Result of FASTA (ccds) for
pFN21AE4123
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4123, 511 aa
1>>>pF1KE4123 511 - 511 aa - 511 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.8116+/-0.00096; mu= 15.6153+/- 0.058
mean_var=84.3097+/-17.251, 0's: 0 Z-trim(106.4): 137 B-trim: 29 in 1/48
Lambda= 0.139680
statistics sampled from 8809 (8968) to 8809 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.643), E-opt: 0.2 (0.275), width: 16
Scan time: 2.610
The best scores are: opt bits E(32554)
CCDS826.1 KCNA10 gene_id:3744|Hs108|chr1 ( 511) 3377 690.8 9.8e-199
CCDS8535.1 KCNA1 gene_id:3736|Hs108|chr12 ( 495) 1951 403.4 3e-112
CCDS827.1 KCNA2 gene_id:3737|Hs108|chr1 ( 499) 1940 401.2 1.4e-111
CCDS828.2 KCNA3 gene_id:3738|Hs108|chr1 ( 575) 1927 398.6 9.8e-111
CCDS55625.1 KCNA2 gene_id:3737|Hs108|chr1 ( 356) 1189 249.7 3.9e-66
CCDS41629.1 KCNA4 gene_id:3739|Hs108|chr11 ( 653) 1120 236.0 9.8e-62
CCDS12755.1 KCNA7 gene_id:3743|Hs108|chr19 ( 456) 1081 228.0 1.7e-59
CCDS8536.1 KCNA5 gene_id:3741|Hs108|chr12 ( 613) 838 179.2 1.2e-44
CCDS8534.1 KCNA6 gene_id:3742|Hs108|chr12 ( 529) 824 176.3 7.5e-44
CCDS13418.1 KCNB1 gene_id:3745|Hs108|chr20 ( 858) 738 159.1 1.8e-38
CCDS6209.1 KCNB2 gene_id:9312|Hs108|chr8 ( 911) 737 158.9 2.2e-38
CCDS13342.1 KCNS1 gene_id:3787|Hs108|chr20 ( 526) 687 148.7 1.5e-35
CCDS14314.1 KCND1 gene_id:3750|Hs108|chrX ( 647) 676 146.5 8.4e-35
CCDS9006.1 KCNC2 gene_id:3747|Hs108|chr12 ( 558) 662 143.7 5.3e-34
CCDS58255.1 KCNC2 gene_id:3747|Hs108|chr12 ( 583) 662 143.7 5.4e-34
CCDS9005.1 KCNC2 gene_id:3747|Hs108|chr12 ( 613) 662 143.7 5.7e-34
CCDS58257.1 KCNC2 gene_id:3747|Hs108|chr12 ( 618) 662 143.7 5.7e-34
CCDS58256.1 KCNC2 gene_id:3747|Hs108|chr12 ( 629) 662 143.7 5.8e-34
CCDS9007.1 KCNC2 gene_id:3747|Hs108|chr12 ( 638) 662 143.7 5.9e-34
CCDS844.1 KCND3 gene_id:3752|Hs108|chr1 ( 636) 654 142.1 1.8e-33
CCDS843.1 KCND3 gene_id:3752|Hs108|chr1 ( 655) 654 142.1 1.8e-33
CCDS6279.1 KCNS2 gene_id:3788|Hs108|chr8 ( 477) 644 140.0 5.7e-33
CCDS7827.1 KCNC1 gene_id:3746|Hs108|chr11 ( 511) 639 139.0 1.2e-32
CCDS44193.1 KCNC4 gene_id:3749|Hs108|chr1 ( 626) 640 139.3 1.2e-32
CCDS821.1 KCNC4 gene_id:3749|Hs108|chr1 ( 635) 640 139.3 1.3e-32
CCDS44547.1 KCNC1 gene_id:3746|Hs108|chr11 ( 585) 639 139.0 1.4e-32
CCDS5776.1 KCND2 gene_id:3751|Hs108|chr7 ( 630) 638 138.9 1.7e-32
CCDS6314.1 KCNV1 gene_id:27012|Hs108|chr8 ( 500) 627 136.6 6.4e-32
CCDS1692.1 KCNS3 gene_id:3790|Hs108|chr2 ( 491) 626 136.4 7.2e-32
CCDS1809.1 KCNG3 gene_id:170850|Hs108|chr2 ( 436) 623 135.7 1e-31
CCDS12793.1 KCNC3 gene_id:3748|Hs108|chr19 ( 757) 620 135.3 2.4e-31
CCDS13436.1 KCNG1 gene_id:3755|Hs108|chr20 ( 513) 594 129.9 6.5e-30
CCDS6447.1 KCNV2 gene_id:169522|Hs108|chr9 ( 545) 585 128.1 2.4e-29
CCDS1676.1 KCNF1 gene_id:3754|Hs108|chr2 ( 494) 584 127.9 2.6e-29
CCDS10945.1 KCNG4 gene_id:93107|Hs108|chr16 ( 519) 551 121.3 2.7e-27
CCDS12019.1 KCNG2 gene_id:26251|Hs108|chr18 ( 466) 539 118.8 1.3e-26
CCDS42674.1 KCNG3 gene_id:170850|Hs108|chr2 ( 425) 526 116.2 7.5e-26
CCDS13521.1 KCNQ2 gene_id:3785|Hs108|chr20 ( 393) 306 71.8 1.6e-12
CCDS46629.1 KCNQ2 gene_id:3785|Hs108|chr20 ( 841) 306 72.0 2.9e-12
CCDS13518.1 KCNQ2 gene_id:3785|Hs108|chr20 ( 844) 306 72.0 2.9e-12
CCDS13519.1 KCNQ2 gene_id:3785|Hs108|chr20 ( 854) 306 72.0 2.9e-12
CCDS13520.1 KCNQ2 gene_id:3785|Hs108|chr20 ( 872) 306 72.0 3e-12
CCDS7736.1 KCNQ1 gene_id:3784|Hs108|chr11 ( 676) 304 71.6 3.2e-12
CCDS456.1 KCNQ4 gene_id:9132|Hs108|chr1 ( 695) 295 69.8 1.2e-11
CCDS55035.1 KCNQ5 gene_id:56479|Hs108|chr6 ( 822) 285 67.8 5.3e-11
CCDS55037.1 KCNQ5 gene_id:56479|Hs108|chr6 ( 923) 285 67.8 5.9e-11
CCDS4976.1 KCNQ5 gene_id:56479|Hs108|chr6 ( 932) 285 67.8 5.9e-11
CCDS55034.1 KCNQ5 gene_id:56479|Hs108|chr6 ( 951) 285 67.8 6e-11
>>CCDS826.1 KCNA10 gene_id:3744|Hs108|chr1 (511 aa)
initn: 3377 init1: 3377 opt: 3377 Z-score: 3681.4 bits: 690.8 E(32554): 9.8e-199
Smith-Waterman score: 3377; 100.0% identity (100.0% similar) in 511 aa overlap (1-511:1-511)
10 20 30 40 50 60
pF1KE4 MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTNHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTNHE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 TAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 TAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 FFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 FFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 EDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 EDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 FREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 RNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 RNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 LQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 LQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 TVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 TVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEI
430 440 450 460 470 480
490 500 510
pF1KE4 ERILNSVGSRMGSTDSLNKTNGGCSTEKSRK
:::::::::::::::::::::::::::::::
CCDS82 ERILNSVGSRMGSTDSLNKTNGGCSTEKSRK
490 500 510
>>CCDS8535.1 KCNA1 gene_id:3736|Hs108|chr12 (495 aa)
initn: 1945 init1: 1592 opt: 1951 Z-score: 2128.6 bits: 403.4 E(32554): 3e-112
Smith-Waterman score: 1951; 69.5% identity (88.7% similar) in 416 aa overlap (64-476:13-427)
40 50 60 70 80 90
pF1KE4 STSPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLN--EGNQRVIIN
: :: : :. . . : .::.::
CCDS85 MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVIN
10 20 30 40
100 110 120 130 140 150
pF1KE4 IAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKI
:.::::::::.::.:::.::::. .:::..:: .::::::::::::::.:::::::::..
CCDS85 ISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRL
50 60 70 80 90 100
160 170 180 190 200 210
pF1KE4 RRPANVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPES
:::.:::.:.:..::.::::: :::..:::::::::. : :: .. .:: :::::::::
CCDS85 RRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPES
110 120 130 140 150 160
220 230 240 250 260 270
pF1KE4 SSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPF
:. ::..:.:::.:..:::.:::::::::...:... . .. . .. ....:::::
CCDS85 SGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVH-RIDNTTVIYNSNIFTDPF
170 180 190 200 210 220
280 290 300 310 320 330
pF1KE4 FMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELV-QETEPS
:.::. ::.::.::::.:: .::::::::.::::.:::..::::: :: ::.. :: . .
CCDS85 FIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQK
230 240 250 260 270 280
340 350 360 370 380 390
pF1KE4 AQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFS
..: ::::::.::::::::::::::::::::::::::::::::::::::::::::::::
CCDS85 GEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFS
290 300 310 320 330 340
400 410 420 430 440 450
pF1KE4 SAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIA
:::::::..: :::::::::.::::::.::::::::: :.: ::::::.:::::::::::
CCDS85 SAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIA
350 360 370 380 390 400
460 470 480 490 500 510
pF1KE4 LPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKSR
:::::::::::::::::::.::. ..
CCDS85 LPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDM
410 420 430 440 450 460
>>CCDS827.1 KCNA2 gene_id:3737|Hs108|chr1 (499 aa)
initn: 1943 init1: 835 opt: 1940 Z-score: 2116.5 bits: 401.2 E(32554): 1.4e-111
Smith-Waterman score: 1940; 66.7% identity (83.1% similar) in 450 aa overlap (66-509:15-456)
40 50 60 70 80 90
pF1KE4 SPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGL
::: : :: . .: .::.:::.::
CCDS82 MTVATGDPADEAAALPGHPQDTYDPE--ADHECCERVVINISGL
10 20 30 40
100 110 120 130 140 150
pF1KE4 RFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPA
::::::.::.::::::::: .:::..:: .::::::::::::::.:::::::::..:::.
CCDS82 RFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPV
50 60 70 80 90 100
160 170 180 190 200 210
pF1KE4 NVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAA
:::.:::..:: ::::: :::..::::::.::. : :: :...:: ::::::::::. :
CCDS82 NVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPA
110 120 130 140 150 160
220 230 240 250 260 270
pF1KE4 RAVAVVSVLVVVISITIFCLETLPEFREDRE----LKVVRDPNLNMSKTVLSQTMFTDPF
: .:.:::.:..:::. ::::::: ::.. : :. : . ..: :::::
CCDS82 RIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPF
170 180 190 200 210 220
280 290 300 310 320 330
pF1KE4 FMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPS-
:.::. ::.::.::...:: .::::. :: ::::::::..::::: :: :::... : .
CCDS82 FIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQ
230 240 250 260 270 280
340 350 360 370 380
pF1KE4 -AQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF
.:: :::::::.:::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF
290 300 310 320 330 340
390 400 410 420 430 440
pF1KE4 SSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTI
::::::::.:: ::.: ::::.::::::.::::::::: ::: ::::::.::::::::::
CCDS82 SSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTI
350 360 370 380 390 400
450 460 470 480 490 500
pF1KE4 ALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKS
::::::::::::::::::::.::. . . . .. :. .:.:. .. . ::
CCDS82 ALPVPVIVSNFNYFYHRETEGEEQA------QYLQVTSCPKIPSSPDLKKSRSASTISKS
410 420 430 440 450
510
pF1KE4 RK
CCDS82 DYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV
460 470 480 490
>>CCDS828.2 KCNA3 gene_id:3738|Hs108|chr1 (575 aa)
initn: 1924 init1: 836 opt: 1927 Z-score: 2101.5 bits: 398.6 E(32554): 9.8e-111
Smith-Waterman score: 1927; 70.8% identity (87.3% similar) in 408 aa overlap (73-473:90-496)
50 60 70 80 90 100
pF1KE4 GSSFSNGKILISESTNHETAFSKLPGDYADPPG-PEPVVLNEGNQRVIINIAGLRFETQL
::. : . ..::.:::.::::::::
CCDS82 HLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE4 RTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDI
.:: ::::::::: ..::..:: .::::::::::::::.:::::::::.::::.::::::
CCDS82 KTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDI
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 FADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVV
:..:: ::.:: :::..:::::::... : :: :..:: ::::::::::. ::..:.:
CCDS82 FSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIV
180 190 200 210 220 230
230 240 250 260 270
pF1KE4 SVLVVVISITIFCLETLPEFREDRELKVVRDPNL------NMSKTVLSQTMFTDPFFMVE
::::..:::.:::::::::::.... . . . . : . . . :.::::.::
CCDS82 SVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVE
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE4 STCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNM
. ::.::.:::..:: .::::. : :::::.:::..::::: :: :::. : . ..:: :
CCDS82 TLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELA-ERQGNGQQAM
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE4 SLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYF
::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 SLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYF
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE4 AEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPV
::.:.: : ::::::.:::::::::::::::: :.: ::::::.::::::::::::::::
CCDS82 AEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPV
420 430 440 450 460 470
460 470 480 490 500 510
pF1KE4 IVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKSRK
::::::::::::::.::.
CCDS82 IVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMN
480 490 500 510 520 530
>>CCDS55625.1 KCNA2 gene_id:3737|Hs108|chr1 (356 aa)
initn: 1205 init1: 816 opt: 1189 Z-score: 1300.8 bits: 249.7 E(32554): 3.9e-66
Smith-Waterman score: 1189; 59.4% identity (79.9% similar) in 308 aa overlap (66-367:15-318)
40 50 60 70 80 90
pF1KE4 SPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGL
::: : :: . .: .::.:::.::
CCDS55 MTVATGDPADEAAALPGHPQDTYDPE--ADHECCERVVINISGL
10 20 30 40
100 110 120 130 140 150
pF1KE4 RFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPA
::::::.::.::::::::: .:::..:: .::::::::::::::.:::::::::..:::.
CCDS55 RFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPV
50 60 70 80 90 100
160 170 180 190 200 210
pF1KE4 NVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAA
:::.:::..:: ::::: :::..::::::.::. : :: :...:: ::::::::::. :
CCDS55 NVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPA
110 120 130 140 150 160
220 230 240 250 260 270
pF1KE4 RAVAVVSVLVVVISITIFCLETLPEFREDRE----LKVVRDPNLNMSKTVLSQTMFTDPF
: .:.:::.:..:::. ::::::: ::.. : :. : . ..: :::::
CCDS55 RIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPF
170 180 190 200 210 220
280 290 300 310 320 330
pF1KE4 FMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPS-
:.::. ::.::.::...:: .::::. :: ::::::::..::::: :: :::... : .
CCDS55 FIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQ
230 240 250 260 270 280
340 350 360 370 380
pF1KE4 -AQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF
.:: :::::::.::: : : .. .. ..: : :. .
CCDS55 QGQQAMSLAILRVIRLER--RPLQSQKSKRGRQHLNTSHDCTLGINLVAGMTVQWTRASG
290 300 310 320 330 340
390 400 410 420 430 440
pF1KE4 SSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTI
CCDS55 PDDRQTPAVTTLHRMY
350
>>CCDS41629.1 KCNA4 gene_id:3739|Hs108|chr11 (653 aa)
initn: 1983 init1: 839 opt: 1120 Z-score: 1221.8 bits: 236.0 E(32554): 9.8e-62
Smith-Waterman score: 1917; 66.0% identity (84.8% similar) in 447 aa overlap (49-476:138-579)
20 30 40 50 60 70
pF1KE4 SDEIQEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTN-HETAFSKL-PGDYADPPGP
:.. ::. . : ... : : : . :
CCDS41 LMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGG-GY
110 120 130 140 150 160
80 90 100 110 120 130
pF1KE4 EPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRP
: .. .::.::..:::::::..::.::::::::: ::: :.:: .:::::::::::
CCDS41 SSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRP
170 180 190 200 210 220
140 150 160 170 180 190
pF1KE4 SFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFREDEGFIKDPET-LLPT
:::.:::::::::...::.:::.:::..:..::.:: ::. .:::::::... : ::
CCDS41 SFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPE
230 240 250 260 270 280
200 210 220 230 240
pF1KE4 NDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDREL--------
:....:.::::::::::: ::..:.:::::..:::.:::::::::::.::.:
CCDS41 NEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGG
290 300 310 320 330 340
250 260 270 280 290 300
pF1KE4 --KVVRD---PNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFRN
.. : :.:. : ..:.:.::::.::..:::::.::.:.: .:::.. ::.:
CCDS41 HGGLLNDTSAPHLENS----GHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKN
350 360 370 380 390 400
310 320 330 340 350
pF1KE4 IMNIIDIISIIPYFATLITELVQET---EPSAQQNMSLAILRIIRLVRVFRIFKLSRHSK
:::::::.::.::: :: :.:.:. . . :: ::.::::::::::::::::::::::
CCDS41 IMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSK
410 420 430 440 450 460
360 370 380 390 400 410
pF1KE4 GLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTM
::::::.::.::::::::::::::::::::::::::::.::: .::.::::.::::::::
CCDS41 GLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTM
470 480 490 500 510 520
420 430 440 450 460 470
pF1KE4 TTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGE
:::::::: : : ::::::.:::::::::::::::::::::::::::::::::. ..
CCDS41 TTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQN
530 540 550 560 570 580
480 490 500 510
pF1KE4 IERILNSVGSRMGSTDSLNKTNGGCSTEKSRK
CCDS41 AVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNN
590 600 610 620 630 640
>>CCDS12755.1 KCNA7 gene_id:3743|Hs108|chr19 (456 aa)
initn: 1785 init1: 818 opt: 1081 Z-score: 1181.6 bits: 228.0 E(32554): 1.7e-59
Smith-Waterman score: 1766; 64.6% identity (85.0% similar) in 412 aa overlap (72-472:2-409)
50 60 70 80 90 100
pF1KE4 GGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQL
.: : : : :...:.:::::::.
CCDS12 MEPRCPPPCGCCE---RLVLNVAGLRFETRA
10 20
110 120 130 140 150 160
pF1KE4 RTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDI
:::..::.::::: .: .:.:. : ::::::.:::::..::::::::..::::.::.:.
CCDS12 RTLGRFPDTLLGDPARRGRFYDDARREYFFDRHRPSFDAVLYYYQSGGRLRRPAHVPLDV
30 40 50 60 70 80
170 180 190 200 210 220
pF1KE4 FADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVV
: .:..:: ::. :. ..::::: :: :: . ::.:::::.::::.:::..:::
CCDS12 FLEEVAFYGLGAAALARLREDEGCPVPPERPLPRRAFARQLWLLFEFPESSQAARVLAVV
90 100 110 120 130 140
230 240 250 260 270
pF1KE4 SVLVVVISITIFCLETLPEFREDRE-----LKVVRDP---NLNMSKTVLS---QTMFTDP
::::...::..:::::::.::.::. .. : :: :. . . . :.::
CCDS12 SVLVILVSIVVFCLETLPDFRDDRDGTGLAAAAAAGPFPAPLNGSSQMPGNPPRLPFNDP
150 160 170 180 190 200
280 290 300 310 320 330
pF1KE4 FFMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPS
::.::. :: ::.:::..:..:::::. ::.:.::.::...:.:::..: :::... .
CCDS12 FFVVETLCICWFSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQ-RGV
210 220 230 240 250 260
340 350 360 370 380 390
pF1KE4 AQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFS
.:: :::::::.::::::::::::::::::::::::::.:::::::::::::::::.:::
CCDS12 GQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFS
270 280 290 300 310 320
400 410 420 430 440 450
pF1KE4 SAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIA
:::::::::. .:::.:::..:::::::::::::::: :.: ::::::.::::::::::.
CCDS12 SAVYFAEVDRVDSHFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTIS
330 340 350 360 370 380
460 470 480 490 500 510
pF1KE4 LPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKSR
::::::::::.::::::::.::
CCDS12 LPVPVIVSNFSYFYHRETEGEEAGMFSHVDMQPCGPLEGKANGGLVDGEVPELPPPLWAP
390 400 410 420 430 440
>>CCDS8536.1 KCNA5 gene_id:3741|Hs108|chr12 (613 aa)
initn: 1662 init1: 835 opt: 838 Z-score: 915.1 bits: 179.2 E(32554): 1.2e-44
Smith-Waterman score: 1872; 69.4% identity (84.3% similar) in 415 aa overlap (85-472:119-531)
60 70 80 90 100 110
pF1KE4 ESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGD
.::: :::.:::::::: ::.:::.:::::
CCDS85 RRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGD
90 100 110 120 130 140
120 130 140 150 160 170
pF1KE4 REKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSE
::...:: .::::::::::::::::::::::::..:::.:: .:.::::: ::.::.:
CCDS85 PAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDE
150 160 170 180 190 200
180 190 200 210 220 230
pF1KE4 AMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFC
::..:::::::::. : :: :...:: ::.:::::::..:::.:.:::::..::: ::
CCDS85 AMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFC
210 220 230 240 250 260
240 250 260 270
pF1KE4 LETLPEFREDREL--------------------KVVRDPNLNMSKTVLSQTMFTDPFFMV
::::::::..::: :. :. .: .:. .::::.:
CCDS85 LETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTL-ADPFFIV
270 280 290 300 310 320
280 290 300 310 320
pF1KE4 ESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEP-----
:.::..::::::..:: .::::. : ::::::::...:.::: :: :::. : .:
CCDS85 ETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELA-EQQPGGGGG
330 340 350 360 370 380
330 340 350 360 370 380
pF1KE4 --SAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVI
..:: :::::::.:::::::::::::::::::::::.::.::::::::::::::::::
CCDS85 GQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVI
390 400 410 420 430 440
390 400 410 420 430 440
pF1KE4 LFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVL
::::::::::.:. .:::::::.:::::::::::::::: : : ::::::.::::::::
CCDS85 LFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVL
450 460 470 480 490 500
450 460 470 480 490 500
pF1KE4 TIALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTE
:::::::::::::::::::::..::
CCDS85 TIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKA
510 520 530 540 550 560
>>CCDS8534.1 KCNA6 gene_id:3742|Hs108|chr12 (529 aa)
initn: 1906 init1: 811 opt: 824 Z-score: 900.8 bits: 176.3 E(32554): 7.5e-44
Smith-Waterman score: 1796; 64.4% identity (78.5% similar) in 452 aa overlap (68-473:26-474)
40 50 60 70 80 90
pF1KE4 KGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRF
::. . : .: :..:::.::::
CCDS85 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSE---RLVINISGLRF
10 20 30 40 50
100 110 120 130 140 150
pF1KE4 ETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANV
:::::::: ::.::::: .:..::: .::::::::::::::.:::::::::..:::.::
CCDS85 ETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNV
60 70 80 90 100 110
160 170 180 190 200 210
pF1KE4 PIDIFADEISFYELGSEAMDQFREDEGFIKD---PETLLPTNDIHRQFWLLFEYPESSSA
:.::: .:: ::.::.::. :::::: . . : ::.. ..:: ::::::::::.
CCDS85 PLDIFLEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGP
120 130 140 150 160 170
220 230 240 250
pF1KE4 ARAVAVVSVLVVVISITIFCLETLPEFRED----------RELKVVR---------DPNL
::..:.:::::..:::.::::::::.:: : : : : : .
CCDS85 ARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSY
180 190 200 210 220 230
260 270 280 290 300
pF1KE4 NM---------------SKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFF
.. : ..:. ..::::::.::. :::::::::..:: .:::: ::
CCDS85 TFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFF
240 250 260 270 280 290
310 320 330 340 350
pF1KE4 RNIMNIIDIISIIPYFATLITELVQETE--PSA-------QQNMSLAILRIIRLVRVFRI
::::::::...:.::: :: :::::. : :.. :: :::::::.:::::::::
CCDS85 RNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRI
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE4 FKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDG
::::::::::::::.::.::::::::::::::::::::::::::::.:. .: : ::::.
CCDS85 FKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDA
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE4 FWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENE
:::::::::::::::: : : ::::::.::::::::::::::::::::::::::::::.:
CCDS85 FWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQE
420 430 440 450 460 470
480 490 500 510
pF1KE4 EKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKSRK
:.
CCDS85 EQGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV
480 490 500 510 520
>>CCDS13418.1 KCNB1 gene_id:3745|Hs108|chr20 (858 aa)
initn: 956 init1: 545 opt: 738 Z-score: 804.0 bits: 159.1 E(32554): 1.8e-38
Smith-Waterman score: 912; 37.6% identity (66.6% similar) in 458 aa overlap (73-498:17-449)
50 60 70 80 90 100
pF1KE4 GSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEG-NQRVIINIAGLRFETQL
:: : .: ... ..:: .:..:: :.
CCDS13 MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLW
10 20 30 40
110 120 130 140 150
pF1KE4 RTLSQFPETLLGD------REKRMQFFDSMR---NEYFFDRNRPSFDGILYYYQSGGKIR
:::...:.: :: ... .. :.. :::::::. .: .:: .:..: ...
CCDS13 RTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTG-RLH
50 60 70 80 90 100
160 170 180 190
pF1KE4 RPANVPIDIFADEISFY---ELGSEAMDQFRE-------DEGFIKDPETLLPTN------
.. :..:.... :. :. : : .: . .. ::: .
CCDS13 MMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDN
110 120 130 140 150 160
200 210 220 230 240 250
pF1KE4 ----DIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRD
. ....: :.: :.:: ::. .:..:.. .:.: . :.::::.. :. :
CCDS13 TCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTD
170 180 190 200 210 220
260 270 280 290 300 310
pF1KE4 -PNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIIS
:.: ::..::.:::.: .:::. :.: ::.. .: ::...
CCDS13 NPQLAH----------------VEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLA
230 240 250 260
320 330 340 350 360 370
pF1KE4 IIPYFATLITELVQETEPSAQQNMSLA-ILRIIRLVRVFRIFKLSRHSKGLQILGQTLKA
:.::..:. .. :.. :. : ... ...:.:..:..::.::.::: ::: :: ::.
CCDS13 ILPYYVTI---FLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRR
270 280 290 300 310 320
380 390 400 410 420 430
pF1KE4 SMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPT
:. ::::::.:: .:...::: :.::: :: ...:.::: .::::..:::::::::. :
CCDS13 SYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPK
330 340 350 360 370 380
440 450 460 470 480 490
pF1KE4 TPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSR
: ::::: :: :::::.::::.:.::.::. ::... ..:. . .:: ..:
CCDS13 TLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALER-----AKR
390 400 410 420 430 440
500 510
pF1KE4 MGSTDSLNKTNGGCSTEKSRK
:: :.:
CCDS13 NGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQDNHLSPNKWKWTKRTLSETSSS
450 460 470 480 490 500
511 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 17:02:13 2016 done: Mon Nov 7 17:02:14 2016
Total Scan time: 2.610 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]