Result of FASTA (omim) for
pFN21AE4070
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4070, 373 aa
1>>>pF1KE4070 373 - 373 aa - 373 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.4486+/-0.000387; mu= 3.3424+/- 0.024
mean_var=218.2077+/-45.027, 0's: 0 Z-trim(119.8): 47 B-trim: 0 in 0/55
Lambda= 0.086824
statistics sampled from 34188 (34245) to 34188 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.741), E-opt: 0.2 (0.402), width: 16
Scan time: 8.650
The best scores are: opt bits E(85289)
NP_919247 (OMIM: 608299) E3 ubiquitin-protein liga ( 373) 2562 333.5 4.9e-91
NP_079402 (OMIM: 608299) E3 ubiquitin-protein liga ( 372) 2548 331.7 1.7e-90
NP_001243787 (OMIM: 608299) E3 ubiquitin-protein l ( 180) 1215 164.5 1.8e-40
NP_001017368 (OMIM: 609735) E3 ubiquitin-protein l ( 363) 981 135.4 2e-31
>>NP_919247 (OMIM: 608299) E3 ubiquitin-protein ligase R (373 aa)
initn: 2562 init1: 2562 opt: 2562 Z-score: 1755.4 bits: 333.5 E(85289): 4.9e-91
Smith-Waterman score: 2562; 100.0% identity (100.0% similar) in 373 aa overlap (1-373:1-373)
10 20 30 40 50 60
pF1KE4 MRKAGATSMWASCCGLLNEVMGTGAVRGQQSAFAGATGPFRFTPNPEFSTYPPAATEGPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 MRKAGATSMWASCCGLLNEVMGTGAVRGQQSAFAGATGPFRFTPNPEFSTYPPAATEGPN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 IVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 VKDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMDTSSLNSSRSQTSSFFTRSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 VKDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMDTSSLNSSRSQTSSFFTRSF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 FSNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQSEITSANTEDDDDDDDEDDDDEEENA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 FSNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQSEITSANTEDDDDDDDEDDDDEEENA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 EDRNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 EDRNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 YKENEENQKSYGERLQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 YKENEENQKSYGERLQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPIC
310 320 330 340 350 360
370
pF1KE4 RQYVVRAVHVFKS
:::::::::::::
NP_919 RQYVVRAVHVFKS
370
>>NP_079402 (OMIM: 608299) E3 ubiquitin-protein ligase R (372 aa)
initn: 2548 init1: 2548 opt: 2548 Z-score: 1745.9 bits: 331.7 E(85289): 1.7e-90
Smith-Waterman score: 2548; 100.0% identity (100.0% similar) in 371 aa overlap (3-373:2-372)
10 20 30 40 50 60
pF1KE4 MRKAGATSMWASCCGLLNEVMGTGAVRGQQSAFAGATGPFRFTPNPEFSTYPPAATEGPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 MKAGATSMWASCCGLLNEVMGTGAVRGQQSAFAGATGPFRFTPNPEFSTYPPAATEGPN
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 IVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 IVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLK
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE4 VKDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMDTSSLNSSRSQTSSFFTRSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 VKDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMDTSSLNSSRSQTSSFFTRSF
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE4 FSNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQSEITSANTEDDDDDDDEDDDDEEENA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 FSNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQSEITSANTEDDDDDDDEDDDDEEENA
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 EDRNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 EDRNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRL
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 YKENEENQKSYGERLQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 YKENEENQKSYGERLQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPIC
300 310 320 330 340 350
370
pF1KE4 RQYVVRAVHVFKS
:::::::::::::
NP_079 RQYVVRAVHVFKS
360 370
>>NP_001243787 (OMIM: 608299) E3 ubiquitin-protein ligas (180 aa)
initn: 1215 init1: 1215 opt: 1215 Z-score: 847.7 bits: 164.5 E(85289): 1.8e-40
Smith-Waterman score: 1215; 99.4% identity (100.0% similar) in 179 aa overlap (195-373:2-180)
170 180 190 200 210 220
pF1KE4 LNSSRSQTSSFFTRSFFSNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQSEITSANTED
.:::::::::::::::::::::::::::::
NP_001 MKGELMDGDQTSRSGVPAQVQSEITSANTED
10 20 30
230 240 250 260 270 280
pF1KE4 DDDDDDEDDDDEEENAEDRNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEILARNFVNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDDDDDEDDDDEEENAEDRNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEILARNFVNY
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE4 SGCCEKWELVEKVNRLYKENEENQKSYGERLQLQDEEDDSLCRICMDAVIDCVLLECGHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGCCEKWELVEKVNRLYKENEENQKSYGERLQLQDEEDDSLCRICMDAVIDCVLLECGHM
100 110 120 130 140 150
350 360 370
pF1KE4 VTCTKCGKRMSECPICRQYVVRAVHVFKS
:::::::::::::::::::::::::::::
NP_001 VTCTKCGKRMSECPICRQYVVRAVHVFKS
160 170 180
>>NP_001017368 (OMIM: 609735) E3 ubiquitin-protein ligas (363 aa)
initn: 939 init1: 432 opt: 981 Z-score: 685.2 bits: 135.4 E(85289): 2e-31
Smith-Waterman score: 981; 43.9% identity (70.0% similar) in 380 aa overlap (9-373:1-363)
10 20 30 40 50
pF1KE4 MRKAGATSMWASCCGLLNEVMGTGAVRGQQSAFAGATGP-FRFTPNPEFSTYP-PAATEG
:::.::. . . :: : .. :: .:..: :.. :
NP_001 MWATCCNWF-------CLDGQPEEVPPPQGARMQAYSNPGYSSFPSPTGLE-
10 20 30 40
60 70 80 90 100 110
pF1KE4 PNIVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRR-CSTCHLLQETAFQRPQLM
:. ::.:: :. .:..: ::::.:: .:: : : : :. .. ::::: .::
NP_001 PS--CKSCGAHFANTARKQTCLDCKKNFCMTCSSQVGNGPRLCLLCQRFRATAFQREELM
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE4 RLKVKDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMD-TSSLNSSRSQTSSFF
..::::::.:: :..: . :::::.:: ::: .. . :..: .:.:. . . ..:.
NP_001 KMKVKDLRDYLSLHDISTEMCREKEELVLLVLGQQPVISQEDRTRASTLSPDFPEQQAFL
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE4 TRSFFSNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQ-SEITSANTEDDDDDDDEDDDD
:. :... :.. .: ... . : ::::: .. ..... .:... ..
NP_001 TQPH-SSMVPPTSP------NLPSSSAQATSVPPAQVQENQQANGHVSQDQEEPVYLESV
170 180 190 200 210
240 250 260 270 280 290
pF1KE4 EEENAEDRNPGLSKERV-----RASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCEK
. :::.. ....: :::::::..:.:.::..:::::::::::::::.:::::
NP_001 ARVPAEDETQSIDSEDSFVPGRRASLSDLTDLEDIEGLTVRQLKEILARNFVNYKGCCEK
220 230 240 250 260 270
300 310 320 330 340
pF1KE4 WELVEKVNRLYKENEENQKSY-GERLQ----LQDEEDDSLCRICMDAVIDCVLLECGHMV
:::.:.:.::::... :. : . : . . ...::.::::. ::::::::::::
NP_001 WELMERVTRLYKDQKGLQHLVSGAEDQNGGAVPSGLEENLCKICMDSPIDCVLLECGHMV
280 290 300 310 320 330
350 360 370
pF1KE4 TCTKCGKRMSECPICRQYVVRAVHVFKS
:::::::::.:::::::::.::::::.:
NP_001 TCTKCGKRMNECPICRQYVIRAVHVFRS
340 350 360
373 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 16:54:55 2016 done: Mon Nov 7 16:54:56 2016
Total Scan time: 8.650 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]