Result of FASTA (ccds) for
pFN21AE4122
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4122, 505 aa
1>>>pF1KE4122 505 - 505 aa - 505 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1048+/-0.000932; mu= 14.3541+/- 0.056
mean_var=81.7034+/-16.329, 0's: 0 Z-trim(106.6): 43 B-trim: 0 in 0/50
Lambda= 0.141891
statistics sampled from 9012 (9055) to 9012 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.665), E-opt: 0.2 (0.278), width: 16
Scan time: 2.640
The best scores are: opt bits E(32554)
CCDS4832.1 TBC1D22B gene_id:55633|Hs108|chr6 ( 505) 3406 707.1 1.1e-203
CCDS63512.1 TBC1D22A gene_id:25771|Hs108|chr22 ( 470) 1805 379.4 4.8e-105
CCDS74877.1 TBC1D22A gene_id:25771|Hs108|chr22 ( 487) 1805 379.4 4.9e-105
CCDS14078.1 TBC1D22A gene_id:25771|Hs108|chr22 ( 517) 1805 379.4 5.2e-105
CCDS63511.1 TBC1D22A gene_id:25771|Hs108|chr22 ( 439) 1655 348.7 7.8e-96
>>CCDS4832.1 TBC1D22B gene_id:55633|Hs108|chr6 (505 aa)
initn: 3406 init1: 3406 opt: 3406 Z-score: 3770.2 bits: 707.1 E(32554): 1.1e-203
Smith-Waterman score: 3406; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505)
10 20 30 40 50 60
pF1KE4 MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS48 MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS48 EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS48 VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS48 REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS48 KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS48 RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS48 GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 RCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS48 RCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNE
430 440 450 460 470 480
490 500
pF1KE4 EIGLLLAEAYRLKYMFADAPNHYRR
:::::::::::::::::::::::::
CCDS48 EIGLLLAEAYRLKYMFADAPNHYRR
490 500
>>CCDS63512.1 TBC1D22A gene_id:25771|Hs108|chr22 (470 aa)
initn: 1912 init1: 1454 opt: 1805 Z-score: 1999.4 bits: 379.4 E(32554): 4.8e-105
Smith-Waterman score: 1964; 62.0% identity (82.2% similar) in 471 aa overlap (48-505:3-470)
20 30 40 50 60 70
pF1KE4 GSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFHEFARNTSDAWDIGDDEE
:.:.: :..:.:.:: ::::::: :.:..
CCDS63 MPTTPVKAKRVSTFQEFESNTSDAWDAGEDDD
10 20 30
80 90 100 110 120
pF1KE4 EDFSSPSFQTLNSKVALATAAQVLENHSK------------LRVKPERSQSTTSDVPANY
: .. . ..:::.:.. :: .::.:::. :. ::. : ..
CCDS63 ELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 KVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTVREKTR
...:: :... : . .. ::...:::: . : . :: .. .. .. :: .:
CCDS63 RLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTL-GGTSDPSTLSSSALSEREASR
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE4 LEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQRKREEY
:.::.:::.. ::::.:::. :: :.:. :::.::.:::::::::..:: :::::..::
CCDS63 LDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEY
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE4 FGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPAS
:.:::.::::::.: :::::::::::::: .: :. :: : :::::::::::::::::
CCDS63 FAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPKVTEIFERILFIWAIRHPAS
220 230 240 250 260
310 320 330 340 350 360
pF1KE4 GYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQD
:::::::::::::::::. ::.: :.:.. ::... ..: .::::..::::::::::::
CCDS63 GYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQD
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE4 NYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTI
:::::::::: ::: ::::::::::::: :. ..::.::::::::::::::::.::::::
CCDS63 NYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTI
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE4 RLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGL
::::::::::.::::::::::::::..::::::.:.::: ::..:::::: :: .:.:.:
CCDS63 RLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISL
390 400 410 420 430 440
490 500
pF1KE4 LLAEAYRLKYMFADAPNHYRR
:::::::::. ::::::::..
CCDS63 LLAEAYRLKFAFADAPNHYKK
450 460 470
>>CCDS74877.1 TBC1D22A gene_id:25771|Hs108|chr22 (487 aa)
initn: 1912 init1: 1454 opt: 1805 Z-score: 1999.2 bits: 379.4 E(32554): 4.9e-105
Smith-Waterman score: 1975; 60.9% identity (81.9% similar) in 481 aa overlap (38-505:10-487)
10 20 30 40 50 60
pF1KE4 QFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFHEFARNTS
.... .:. :.:.: :..:.:.:: :::
CCDS74 MWEPQPDVGSLLRSTAKMPTTPVKAKRVSTFQEFESNTS
10 20 30
70 80 90 100 110
pF1KE4 DAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSK------------LRVKPERSQ
:::: :.:..: .. . ..:::.:.. :: .::.:::. :. ::.
CCDS74 DAWDAGEDDDELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEA
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE4 STTSDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGA
: .. ...:: :... : . .. ::...:::: . : . :: .. ..
CCDS74 EPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTL-GGTSDPSTLSS
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE4 PPMTVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRK
.. :: .::.::.:::.. ::::.:::. :: :.:. :::.::.:::::::::..::
CCDS74 SALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRP
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE4 LTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERIL
:::::..:::.:::.::::::.: :::::::::::::: .: :. :: : :::::::
CCDS74 ATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPKVTEIFERIL
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE4 FIWAIRHPASGYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLRSIEADSFWC
:::::::::::::::::::::::::::. ::.: :.:.. ::... ..: .::::..::
CCDS74 FIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWC
280 290 300 310 320 330
360 370 380 390 400 410
pF1KE4 MSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLL
:::::::::::::::::::: ::: ::::::::::::: :. ..::.:::::::::::::
CCDS74 MSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLL
340 350 360 370 380 390
420 430 440 450 460 470
pF1KE4 MRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPT
:::.::::::::::::::::.::::::::::::::..::::::.:.::: ::..::::::
CCDS74 MREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPT
400 410 420 430 440 450
480 490 500
pF1KE4 IHWGNEEIGLLLAEAYRLKYMFADAPNHYRR
:: .:.:.::::::::::. ::::::::..
CCDS74 AHWDDEDISLLLAEAYRLKFAFADAPNHYKK
460 470 480
>>CCDS14078.1 TBC1D22A gene_id:25771|Hs108|chr22 (517 aa)
initn: 2100 init1: 1454 opt: 1805 Z-score: 1998.8 bits: 379.4 E(32554): 5.2e-105
Smith-Waterman score: 2145; 61.5% identity (82.1% similar) in 520 aa overlap (1-505:1-517)
10 20 30 40 50
pF1KE4 MAAENS-KQFWKRS-AKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASS
::.... ::::::: .::::::: ::::::::.:: : .... .:. :.:.: :..:.
CCDS14 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
10 20 30 40 50 60
60 70 80 90 100
pF1KE4 FHEFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSK------------
:.:: ::::::: :.:..: .. . ..:::.:.. :: .::.:::.
CCDS14 FQEFESNTSDAWDAGEDDDELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRPTLQEGPG
70 80 90 100 110
110 120 130 140 150 160
pF1KE4 LRVKPERSQSTTSDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVAR
:. ::. : .. ...:: :... : . .. ::...:::: . : .
CCDS14 LQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTL-GG
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 ISDQNASGAPPMTVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGY
:: .. .. .. :: .::.::.:::.. ::::.:::. :: :.:. :::.::.:::::
CCDS14 TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGY
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 LPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPL
::::..:: :::::..:::.:::.::::::.: :::::::::::::: .: :. ::
CCDS14 LPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPK
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 VQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLR
: ::::::::::::::::::::::::::::::::::. ::.: :.:.. ::... ..:
CCDS14 VTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLC
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 SIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQF
.::::..:::::::::::::::::::::: ::: ::::::::::::: :. ..::.::::
CCDS14 NIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQF
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 AFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGL
::::::::::::.::::::::::::::::.::::::::::::::..::::::.:.::: :
CCDS14 AFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQEL
420 430 440 450 460 470
470 480 490 500
pF1KE4 LMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR
:..:::::: :: .:.:.::::::::::. ::::::::..
CCDS14 LLFLQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK
480 490 500 510
>>CCDS63511.1 TBC1D22A gene_id:25771|Hs108|chr22 (439 aa)
initn: 1792 init1: 1354 opt: 1655 Z-score: 1834.0 bits: 348.7 E(32554): 7.8e-96
Smith-Waterman score: 1799; 57.1% identity (73.8% similar) in 508 aa overlap (1-505:1-439)
10 20 30 40 50
pF1KE4 MAAENS-KQFWKRS-AKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASS
::.... ::::::: .:::::. .. .:. :.:.: :..:.
CCDS63 MASDGARKQFWKRSNSKLPGSL-------------------LRSTAKMPTTPVKAKRVST
10 20 30 40
60 70 80 90 100 110
pF1KE4 FHEFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTT
:.:: ::::::: :.:..: .. . ..:::.:.. :: .::.:::. . .:
CCDS63 FQEFESNTSDAWDAGEDDDELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRP-------
50 60 70 80 90
120 130 140 150 160 170
pF1KE4 SDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPM
: ..: .:. : :: . ::
CCDS63 ------------------------TLQEGPGLQQK--P-RP-------------EAEPPS
100 110
180 190 200 210 220 230
pF1KE4 TVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTL
:: : . : . .:::. :: :.:. :::.::.:::::::::..:: ::
CCDS63 PPSGDLRLVKSVSE-SHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATL
120 130 140 150 160 170
240 250 260 270 280 290
pF1KE4 QRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIW
:::..:::.:::.::::::.: :::::::::::::: .: :. :: : ::::::::::
CCDS63 QRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPKVTEIFERILFIW
180 190 200 210 220 230
300 310 320 330 340 350
pF1KE4 AIRHPASGYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLRSIEADSFWCMSK
::::::::::::::::::::::::. ::.: :.:.. ::... ..: .::::..:::::
CCDS63 AIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSK
240 250 260 270 280 290
360 370 380 390 400 410
pF1KE4 LLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRE
::::::::::::::::: ::: ::::::::::::: :. ..::.::::::::::::::::
CCDS63 LLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMRE
300 310 320 330 340 350
420 430 440 450 460 470
pF1KE4 LPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHW
.::::::::::::::::.::::::::::::::..::::::.:.::: ::..:::::: ::
CCDS63 VPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHW
360 370 380 390 400 410
480 490 500
pF1KE4 GNEEIGLLLAEAYRLKYMFADAPNHYRR
.:.:.::::::::::. ::::::::..
CCDS63 DDEDISLLLAEAYRLKFAFADAPNHYKK
420 430
505 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:10:29 2016 done: Sun Nov 6 04:10:30 2016
Total Scan time: 2.640 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]