.3 E(85289): 8.4e-14
Smith-Waterman score: 506; 31.7% identity (59.5% similar) in 341 aa overlap (85-422:10-331)
60 70 80 90 100 110
pF1KE4 CKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGC
::: . .: :. : .:. ..: :
NP_665 MDGTTAPVTKSGAAKLVKRN-------FLEALKSNDFGK
10 20 30
120 130 140 150 160 170
pF1KE4 VSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELT--TPLHVAASRG
.. :: . . . :.::.. : ... . : .:. . . : ::... :
NP_665 LKAILIQRQIDV--DTVFEVED----ENMVLASYKQGYWLPSYKLKSSWATGLHLSVLFG
40 50 60 70 80
180 190 200 210 220 230
pF1KE4 HTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHL
:.: : .:: . : . :.:.: :: :: ... ::..: :: : . .:. ::.
NP_665 HVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHF
90 100 110 120 130 140
240 250 260 270 280 290
pF1KE4 CRGPGTLECAELLLRFGARVDGRSE-EEEETPLHVAARLGHVELADLLLRRGACPDARNA
: :... ::. :. :: :. ... ..::::::.::..: ::. . ...:: :. ::
NP_665 CTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNA
150 160 170 180 190 200
300 310 320 330 340 350
pF1KE4 EGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGH
. ::: : . . : .: . : .: .::. :...: :.: . ::: :
NP_665 HMETPL-AIAAYWALRFKEQEYSTEHHL-VCRMLLDYKAEVNARDDDFKSPLHKAAWNCD
210 220 230 240 250 260
360 370 380 390 400 410
pF1KE4 AAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGAL
......: :. :: :: .: . .. .:. .. : .:: . ::::::.:..: .
NP_665 HVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQF
270 280 290 300 310 320
420 430 440 450 460 470
pF1KE4 PKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQ
:: ::
NP_665 HKV----RLCPVVSRLRKIQMAALSEISK
330 340
>>NP_079511 (OMIM: 607128) tankyrase-2 [Homo sapiens] (1166 aa)
initn: 422 init1: 169 opt: 372 Z-score: 273.4 bits: 61.4 E(85289): 1.7e-08
Smith-Waterman score: 372; 34.3% identity (54.7% similar) in 254 aa overlap (162-403:59-301)
140 150 160 170 180
pF1KE4 FDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRR----RARP
.:::: ::. :. .:.. ::. .::
NP_079 FEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARD
30 40 50 60 70 80
190 200 210 220 230 240
pF1KE4 DSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR
: :: ::.::. ::. :..:: ::::: :. . ::: : .. .::.
NP_079 D---GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ
90 100 110 120 130 140
250 260 270 280 290 300
pF1KE4 FGAR-----VDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC-
::. .:::. . : :. :. . .:: . . . ::: . :
NP_079 HGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCH
150 160 170 180 190 200
310 320 330 340 350
pF1KE4 --DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL
: : .. : : ... .:::. :::. : :. ::: :: :: :.:::.
NP_079 ASDGRKSTPLHLAAGYNR-VKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLV
210 220 230 240 250 260
360 370 380 390 400 410
pF1KE4 SCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWS
. :. .:.:: :::: : ... .: ::..::
NP_079 KHGACVNAMDLWQFTPLH-------EAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA
270 280 290 300 310
420 430 440 450 460 470
pF1KE4 TCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALR
NP_079 PTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYP
320 330 340 350 360 370
>>XP_016872185 (OMIM: 607128) PREDICTED: tankyrase-2 iso (1169 aa)
initn: 422 init1: 169 opt: 372 Z-score: 273.4 bits: 61.4 E(85289): 1.7e-08
Smith-Waterman score: 372; 34.3% identity (54.7% similar) in 254 aa overlap (162-403:59-301)
140 150 160 170 180
pF1KE4 FDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRR----RARP
.:::: ::. :. .:.. ::. .::
XP_016 FEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARD
30 40 50 60 70 80
190 200 210 220 230 240
pF1KE4 DSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR
: :: ::.::. ::. :..:: ::::: :. . ::: : .. .::.
XP_016 D---GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ
90 100 110 120 130 140
250 260 270 280 290 300
pF1KE4 FGAR-----VDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC-
::. .:::. . : :. :. . .:: . . . ::: . :
XP_016 HGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCH
150 160 170 180 190 200
310 320 330 340 350
pF1KE4 --DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL
: : .. : : ... .:::. :::. : :. ::: :: :: :.:::.
XP_016 ASDGRKSTPLHLAAGYNR-VKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLV
210 220 230 240 250 260
360 370 380 390 400 410
pF1KE4 SCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWS
. :. .:.:: :::: : ... .: ::..::
XP_016 KHGACVNAMDLWQFTPLH-------EAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA
270 280 290 300 310
420 430 440 450 460 470
pF1KE4 TCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALR
XP_016 PTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYP
320 330 340 350 360 370
>>XP_011542149 (OMIM: 603303) PREDICTED: tankyrase-1 iso (1223 aa)
initn: 424 init1: 171 opt: 371 Z-score: 272.5 bits: 61.3 E(85289): 1.9e-08
Smith-Waterman score: 379; 31.1% identity (50.9% similar) in 334 aa overlap (162-480:217-532)
140 150 160 170 180
pF1KE4 FDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRR----RARP
..::: ::. :. .:.. ::. .::
XP_011 LEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARD
190 200 210 220 230 240
190 200 210 220 230 240
pF1KE4 DSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR
: :: ::.::. ::. : .:: ::::: :. . ::: : .. .::.
XP_011 D---GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ
250 260 270 280 290 300
250 260 270 280 290 300
pF1KE4 FGA-----RVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC-
:: .::.: . : :. :. . .:: . . . ::: . :
XP_011 HGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCH
310 320 330 340 350 360
310 320 330 340 350
pF1KE4 --DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL
: : .. : : ... .:::. :::. : :. ::: :: :: :.::::
XP_011 ASDGRKSTPLHLAAGYNR-VRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLL
370 380 390 400 410 420
360 370 380 390 400 410
pF1KE4 SCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWS
. :. .:.:: :::: : ... .: ::.::: . . : .
XP_011 KHGACVNAMDLWQFTPLH-------EAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA
430 440 450 460 470
420 430 440 450 460 470
pF1KE4 TCPRTIEVLMNTY---SVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRC
:. : : . :..: .:: : : .. . . .::.: . .:
XP_011 PTPELRERLTYEFKGHSLLQAAREA-------DLAKVKKTLALEIINFKQPQSHETALHC
480 490 500 510 520
480 490 500 510
pF1KE4 ALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY
:. :
XP_011 AVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALD
530 540 550 560 570 580
512 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 02:27:01 2016 done: Sun Nov 6 02:27:03 2016
Total Scan time: 11.680 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]