FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE4032, 242 aa
  1>>>pF1KE4032 242 - 242 aa - 242 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.6624+/-0.000356; mu= 3.4009+/- 0.022
 mean_var=316.9505+/-64.995, 0's: 0 Z-trim(124.0): 6  B-trim: 0 in 0/57
 Lambda= 0.072041
 statistics sampled from 44724 (44742) to 44724 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.814), E-opt: 0.2 (0.525), width:  16
 Scan time:  8.170

The best scores are:                                      opt bits E(85289)
NP_667339 (OMIM: 612061) E3 ubiquitin-protein liga ( 242) 1678 186.7 3.1e-47
NP_115644 (OMIM: 612060) E3 ubiquitin-protein liga ( 227)  609 75.6 8.4e-14
XP_016879282 (OMIM: 612060) PREDICTED: E3 ubiquiti ( 227)  609 75.6 8.4e-14


>>NP_667339 (OMIM: 612061) E3 ubiquitin-protein ligase Z  (242 aa)
 initn: 1678 init1: 1678 opt: 1678  Z-score: 968.9  bits: 186.7 E(85289): 3.1e-47
Smith-Waterman score: 1678; 100.0% identity (100.0% similar) in 242 aa overlap (1-242:1-242)

               10        20        30        40        50        60
pF1KE4 MGAKQSGPAAANGRTRAYSGSDLPSSSSGGANGTAGGGGGARAAAAGRFPAQVPSAHQPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_667 MGAKQSGPAAANGRTRAYSGSDLPSSSSGGANGTAGGGGGARAAAAGRFPAQVPSAHQPS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE4 ASGGAAAAAAAPAAPAAPRSRSLGGAVGSVASGARAAQSPFSIPNSSSGPYGSQDSVHSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_667 ASGGAAAAAAAPAAPAAPRSRSLGGAVGSVASGARAAQSPFSIPNSSSGPYGSQDSVHSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE4 PEDGGGGRDRPVGGSPGGPRLVIGSLPAHLSPHMFGGFKCPVCSKFVSSDEMDLHLVMCL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_667 PEDGGGGRDRPVGGSPGGPRLVIGSLPAHLSPHMFGGFKCPVCSKFVSSDEMDLHLVMCL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE4 TKPRITYNEDVLSKDAGECAICLEELQQGDTIARLPCLCIYHKGCIDEWFEVNRSCPEHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_667 TKPRITYNEDVLSKDAGECAICLEELQQGDTIARLPCLCIYHKGCIDEWFEVNRSCPEHP
              190       200       210       220       230       240

         
pF1KE4 SD
       ::
NP_667 SD
         

>>NP_115644 (OMIM: 612060) E3 ubiquitin-protein ligase Z  (227 aa)
 initn: 671 init1: 553 opt: 609  Z-score: 368.8  bits: 75.6 E(85289): 8.4e-14
Smith-Waterman score: 664; 45.6% identity (65.3% similar) in 248 aa overlap (1-242:1-227)

               10        20        30          40        50        
pF1KE4 MGAKQSGPAAANGRTRAYSGSDLPSSSSGGAN--GTAGGGGGARAAAAGRFPAQVPSAHQ
       ::.:::  : . :   . : .:      :::   :    :::: .  .    . .  . .
NP_115 MGGKQSTAARSRGPFPGVSTDDSAVPPPGGAPHFGHYRTGGGAMGLRSRSVSSVAGMGMD
               10        20        30        40        50        60

       60        70        80        90       100       110        
pF1KE4 PSASGGAAAAAAAPAAPAAPRSRSLGGAVGSVASGARAAQSPFSIPNSSSGPYGSQDSVH
       ::..::.      : .  .: ::. : .  . ..:. :..: ..  :      : :..  
NP_115 PSTAGGV------PFGLYTPASRGTGDSERAPGGGGSASDSTYAHGN------GYQET--
                     70        80        90       100              

      120       130       140        150          160       170    
pF1KE4 SSPEDGGGGRDRPVGGSPGGPRLVIG-SLPAHLSPHMFG---GFKCPVCSKFVSSDEMDL
             :::. :  :    : :  .. .:: :..:. :.   :::::.::: :.::::..
NP_115 ------GGGHHRD-GMLYLGSRASLADALPLHIAPRWFSSHSGFKCPICSKSVASDEMEM
              110        120       130       140       150         

          180       190       200       210       220       230    
pF1KE4 HLVMCLTKPRITYNEDVLSKDAGECAICLEELQQGDTIARLPCLCIYHKGCIDEWFEVNR
       :..:::.:::..::.:::.::::::.:::::: ::::::::::::::::.::: ::::::
NP_115 HFIMCLSKPRLSYNDDVLTKDAGECVICLEELLQGDTIARLPCLCIYHKSCIDSWFEVNR
     160       170       180       190       200       210         

          240  
pF1KE4 SCPEHPSD
       ::::::.:
NP_115 SCPEHPAD
     220       

>>XP_016879282 (OMIM: 612060) PREDICTED: E3 ubiquitin-pr  (227 aa)
 initn: 671 init1: 553 opt: 609  Z-score: 368.8  bits: 75.6 E(85289): 8.4e-14
Smith-Waterman score: 664; 45.6% identity (65.3% similar) in 248 aa overlap (1-242:1-227)

               10        20        30          40        50        
pF1KE4 MGAKQSGPAAANGRTRAYSGSDLPSSSSGGAN--GTAGGGGGARAAAAGRFPAQVPSAHQ
       ::.:::  : . :   . : .:      :::   :    :::: .  .    . .  . .
XP_016 MGGKQSTAARSRGPFPGVSTDDSAVPPPGGAPHFGHYRTGGGAMGLRSRSVSSVAGMGMD
               10        20        30        40        50        60

       60        70        80        90       100       110        
pF1KE4 PSASGGAAAAAAAPAAPAAPRSRSLGGAVGSVASGARAAQSPFSIPNSSSGPYGSQDSVH
       ::..::.      : .  .: ::. : .  . ..:. :..: ..  :      : :..  
XP_016 PSTAGGV------PFGLYTPASRGTGDSERAPGGGGSASDSTYAHGN------GYQET--
                     70        80        90       100              

      120       130       140        150          160       170    
pF1KE4 SSPEDGGGGRDRPVGGSPGGPRLVIG-SLPAHLSPHMFG---GFKCPVCSKFVSSDEMDL
             :::. :  :    : :  .. .:: :..:. :.   :::::.::: :.::::..
XP_016 ------GGGHHRD-GMLYLGSRASLADALPLHIAPRWFSSHSGFKCPICSKSVASDEMEM
              110        120       130       140       150         

          180       190       200       210       220       230    
pF1KE4 HLVMCLTKPRITYNEDVLSKDAGECAICLEELQQGDTIARLPCLCIYHKGCIDEWFEVNR
       :..:::.:::..::.:::.::::::.:::::: ::::::::::::::::.::: ::::::
XP_016 HFIMCLSKPRLSYNDDVLTKDAGECVICLEELLQGDTIARLPCLCIYHKSCIDSWFEVNR
     160       170       180       190       200       210         

          240  
pF1KE4 SCPEHPSD
       ::::::.:
XP_016 SCPEHPAD
     220       




242 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Mon Nov  7 16:20:52 2016 done: Mon Nov  7 16:20:54 2016
 Total Scan time:  8.170 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]