Result of FASTA (omim) for
pFN21AE4044
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4044, 267 aa
1>>>pF1KE4044 267 - 267 aa - 267 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6466+/-0.000284; mu= 14.1152+/- 0.018
mean_var=76.7220+/-15.826, 0's: 0 Z-trim(120.5): 17 B-trim: 1020 in 2/51
Lambda= 0.146425
statistics sampled from 35829 (35846) to 35829 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.769), E-opt: 0.2 (0.42), width: 16
Scan time: 8.040
The best scores are: opt bits E(85289)
NP_001139788 (OMIM: 611658) SPRY domain-containing ( 263) 1550 336.0 4.3e-92
NP_001306599 (OMIM: 611658) SPRY domain-containing ( 263) 1550 336.0 4.3e-92
NP_116030 (OMIM: 611658) SPRY domain-containing SO ( 263) 1550 336.0 4.3e-92
XP_016862998 (OMIM: 611660) PREDICTED: SPRY domain ( 233) 783 173.9 2.3e-43
NP_543138 (OMIM: 611660) SPRY domain-containing SO ( 273) 783 174.0 2.7e-43
NP_079382 (OMIM: 611657) SPRY domain-containing SO ( 273) 754 167.8 1.9e-41
NP_001099043 (OMIM: 609112) F-box/SPRY domain-cont ( 286) 540 122.6 7.8e-28
NP_001311010 (OMIM: 611659) SPRY domain-containing ( 355) 152 40.7 0.0044
NP_543137 (OMIM: 611659) SPRY domain-containing SO ( 355) 152 40.7 0.0044
XP_005255730 (OMIM: 611659) PREDICTED: SPRY domain ( 410) 152 40.8 0.005
>>NP_001139788 (OMIM: 611658) SPRY domain-containing SOC (263 aa)
initn: 1543 init1: 1543 opt: 1550 Z-score: 1774.3 bits: 336.0 E(85289): 4.3e-92
Smith-Waterman score: 1550; 88.8% identity (91.9% similar) in 260 aa overlap (1-260:1-253)
10 20 30 40 50 60
pF1KE4 MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 EGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 AALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 AIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRGEAWGRRGENFLSLVAVVW
:::::::::::::::::::::::::::::::::::::::::.: ...: : .
NP_001 AIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEP-----HSLLHLSRLCV
190 200 210 220 230
250 260
pF1KE4 DGNSSDKSRGDGPSSSLPQPLFSAGKG
: .: :. :.:: :
NP_001 RHNLGDTRLGQ--VSALPLPPAMKRYLLYQ
240 250 260
>>NP_001306599 (OMIM: 611658) SPRY domain-containing SOC (263 aa)
initn: 1543 init1: 1543 opt: 1550 Z-score: 1774.3 bits: 336.0 E(85289): 4.3e-92
Smith-Waterman score: 1550; 88.8% identity (91.9% similar) in 260 aa overlap (1-260:1-253)
10 20 30 40 50 60
pF1KE4 MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 EGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 AALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 AIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRGEAWGRRGENFLSLVAVVW
:::::::::::::::::::::::::::::::::::::::::.: ...: : .
NP_001 AIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEP-----HSLLHLSRLCV
190 200 210 220 230
250 260
pF1KE4 DGNSSDKSRGDGPSSSLPQPLFSAGKG
: .: :. :.:: :
NP_001 RHNLGDTRLGQ--VSALPLPPAMKRYLLYQ
240 250 260
>>NP_116030 (OMIM: 611658) SPRY domain-containing SOCS b (263 aa)
initn: 1543 init1: 1543 opt: 1550 Z-score: 1774.3 bits: 336.0 E(85289): 4.3e-92
Smith-Waterman score: 1550; 88.8% identity (91.9% similar) in 260 aa overlap (1-260:1-253)
10 20 30 40 50 60
pF1KE4 MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 EGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 EGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 AALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 AALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 AIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRGEAWGRRGENFLSLVAVVW
:::::::::::::::::::::::::::::::::::::::::.: ...: : .
NP_116 AIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEP-----HSLLHLSRLCV
190 200 210 220 230
250 260
pF1KE4 DGNSSDKSRGDGPSSSLPQPLFSAGKG
: .: :. :.:: :
NP_116 RHNLGDTRLGQ--VSALPLPPAMKRYLLYQ
240 250 260
>>XP_016862998 (OMIM: 611660) PREDICTED: SPRY domain-con (233 aa)
initn: 774 init1: 431 opt: 783 Z-score: 899.4 bits: 173.9 E(85289): 2.3e-43
Smith-Waterman score: 783; 59.0% identity (81.0% similar) in 195 aa overlap (26-217:34-227)
10 20 30 40 50
pF1KE4 MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSE
: :..::. : :..: ::.:::.: :
XP_016 KLSGSLKSVEVREPALRPAKRELRGAEPGRPARLDQLLDMPAAGLAVQLRHAWNPEDRSL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 NIEVKEGG-LYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAP
:. ::. : :.:.:::::::: ::: :..::::::.:.:: .::::::::::::: ::
XP_016 NVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAVVGVATARAP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 LQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPA--GTQGEQLEVPERLLVVLD
:.. :.::.::..::::::.::..:::..:. . ::: : . : . .:. ::::::
XP_016 LHSVGYTALVGSDAESWGWDLGRSRLYHDGKNQPGVAYPAFLGPD-EAFALPDSLLVVLD
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 MEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRGEAWGRRGENF
:.::::.. . : ::: :::::::. :::.::::::.:.: .::.
XP_016 MDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDQN
190 200 210 220 230
240 250 260
pF1KE4 LSLVAVVWDGNSSDKSRGDGPSSSLPQPLFSAGKG
>>NP_543138 (OMIM: 611660) SPRY domain-containing SOCS b (273 aa)
initn: 774 init1: 431 opt: 783 Z-score: 898.4 bits: 174.0 E(85289): 2.7e-43
Smith-Waterman score: 783; 59.0% identity (81.0% similar) in 195 aa overlap (26-217:34-227)
10 20 30 40 50
pF1KE4 MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSE
: :..::. : :..: ::.:::.: :
NP_543 KLSGSLKSVEVREPALRPAKRELRGAEPGRPARLDQLLDMPAAGLAVQLRHAWNPEDRSL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 NIEVKEGG-LYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAP
:. ::. : :.:.:::::::: ::: :..::::::.:.:: .::::::::::::: ::
NP_543 NVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAVVGVATARAP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 LQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPA--GTQGEQLEVPERLLVVLD
:.. :.::.::..::::::.::..:::..:. . ::: : . : . .:. ::::::
NP_543 LHSVGYTALVGSDAESWGWDLGRSRLYHDGKNQPGVAYPAFLGPD-EAFALPDSLLVVLD
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 MEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRGEAWGRRGENF
:.::::.. . : ::: :::::::. :::.::::::.:.: .::.
NP_543 MDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDLCR
190 200 210 220 230 240
240 250 260
pF1KE4 LSLVAVVWDGNSSDKSRGDGPSSSLPQPLFSAGKG
NP_543 RSIRSALGRQRLQDISSLPLPQSLKNYLQYQ
250 260 270
>>NP_079382 (OMIM: 611657) SPRY domain-containing SOCS b (273 aa)
initn: 749 init1: 417 opt: 754 Z-score: 865.3 bits: 167.8 E(85289): 1.9e-41
Smith-Waterman score: 759; 51.5% identity (74.9% similar) in 227 aa overlap (1-217:1-227)
10 20 30 40 50
pF1KE4 MGQTALAGGSS---STPTPQALYPDLS----C-PEGLEELLSAPPPDLGAQRRHGWNPKD
::: . .: .. :: . : .:. : : :. ::. :: . .: :.:: .:
NP_079 MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNND
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 CSENIEVKEGG-LYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATA
: :. ::: : :.:.:::::::. ::: ::.::::.:.:.: ..:::::::::::::
NP_079 RSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 LAPLQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQ-GEQLEVPERLLVV
:::.. :..:.:.: ::::::.::..:::..:. . ::: . : . ::. .::.
NP_079 DAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 LDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRGEAWGRRGE
:::..:::.. . : :.: :::::::. :::.::::::.:..:.:::
NP_079 LDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDL
190 200 210 220 230 240
240 250 260
pF1KE4 NFLSLVAVVWDGNSSDKSRGDGPSSSLPQPLFSAGKG
NP_079 CRRSVRLALGRERLGEIHTLPLPASLKAYLLYQ
250 260 270
>>NP_001099043 (OMIM: 609112) F-box/SPRY domain-containi (286 aa)
initn: 515 init1: 209 opt: 540 Z-score: 620.7 bits: 122.6 E(85289): 7.8e-28
Smith-Waterman score: 540; 46.3% identity (75.1% similar) in 177 aa overlap (45-219:111-282)
20 30 40 50 60 70
pF1KE4 TPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQS
.:... .:::.:. .:..:. ..: :.:::
NP_001 SLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQS
90 100 110 120 130 140
80 90 100 110 120 130
pF1KE4 TDGARGKRGYSRGLHAWEISW--PLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWG
::::: : :.:.: ::::. : :: :: ::.:.:: ::.: . :.:::::...:::
NP_001 TDGARTKIGFSEGRHAWEVWWEGPL---GTVAVIGIATKRAPMQCQGYVALLGSDDQSWG
150 160 170 180 190
140 150 160 170 180 190
pF1KE4 WDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFR
:.. ..: :... :. .: ... . .. ::. :.::::. ::.. : .:: :::
NP_001 WNLVDNNLLHNGEVNGS--FPQCNNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFR
200 210 220 230 240 250
200 210 220 230 240 250
pF1KE4 GLKGRTLYPAVSAVWGQCQVRIRYLGERRGEAWGRRGENFLSLVAVVWDGNSSDKSRGDG
:: ::::::::.:. .: . :::.
NP_001 GLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG
260 270 280
>>NP_001311010 (OMIM: 611659) SPRY domain-containing SOC (355 aa)
initn: 160 init1: 77 opt: 152 Z-score: 176.3 bits: 40.7 E(85289): 0.0044
Smith-Waterman score: 152; 28.2% identity (52.8% similar) in 142 aa overlap (75-214:135-267)
50 60 70 80 90 100
pF1KE4 RHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHA
: . :: . ..: : :::. ::
NP_001 WVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGEGQHFWEIKMTSPVYGTDM
110 120 130 140 150 160
110 120 130 140 150 160
pF1KE4 VVGVATALAPL-QTDH-YAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLE
.::..:. . : . : . .::: . .::: . : :.: :: . :: .
NP_001 MVGIGTSDVDLDKYRHTFCSLLGRDEDSWGLSY-TGLLHH--KGDKTSFSSRFGQGSIIG
170 180 190 200 210 220
170 180 190 200 210 220
pF1KE4 VPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRG
: :: .::: . . .: : :... .:: : .. .. ....
NP_001 VH------LDTWHGTLTFFKNRKCIGVAATKLQNKRFYPMVCSTAARSSMKVTRSCASAT
230 240 250 260 270
230 240 250 260
pF1KE4 EAWGRRGENFLSLVAVVWDGNSSDKSRGDGPSSSLPQPLFSAGKG
NP_001 SLQYLCCHRLRQLRPDSGDTLEGLPLPPGLKQVLHNKLGWVLSMSCSRRKAPVSDPQAAT
280 290 300 310 320 330
>>NP_543137 (OMIM: 611659) SPRY domain-containing SOCS b (355 aa)
initn: 160 init1: 77 opt: 152 Z-score: 176.3 bits: 40.7 E(85289): 0.0044
Smith-Waterman score: 152; 28.2% identity (52.8% similar) in 142 aa overlap (75-214:135-267)
50 60 70 80 90 100
pF1KE4 RHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHA
: . :: . ..: : :::. ::
NP_543 WVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGEGQHFWEIKMTSPVYGTDM
110 120 130 140 150 160
110 120 130 140 150 160
pF1KE4 VVGVATALAPL-QTDH-YAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLE
.::..:. . : . : . .::: . .::: . : :.: :: . :: .
NP_543 MVGIGTSDVDLDKYRHTFCSLLGRDEDSWGLSY-TGLLHH--KGDKTSFSSRFGQGSIIG
170 180 190 200 210 220
170 180 190 200 210 220
pF1KE4 VPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRG
: :: .::: . . .: : :... .:: : .. .. ....
NP_543 VH------LDTWHGTLTFFKNRKCIGVAATKLQNKRFYPMVCSTAARSSMKVTRSCASAT
230 240 250 260 270
230 240 250 260
pF1KE4 EAWGRRGENFLSLVAVVWDGNSSDKSRGDGPSSSLPQPLFSAGKG
NP_543 SLQYLCCHRLRQLRPDSGDTLEGLPLPPGLKQVLHNKLGWVLSMSCSRRKAPVSDPQAAT
280 290 300 310 320 330
>>XP_005255730 (OMIM: 611659) PREDICTED: SPRY domain-con (410 aa)
initn: 160 init1: 77 opt: 152 Z-score: 175.4 bits: 40.8 E(85289): 0.005
Smith-Waterman score: 152; 28.2% identity (52.8% similar) in 142 aa overlap (75-214:190-322)
50 60 70 80 90 100
pF1KE4 RHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHA
: . :: . ..: : :::. ::
XP_005 WVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGEGQHFWEIKMTSPVYGTDM
160 170 180 190 200 210
110 120 130 140 150 160
pF1KE4 VVGVATALAPL-QTDH-YAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLE
.::..:. . : . : . .::: . .::: . : :.: :: . :: .
XP_005 MVGIGTSDVDLDKYRHTFCSLLGRDEDSWGLSY-TGLLHH--KGDKTSFSSRFGQGSIIG
220 230 240 250 260 270
170 180 190 200 210 220
pF1KE4 VPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRG
: :: .::: . . .: : :... .:: : .. .. ....
XP_005 VH------LDTWHGTLTFFKNRKCIGVAATKLQNKRFYPMVCSTAARSSMKVTRSCASAT
280 290 300 310 320 330
230 240 250 260
pF1KE4 EAWGRRGENFLSLVAVVWDGNSSDKSRGDGPSSSLPQPLFSAGKG
XP_005 SLQYLCCHRLRQLRPDSGDTLEGLPLPPGLKQVLHNKLGWVLSMSCSRRKAPVSDPQAAT
340 350 360 370 380 390
267 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:17:15 2016 done: Sun Nov 6 04:17:16 2016
Total Scan time: 8.040 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]