Result of FASTA (omim) for
pFN21AE4122
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4122, 505 aa
1>>>pF1KE4122 505 - 505 aa - 505 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2461+/-0.000402; mu= 13.5134+/- 0.025
mean_var=85.7467+/-17.939, 0's: 0 Z-trim(113.6): 157 B-trim: 581 in 1/51
Lambda= 0.138505
statistics sampled from 22838 (23000) to 22838 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.657), E-opt: 0.2 (0.27), width: 16
Scan time: 9.450
The best scores are: opt bits E(85289)
NP_060242 (OMIM: 616880) TBC1 domain family member ( 505) 3406 690.8 2.4e-198
XP_011513040 (OMIM: 616880) PREDICTED: TBC1 domain ( 504) 3129 635.5 1.1e-181
XP_011513041 (OMIM: 616880) PREDICTED: TBC1 domain ( 389) 2581 525.9 8.2e-149
XP_016884233 (OMIM: 616879) PREDICTED: TBC1 domain ( 470) 1805 370.9 4.6e-102
NP_001271234 (OMIM: 616879) TBC1 domain family mem ( 470) 1805 370.9 4.6e-102
NP_001271233 (OMIM: 616879) TBC1 domain family mem ( 487) 1805 370.9 4.7e-102
NP_055161 (OMIM: 616879) TBC1 domain family member ( 517) 1805 370.9 5e-102
NP_001271232 (OMIM: 616879) TBC1 domain family mem ( 439) 1655 340.9 4.6e-93
XP_016884234 (OMIM: 616879) PREDICTED: TBC1 domain ( 458) 1655 340.9 4.7e-93
XP_011528401 (OMIM: 616879) PREDICTED: TBC1 domain ( 491) 1590 327.9 4.1e-89
XP_016884232 (OMIM: 616879) PREDICTED: TBC1 domain ( 530) 1590 327.9 4.4e-89
XP_011528402 (OMIM: 616879) PREDICTED: TBC1 domain ( 401) 1116 233.2 1.1e-60
XP_011528403 (OMIM: 616879) PREDICTED: TBC1 domain ( 376) 974 204.8 3.7e-52
XP_016884235 (OMIM: 616879) PREDICTED: TBC1 domain ( 388) 972 204.4 5e-52
XP_011528404 (OMIM: 616879) PREDICTED: TBC1 domain ( 362) 838 177.6 5.4e-44
XP_016884236 (OMIM: 616879) PREDICTED: TBC1 domain ( 364) 833 176.6 1.1e-43
XP_005261553 (OMIM: 616879) PREDICTED: TBC1 domain ( 371) 831 176.2 1.4e-43
XP_016884231 (OMIM: 616879) PREDICTED: TBC1 domain ( 549) 833 176.7 1.5e-43
XP_005252117 (OMIM: 616218) PREDICTED: TBC1 domain ( 324) 225 55.1 3.6e-07
NP_060671 (OMIM: 616218) TBC1 domain family member ( 400) 225 55.1 4.4e-07
XP_011536984 (OMIM: 612662) PREDICTED: TBC1 domain ( 445) 220 54.2 9.6e-07
XP_006719630 (OMIM: 612662) PREDICTED: TBC1 domain ( 445) 220 54.2 9.6e-07
XP_016875317 (OMIM: 612662) PREDICTED: TBC1 domain ( 530) 220 54.2 1.1e-06
XP_016875316 (OMIM: 612662) PREDICTED: TBC1 domain ( 547) 220 54.2 1.1e-06
XP_016875314 (OMIM: 612662) PREDICTED: TBC1 domain ( 575) 220 54.2 1.2e-06
XP_016875315 (OMIM: 612662) PREDICTED: TBC1 domain ( 575) 220 54.2 1.2e-06
XP_006719629 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 220 54.2 1.2e-06
XP_011536982 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 220 54.2 1.2e-06
XP_011536981 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 220 54.2 1.2e-06
XP_016875313 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 220 54.2 1.2e-06
NP_001139685 (OMIM: 612662) TBC1 domain family mem ( 674) 220 54.2 1.4e-06
XP_006719628 (OMIM: 612662) PREDICTED: TBC1 domain ( 682) 220 54.2 1.4e-06
NP_001139686 (OMIM: 612662) TBC1 domain family mem ( 682) 220 54.2 1.4e-06
NP_073608 (OMIM: 612662) TBC1 domain family member ( 691) 220 54.2 1.4e-06
XP_006719627 (OMIM: 612662) PREDICTED: TBC1 domain ( 699) 220 54.2 1.4e-06
XP_011522624 (OMIM: 616637) PREDICTED: TBC1 domain ( 753) 190 48.3 9.6e-05
NP_001161694 (OMIM: 616659) TBC1 domain family mem ( 615) 186 47.4 0.00014
NP_078958 (OMIM: 616659) TBC1 domain family member ( 648) 186 47.4 0.00015
NP_001258775 (OMIM: 616637) TBC1 domain family mem ( 278) 179 45.9 0.00019
NP_001273701 (OMIM: 616218) TBC1 domain family mem ( 275) 177 45.5 0.00024
NP_001258773 (OMIM: 616637) TBC1 domain family mem ( 392) 179 45.9 0.00025
XP_011522626 (OMIM: 616637) PREDICTED: TBC1 domain ( 396) 179 45.9 0.00025
NP_001258774 (OMIM: 616637) TBC1 domain family mem ( 405) 179 45.9 0.00026
XP_016879677 (OMIM: 616637) PREDICTED: TBC1 domain ( 462) 179 46.0 0.00029
XP_011522625 (OMIM: 616637) PREDICTED: TBC1 domain ( 521) 179 46.0 0.00032
XP_016879676 (OMIM: 616637) PREDICTED: TBC1 domain ( 543) 179 46.0 0.00033
XP_016879675 (OMIM: 616637) PREDICTED: TBC1 domain ( 599) 179 46.0 0.00036
XP_006721758 (OMIM: 616637) PREDICTED: TBC1 domain ( 634) 179 46.0 0.00038
XP_016879674 (OMIM: 616637) PREDICTED: TBC1 domain ( 639) 179 46.0 0.00038
XP_005257109 (OMIM: 616637) PREDICTED: TBC1 domain ( 640) 179 46.0 0.00038
>>NP_060242 (OMIM: 616880) TBC1 domain family member 22B (505 aa)
initn: 3406 init1: 3406 opt: 3406 Z-score: 3681.8 bits: 690.8 E(85289): 2.4e-198
Smith-Waterman score: 3406; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505)
10 20 30 40 50 60
pF1KE4 MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 RCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNE
430 440 450 460 470 480
490 500
pF1KE4 EIGLLLAEAYRLKYMFADAPNHYRR
:::::::::::::::::::::::::
NP_060 EIGLLLAEAYRLKYMFADAPNHYRR
490 500
>>XP_011513040 (OMIM: 616880) PREDICTED: TBC1 domain fam (504 aa)
initn: 3128 init1: 3128 opt: 3129 Z-score: 3382.7 bits: 635.5 E(85289): 1.1e-181
Smith-Waterman score: 3129; 97.7% identity (98.7% similar) in 478 aa overlap (1-477:1-478)
10 20 30 40 50 60
pF1KE4 MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPL
370 380 390 400 410 420
430 440 450 460 470
pF1KE4 RCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLML-LQNLPTIHWGN
::::::::::::::::::::::::::::::::::::::::::: ::. ...: . :
XP_011 RCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQPLLQSKISQLLVTSWVT
430 440 450 460 470 480
480 490 500
pF1KE4 EEIGLLLAEAYRLKYMFADAPNHYRR
XP_011 LVAGKDQEEAEEEVAPMIKIHSRI
490 500
>>XP_011513041 (OMIM: 616880) PREDICTED: TBC1 domain fam (389 aa)
initn: 2581 init1: 2581 opt: 2581 Z-score: 2792.7 bits: 525.9 E(85289): 8.2e-149
Smith-Waterman score: 2581; 100.0% identity (100.0% similar) in 388 aa overlap (1-388:1-388)
10 20 30 40 50 60
pF1KE4 MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPL
::::::::::::::::::::::::::::
XP_011 GIQDNYTFAQPGIQKKVKALEELVSRIDV
370 380
>>XP_016884233 (OMIM: 616879) PREDICTED: TBC1 domain fam (470 aa)
initn: 1912 init1: 1454 opt: 1805 Z-score: 1953.4 bits: 370.9 E(85289): 4.6e-102
Smith-Waterman score: 1964; 62.0% identity (82.2% similar) in 471 aa overlap (48-505:3-470)
20 30 40 50 60 70
pF1KE4 GSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFHEFARNTSDAWDIGDDEE
:.:.: :..:.:.:: ::::::: :.:..
XP_016 MPTTPVKAKRVSTFQEFESNTSDAWDAGEDDD
10 20 30
80 90 100 110 120
pF1KE4 EDFSSPSFQTLNSKVALATAAQVLENHSK------------LRVKPERSQSTTSDVPANY
: .. . ..:::.:.. :: .::.:::. :. ::. : ..
XP_016 ELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 KVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTVREKTR
...:: :... : . .. ::...:::: . : . :: .. .. .. :: .:
XP_016 RLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTL-GGTSDPSTLSSSALSEREASR
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE4 LEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQRKREEY
:.::.:::.. ::::.:::. :: :.:. :::.::.:::::::::..:: :::::..::
XP_016 LDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEY
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE4 FGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPAS
:.:::.::::::.: :::::::::::::: .: :. :: : :::::::::::::::::
XP_016 FAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPKVTEIFERILFIWAIRHPAS
220 230 240 250 260
310 320 330 340 350 360
pF1KE4 GYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQD
:::::::::::::::::. ::.: :.:.. ::... ..: .::::..::::::::::::
XP_016 GYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQD
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE4 NYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTI
:::::::::: ::: ::::::::::::: :. ..::.::::::::::::::::.::::::
XP_016 NYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTI
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE4 RLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGL
::::::::::.::::::::::::::..::::::.:.::: ::..:::::: :: .:.:.:
XP_016 RLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISL
390 400 410 420 430 440
490 500
pF1KE4 LLAEAYRLKYMFADAPNHYRR
:::::::::. ::::::::..
XP_016 LLAEAYRLKFAFADAPNHYKK
450 460 470
>>NP_001271234 (OMIM: 616879) TBC1 domain family member (470 aa)
initn: 1912 init1: 1454 opt: 1805 Z-score: 1953.4 bits: 370.9 E(85289): 4.6e-102
Smith-Waterman score: 1964; 62.0% identity (82.2% similar) in 471 aa overlap (48-505:3-470)
20 30 40 50 60 70
pF1KE4 GSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFHEFARNTSDAWDIGDDEE
:.:.: :..:.:.:: ::::::: :.:..
NP_001 MPTTPVKAKRVSTFQEFESNTSDAWDAGEDDD
10 20 30
80 90 100 110 120
pF1KE4 EDFSSPSFQTLNSKVALATAAQVLENHSK------------LRVKPERSQSTTSDVPANY
: .. . ..:::.:.. :: .::.:::. :. ::. : ..
NP_001 ELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 KVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTVREKTR
...:: :... : . .. ::...:::: . : . :: .. .. .. :: .:
NP_001 RLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTL-GGTSDPSTLSSSALSEREASR
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE4 LEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQRKREEY
:.::.:::.. ::::.:::. :: :.:. :::.::.:::::::::..:: :::::..::
NP_001 LDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEY
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE4 FGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPAS
:.:::.::::::.: :::::::::::::: .: :. :: : :::::::::::::::::
NP_001 FAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPKVTEIFERILFIWAIRHPAS
220 230 240 250 260
310 320 330 340 350 360
pF1KE4 GYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQD
:::::::::::::::::. ::.: :.:.. ::... ..: .::::..::::::::::::
NP_001 GYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQD
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE4 NYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTI
:::::::::: ::: ::::::::::::: :. ..::.::::::::::::::::.::::::
NP_001 NYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTI
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE4 RLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGL
::::::::::.::::::::::::::..::::::.:.::: ::..:::::: :: .:.:.:
NP_001 RLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISL
390 400 410 420 430 440
490 500
pF1KE4 LLAEAYRLKYMFADAPNHYRR
:::::::::. ::::::::..
NP_001 LLAEAYRLKFAFADAPNHYKK
450 460 470
>>NP_001271233 (OMIM: 616879) TBC1 domain family member (487 aa)
initn: 1912 init1: 1454 opt: 1805 Z-score: 1953.1 bits: 370.9 E(85289): 4.7e-102
Smith-Waterman score: 1975; 60.9% identity (81.9% similar) in 481 aa overlap (38-505:10-487)
10 20 30 40 50 60
pF1KE4 QFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFHEFARNTS
.... .:. :.:.: :..:.:.:: :::
NP_001 MWEPQPDVGSLLRSTAKMPTTPVKAKRVSTFQEFESNTS
10 20 30
70 80 90 100 110
pF1KE4 DAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSK------------LRVKPERSQ
:::: :.:..: .. . ..:::.:.. :: .::.:::. :. ::.
NP_001 DAWDAGEDDDELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEA
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE4 STTSDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGA
: .. ...:: :... : . .. ::...:::: . : . :: .. ..
NP_001 EPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTL-GGTSDPSTLSS
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE4 PPMTVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRK
.. :: .::.::.:::.. ::::.:::. :: :.:. :::.::.:::::::::..::
NP_001 SALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRP
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE4 LTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERIL
:::::..:::.:::.::::::.: :::::::::::::: .: :. :: : :::::::
NP_001 ATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPKVTEIFERIL
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE4 FIWAIRHPASGYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLRSIEADSFWC
:::::::::::::::::::::::::::. ::.: :.:.. ::... ..: .::::..::
NP_001 FIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWC
280 290 300 310 320 330
360 370 380 390 400 410
pF1KE4 MSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLL
:::::::::::::::::::: ::: ::::::::::::: :. ..::.:::::::::::::
NP_001 MSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLL
340 350 360 370 380 390
420 430 440 450 460 470
pF1KE4 MRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPT
:::.::::::::::::::::.::::::::::::::..::::::.:.::: ::..::::::
NP_001 MREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPT
400 410 420 430 440 450
480 490 500
pF1KE4 IHWGNEEIGLLLAEAYRLKYMFADAPNHYRR
:: .:.:.::::::::::. ::::::::..
NP_001 AHWDDEDISLLLAEAYRLKFAFADAPNHYKK
460 470 480
>>NP_055161 (OMIM: 616879) TBC1 domain family member 22A (517 aa)
initn: 2100 init1: 1454 opt: 1805 Z-score: 1952.7 bits: 370.9 E(85289): 5e-102
Smith-Waterman score: 2145; 61.5% identity (82.1% similar) in 520 aa overlap (1-505:1-517)
10 20 30 40 50
pF1KE4 MAAENS-KQFWKRS-AKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASS
::.... ::::::: .::::::: ::::::::.:: : .... .:. :.:.: :..:.
NP_055 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
10 20 30 40 50 60
60 70 80 90 100
pF1KE4 FHEFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSK------------
:.:: ::::::: :.:..: .. . ..:::.:.. :: .::.:::.
NP_055 FQEFESNTSDAWDAGEDDDELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRPTLQEGPG
70 80 90 100 110
110 120 130 140 150 160
pF1KE4 LRVKPERSQSTTSDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVAR
:. ::. : .. ...:: :... : . .. ::...:::: . : .
NP_055 LQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTL-GG
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 ISDQNASGAPPMTVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGY
:: .. .. .. :: .::.::.:::.. ::::.:::. :: :.:. :::.::.:::::
NP_055 TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGY
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 LPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPL
::::..:: :::::..:::.:::.::::::.: :::::::::::::: .: :. ::
NP_055 LPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPK
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 VQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLR
: ::::::::::::::::::::::::::::::::::. ::.: :.:.. ::... ..:
NP_055 VTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLC
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 SIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQF
.::::..:::::::::::::::::::::: ::: ::::::::::::: :. ..::.::::
NP_055 NIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQF
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 AFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGL
::::::::::::.::::::::::::::::.::::::::::::::..::::::.:.::: :
NP_055 AFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQEL
420 430 440 450 460 470
470 480 490 500
pF1KE4 LMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR
:..:::::: :: .:.:.::::::::::. ::::::::..
NP_055 LLFLQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK
480 490 500 510
>>NP_001271232 (OMIM: 616879) TBC1 domain family member (439 aa)
initn: 1792 init1: 1354 opt: 1655 Z-score: 1791.8 bits: 340.9 E(85289): 4.6e-93
Smith-Waterman score: 1799; 57.1% identity (73.8% similar) in 508 aa overlap (1-505:1-439)
10 20 30 40 50
pF1KE4 MAAENS-KQFWKRS-AKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASS
::.... ::::::: .:::::. .. .:. :.:.: :..:.
NP_001 MASDGARKQFWKRSNSKLPGSL-------------------LRSTAKMPTTPVKAKRVST
10 20 30 40
60 70 80 90 100 110
pF1KE4 FHEFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTT
:.:: ::::::: :.:..: .. . ..:::.:.. :: .::.:::. . .:
NP_001 FQEFESNTSDAWDAGEDDDELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRP-------
50 60 70 80 90
120 130 140 150 160 170
pF1KE4 SDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPM
: ..: .:. : :: . ::
NP_001 ------------------------TLQEGPGLQQK--P-RP-------------EAEPPS
100 110
180 190 200 210 220 230
pF1KE4 TVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTL
:: : . : . .:::. :: :.:. :::.::.:::::::::..:: ::
NP_001 PPSGDLRLVKSVSE-SHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATL
120 130 140 150 160 170
240 250 260 270 280 290
pF1KE4 QRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIW
:::..:::.:::.::::::.: :::::::::::::: .: :. :: : ::::::::::
NP_001 QRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPKVTEIFERILFIW
180 190 200 210 220 230
300 310 320 330 340 350
pF1KE4 AIRHPASGYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLRSIEADSFWCMSK
::::::::::::::::::::::::. ::.: :.:.. ::... ..: .::::..:::::
NP_001 AIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSK
240 250 260 270 280 290
360 370 380 390 400 410
pF1KE4 LLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRE
::::::::::::::::: ::: ::::::::::::: :. ..::.::::::::::::::::
NP_001 LLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMRE
300 310 320 330 340 350
420 430 440 450 460 470
pF1KE4 LPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHW
.::::::::::::::::.::::::::::::::..::::::.:.::: ::..:::::: ::
NP_001 VPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHW
360 370 380 390 400 410
480 490 500
pF1KE4 GNEEIGLLLAEAYRLKYMFADAPNHYRR
.:.:.::::::::::. ::::::::..
NP_001 DDEDISLLLAEAYRLKFAFADAPNHYKK
420 430
>>XP_016884234 (OMIM: 616879) PREDICTED: TBC1 domain fam (458 aa)
initn: 1940 init1: 1354 opt: 1655 Z-score: 1791.6 bits: 340.9 E(85289): 4.7e-93
Smith-Waterman score: 1936; 59.6% identity (76.8% similar) in 508 aa overlap (1-505:1-458)
10 20 30 40 50
pF1KE4 MAAENS-KQFWKRS-AKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASS
::.... ::::::: .::::::: ::::::::.:: : .... .:. :.:.: :..:.
XP_016 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 FHEFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTT
:.:: ::::::: :.:..: .. . ..:::.:.. :: .::.:::. . .:
XP_016 FQEFESNTSDAWDAGEDDDELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRP-------
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 SDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPM
: ..: .:. : :: . ::
XP_016 ------------------------TLQEGPGLQQK--P-RP-------------EAEPPS
120 130
180 190 200 210 220 230
pF1KE4 TVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTL
:: : . : . .:::. :: :.:. :::.::.:::::::::..:: ::
XP_016 PPSGDLRLVKSVSE-SHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATL
140 150 160 170 180 190
240 250 260 270 280 290
pF1KE4 QRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIW
:::..:::.:::.::::::.: :::::::::::::: .: :. :: : ::::::::::
XP_016 QRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPKVTEIFERILFIW
200 210 220 230 240 250
300 310 320 330 340 350
pF1KE4 AIRHPASGYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLRSIEADSFWCMSK
::::::::::::::::::::::::. ::.: :.:.. ::... ..: .::::..:::::
XP_016 AIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSK
260 270 280 290 300 310
360 370 380 390 400 410
pF1KE4 LLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRE
::::::::::::::::: ::: ::::::::::::: :. ..::.::::::::::::::::
XP_016 LLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMRE
320 330 340 350 360 370
420 430 440 450 460 470
pF1KE4 LPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHW
.::::::::::::::::.::::::::::::::..::::::.:.::: ::..:::::: ::
XP_016 VPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHW
380 390 400 410 420 430
480 490 500
pF1KE4 GNEEIGLLLAEAYRLKYMFADAPNHYRR
.:.:.::::::::::. ::::::::..
XP_016 DDEDISLLLAEAYRLKFAFADAPNHYKK
440 450
>>XP_011528401 (OMIM: 616879) PREDICTED: TBC1 domain fam (491 aa)
initn: 1620 init1: 1239 opt: 1590 Z-score: 1720.9 bits: 327.9 E(85289): 4.1e-89
Smith-Waterman score: 1930; 60.7% identity (81.4% similar) in 478 aa overlap (1-463:1-475)
10 20 30 40 50
pF1KE4 MAAENS-KQFWKRS-AKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASS
::.... ::::::: .::::::: ::::::::.:: : .... .:. :.:.: :..:.
XP_011 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
10 20 30 40 50 60
60 70 80 90 100
pF1KE4 FHEFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSK------------
:.:: ::::::: :.:..: .. . ..:::.:.. :: .::.:::.
XP_011 FQEFESNTSDAWDAGEDDDELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRPTLQEGPG
70 80 90 100 110
110 120 130 140 150 160
pF1KE4 LRVKPERSQSTTSDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVAR
:. ::. : .. ...:: :... : . .. ::...:::: . : .
XP_011 LQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTL-GG
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 ISDQNASGAPPMTVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGY
:: .. .. .. :: .::.::.:::.. ::::.:::. :: :.:. :::.::.:::::
XP_011 TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGY
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 LPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPL
::::..:: :::::..:::.:::.::::::.: :::::::::::::: .: :. ::
XP_011 LPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPK
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 VQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLR
: ::::::::::::::::::::::::::::::::::. ::.: :.:.. ::... ..:
XP_011 VTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLC
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 SIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQF
.::::..:::::::::::::::::::::: ::: ::::::::::::: :. ..::.::::
XP_011 NIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQF
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 AFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGL
::::::::::::.::::::::::::::::.::::::::::::::..::::::.:.:::
XP_011 AFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQHC
420 430 440 450 460 470
470 480 490 500
pF1KE4 LMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR
XP_011 RLRRTGHFYSPSIQ
480 490
505 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:10:30 2016 done: Sun Nov 6 04:10:31 2016
Total Scan time: 9.450 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]