Result of FASTA (omim) for
pFN21AE4031
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4031, 242 aa
1>>>pF1KE4031 242 - 242 aa - 242 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7808+/-0.00041; mu= 14.6358+/- 0.026
mean_var=142.6699+/-31.097, 0's: 0 Z-trim(116.0): 108 B-trim: 2052 in 2/51
Lambda= 0.107376
statistics sampled from 26716 (26860) to 26716 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.315), width: 16
Scan time: 5.900
The best scores are: opt bits E(85289)
NP_116062 (OMIM: 610231) polycomb group RING finge ( 259) 448 80.6 2.9e-15
NP_009075 (OMIM: 600346) polycomb group RING finge ( 344) 426 77.3 3.7e-14
XP_005257698 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 426 77.3 3.7e-14
XP_005257699 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 426 77.3 3.7e-14
XP_005257697 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 426 77.3 3.7e-14
XP_016880505 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 426 77.3 3.7e-14
NP_005171 (OMIM: 164831) polycomb complex protein ( 326) 415 75.6 1.2e-13
NP_001011663 (OMIM: 607816) polycomb group RING fi ( 350) 411 75.0 1.9e-13
NP_115530 (OMIM: 607816) polycomb group RING finge ( 275) 291 56.3 6.4e-08
>>NP_116062 (OMIM: 610231) polycomb group RING finger pr (259 aa)
initn: 612 init1: 448 opt: 448 Z-score: 394.9 bits: 80.6 E(85289): 2.9e-15
Smith-Waterman score: 599; 40.8% identity (69.3% similar) in 238 aa overlap (5-238:35-255)
10 20 30
pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTECL
..:. :.: ::.: ::.::..::::.::::
NP_116 QGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECL
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE4 HTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQR
::::.::.::::. .. :: : : ::...:: . ::.:::::::::::::..: .. :
NP_116 HTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIR
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE4 EFYHKLGMEVPGDIKGETCSAKQHLDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQ
:::.. :.. . :: . :.. .. : :. . :.: :::
NP_116 EFYQSRGLDRVTQPTGE----EPALSNLGLPFSSFDHSKAH------------YYRYDEQ
130 140 150 160
160 170 180 190 200 210
pF1KE4 VSICLE-CNSSKLRG---LKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEIL
...::: .:.: .. :. :..:::..: : ::.. . ..: :. .....: ..:.:
NP_116 LNLCLERLSSGKDKNKSVLQNKYVRCSVRAEVRHLRRVLCHRLMLNP-QHVQLLFDNEVL
170 180 190 200 210 220
220 230 240
pF1KE4 GKDHTLKFVVVTRWRFKKAPLLLHYRPKMDLL
:.: . ..:: : .::::.: :
NP_116 PDHMTMKQIWLSRWFGKPSPLLLQYSVKEKRR
230 240 250
>>NP_009075 (OMIM: 600346) polycomb group RING finger pr (344 aa)
initn: 530 init1: 419 opt: 426 Z-score: 375.1 bits: 77.3 E(85289): 3.7e-14
Smith-Waterman score: 528; 36.4% identity (66.9% similar) in 236 aa overlap (3-236:4-228)
10 20 30 40 50
pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVI
: .::. ..: :. : ::.::.:::::..::::.::..:.:.::: :. :: : . .
NP_009 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 HQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGM-EVPGDIKGETCSAKQH
:...:: : :.:.::::::::::: . ::...:.:: . :::. : . . .
NP_009 HKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPN---GSNEDRGEV
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 LDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSA
:.... : . :. . . .: : ... :: ... . ...:: :
NP_009 LEQEK-GALSDDEIVSLSIEFYEGARDRDEKKGP------LENGDGDKEKTGVRFLRCPA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 QATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTL-KFVVVTRWRFKKAPLLLHYRP
::.:: ::. .:... : ....: ..: : . .:: .. . :: ...:: :.::
NP_009 AMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWR-RNGPLPLKYRV
180 190 200 210 220
240
pF1KE4 KMDLL
NP_009 QPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSS
230 240 250 260 270 280
>>XP_005257698 (OMIM: 600346) PREDICTED: polycomb group (344 aa)
initn: 530 init1: 419 opt: 426 Z-score: 375.1 bits: 77.3 E(85289): 3.7e-14
Smith-Waterman score: 528; 36.4% identity (66.9% similar) in 236 aa overlap (3-236:4-228)
10 20 30 40 50
pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVI
: .::. ..: :. : ::.::.:::::..::::.::..:.:.::: :. :: : . .
XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 HQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGM-EVPGDIKGETCSAKQH
:...:: : :.:.::::::::::: . ::...:.:: . :::. : . . .
XP_005 HKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPN---GSNEDRGEV
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 LDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSA
:.... : . :. . . .: : ... :: ... . ...:: :
XP_005 LEQEK-GALSDDEIVSLSIEFYEGARDRDEKKGP------LENGDGDKEKTGVRFLRCPA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 QATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTL-KFVVVTRWRFKKAPLLLHYRP
::.:: ::. .:... : ....: ..: : . .:: .. . :: ...:: :.::
XP_005 AMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWR-RNGPLPLKYRV
180 190 200 210 220
240
pF1KE4 KMDLL
XP_005 QPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSS
230 240 250 260 270 280
>>XP_005257699 (OMIM: 600346) PREDICTED: polycomb group (344 aa)
initn: 530 init1: 419 opt: 426 Z-score: 375.1 bits: 77.3 E(85289): 3.7e-14
Smith-Waterman score: 528; 36.4% identity (66.9% similar) in 236 aa overlap (3-236:4-228)
10 20 30 40 50
pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVI
: .::. ..: :. : ::.::.:::::..::::.::..:.:.::: :. :: : . .
XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 HQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGM-EVPGDIKGETCSAKQH
:...:: : :.:.::::::::::: . ::...:.:: . :::. : . . .
XP_005 HKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPN---GSNEDRGEV
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 LDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSA
:.... : . :. . . .: : ... :: ... . ...:: :
XP_005 LEQEK-GALSDDEIVSLSIEFYEGARDRDEKKGP------LENGDGDKEKTGVRFLRCPA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 QATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTL-KFVVVTRWRFKKAPLLLHYRP
::.:: ::. .:... : ....: ..: : . .:: .. . :: ...:: :.::
XP_005 AMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWR-RNGPLPLKYRV
180 190 200 210 220
240
pF1KE4 KMDLL
XP_005 QPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSS
230 240 250 260 270 280
>>XP_005257697 (OMIM: 600346) PREDICTED: polycomb group (344 aa)
initn: 530 init1: 419 opt: 426 Z-score: 375.1 bits: 77.3 E(85289): 3.7e-14
Smith-Waterman score: 528; 36.4% identity (66.9% similar) in 236 aa overlap (3-236:4-228)
10 20 30 40 50
pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVI
: .::. ..: :. : ::.::.:::::..::::.::..:.:.::: :. :: : . .
XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 HQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGM-EVPGDIKGETCSAKQH
:...:: : :.:.::::::::::: . ::...:.:: . :::. : . . .
XP_005 HKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPN---GSNEDRGEV
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 LDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSA
:.... : . :. . . .: : ... :: ... . ...:: :
XP_005 LEQEK-GALSDDEIVSLSIEFYEGARDRDEKKGP------LENGDGDKEKTGVRFLRCPA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 QATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTL-KFVVVTRWRFKKAPLLLHYRP
::.:: ::. .:... : ....: ..: : . .:: .. . :: ...:: :.::
XP_005 AMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWR-RNGPLPLKYRV
180 190 200 210 220
240
pF1KE4 KMDLL
XP_005 QPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSS
230 240 250 260 270 280
>>XP_016880505 (OMIM: 600346) PREDICTED: polycomb group (344 aa)
initn: 530 init1: 419 opt: 426 Z-score: 375.1 bits: 77.3 E(85289): 3.7e-14
Smith-Waterman score: 528; 36.4% identity (66.9% similar) in 236 aa overlap (3-236:4-228)
10 20 30 40 50
pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVI
: .::. ..: :. : ::.::.:::::..::::.::..:.:.::: :. :: : . .
XP_016 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 HQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGM-EVPGDIKGETCSAKQH
:...:: : :.:.::::::::::: . ::...:.:: . :::. : . . .
XP_016 HKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPN---GSNEDRGEV
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 LDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSA
:.... : . :. . . .: : ... :: ... . ...:: :
XP_016 LEQEK-GALSDDEIVSLSIEFYEGARDRDEKKGP------LENGDGDKEKTGVRFLRCPA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 QATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTL-KFVVVTRWRFKKAPLLLHYRP
::.:: ::. .:... : ....: ..: : . .:: .. . :: ...:: :.::
XP_016 AMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWR-RNGPLPLKYRV
180 190 200 210 220
240
pF1KE4 KMDLL
XP_016 QPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSS
230 240 250 260 270 280
>>NP_005171 (OMIM: 164831) polycomb complex protein BMI- (326 aa)
initn: 558 init1: 412 opt: 415 Z-score: 366.2 bits: 75.6 E(85289): 1.2e-13
Smith-Waterman score: 524; 36.6% identity (66.0% similar) in 238 aa overlap (3-236:4-226)
10 20 30 40 50
pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVI
: .::. ..: :. : ::.::.:::::. ::::.::..:.:.::: .. :: : . .
NP_005 MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 HQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGMEVPGDIKGETCSAKQHL
:...:: : :.:.::::::::::: . ::...:.:: . .: .
NP_005 HKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFY----------AAHPSADAANGS
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 DSHRNGETKADDS---SNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRC
. : ::. .:. .. : . : : .: :..:. . ..:: . ....::
NP_005 NEDR-GEVADEDKRIITDDEIISLSIEF-FDQNRLDRKVN--KDKEKSKEEVNDKRYLRC
120 130 140 150 160
180 190 200 210 220 230
pF1KE4 SAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTL-KFVVVTRWRFKKAPLLLHY
: ::.::.::. .:... . ..:.. .:: : .:: .. . :: ...:: :.:
NP_005 PAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWR-RNGPLPLKY
170 180 190 200 210 220
240
pF1KE4 RPKMDLL
:
NP_005 RVRPTCKRMKISHQRDGLTNAGELESDSGSDKANSPAGGIPSTSSCLPSPSTPVQSPHPQ
230 240 250 260 270 280
>>NP_001011663 (OMIM: 607816) polycomb group RING finger (350 aa)
initn: 532 init1: 411 opt: 411 Z-score: 362.5 bits: 75.0 E(85289): 1.9e-13
Smith-Waterman score: 506; 36.3% identity (67.9% similar) in 234 aa overlap (4-235:121-340)
10 20 30
pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTEC
: :.: ... .: : .:.::::::::.:::
NP_001 EEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITEC
100 110 120 130 140 150
40 50 60 70 80 90
pF1KE4 LHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQ
:::::.::.:... .: :: : ::.::..:: : :: .:::::::: .:.: : ...
NP_001 LHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQM
160 170 180 190 200 210
100 110 120 130 140 150
pF1KE4 REFYHKLGMEVPGDIKGETCSAKQHLDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDE
..::.. :.::: .. : . : .. :. .: . :: : :
NP_001 HDFYKERGLEVPKP------AVPQPVPSSKGRSKKVLESVFRI----PPELDM----SLL
220 230 240 250
160 170 180 190 200 210
pF1KE4 QVSICLECNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKD
: . ...... :..:..: :..::. :..::. .:..:. ..::.:....: .
NP_001 LEFIGANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQY
260 270 280 290 300 310
220 230 240
pF1KE4 HTLKFV--VVTRWRFKKAPLLLHYRPKMDLL
.::. . .. .. . :.:::
NP_001 QTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT
320 330 340 350
>>NP_115530 (OMIM: 607816) polycomb group RING finger pr (275 aa)
initn: 407 init1: 286 opt: 291 Z-score: 263.2 bits: 56.3 E(85289): 6.4e-08
Smith-Waterman score: 291; 42.1% identity (69.2% similar) in 107 aa overlap (4-103:121-224)
10 20 30
pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTEC
: :.: ... .: : .:.::::::::.:::
NP_115 EEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITEC
100 110 120 130 140 150
40 50 60 70 80
pF1KE4 LHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYI------GHDRTMQDIVYKLVPGLQE
:::::.::.:... .: :: : ::.::..:: : :: . .. . : : :
NP_115 LHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNISANEGTGHFKPLEKKFVR-VSG--E
160 170 180 190 200
90 100 110 120 130 140
pF1KE4 AEMRKQREFYH-KLGMEVPGDIKGETCSAKQHLDSHRNGETKADDSSNKEAAEEKPEEDN
: . . ..: . :.:..
NP_115 ATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGL
210 220 230 240 250 260
242 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:18:19 2016 done: Sun Nov 6 04:18:20 2016
Total Scan time: 5.900 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]