Result of FASTA (omim) for
pFN21AE4119
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4119, 474 aa
1>>>pF1KE4119 474 - 474 aa - 474 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.9689+/-0.00041; mu= 12.3599+/- 0.025
mean_var=215.8363+/-46.761, 0's: 0 Z-trim(118.3): 245 B-trim: 1356 in 2/58
Lambda= 0.087300
statistics sampled from 30741 (31088) to 30741 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.722), E-opt: 0.2 (0.365), width: 16
Scan time: 9.760
The best scores are: opt bits E(85289)
NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 842 119.2 2.7e-26
NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468) 816 115.9 2.5e-25
XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467) 805 114.5 6.5e-25
XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 774 110.6 9.9e-24
NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 774 110.6 9.9e-24
XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 774 110.6 9.9e-24
NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 774 110.6 9.9e-24
XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 774 110.6 9.9e-24
NP_006769 (OMIM: 605701) tripartite motif-containi ( 481) 748 107.3 9.6e-23
NP_001128327 (OMIM: 606123) E3 ubiquitin-protein l ( 343) 745 106.7 1e-22
NP_003132 (OMIM: 109092) E3 ubiquitin-protein liga ( 475) 723 104.2 8.5e-22
XP_016856907 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 713 102.6 1.4e-21
XP_016856908 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 713 102.6 1.4e-21
XP_011512525 (OMIM: 605701) PREDICTED: tripartite ( 499) 702 101.5 5.5e-21
XP_011512523 (OMIM: 605701) PREDICTED: tripartite ( 499) 702 101.5 5.5e-21
XP_011512524 (OMIM: 605701) PREDICTED: tripartite ( 499) 702 101.5 5.5e-21
NP_060543 (OMIM: 613184) E3 ubiquitin-protein liga ( 485) 693 100.4 1.2e-20
XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 450) 669 97.3 9.1e-20
NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 667 97.1 1.1e-19
XP_005253240 (OMIM: 608487) PREDICTED: tripartite ( 493) 656 95.7 3e-19
NP_149023 (OMIM: 608487) tripartite motif-containi ( 493) 656 95.7 3e-19
NP_067629 (OMIM: 605684) tripartite motif-containi ( 488) 634 93.0 2e-18
NP_001003827 (OMIM: 605684) tripartite motif-conta ( 488) 634 93.0 2e-18
NP_439893 (OMIM: 605701) tripartite motif-containi ( 395) 624 91.6 4.3e-18
NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 617 90.8 9e-18
NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 617 90.9 9.3e-18
NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 602 89.0 3.5e-17
NP_892030 (OMIM: 616017) E3 ubiquitin-protein liga ( 500) 601 88.8 3.7e-17
XP_011512527 (OMIM: 605701) PREDICTED: tripartite ( 413) 578 85.8 2.4e-16
NP_976038 (OMIM: 609315) tripartite motif-containi ( 511) 570 84.9 5.6e-16
NP_065091 (OMIM: 606124) tripartite motif-containi ( 452) 559 83.5 1.4e-15
XP_016873951 (OMIM: 608487) PREDICTED: tripartite ( 300) 554 82.6 1.6e-15
NP_149084 (OMIM: 608487) tripartite motif-containi ( 326) 554 82.7 1.7e-15
XP_005253241 (OMIM: 608487) PREDICTED: tripartite ( 326) 554 82.7 1.7e-15
NP_149083 (OMIM: 608487) tripartite motif-containi ( 347) 554 82.7 1.8e-15
XP_016873950 (OMIM: 608487) PREDICTED: tripartite ( 310) 542 81.1 4.8e-15
XP_011518728 (OMIM: 608487) PREDICTED: tripartite ( 310) 542 81.1 4.8e-15
XP_006718421 (OMIM: 608487) PREDICTED: tripartite ( 265) 540 80.8 5.1e-15
XP_016873952 (OMIM: 608487) PREDICTED: tripartite ( 265) 540 80.8 5.1e-15
NP_741983 (OMIM: 617007) tripartite motif-containi ( 493) 544 81.6 5.3e-15
NP_569074 (OMIM: 605684) tripartite motif-containi ( 270) 534 80.0 8.8e-15
XP_011518729 (OMIM: 608487) PREDICTED: tripartite ( 271) 533 79.9 9.6e-15
XP_011512567 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 421) 536 80.5 9.7e-15
NP_008959 (OMIM: 609316) E3 ubiquitin-protein liga ( 425) 536 80.5 9.7e-15
XP_016873949 (OMIM: 608487) PREDICTED: tripartite ( 314) 531 79.7 1.3e-14
XP_011512566 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 424) 532 80.0 1.4e-14
XP_011512568 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 261) 522 78.5 2.5e-14
XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 391) 520 78.5 3.7e-14
NP_006065 (OMIM: 606559) E3 ubiquitin-protein liga ( 498) 518 78.4 5.2e-14
NP_001186502 (OMIM: 606559) E3 ubiquitin-protein l ( 494) 500 76.1 2.5e-13
>>NP_006501 (OMIM: 602165) zinc finger protein RFP [Homo (513 aa)
initn: 714 init1: 321 opt: 842 Z-score: 593.0 bits: 119.2 E(85289): 2.7e-26
Smith-Waterman score: 887; 32.9% identity (59.9% similar) in 514 aa overlap (3-471:7-493)
10 20 30 40 50
pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGPFPCPECRHPS
:: .:.: :::.::.:: .:. ..::::.: .:: : :. . ::.::.
NP_006 MASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVSCPQCRETF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 APAALRPNWALARLTEKT-QRRRLGPVPPG----LCGRHWEPLRLFCEDDQRPVCLVCRE
.::: :: .:. . : : : :: .: .: :::.:.::.:: :.:.:: .
NP_006 PQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDR
70 80 90 100 110 120
120 130 140 150 160
pF1KE4 SQEHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIKS---
:.::. :.. :..:: :...:.. .: . ..:.: :. . .. : . .. :
NP_006 SREHRGHSVLPLEEAVEGFKEQI----QNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQ
130 140 150 160 170
170 180 190 200 210 220
pF1KE4 -QRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEV
.: .: :: .:.. : :.: .: ::.. . ...: ... .:. :..:: ..
NP_006 MEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQFSCNISHLSSLIAQL
180 190 200 210 220 230
230 240 250 260
pF1KE4 GEKSQAPTLELLQNPKEVLTRSE-------------IQD-----------VNYSLEAVKV
::.: :: ::::. ..:.:.: .:. .. ::.
NP_006 EEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTE
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE4 KTVCQIPLMKEM--LKRFQVAVNLAEDTAHPKLVFSQEGRYVKNTASASSWPVFSSAWNY
: .. ..:. . ..: :.: :::.:.:..:.. : :. . .. :
NP_006 KMQSDMEKIQELREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLP--------
300 310 320 330 340
330 340 350 360 370
pF1KE4 FAGWRNPQKTAFVERFQHLPCVLGKNVFTSGKHYWEVESRDSLEVAVGVCREDVM---GI
:: :::. .:::::. : .:.:::::: :. . ..:::...: :.
NP_006 ----DNP------ERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGV
350 360 370 380 390
380 390 400 410 420 430
pF1KE4 TDRSKMSPDVGIWAI-YWSAAGYWPLIGFPGTPTQQEPALHRVGVYLDRGTGNVSFYSAV
:. .:. :.::. : . :: : . : : . :.:::..:: .:.::::...
NP_006 TS----APQNGFWAVSLWYGKEYWALTS-PMTALPLRTPLQRVGIFLDYDAGEVSFYNVT
400 410 420 430 440 450
440 450 460 470
pF1KE4 DGVHLHTFSCSSV-SRLRPFFWLS-----PLASLVIPPVTDRK
. : ::: .. . .::.: :: : :.: :..
NP_006 ERCHTFTFSHATFCGPVRPYFSLSYSGGKSAAPLIICPMSGIDGFSGHVGNHGHSMETSP
460 470 480 490 500 510
>>NP_660215 (OMIM: 607868) E3 ubiquitin-protein ligase T (468 aa)
initn: 1059 init1: 399 opt: 816 Z-score: 575.7 bits: 115.9 E(85289): 2.5e-25
Smith-Waterman score: 1078; 39.9% identity (64.1% similar) in 471 aa overlap (5-468:9-451)
10 20 30 40 50
pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGPFPCPECRHPS
..::: :: :::::: ::: .::::::: :..: :. ::. :::::. :
NP_660 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 APAALRPNWALARLTEKTQRRRL---GPVPPGLCGRHWEPLRLFCEDDQRPVCLVCRESQ
:::: ::...: . ::: .::: :.: : ::: :: :. : .: .:..:
NP_660 PQRNLRPNRPLAKMAEMA--RRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSG
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 EHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIKSQRMRI
:: .: . :...: :. . :: :: ..: .:. .. .: .. . :. ..:::. .
NP_660 EHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 STEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEVGEKSQA
:: .:. .:.:::. .::::..:: :. .: :.. .:.: : : .:: :. . :
NP_660 LGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 PTLELLQNPKEVLTRSEIQDVNYSLEAV---KVKTVCQIPLMKEMLKRFQVAVNLAEDTA
:.: :::. :..: : .:::. . : ...:::..: . : :.::. :.: :::
NP_660 PALGLLQDIKDALRR--VQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTA
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE4 HPKLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCVLGKNVFT
.:.:..:.. : :. .. : .: :::. :::::.. ::
NP_660 NPELILSEDRRSVQRGDLRQALP------------DSP------ERFDPGPCVLGQERFT
300 310 320 330
360 370 380 390 400 410
pF1KE4 SGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGYWPLIGFPGTP
::.:::::: : :.:::::.: . .....: :.: . . .. :. .:
NP_660 SGRHYWEVEVGDRTSWALGVCRENV-NRKEKGELSAGNGFWILVFLGS-YYNSSERALAP
340 350 360 370 380 390
420 430 440 450 460
pF1KE4 TQQEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSVS-RLRPFFWLSPLASLVIPP
.. : .:::..:: .:..:::::.:: : : : :::.: :::.: :
NP_660 LRDPP--RRVGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLF--SPLSSSPTPM
400 410 420 430 440 450
470
pF1KE4 VTDRK
NP_660 TICRPKGGSGDTLAPQ
460
>>XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquitin-pr (467 aa)
initn: 923 init1: 416 opt: 805 Z-score: 568.2 bits: 114.5 E(85289): 6.5e-25
Smith-Waterman score: 1067; 39.9% identity (64.1% similar) in 471 aa overlap (5-468:9-450)
10 20 30 40 50
pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGPFPCPECRHPS
..::: :: :::::: ::: .::::::: :..: :. ::. :::::. :
XP_016 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 APAALRPNWALARLTEKTQRRRL---GPVPPGLCGRHWEPLRLFCEDDQRPVCLVCRESQ
:::: ::...: . ::: .::: :.: : ::: :: :. : .: .:..:
XP_016 PQRNLRPNRPLAKMAEMA--RRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSG
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 EHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIKSQRMRI
:: .: . :...: :. . :: :: ..: .:. .. .: .. . :. ..:::. .
XP_016 EHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQ-MVESQRQNV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 STEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEVGEKSQA
:: .:. .:.:::. .::::..:: :. .: :.. .:.: : : .:: :. . :
XP_016 LGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 PTLELLQNPKEVLTRSEIQDVNYSLEAV---KVKTVCQIPLMKEMLKRFQVAVNLAEDTA
:.: :::. :..: : .:::. . : ...:::..: . : :.::. :.: :::
XP_016 PALGLLQDIKDALRR--VQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTA
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE4 HPKLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCVLGKNVFT
.:.:..:.. : :. .. : .: :::. :::::.. ::
XP_016 NPELILSEDRRSVQRGDLRQALP------------DSP------ERFDPGPCVLGQERFT
300 310 320 330
360 370 380 390 400 410
pF1KE4 SGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGYWPLIGFPGTP
::.:::::: : :.:::::.: . .....: :.: . . .. :. .:
XP_016 SGRHYWEVEVGDRTSWALGVCRENV-NRKEKGELSAGNGFWILVFLGS-YYNSSERALAP
340 350 360 370 380 390
420 430 440 450 460
pF1KE4 TQQEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSVS-RLRPFFWLSPLASLVIPP
.. : .:::..:: .:..:::::.:: : : : :::.: :::.: :
XP_016 LRDPP--RRVGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLF--SPLSSSPTPM
400 410 420 430 440 450
470
pF1KE4 VTDRK
XP_016 TICRPKGGSGDTLAPQ
460
>>XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa)
initn: 987 init1: 452 opt: 774 Z-score: 547.0 bits: 110.6 E(85289): 9.9e-24
Smith-Waterman score: 1023; 39.0% identity (63.7% similar) in 490 aa overlap (3-471:7-472)
10 20 30 40
pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNW--APGG-------GPF
:. .::: :: :::::: ::: :::::::.:.. .: : : : :
XP_011 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 PCPECRHPSAPAALRPNWALARLTEKTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCL
::::::. : : :: :....: .:.. : :: .: :::.:::. :: :.:.
XP_011 PCPECREMSPQRNLLPNRLLTKVAEMAQQHP-GLQKQDLCQEHHEPLKLFCQKDQSPICV
70 80 90 100 110
110 120 130 140 150 160
pF1KE4 VCRESQEHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIK
:::::.::. : . : .:: ..:. :: .... : .. .. .:: : .. ..:. :.:
XP_011 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 SQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEV
.: :: :: :.. .:::::. .:: :. ::::: ..: :.. :.. ::. :.:..
XP_011 ERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 GEKSQAPTLELLQNPKEVLTRSEIQDVNYSLEA--VKVKTVCQIPLMKEMLKRFQVAVNL
:.: :..::. :: :.:.. .:. : .. .:::..: . :.:. : :
XP_011 EERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVVP
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 AEDTAHPKLVF--SQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCV
.:.: :.. :.. ::. .. .:. : : .:: ::.
XP_011 DATSAYPYLLLYESRQRRYLGSSPEGSG---FCSK----------------DRFVAYPCA
300 310 320 330 340
350 360 370 380 390 400
pF1KE4 LGKNVFTSGKHYWEVE---SRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGY
.:...:.::.::::: . :.: :.::::..: . :: :. :.:.. : :
XP_011 VGQTAFSSGRHYWEVGMNITGDALW-ALGVCRDNV-SRKDRVPKCPENGFWVVQLSK-GT
350 360 370 380 390
410 420 430 440 450
pF1KE4 WPLIGFPG-TPTQ-QEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSV-SRLRPFF
: : . ::.. .:: : .:..:: .:.:::::. :: ::::.: .. . :.:::
XP_011 KYLSTFSALTPVMLMEPPSH-MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFF
400 410 420 430 440 450
460 470
pF1KE4 WLSPLAS--LVIPPVTDRK
:. : .:: ::
XP_011 CLGAPKSGQMVISTVTMWVKG
460 470
>>NP_057186 (OMIM: 606123) E3 ubiquitin-protein ligase T (477 aa)
initn: 987 init1: 452 opt: 774 Z-score: 547.0 bits: 110.6 E(85289): 9.9e-24
Smith-Waterman score: 1023; 39.0% identity (63.7% similar) in 490 aa overlap (3-471:7-472)
10 20 30 40
pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNW--APGG-------GPF
:. .::: :: :::::: ::: :::::::.:.. .: : : : :
NP_057 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 PCPECRHPSAPAALRPNWALARLTEKTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCL
::::::. : : :: :....: .:.. : :: .: :::.:::. :: :.:.
NP_057 PCPECREMSPQRNLLPNRLLTKVAEMAQQHP-GLQKQDLCQEHHEPLKLFCQKDQSPICV
70 80 90 100 110
110 120 130 140 150 160
pF1KE4 VCRESQEHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIK
:::::.::. : . : .:: ..:. :: .... : .. .. .:: : .. ..:. :.:
NP_057 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 SQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEV
.: :: :: :.. .:::::. .:: :. ::::: ..: :.. :.. ::. :.:..
NP_057 ERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 GEKSQAPTLELLQNPKEVLTRSEIQDVNYSLEA--VKVKTVCQIPLMKEMLKRFQVAVNL
:.: :..::. :: :.:.. .:. : .. .:::..: . :.:. : :
NP_057 EERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVVP
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 AEDTAHPKLVF--SQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCV
.:.: :.. :.. ::. .. .:. : : .:: ::.
NP_057 DATSAYPYLLLYESRQRRYLGSSPEGSG---FCSK----------------DRFVAYPCA
300 310 320 330 340
350 360 370 380 390 400
pF1KE4 LGKNVFTSGKHYWEVE---SRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGY
.:...:.::.::::: . :.: :.::::..: . :: :. :.:.. : :
NP_057 VGQTAFSSGRHYWEVGMNITGDALW-ALGVCRDNV-SRKDRVPKCPENGFWVVQLSK-GT
350 360 370 380 390
410 420 430 440 450
pF1KE4 WPLIGFPG-TPTQ-QEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSV-SRLRPFF
: : . ::.. .:: : .:..:: .:.:::::. :: ::::.: .. . :.:::
NP_057 KYLSTFSALTPVMLMEPPSH-MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFF
400 410 420 430 440 450
460 470
pF1KE4 WLSPLAS--LVIPPVTDRK
:. : .:: ::
NP_057 CLGAPKSGQMVISTVTMWVKG
460 470
>>XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa)
initn: 987 init1: 452 opt: 774 Z-score: 547.0 bits: 110.6 E(85289): 9.9e-24
Smith-Waterman score: 1023; 39.0% identity (63.7% similar) in 490 aa overlap (3-471:7-472)
10 20 30 40
pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNW--APGG-------GPF
:. .::: :: :::::: ::: :::::::.:.. .: : : : :
XP_006 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 PCPECRHPSAPAALRPNWALARLTEKTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCL
::::::. : : :: :....: .:.. : :: .: :::.:::. :: :.:.
XP_006 PCPECREMSPQRNLLPNRLLTKVAEMAQQHP-GLQKQDLCQEHHEPLKLFCQKDQSPICV
70 80 90 100 110
110 120 130 140 150 160
pF1KE4 VCRESQEHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIK
:::::.::. : . : .:: ..:. :: .... : .. .. .:: : .. ..:. :.:
XP_006 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 SQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEV
.: :: :: :.. .:::::. .:: :. ::::: ..: :.. :.. ::. :.:..
XP_006 ERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 GEKSQAPTLELLQNPKEVLTRSEIQDVNYSLEA--VKVKTVCQIPLMKEMLKRFQVAVNL
:.: :..::. :: :.:.. .:. : .. .:::..: . :.:. : :
XP_006 EERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVVP
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 AEDTAHPKLVF--SQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCV
.:.: :.. :.. ::. .. .:. : : .:: ::.
XP_006 DATSAYPYLLLYESRQRRYLGSSPEGSG---FCSK----------------DRFVAYPCA
300 310 320 330 340
350 360 370 380 390 400
pF1KE4 LGKNVFTSGKHYWEVE---SRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGY
.:...:.::.::::: . :.: :.::::..: . :: :. :.:.. : :
XP_006 VGQTAFSSGRHYWEVGMNITGDALW-ALGVCRDNV-SRKDRVPKCPENGFWVVQLSK-GT
350 360 370 380 390
410 420 430 440 450
pF1KE4 WPLIGFPG-TPTQ-QEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSV-SRLRPFF
: : . ::.. .:: : .:..:: .:.:::::. :: ::::.: .. . :.:::
XP_006 KYLSTFSALTPVMLMEPPSH-MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFF
400 410 420 430 440 450
460 470
pF1KE4 WLSPLAS--LVIPPVTDRK
:. : .:: ::
XP_006 CLGAPKSGQMVISTVTMWVKG
460 470
>>NP_001020111 (OMIM: 606123) E3 ubiquitin-protein ligas (477 aa)
initn: 987 init1: 452 opt: 774 Z-score: 547.0 bits: 110.6 E(85289): 9.9e-24
Smith-Waterman score: 1023; 39.0% identity (63.7% similar) in 490 aa overlap (3-471:7-472)
10 20 30 40
pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNW--APGG-------GPF
:. .::: :: :::::: ::: :::::::.:.. .: : : : :
NP_001 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 PCPECRHPSAPAALRPNWALARLTEKTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCL
::::::. : : :: :....: .:.. : :: .: :::.:::. :: :.:.
NP_001 PCPECREMSPQRNLLPNRLLTKVAEMAQQHP-GLQKQDLCQEHHEPLKLFCQKDQSPICV
70 80 90 100 110
110 120 130 140 150 160
pF1KE4 VCRESQEHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIK
:::::.::. : . : .:: ..:. :: .... : .. .. .:: : .. ..:. :.:
NP_001 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 SQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEV
.: :: :: :.. .:::::. .:: :. ::::: ..: :.. :.. ::. :.:..
NP_001 ERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 GEKSQAPTLELLQNPKEVLTRSEIQDVNYSLEA--VKVKTVCQIPLMKEMLKRFQVAVNL
:.: :..::. :: :.:.. .:. : .. .:::..: . :.:. : :
NP_001 EERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVVP
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 AEDTAHPKLVF--SQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCV
.:.: :.. :.. ::. .. .:. : : .:: ::.
NP_001 DATSAYPYLLLYESRQRRYLGSSPEGSG---FCSK----------------DRFVAYPCA
300 310 320 330 340
350 360 370 380 390 400
pF1KE4 LGKNVFTSGKHYWEVE---SRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGY
.:...:.::.::::: . :.: :.::::..: . :: :. :.:.. : :
NP_001 VGQTAFSSGRHYWEVGMNITGDALW-ALGVCRDNV-SRKDRVPKCPENGFWVVQLSK-GT
350 360 370 380 390
410 420 430 440 450
pF1KE4 WPLIGFPG-TPTQ-QEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSV-SRLRPFF
: : . ::.. .:: : .:..:: .:.:::::. :: ::::.: .. . :.:::
NP_001 KYLSTFSALTPVMLMEPPSH-MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFF
400 410 420 430 440 450
460 470
pF1KE4 WLSPLAS--LVIPPVTDRK
:. : .:: ::
NP_001 CLGAPKSGQMVISTVTMWVKG
460 470
>>XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa)
initn: 987 init1: 452 opt: 774 Z-score: 547.0 bits: 110.6 E(85289): 9.9e-24
Smith-Waterman score: 1023; 39.0% identity (63.7% similar) in 490 aa overlap (3-471:7-472)
10 20 30 40
pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNW--APGG-------GPF
:. .::: :: :::::: ::: :::::::.:.. .: : : : :
XP_011 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 PCPECRHPSAPAALRPNWALARLTEKTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCL
::::::. : : :: :....: .:.. : :: .: :::.:::. :: :.:.
XP_011 PCPECREMSPQRNLLPNRLLTKVAEMAQQHP-GLQKQDLCQEHHEPLKLFCQKDQSPICV
70 80 90 100 110
110 120 130 140 150 160
pF1KE4 VCRESQEHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIK
:::::.::. : . : .:: ..:. :: .... : .. .. .:: : .. ..:. :.:
XP_011 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 SQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEV
.: :: :: :.. .:::::. .:: :. ::::: ..: :.. :.. ::. :.:..
XP_011 ERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 GEKSQAPTLELLQNPKEVLTRSEIQDVNYSLEA--VKVKTVCQIPLMKEMLKRFQVAVNL
:.: :..::. :: :.:.. .:. : .. .:::..: . :.:. : :
XP_011 EERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVVP
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 AEDTAHPKLVF--SQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCV
.:.: :.. :.. ::. .. .:. : : .:: ::.
XP_011 DATSAYPYLLLYESRQRRYLGSSPEGSG---FCSK----------------DRFVAYPCA
300 310 320 330 340
350 360 370 380 390 400
pF1KE4 LGKNVFTSGKHYWEVE---SRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGY
.:...:.::.::::: . :.: :.::::..: . :: :. :.:.. : :
XP_011 VGQTAFSSGRHYWEVGMNITGDALW-ALGVCRDNV-SRKDRVPKCPENGFWVVQLSK-GT
350 360 370 380 390
410 420 430 440 450
pF1KE4 WPLIGFPG-TPTQ-QEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSV-SRLRPFF
: : . ::.. .:: : .:..:: .:.:::::. :: ::::.: .. . :.:::
XP_011 KYLSTFSALTPVMLMEPPSH-MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFF
400 410 420 430 440 450
460 470
pF1KE4 WLSPLAS--LVIPPVTDRK
:. : .:: ::
XP_011 CLGAPKSGQMVISTVTMWVKG
460 470
>>NP_006769 (OMIM: 605701) tripartite motif-containing p (481 aa)
initn: 730 init1: 330 opt: 748 Z-score: 529.3 bits: 107.3 E(85289): 9.6e-23
Smith-Waterman score: 765; 31.5% identity (60.2% similar) in 483 aa overlap (6-459:10-470)
10 20 30 40 50
pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGP----FP-CPE
. .:..:::: ...::.:.:::::::.:: : . :: : ::
NP_006 MASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTR-YCEIPGPDLEESPTCPL
10 20 30 40 50
60 70 80 90 100
pF1KE4 CRHPSAPAALRPNWALARLTEKTQRRRL----GPVPPGLCGRHWEPLRLFCEDDQRPVCL
:..: :...:::: :: ..:. .: .: : .: .: : . .:::::. .:.
NP_006 CKEPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEEDVCQEHGEKIYFFCEDDEMQLCV
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE4 VCRESQEHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIK
::::. :: ::.: ...: :::.. : . : . ......:. : : ...
NP_006 VCREAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEIQEIQSRENKRMQVLLTQVS
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 SQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEV
..:... .::..:..:: :.....: .:.... . .. .: : . : .. :: :.
NP_006 TKRQQVISEFAHLRKFLEEQQSILLAQLESQDGDILRQRDEFDLLVAGEICRFSALIEEL
180 190 200 210 220 230
230 240 250 260 270
pF1KE4 GEKSQAPTLELLQNPKEVLTRSEI----QDVNYSLE-AVKVKTVCQ--IPLMKEM---LK
::.. :. ::: . . .: : : . : : : . ... : .::..:: :.
NP_006 EEKNERPARELLTDIRSTLIRCETRKCRKPVAVSPELGQRIRDFPQQALPLQREMKMFLE
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE4 R--FQVA-----VNLAEDTAHPKLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQK
. :.. ..: .:.::::..:.. . .. :: :. . :::
NP_006 KLCFELDYEPAHISLDPQTSHPKLLLSEDHQRAQ----------FSYKWQ--NSPDNPQ-
300 310 320 330 340
340 350 360 370 380
pF1KE4 TAFVERFQHLPCVLGKNVFTSGKHYW--EVESRDSLEVAVGVCREDVMGITDRSKMSPDV
::.. :::... .:.:.: : .. . .::: :::. . .. :.
NP_006 -----RFDRATCVLAHTGITGGRHTWVVSIDLAHGGSCTVGVVSEDVQR-KGELRLRPEE
350 360 370 380 390 400
390 400 410 420 430 440
pF1KE4 GIWAIYWSAAGYWPLIG-FPGTPTQQEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSC
:.::. : :. .: :: : .: ..: : :: .: :.: .:: ..::.
NP_006 GVWAVRL-AWGFVSALGSFPTRLTLKEQP-RQVRVSLDYEVGWVTFTNAVTREPIYTFTA
410 420 430 440 450
450 460 470
pF1KE4 SSVSRLRPFFWLSPLASLVIPPVTDRK
: . .. ::: :
NP_006 SFTRKVIPFFGLWGRGSSFSLSS
460 470 480
>>NP_001128327 (OMIM: 606123) E3 ubiquitin-protein ligas (343 aa)
initn: 724 init1: 452 opt: 745 Z-score: 528.9 bits: 106.7 E(85289): 1e-22
Smith-Waterman score: 745; 41.7% identity (67.7% similar) in 288 aa overlap (3-279:7-293)
10 20 30 40
pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNW--APGG-------GPF
:. .::: :: :::::: ::: :::::::.:.. .: : : : :
NP_001 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 PCPECRHPSAPAALRPNWALARLTEKTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCL
::::::. : : :: :....: .:.. : :: .: :::.:::. :: :.:.
NP_001 PCPECREMSPQRNLLPNRLLTKVAEMAQQHP-GLQKQDLCQEHHEPLKLFCQKDQSPICV
70 80 90 100 110
110 120 130 140 150 160
pF1KE4 VCRESQEHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIK
:::::.::. : . : .:: ..:. :: .... : .. .. .:: : .. ..:. :.:
NP_001 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 SQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEV
.: :: :: :.. .:::::. .:: :. ::::: ..: :.. :.. ::. :.:..
NP_001 ERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 GEKSQAPTLELLQNPKEVLTRSEIQDVNYSLEA--VKVKTVCQIPLMKEMLKRFQVAVNL
:.: :..::. :: :.:.. .:. : .. .:::..: . :.:. :
NP_001 EERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLGKWAP
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 AEDTAHPKLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCVLG
NP_001 RARTSDPGSLGDAPLYPLASEATNGGGSTSALPGDGHWLFTVPS
300 310 320 330 340
474 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 16:13:45 2016 done: Mon Nov 7 16:13:47 2016
Total Scan time: 9.760 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]