Result of FASTA (omim) for
pFN21AE4024
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4024, 227 aa
1>>>pF1KE4024 227 - 227 aa - 227 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6632+/-0.000335; mu= 13.7782+/- 0.021
mean_var=125.4282+/-26.324, 0's: 0 Z-trim(119.0): 96 B-trim: 949 in 1/49
Lambda= 0.114519
statistics sampled from 32393 (32520) to 32393 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.381), width: 16
Scan time: 6.420
The best scores are: opt bits E(85289)
NP_061935 (OMIM: 617163) RING finger protein 186 [ ( 227) 1569 269.7 2.8e-72
XP_005266709 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 202 43.8 0.00025
XP_005266707 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 202 43.8 0.00025
XP_011524181 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 202 43.8 0.00025
XP_016881102 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 202 43.8 0.00025
XP_011524180 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 202 43.8 0.00025
NP_775828 (OMIM: 616512) E3 ubiquitin-protein liga ( 203) 202 43.8 0.00025
XP_016881101 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 202 43.8 0.00025
XP_016872587 (OMIM: 605493) PREDICTED: tripartite ( 744) 179 40.7 0.0081
NP_001234935 (OMIM: 605493) tripartite motif-conta ( 744) 179 40.7 0.0081
NP_006449 (OMIM: 605493) tripartite motif-containi ( 744) 179 40.7 0.0081
NP_150594 (OMIM: 605493) tripartite motif-containi ( 744) 179 40.7 0.0081
XP_011518146 (OMIM: 605493) PREDICTED: tripartite ( 744) 179 40.7 0.0081
>>NP_061935 (OMIM: 617163) RING finger protein 186 [Homo (227 aa)
initn: 1569 init1: 1569 opt: 1569 Z-score: 1418.7 bits: 269.7 E(85289): 2.8e-72
Smith-Waterman score: 1569; 100.0% identity (100.0% similar) in 227 aa overlap (1-227:1-227)
10 20 30 40 50 60
pF1KE4 MACTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 MACTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 AFCAICLKLLLCVQDNTWSITCPLCRKVTAVPGGLICSLRDHEAVVGQLAQPCTEVSLCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 AFCAICLKLLLCVQDNTWSITCPLCRKVTAVPGGLICSLRDHEAVVGQLAQPCTEVSLCP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 QGLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 QGLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRW
130 140 150 160 170 180
190 200 210 220
pF1KE4 VLTFIIALALLMSTLFCCLPSTRGSCWPSSRTLFCREQKHSHISSIA
:::::::::::::::::::::::::::::::::::::::::::::::
NP_061 VLTFIIALALLMSTLFCCLPSTRGSCWPSSRTLFCREQKHSHISSIA
190 200 210 220
>>XP_005266709 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa)
initn: 182 init1: 129 opt: 202 Z-score: 198.7 bits: 43.8 E(85289): 0.00025
Smith-Waterman score: 202; 38.6% identity (60.2% similar) in 83 aa overlap (33-114:5-84)
10 20 30 40 50 60
pF1KE4 CTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAF
: . ::: .: . :: : :::: :.:.
XP_005 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTC
10 20 30
70 80 90 100 110 120
pF1KE4 CAICLKLLLCVQDNTWSITCPLCRKVTAVPGGL-ICSLRDHEAVVGQLAQPCTEVSLCPQ
:..::. . : . . :: :: :: .: :. . .: : :.. .: : :
XP_005 CSVCLQQMRTSQKD---VRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 GLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWV
XP_005 IKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAV
100 110 120 130 140 150
>>XP_005266707 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa)
initn: 182 init1: 129 opt: 202 Z-score: 198.7 bits: 43.8 E(85289): 0.00025
Smith-Waterman score: 202; 38.6% identity (60.2% similar) in 83 aa overlap (33-114:5-84)
10 20 30 40 50 60
pF1KE4 CTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAF
: . ::: .: . :: : :::: :.:.
XP_005 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTC
10 20 30
70 80 90 100 110 120
pF1KE4 CAICLKLLLCVQDNTWSITCPLCRKVTAVPGGL-ICSLRDHEAVVGQLAQPCTEVSLCPQ
:..::. . : . . :: :: :: .: :. . .: : :.. .: : :
XP_005 CSVCLQQMRTSQKD---VRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 GLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWV
XP_005 IKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAV
100 110 120 130 140 150
>>XP_011524181 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa)
initn: 182 init1: 129 opt: 202 Z-score: 198.7 bits: 43.8 E(85289): 0.00025
Smith-Waterman score: 202; 38.6% identity (60.2% similar) in 83 aa overlap (33-114:5-84)
10 20 30 40 50 60
pF1KE4 CTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAF
: . ::: .: . :: : :::: :.:.
XP_011 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTC
10 20 30
70 80 90 100 110 120
pF1KE4 CAICLKLLLCVQDNTWSITCPLCRKVTAVPGGL-ICSLRDHEAVVGQLAQPCTEVSLCPQ
:..::. . : . . :: :: :: .: :. . .: : :.. .: : :
XP_011 CSVCLQQMRTSQKD---VRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 GLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWV
XP_011 IKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAV
100 110 120 130 140 150
>>XP_016881102 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa)
initn: 182 init1: 129 opt: 202 Z-score: 198.7 bits: 43.8 E(85289): 0.00025
Smith-Waterman score: 202; 38.6% identity (60.2% similar) in 83 aa overlap (33-114:5-84)
10 20 30 40 50 60
pF1KE4 CTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAF
: . ::: .: . :: : :::: :.:.
XP_016 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTC
10 20 30
70 80 90 100 110 120
pF1KE4 CAICLKLLLCVQDNTWSITCPLCRKVTAVPGGL-ICSLRDHEAVVGQLAQPCTEVSLCPQ
:..::. . : . . :: :: :: .: :. . .: : :.. .: : :
XP_016 CSVCLQQMRTSQKD---VRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 GLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWV
XP_016 IKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAV
100 110 120 130 140 150
>>XP_011524180 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa)
initn: 182 init1: 129 opt: 202 Z-score: 198.7 bits: 43.8 E(85289): 0.00025
Smith-Waterman score: 202; 38.6% identity (60.2% similar) in 83 aa overlap (33-114:5-84)
10 20 30 40 50 60
pF1KE4 CTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAF
: . ::: .: . :: : :::: :.:.
XP_011 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTC
10 20 30
70 80 90 100 110 120
pF1KE4 CAICLKLLLCVQDNTWSITCPLCRKVTAVPGGL-ICSLRDHEAVVGQLAQPCTEVSLCPQ
:..::. . : . . :: :: :: .: :. . .: : :.. .: : :
XP_011 CSVCLQQMRTSQKD---VRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 GLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWV
XP_011 IKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAV
100 110 120 130 140 150
>>NP_775828 (OMIM: 616512) E3 ubiquitin-protein ligase R (203 aa)
initn: 182 init1: 129 opt: 202 Z-score: 198.7 bits: 43.8 E(85289): 0.00025
Smith-Waterman score: 202; 38.6% identity (60.2% similar) in 83 aa overlap (33-114:5-84)
10 20 30 40 50 60
pF1KE4 CTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAF
: . ::: .: . :: : :::: :.:.
NP_775 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTC
10 20 30
70 80 90 100 110 120
pF1KE4 CAICLKLLLCVQDNTWSITCPLCRKVTAVPGGL-ICSLRDHEAVVGQLAQPCTEVSLCPQ
:..::. . : . . :: :: :: .: :. . .: : :.. .: : :
NP_775 CSVCLQQMRTSQKD---VRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 GLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWV
NP_775 IKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAV
100 110 120 130 140 150
>>XP_016881101 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa)
initn: 182 init1: 129 opt: 202 Z-score: 198.7 bits: 43.8 E(85289): 0.00025
Smith-Waterman score: 202; 38.6% identity (60.2% similar) in 83 aa overlap (33-114:5-84)
10 20 30 40 50 60
pF1KE4 CTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAF
: . ::: .: . :: : :::: :.:.
XP_016 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTC
10 20 30
70 80 90 100 110 120
pF1KE4 CAICLKLLLCVQDNTWSITCPLCRKVTAVPGGL-ICSLRDHEAVVGQLAQPCTEVSLCPQ
:..::. . : . . :: :: :: .: :. . .: : :.. .: : :
XP_016 CSVCLQQMRTSQKD---VRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 GLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWV
XP_016 IKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAV
100 110 120 130 140 150
>>XP_016872587 (OMIM: 605493) PREDICTED: tripartite moti (744 aa)
initn: 127 init1: 83 opt: 179 Z-score: 171.6 bits: 40.7 E(85289): 0.0081
Smith-Waterman score: 180; 30.1% identity (58.4% similar) in 113 aa overlap (38-149:20-118)
10 20 30 40 50 60
pF1KE4 QQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAFCAICL
: : .: . :.:: :.: : :.:: ::
XP_016 MAKREDSPGPEVQPMDKQFLVCSICLDRYQCP---KVLPCLHTFCERCL
10 20 30 40
70 80 90 100 110 120
pF1KE4 KLLLCVQDNTWSITCPLCRKVTAVPGGLICSLRDHEAVVGQLAQPCTEVSLCPQGLVDPA
. . .: . ...::.::... .: . .:... ...: . .. :.: ::
XP_016 QNYIPAQ--SLTLSCPVCRQTSILPEQGVSALQNNF-FISSLMEAMQQA---PDGAHDPE
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE4 DLAAGHP-SLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWVLTFII
: :: :.:. :. ::
XP_016 D---PHPLSVVA--GRPLSCPNHEGKTMEFYCEACETAMCGECRAGEHREHGTVLLRDVV
110 120 130 140 150
>>NP_001234935 (OMIM: 605493) tripartite motif-containin (744 aa)
initn: 127 init1: 83 opt: 179 Z-score: 171.6 bits: 40.7 E(85289): 0.0081
Smith-Waterman score: 180; 30.1% identity (58.4% similar) in 113 aa overlap (38-149:20-118)
10 20 30 40 50 60
pF1KE4 QQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAFCAICL
: : .: . :.:: :.: : :.:: ::
NP_001 MAKREDSPGPEVQPMDKQFLVCSICLDRYQCP---KVLPCLHTFCERCL
10 20 30 40
70 80 90 100 110 120
pF1KE4 KLLLCVQDNTWSITCPLCRKVTAVPGGLICSLRDHEAVVGQLAQPCTEVSLCPQGLVDPA
. . .: . ...::.::... .: . .:... ...: . .. :.: ::
NP_001 QNYIPAQ--SLTLSCPVCRQTSILPEQGVSALQNNF-FISSLMEAMQQA---PDGAHDPE
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE4 DLAAGHP-SLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWVLTFII
: :: :.:. :. ::
NP_001 D---PHPLSVVA--GRPLSCPNHEGKTMEFYCEACETAMCGECRAGEHREHGTVLLRDVV
110 120 130 140 150
227 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 03:25:50 2016 done: Sun Nov 6 03:25:51 2016
Total Scan time: 6.420 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]