Result of FASTA (omim) for
pFN21AE4103
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4103, 472 aa
1>>>pF1KE4103 472 - 472 aa - 472 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6368+/-0.00049; mu= 16.0618+/- 0.030
mean_var=77.1817+/-16.079, 0's: 0 Z-trim(109.4): 196 B-trim: 1279 in 2/52
Lambda= 0.145988
statistics sampled from 17320 (17534) to 17320 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.568), E-opt: 0.2 (0.206), width: 16
Scan time: 7.530
The best scores are: opt bits E(85289)
NP_001287664 (OMIM: 614532) ras-GEF domain-contain ( 472) 3162 676.2 5.4e-194
NP_689758 (OMIM: 614532) ras-GEF domain-containing ( 473) 3150 673.6 3.1e-193
XP_016863302 (OMIM: 614532) PREDICTED: ras-GEF dom ( 473) 3150 673.6 3.1e-193
NP_001287665 (OMIM: 614532) ras-GEF domain-contain ( 431) 2474 531.2 2.1e-150
XP_016863301 (OMIM: 614532) PREDICTED: ras-GEF dom ( 432) 2462 528.7 1.2e-149
NP_660356 (OMIM: 614531) ras-GEF domain-containing ( 481) 1905 411.4 2.7e-114
NP_001269791 (OMIM: 614531) ras-GEF domain-contain ( 489) 1905 411.4 2.8e-114
XP_005271866 (OMIM: 614531) PREDICTED: ras-GEF dom ( 401) 1671 362.1 1.6e-99
XP_011537802 (OMIM: 614531) PREDICTED: ras-GEF dom ( 401) 1671 362.1 1.6e-99
NP_055062 (OMIM: 609530) rap guanine nucleotide ex (1499) 345 83.1 5.6e-15
XP_016864348 (OMIM: 609530) PREDICTED: rap guanine (1524) 345 83.1 5.7e-15
XP_011530729 (OMIM: 609530) PREDICTED: rap guanine (1540) 345 83.2 5.8e-15
XP_016864347 (OMIM: 609530) PREDICTED: rap guanine (1544) 345 83.2 5.8e-15
XP_016864346 (OMIM: 609530) PREDICTED: rap guanine (1544) 345 83.2 5.8e-15
XP_011530728 (OMIM: 609530) PREDICTED: rap guanine (1585) 345 83.2 5.9e-15
XP_006714485 (OMIM: 609530) PREDICTED: rap guanine (1585) 345 83.2 5.9e-15
XP_011530727 (OMIM: 609530) PREDICTED: rap guanine (1589) 345 83.2 5.9e-15
XP_005263418 (OMIM: 609530) PREDICTED: rap guanine (1654) 345 83.2 6.1e-15
XP_005263417 (OMIM: 609530) PREDICTED: rap guanine (1660) 345 83.2 6.1e-15
XP_006714484 (OMIM: 609530) PREDICTED: rap guanine (1685) 345 83.2 6.2e-15
XP_006714483 (OMIM: 609530) PREDICTED: rap guanine (1695) 345 83.2 6.2e-15
XP_005263415 (OMIM: 609530) PREDICTED: rap guanine (1701) 345 83.2 6.3e-15
XP_016864345 (OMIM: 609530) PREDICTED: rap guanine (1652) 341 82.3 1.1e-14
XP_005263416 (OMIM: 609530) PREDICTED: rap guanine (1693) 341 82.3 1.1e-14
NP_001157861 (OMIM: 610499) rap guanine nucleotide (1391) 312 76.2 6.6e-13
NP_001157860 (OMIM: 610499) rap guanine nucleotide (1504) 312 76.2 7e-13
NP_001157859 (OMIM: 610499) rap guanine nucleotide (1509) 312 76.2 7e-13
NP_057424 (OMIM: 610499) rap guanine nucleotide ex (1601) 312 76.2 7.4e-13
NP_001157858 (OMIM: 610499) rap guanine nucleotide (1609) 312 76.2 7.4e-13
XP_016865171 (OMIM: 606614) PREDICTED: ras-specifi (1142) 303 74.2 2.1e-12
NP_008840 (OMIM: 606614) ras-specific guanine nucl (1237) 303 74.3 2.2e-12
NP_722522 (OMIM: 606600) ras-specific guanine nucl ( 489) 295 72.3 3.3e-12
NP_001139120 (OMIM: 606600) ras-specific guanine n (1257) 295 72.6 7.2e-12
XP_016877945 (OMIM: 606600) PREDICTED: ras-specifi (1260) 295 72.6 7.2e-12
XP_016877944 (OMIM: 606600) PREDICTED: ras-specifi (1270) 295 72.6 7.3e-12
NP_002882 (OMIM: 606600) ras-specific guanine nucl (1273) 295 72.6 7.3e-12
NP_001269830 (OMIM: 606058) rap guanine nucleotide ( 791) 278 68.9 5.9e-11
NP_001269829 (OMIM: 606058) rap guanine nucleotide ( 840) 278 68.9 6.2e-11
XP_006712268 (OMIM: 606058) PREDICTED: rap guanine ( 840) 278 68.9 6.2e-11
XP_016858686 (OMIM: 606058) PREDICTED: rap guanine ( 849) 278 68.9 6.3e-11
NP_001269828 (OMIM: 606058) rap guanine nucleotide ( 858) 278 68.9 6.3e-11
NP_001093867 (OMIM: 606058) rap guanine nucleotide ( 867) 278 68.9 6.4e-11
XP_011508807 (OMIM: 606058) PREDICTED: rap guanine ( 881) 278 68.9 6.4e-11
XP_016858685 (OMIM: 606058) PREDICTED: rap guanine ( 960) 278 68.9 6.9e-11
XP_005246303 (OMIM: 606058) PREDICTED: rap guanine ( 993) 278 68.9 7.1e-11
NP_008954 (OMIM: 606058) rap guanine nucleotide ex (1011) 278 68.9 7.2e-11
XP_005268628 (OMIM: 606057) PREDICTED: rap guanine ( 495) 266 66.2 2.3e-10
NP_001293015 (OMIM: 603962) RAS guanyl-releasing p ( 597) 266 66.3 2.7e-10
XP_011519453 (OMIM: 603962) PREDICTED: RAS guanyl- ( 632) 266 66.3 2.8e-10
XP_005254171 (OMIM: 603962) PREDICTED: RAS guanyl- ( 746) 266 66.3 3.2e-10
>>NP_001287664 (OMIM: 614532) ras-GEF domain-containing (472 aa)
initn: 3162 init1: 3162 opt: 3162 Z-score: 3603.7 bits: 676.2 E(85289): 5.4e-194
Smith-Waterman score: 3162; 100.0% identity (100.0% similar) in 472 aa overlap (1-472:1-472)
10 20 30 40 50 60
pF1KE4 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 FPYDFRDERMMRNLKDLAHRIASGEETYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPYDFRDERMMRNLKDLAHRIASGEETYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 TDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 DKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 FNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 AHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECP
370 380 390 400 410 420
430 440 450 460 470
pF1KE4 FERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV
430 440 450 460 470
>>NP_689758 (OMIM: 614532) ras-GEF domain-containing fam (473 aa)
initn: 2163 init1: 2163 opt: 3150 Z-score: 3590.1 bits: 673.6 E(85289): 3.1e-193
Smith-Waterman score: 3150; 99.8% identity (99.8% similar) in 473 aa overlap (1-472:1-473)
10 20 30 40 50 60
pF1KE4 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET
70 80 90 100 110 120
130 140 150 160 170
pF1KE4 FPYDFRDERMMRNLKDLAHRIASGEE-TYRKNVQQMMQCLIRKLAALSQYEEVLAKISST
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_689 FPYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISST
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE4 NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE4 TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE4 PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV
430 440 450 460 470
>>XP_016863302 (OMIM: 614532) PREDICTED: ras-GEF domain- (473 aa)
initn: 2163 init1: 2163 opt: 3150 Z-score: 3590.1 bits: 673.6 E(85289): 3.1e-193
Smith-Waterman score: 3150; 99.8% identity (99.8% similar) in 473 aa overlap (1-472:1-473)
10 20 30 40 50 60
pF1KE4 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET
70 80 90 100 110 120
130 140 150 160 170
pF1KE4 FPYDFRDERMMRNLKDLAHRIASGEE-TYRKNVQQMMQCLIRKLAALSQYEEVLAKISST
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
XP_016 FPYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISST
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE4 NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE4 TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE4 PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV
430 440 450 460 470
>>NP_001287665 (OMIM: 614532) ras-GEF domain-containing (431 aa)
initn: 2862 init1: 2463 opt: 2474 Z-score: 2821.2 bits: 531.2 E(85289): 2.1e-150
Smith-Waterman score: 2784; 91.3% identity (91.3% similar) in 472 aa overlap (1-472:1-431)
10 20 30 40 50 60
pF1KE4 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPD-
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET
::::::::::::::::::::
NP_001 ----------------------------------------NQMRKIAPKILQLLTEWTET
60 70
130 140 150 160 170 180
pF1KE4 FPYDFRDERMMRNLKDLAHRIASGEETYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPYDFRDERMMRNLKDLAHRIASGEETYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTS
80 90 100 110 120 130
190 200 210 220 230 240
pF1KE4 TDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDN
140 150 160 170 180 190
250 260 270 280 290 300
pF1KE4 DKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGN
200 210 220 230 240 250
310 320 330 340 350 360
pF1KE4 FNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLT
260 270 280 290 300 310
370 380 390 400 410 420
pF1KE4 AHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECP
320 330 340 350 360 370
430 440 450 460 470
pF1KE4 FERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV
380 390 400 410 420 430
>>XP_016863301 (OMIM: 614532) PREDICTED: ras-GEF domain- (432 aa)
initn: 2562 init1: 2163 opt: 2462 Z-score: 2807.5 bits: 528.7 E(85289): 1.2e-149
Smith-Waterman score: 2772; 91.1% identity (91.1% similar) in 473 aa overlap (1-472:1-432)
10 20 30 40 50 60
pF1KE4 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPD-
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET
::::::::::::::::::::
XP_016 ----------------------------------------NQMRKIAPKILQLLTEWTET
60 70
130 140 150 160 170
pF1KE4 FPYDFRDERMMRNLKDLAHRIASGEE-TYRKNVQQMMQCLIRKLAALSQYEEVLAKISST
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
XP_016 FPYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISST
80 90 100 110 120 130
180 190 200 210 220 230
pF1KE4 STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD
140 150 160 170 180 190
240 250 260 270 280 290
pF1KE4 NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG
200 210 220 230 240 250
300 310 320 330 340 350
pF1KE4 NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL
260 270 280 290 300 310
360 370 380 390 400 410
pF1KE4 TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC
320 330 340 350 360 370
420 430 440 450 460 470
pF1KE4 PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV
380 390 400 410 420 430
>>NP_660356 (OMIM: 614531) ras-GEF domain-containing fam (481 aa)
initn: 1863 init1: 1160 opt: 1905 Z-score: 2172.8 bits: 411.4 E(85289): 2.7e-114
Smith-Waterman score: 1906; 58.6% identity (82.7% similar) in 481 aa overlap (1-471:1-480)
10 20 30 40 50
pF1KE4 MPQTPP-FSAMFDSSGYNR---NLYQSAEDSCGG---LYYHDNNLLSGSLEALIQHLVPN
:::: ::... : .. .. . . . :: : ..:..:.:::::::..::::.
NP_660 MPQTSVVFSSILGPSCSGQVQPGMGERGGGAGGGSGDLIFQDGHLISGSLEALMEHLVPT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 VDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQL
::::::::::::::::::.:: :..:.:.: ..:::... . .: ...... ::.::
NP_660 VDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 LTEWTETFPYDFRDERMMRNLKDLAHRIASGEE---TYRKNVQQMMQCLIRKLAALSQYE
: ::::.:::::.::. : .:: ..::... .: : .: . :: : :. .::: :: .
NP_660 LKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQ
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 EVLAKISSTSTDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQ
:. :. ..:. .::::: . :.::. :: :: .::::::::::.:.. : ::...:
NP_660 ELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQ
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 AFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFID
. : ::: . : .. :: .:::: .::: ::.:::::.: ::::::.::.:.:::
NP_660 IVSHMDSLDNHR-CRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFID
250 260 270 280 290
300 310 320 330 340 350
pF1KE4 VARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTA
:::::::::::::.::::::::.:::.::::::.::::::::.:::.::::::: :::::
NP_660 VARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTA
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE4 LRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSE
:.::.::: :.::::::::: :.:..::::::.. .:.:::::.::.::::...:. :
NP_660 LQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHE
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE4 FMTWKQVECPFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLG
:::: :::::::.:.:: .::::.:..::.::..::.::::::::.::: ::.::..::.
NP_660 FMTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDSWKTLRTTLLN
420 430 440 450 460 470
pF1KE4 RV
:
NP_660 RA
480
>>NP_001269791 (OMIM: 614531) ras-GEF domain-containing (489 aa)
initn: 1863 init1: 1160 opt: 1905 Z-score: 2172.7 bits: 411.4 E(85289): 2.8e-114
Smith-Waterman score: 1906; 58.6% identity (82.7% similar) in 481 aa overlap (1-471:9-488)
10 20 30 40
pF1KE4 MPQTPP-FSAMFDSSGYNR---NLYQSAEDSCGG---LYYHDNNLLSGSLEA
:::: ::... : .. .. . . . :: : ..:..:.::::::
NP_001 MFLEPQETMPQTSVVFSSILGPSCSGQVQPGMGERGGGAGGGSGDLIFQDGHLISGSLEA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 LIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRK
:..::::.::::::::::::::::::.:: :..:.:.: ..:::... . .: ....
NP_001 LMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE4 IAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEE---TYRKNVQQMMQCLIRK
.. ::.::: ::::.:::::.::. : .:: ..::... .: : .: . :: : :. .
NP_001 FSAKIVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLLLS
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE4 LAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNY
::: :: .:. :. ..:. .::::: . :.::. :: :: .::::::::::.:..
NP_001 LAARSQLQELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSS
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE4 IGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRA
: ::...: . : ::: . : .. :: .:::: .::: ::.:::::.: ::::::.
NP_001 IYPEDLMQIVSHMDSLDNHR-CRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRT
250 260 270 280 290
290 300 310 320 330 340
pF1KE4 RMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSS
::.:.::::::::::::::::.::::::::.:::.::::::.::::::::.:::.:::::
NP_001 RMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSS
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 NFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFW
:: ::::::.::.::: :.::::::::: :.:..::::::.. .:.:::::.::.:::
NP_001 NFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFW
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 ELAKQVSEFMTWKQVECPFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWK
:...:. ::::: :::::::.:.:: .::::.:..::.::..::.::::::::.::: ::
NP_001 EISRQIHEFMTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDSWK
420 430 440 450 460 470
470
pF1KE4 SLRSSLLGRV
.::..::.:
NP_001 TLRTTLLNRA
480
>>XP_005271866 (OMIM: 614531) PREDICTED: ras-GEF domain- (401 aa)
initn: 1621 init1: 1160 opt: 1671 Z-score: 1907.6 bits: 362.1 E(85289): 1.6e-99
Smith-Waterman score: 1671; 59.9% identity (84.0% similar) in 401 aa overlap (74-471:1-400)
50 60 70 80 90 100
pF1KE4 EALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQM
: :..:.:.: ..:::... . .: ..
XP_005 MPPHDLLARVGQICVEQKQQLEAGPEKAKL
10 20 30
110 120 130 140 150 160
pF1KE4 RKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEE---TYRKNVQQMMQCLI
.... ::.::: ::::.:::::.::. : .:: ..::... .: : .: . :: : :.
XP_005 KSFSAKIVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLL
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE4 RKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERL
.::: :: .:. :. ..:. .::::: . :.::. :: :: .::::::::::.:.
XP_005 LSLAARSQLQELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRV
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE4 NYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKH
. : ::...: . : ::: . : .. :: .:::: .::: ::.:::::.: :::::
XP_005 SSIYPEDLMQIVSHMDSLDNHR-CRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKH
160 170 180 190 200
290 300 310 320 330 340
pF1KE4 RARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDP
:.::.:.::::::::::::::::.::::::::.:::.::::::.::::::::.:::.:::
XP_005 RTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDP
210 220 230 240 250 260
350 360 370 380 390 400
pF1KE4 SSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEK
:::: ::::::.::.::: :.::::::::: :.:..::::::.. .:.:::::.::.:
XP_005 SSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKK
270 280 290 300 310 320
410 420 430 440 450 460
pF1KE4 FWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDR
:::...:. ::::: :::::::.:.:: .::::.:..::.::..::.::::::::.:::
XP_005 FWEISRQIHEFMTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDS
330 340 350 360 370 380
470
pF1KE4 WKSLRSSLLGRV
::.::..::.:
XP_005 WKTLRTTLLNRA
390 400
>>XP_011537802 (OMIM: 614531) PREDICTED: ras-GEF domain- (401 aa)
initn: 1621 init1: 1160 opt: 1671 Z-score: 1907.6 bits: 362.1 E(85289): 1.6e-99
Smith-Waterman score: 1671; 59.9% identity (84.0% similar) in 401 aa overlap (74-471:1-400)
50 60 70 80 90 100
pF1KE4 EALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQM
: :..:.:.: ..:::... . .: ..
XP_011 MPPHDLLARVGQICVEQKQQLEAGPEKAKL
10 20 30
110 120 130 140 150 160
pF1KE4 RKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEE---TYRKNVQQMMQCLI
.... ::.::: ::::.:::::.::. : .:: ..::... .: : .: . :: : :.
XP_011 KSFSAKIVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLL
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE4 RKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERL
.::: :: .:. :. ..:. .::::: . :.::. :: :: .::::::::::.:.
XP_011 LSLAARSQLQELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRV
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE4 NYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKH
. : ::...: . : ::: . : .. :: .:::: .::: ::.:::::.: :::::
XP_011 SSIYPEDLMQIVSHMDSLDNHR-CRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKH
160 170 180 190 200
290 300 310 320 330 340
pF1KE4 RARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDP
:.::.:.::::::::::::::::.::::::::.:::.::::::.::::::::.:::.:::
XP_011 RTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDP
210 220 230 240 250 260
350 360 370 380 390 400
pF1KE4 SSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEK
:::: ::::::.::.::: :.::::::::: :.:..::::::.. .:.:::::.::.:
XP_011 SSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKK
270 280 290 300 310 320
410 420 430 440 450 460
pF1KE4 FWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDR
:::...:. ::::: :::::::.:.:: .::::.:..::.::..::.::::::::.:::
XP_011 FWEISRQIHEFMTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDS
330 340 350 360 370 380
470
pF1KE4 WKSLRSSLLGRV
::.::..::.:
XP_011 WKTLRTTLLNRA
390 400
>>NP_055062 (OMIM: 609530) rap guanine nucleotide exchan (1499 aa)
initn: 352 init1: 214 opt: 345 Z-score: 389.8 bits: 83.1 E(85289): 5.6e-15
Smith-Waterman score: 352; 30.2% identity (60.9% similar) in 258 aa overlap (208-458:721-958)
180 190 200 210 220 230
pF1KE4 STSTDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDP
.: ::. ..: . : : :... . .
NP_055 METETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFK---
700 710 720 730 740
240 250 260 270 280 290
pF1KE4 LDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFN
: . :: ::. . : .:. .. ::.:: ... .: ..:..:: .: .: .
NP_055 LRSKTSCA-------NLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRE
750 760 770 780 790 800
300 310 320 330 340 350
pF1KE4 IGNFNSLMAIISGMNMSPVSRLKKTWAKV--KTAK-FDILEHQMDPSSNFYNYRTALRGA
::::..:::::.:..::.::. :: :. : : :. :. .::: :. .::..: .
NP_055 CKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNS-
810 820 830 840 850
360 370 380 390 400 410
pF1KE4 AQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTW
.. . .::.: .. ::. ::.:: ... .: :::::. .::.. .
NP_055 --------QNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRM
860 870 880 890 900 910
420 430 440 450 460 470
pF1KE4 KQVEC-P---FERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLG
.:. : :. .: . : .. : .: : .. : ......
NP_055 ASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYED
920 930 940 950 960 970
pF1KE4 RV
NP_055 AQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGS
980 990 1000 1010 1020 1030
472 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 18:13:23 2016 done: Mon Nov 7 18:13:25 2016
Total Scan time: 7.530 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]