Result of FASTA (omim) for
pFN21AE4016
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4016, 195 aa
1>>>pF1KE4016 195 - 195 aa - 195 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0983+/-0.000384; mu= 14.9392+/- 0.024
mean_var=82.7363+/-15.354, 0's: 0 Z-trim(113.7): 192 B-trim: 34 in 1/55
Lambda= 0.141002
statistics sampled from 22937 (23162) to 22937 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.272), width: 16
Scan time: 5.570
The best scores are: opt bits E(85289)
NP_009167 (OMIM: 606988) calcineurin B homologous ( 195) 1261 265.9 2.9e-71
XP_016877368 (OMIM: 606988) PREDICTED: calcineurin ( 123) 766 165.1 4.2e-41
NP_000936 (OMIM: 601302) calcineurin subunit B typ ( 170) 289 68.2 8.6e-12
XP_016875021 (OMIM: 611585) PREDICTED: calcineurin ( 251) 284 67.3 2.3e-11
NP_671709 (OMIM: 613821) calcineurin subunit B typ ( 173) 257 61.7 7.9e-10
NP_060369 (OMIM: 611585) calcineurin B homologous ( 214) 253 60.9 1.6e-09
XP_016875022 (OMIM: 611585) PREDICTED: calcineurin ( 216) 224 55.0 9.8e-08
XP_011536805 (OMIM: 611585) PREDICTED: calcineurin ( 202) 210 52.2 6.7e-07
NP_006374 (OMIM: 605564,609439,614869) calcium and ( 187) 200 50.1 2.6e-06
XP_005254183 (OMIM: 605564,609439,614869) PREDICTE ( 210) 198 49.7 3.7e-06
NP_775285 (OMIM: 604661) Kv channel-interacting pr ( 227) 186 47.3 2.2e-05
NP_473454 (OMIM: 610645) calcium and integrin-bind ( 187) 173 44.6 0.00012
NP_001161797 (OMIM: 611585) calcineurin B homologo ( 187) 167 43.4 0.00027
NP_001258818 (OMIM: 605564,609439,614869) calcium ( 138) 155 40.8 0.0012
NP_001258817 (OMIM: 605564,609439,614869) calcium ( 144) 155 40.8 0.0012
XP_006720437 (OMIM: 605564,609439,614869) PREDICTE ( 144) 155 40.8 0.0012
NP_001288153 (OMIM: 605564,609439,614869) calcium ( 192) 155 40.9 0.0015
XP_011519463 (OMIM: 605564,609439,614869) PREDICTE ( 167) 153 40.5 0.0018
NP_004335 (OMIM: 300006) centrin-2 [Homo sapiens] ( 172) 150 39.9 0.0028
XP_011512186 (OMIM: 608182) PREDICTED: Kv channel- ( 236) 150 40.0 0.0035
XP_011512187 (OMIM: 608182) PREDICTED: Kv channel- ( 232) 148 39.6 0.0046
NP_004057 (OMIM: 603187) centrin-1 [Homo sapiens] ( 172) 146 39.1 0.005
XP_011512191 (OMIM: 608182) PREDICTED: Kv channel- ( 195) 146 39.1 0.0054
XP_011512189 (OMIM: 608182) PREDICTED: Kv channel- ( 195) 146 39.1 0.0054
NP_004267 (OMIM: 605563) calcium-binding protein 1 ( 167) 145 38.9 0.0056
XP_011512188 (OMIM: 608182) PREDICTED: Kv channel- ( 223) 146 39.2 0.006
NP_112482 (OMIM: 605563) calcium-binding protein 1 ( 227) 146 39.2 0.0061
XP_011512185 (OMIM: 608182) PREDICTED: Kv channel- ( 240) 146 39.2 0.0063
NP_001122298 (OMIM: 603315) neuronal calcium senso ( 172) 144 38.7 0.0066
XP_011512184 (OMIM: 608182) PREDICTED: Kv channel- ( 257) 146 39.2 0.0066
NP_055101 (OMIM: 603315) neuronal calcium sensor 1 ( 190) 144 38.7 0.0071
XP_006715136 (OMIM: 600364,602093) PREDICTED: guan ( 128) 141 37.9 0.0081
>>NP_009167 (OMIM: 606988) calcineurin B homologous prot (195 aa)
initn: 1261 init1: 1261 opt: 1261 Z-score: 1400.5 bits: 265.9 E(85289): 2.9e-71
Smith-Waterman score: 1261; 100.0% identity (100.0% similar) in 195 aa overlap (1-195:1-195)
10 20 30 40 50 60
pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVL
130 140 150 160 170 180
190
pF1KE4 EKVDVEQKMSIRFLH
:::::::::::::::
NP_009 EKVDVEQKMSIRFLH
190
>>XP_016877368 (OMIM: 606988) PREDICTED: calcineurin B h (123 aa)
initn: 765 init1: 765 opt: 766 Z-score: 858.9 bits: 165.1 E(85289): 4.2e-41
Smith-Waterman score: 766; 95.9% identity (97.5% similar) in 122 aa overlap (1-122:1-122)
10 20 30 40 50 60
pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::. .
XP_016 PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHLEEE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVL
:
XP_016 RYI
>>NP_000936 (OMIM: 601302) calcineurin subunit B type 1 (170 aa)
initn: 436 init1: 287 opt: 289 Z-score: 332.7 bits: 68.2 E(85289): 8.6e-12
Smith-Waterman score: 431; 43.2% identity (69.8% similar) in 169 aa overlap (23-191:15-168)
10 20 30 40 50 60
pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN
:. ..: :: .:: .:: ..:.:: :.:. .::: :
NP_000 MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQN
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFR
:: .:.:. : .:. .:.:. :.. ...: :.:. ::.::::
NP_000 PLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQ---------------KLRFAFR
60 70 80 90
130 140 150 160 170 180
pF1KE4 LYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVL
.::.::: :: ::.:::.:::: :..: :: .:.:.:: .::.:::. ::: :: :.
NP_000 IYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVV
100 110 120 130 140 150
190
pF1KE4 EKVDVEQKMSIRFLH
.:...:: .
NP_000 GGLDIHKKMVVDV
160 170
>>XP_016875021 (OMIM: 611585) PREDICTED: calcineurin B h (251 aa)
initn: 357 init1: 102 opt: 284 Z-score: 325.0 bits: 67.3 E(85289): 2.3e-11
Smith-Waterman score: 346; 33.0% identity (66.5% similar) in 206 aa overlap (1-195:54-243)
10 20 30
pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITR
::. :. .::..:.. .:::: .:: .
XP_016 RTRGQSRRCAAEASAGPERDARPGAPAAGTMGAAHSA---SEEVRELEGKTGFSSDQIEQ
30 40 50 60 70 80
40 50 60 70 80
pF1KE4 LYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFF--------PEG-EDQVNFR
:. :: .:. :.. :. .:.:. .:.: .::. ..:. ::: : : :..::.
XP_016 LHRRFKQLS-GDQPTIRKENFNNVPDLELNPIRSKIVRAFFDNRNLRKGPSGLADEINFE
90 100 110 120 130
90 100 110 120 130 140
pF1KE4 GFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDEKISRDELLQVLRM
:. ...::::. . ..:. ::..::.: :..:: :.: .:. .: .:..
XP_016 DFLTIMSYFRPIDTTMDEEQVEL-----SRKEKLRFLFHMYDSDSDGRITLEEYRNVVEE
140 150 160 170 180 190
150 160 170 180 190
pF1KE4 MVGVN--ISDEQLGSIADRTIQEADQDGDSAISFTEFVKVLEKVDVEQKMSIRFLH
... : : :. :::: ...:: ... . ... . .:.: :: .:::.
XP_016 LLSGNPHIEKESARSIADGAMMEA-----ASVCMGQMI--WQGIDIETKMHVRFLNMETM
200 210 220 230 240
XP_016 ALCH
250
>>NP_671709 (OMIM: 613821) calcineurin subunit B type 2 (173 aa)
initn: 400 init1: 257 opt: 257 Z-score: 297.4 bits: 61.7 E(85289): 7.9e-10
Smith-Waterman score: 399; 41.3% identity (68.9% similar) in 167 aa overlap (23-189:18-169)
10 20 30 40 50 60
pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN
:....: :: :: .:: ..:.:: :.:. .::: :
NP_671 MSTMGNEASYPAEMCSHFDNDEIKRLGRRFKKLDLDKSGSLSVEEFMSLPELRHN
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFR
:: :.:..: .:. .:.:. :. ..: .:.: : .::.:::
NP_671 PLVRRVIDVFDTDGDGEVDFKEFILGTSQF----------SVKGDEE-----QKLRFAFS
60 70 80 90 100
130 140 150 160 170 180
pF1KE4 LYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVL
.::.::: :: ::.:::.:::: :..: :: ...:.:: :.:::. ::: :: :.
NP_671 IYDMDKDGYISNGELFQVLKMMVGNNLTDWQLQQLVDKTIIILDKDGDGKISFEEFSAVV
110 120 130 140 150 160
190
pF1KE4 EKVDVEQKMSIRFLH
. .....:.
NP_671 RDLEIHKKLVLIV
170
>>NP_060369 (OMIM: 611585) calcineurin B homologous prot (214 aa)
initn: 334 init1: 102 opt: 253 Z-score: 291.8 bits: 60.9 E(85289): 1.6e-09
Smith-Waterman score: 376; 34.0% identity (67.0% similar) in 215 aa overlap (1-195:1-206)
10 20 30 40 50 60
pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN
::. :. .::..:.. .:::: .:: .:. :: .:. :.. :. .:.:. .:.: .:
NP_060 MGAAHSA---SEEVRELEGKTGFSSDQIEQLHRRFKQLS-GDQPTIRKENFNNVPDLELN
10 20 30 40 50
70 80 90 100 110
pF1KE4 PLGDRIINAFF--------PEG-EDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSR
:. ..:. ::: : : :..::. :. ...::::. . ..:. ::
NP_060 PIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPIDTTMDEEQVEL-----SR
60 70 80 90 100 110
120 130 140 150 160
pF1KE4 SNKLHFAFRLYDLDKDEKISRDELLQVLRMMVGVN--ISDEQLGSIADRTIQEA------
..::.: :..:: :.: .:. .: .:.. ... : : :. :::: ...::
NP_060 KEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADGAMMEAASVCMG
120 130 140 150 160 170
170 180 190
pF1KE4 DQDGDSA---ISFTEFVKVLEKVDVEQKMSIRFLH
... :.. :.: .:.:. . .:.: :: .:::.
NP_060 QMEPDQVYEGITFEDFLKIWQGIDIETKMHVRFLNMETMALCH
180 190 200 210
>>XP_016875022 (OMIM: 611585) PREDICTED: calcineurin B h (216 aa)
initn: 286 init1: 102 opt: 224 Z-score: 259.9 bits: 55.0 E(85289): 9.8e-08
Smith-Waterman score: 286; 35.4% identity (68.0% similar) in 147 aa overlap (1-138:54-191)
10 20 30
pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITR
::. :. .::..:.. .:::: .:: .
XP_016 RTRGQSRRCAAEASAGPERDARPGAPAAGTMGAAHSA---SEEVRELEGKTGFSSDQIEQ
30 40 50 60 70 80
40 50 60 70 80
pF1KE4 LYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFF--------PEG-EDQVNFR
:. :: .:. :.. :. .:.:. .:.: .::. ..:. ::: : : :..::.
XP_016 LHRRFKQLS-GDQPTIRKENFNNVPDLELNPIRSKIVRAFFDNRNLRKGPSGLADEINFE
90 100 110 120 130
90 100 110 120 130 140
pF1KE4 GFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDEKISRDELLQVLRM
:. ...::::. . ..:. ::..::.: :..:: :.: .:. .: .:
XP_016 DFLTIMSYFRPIDTTMDEEQVEL-----SRKEKLRFLFHMYDSDSDGRITLEEYRNVKWS
140 150 160 170 180 190
150 160 170 180 190
pF1KE4 MVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVLEKVDVEQKMSIRFLH
XP_016 RSCCRETLTSRRSPLAPSPTGP
200 210
>>XP_011536805 (OMIM: 611585) PREDICTED: calcineurin B h (202 aa)
initn: 288 init1: 102 opt: 210 Z-score: 244.9 bits: 52.2 E(85289): 6.7e-07
Smith-Waterman score: 333; 33.3% identity (66.1% similar) in 192 aa overlap (24-195:9-194)
10 20 30 40 50 60
pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN
: .:: .:. :: .:. :.. :. .:.:. .:.: .:
XP_011 MESSQEHVSSDQIEQLHRRFKQLS-GDQPTIRKENFNNVPDLELN
10 20 30 40
70 80 90 100 110
pF1KE4 PLGDRIINAFF--------PEG-EDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSR
:. ..:. ::: : : :..::. :. ...::::. . ..:. ::
XP_011 PIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPIDTTMDEEQVEL-----SR
50 60 70 80 90
120 130 140 150 160
pF1KE4 SNKLHFAFRLYDLDKDEKISRDELLQVLRMMVGVN--ISDEQLGSIADRTIQEA------
..::.: :..:: :.: .:. .: .:.. ... : : :. :::: ...::
XP_011 KEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADGAMMEAASVCMG
100 110 120 130 140 150
170 180 190
pF1KE4 DQDGDSA---ISFTEFVKVLEKVDVEQKMSIRFLH
... :.. :.: .:.:. . .:.: :: .:::.
XP_011 QMEPDQVYEGITFEDFLKIWQGIDIETKMHVRFLNMETMALCH
160 170 180 190 200
>>NP_006374 (OMIM: 605564,609439,614869) calcium and int (187 aa)
initn: 264 init1: 142 opt: 200 Z-score: 234.3 bits: 50.1 E(85289): 2.6e-06
Smith-Waterman score: 234; 26.7% identity (60.4% similar) in 202 aa overlap (1-192:1-186)
10 20 30 40 50
pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSRED---------F
::.. .:.. .:.:.. . : :....: .:.::: : . :.. .
NP_006 MGNK-QTIFTEEQLDNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLI
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 QRIPELAINPLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSR
..::: ::. .::. :: .:: ...: :. : . .. .:. :
NP_006 IQMPELRENPFKERIVAAFSEDGEGNLTFNDFV---DMFSVLCES-------APREL---
60 70 80 90 100
120 130 140 150 160 170
pF1KE4 SNKLHFAFRLYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAI
: ..::..::.. :. : ...: .: .. ....:.. . :..:.::: :::. .
NP_006 --KANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEEEVVLVCDKVIEEADLDGDGKL
110 120 130 140 150 160
180 190
pF1KE4 SFTEFVKVLEKV-DVEQKMSIRFLH
.:..: .. :. : . . ::
NP_006 GFADFEDMIAKAPDFLSTFHIRI
170 180
>>XP_005254183 (OMIM: 605564,609439,614869) PREDICTED: c (210 aa)
initn: 250 init1: 142 opt: 198 Z-score: 231.4 bits: 49.7 E(85289): 3.7e-06
Smith-Waterman score: 232; 26.7% identity (60.7% similar) in 191 aa overlap (1-182:1-175)
10 20 30 40 50
pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSRED---------F
::.. .:.. .:.:.. . : :....: .:.::: : . :.. .
XP_005 MGNK-QTIFTEEQLDNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLI
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 QRIPELAINPLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSR
..::: ::. .::. :: .:: ...: :. : . . ..:. :
XP_005 IQMPELRENPFKERIVAAFSEDGEGNLTFNDFVD---MFSVLCE-------SAPREL---
60 70 80 90 100
120 130 140 150 160 170
pF1KE4 SNKLHFAFRLYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAI
: ..::..::.. :. : ...: .: .. ....:.. . :..:.::: :::. .
XP_005 --KANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEEEVVLVCDKVIEEADLDGDGKL
110 120 130 140 150 160
180 190
pF1KE4 SFTEFVKVLEKVDVEQKMSIRFLH
.:..: .. :
XP_005 GFADFEDMIAKAPDFLRCCHYRGRAWAGQSRAGRDVGAEAPITRYL
170 180 190 200 210
195 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:21:22 2016 done: Sun Nov 6 04:21:23 2016
Total Scan time: 5.570 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]