Result of FASTA (omim) for
pFN21AE3994
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3994, 421 aa
1>>>pF1KE3994 421 - 421 aa - 421 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.1278+/-0.000534; mu= 7.6449+/- 0.033
mean_var=190.3190+/-38.481, 0's: 0 Z-trim(114.3): 289 B-trim: 36 in 1/50
Lambda= 0.092968
statistics sampled from 23669 (24059) to 23669 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.666), E-opt: 0.2 (0.282), width: 16
Scan time: 8.140
The best scores are: opt bits E(85289)
NP_060343 (OMIM: 615051) ankyrin repeat and SOCS b ( 421) 2820 391.5 2.1e-108
NP_001189332 (OMIM: 615051) ankyrin repeat and SOC ( 392) 1576 224.6 3.4e-58
NP_821066 (OMIM: 615051) ankyrin repeat and SOCS b ( 197) 873 130.0 5.2e-30
NP_065082 (OMIM: 610734) ankyrin repeat domain-con ( 360) 226 43.5 0.001
NP_001278147 (OMIM: 610734) ankyrin repeat domain- ( 446) 226 43.6 0.0012
XP_005254586 (OMIM: 612516) PREDICTED: uveal autoa (1392) 221 43.5 0.004
XP_016877884 (OMIM: 612516) PREDICTED: uveal autoa (1399) 221 43.5 0.004
NP_001008225 (OMIM: 612516) uveal autoantigen with (1403) 221 43.5 0.004
XP_016877883 (OMIM: 612516) PREDICTED: uveal autoa (1405) 221 43.5 0.004
NP_060473 (OMIM: 612516) uveal autoantigen with co (1416) 221 43.5 0.004
XP_011520055 (OMIM: 612516) PREDICTED: uveal autoa (1425) 221 43.5 0.004
XP_011520054 (OMIM: 612516) PREDICTED: uveal autoa (1436) 221 43.5 0.0041
XP_005251814 (OMIM: 600831) PREDICTED: death-assoc ( 839) 214 42.3 0.0054
>>NP_060343 (OMIM: 615051) ankyrin repeat and SOCS box p (421 aa)
initn: 2820 init1: 2820 opt: 2820 Z-score: 2067.2 bits: 391.5 E(85289): 2.1e-108
Smith-Waterman score: 2820; 100.0% identity (100.0% similar) in 421 aa overlap (1-421:1-421)
10 20 30 40 50 60
pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 LLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 SSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 QVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 QVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 HIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 HIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 LHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDD
370 380 390 400 410 420
pF1KE3 I
:
NP_060 I
>>NP_001189332 (OMIM: 615051) ankyrin repeat and SOCS bo (392 aa)
initn: 1528 init1: 1528 opt: 1576 Z-score: 1165.9 bits: 224.6 E(85289): 3.4e-58
Smith-Waterman score: 2574; 93.1% identity (93.1% similar) in 421 aa overlap (1-421:1-392)
10 20 30 40 50 60
pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 LLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALA
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHG---------
130 140 150 160 170
190 200 210 220 230 240
pF1KE3 SSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCF
::::::::::::::::::::::::::::::::::::::::
NP_001 --------------------ADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCF
180 190 200 210
250 260 270 280 290 300
pF1KE3 QVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGF
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE3 HIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQA
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE3 LHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDD
340 350 360 370 380 390
pF1KE3 I
:
NP_001 I
>>NP_821066 (OMIM: 615051) ankyrin repeat and SOCS box p (197 aa)
initn: 915 init1: 873 opt: 873 Z-score: 659.8 bits: 130.0 E(85289): 5.2e-30
Smith-Waterman score: 873; 100.0% identity (100.0% similar) in 134 aa overlap (1-134:1-134)
10 20 30 40 50 60
pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_821 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_821 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 LLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALA
::::::::::::::
NP_821 LLVHHGADVNRRDREKLLCSMLWPAATGCRSTILRTFVSYWKEGQTSRPPPKMGTQCSPA
130 140 150 160 170 180
>>NP_065082 (OMIM: 610734) ankyrin repeat domain-contain (360 aa)
initn: 194 init1: 85 opt: 226 Z-score: 187.7 bits: 43.5 E(85289): 0.001
Smith-Waterman score: 226; 30.5% identity (62.6% similar) in 187 aa overlap (30-212:138-315)
10 20 30 40 50
pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQE---SLDRPSYV-ASEESRILVLTEL
:: .: .:. ... :. :... :. ..
NP_065 DVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKF
110 120 130 140 150 160
60 70 80 90 100 110
pF1KE3 LERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQ
: . . .. .:: . . : . . :: .::...:.: . ::.: : ..
NP_065 LADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDC-TAMHWACRGGH
170 180 190 200 210 220
120 130 140 150 160 170
pF1KE3 PDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTAL
..:.:: ::::.: ::.. :.:: .: . . . ....:.:: ..:: :..: :::
NP_065 LEVVKLLQSHGADTNVRDKLL-STPLHVAVRTGQ-VEIVEHFLSLGLEINARDREGDTAL
230 240 250 260 270 280
180 190 200 210 220 230
pF1KE3 LHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMI
: :.:... . :.::: :::. . . : :
NP_065 -H-----DAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGA
290 300 310 320 330
240 250 260 270 280 290
pF1KE3 NRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGAS
NP_065 EHNGLEGPNDSGRETPQPVPAQ
340 350 360
>>NP_001278147 (OMIM: 610734) ankyrin repeat domain-cont (446 aa)
initn: 194 init1: 85 opt: 226 Z-score: 186.6 bits: 43.6 E(85289): 0.0012
Smith-Waterman score: 226; 30.5% identity (62.6% similar) in 187 aa overlap (30-212:224-401)
10 20 30 40 50
pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQE---SLDRPSYV-ASEESRILVLTEL
:: .: .:. ... :. :... :. ..
NP_001 DVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKF
200 210 220 230 240 250
60 70 80 90 100 110
pF1KE3 LERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQ
: . . .. .:: . . : . . :: .::...:.: . ::.: : ..
NP_001 LADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDC-TAMHWACRGGH
260 270 280 290 300 310
120 130 140 150 160 170
pF1KE3 PDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTAL
..:.:: ::::.: ::.. :.:: .: . . . ....:.:: ..:: :..: :::
NP_001 LEVVKLLQSHGADTNVRDKLL-STPLHVAVRTGQ-VEIVEHFLSLGLEINARDREGDTAL
320 330 340 350 360 370
180 190 200 210 220 230
pF1KE3 LHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMI
: :.:... . :.::: :::. . . : :
NP_001 -H-----DAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGA
380 390 400 410 420
240 250 260 270 280 290
pF1KE3 NRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGAS
NP_001 EHNGLEGPNDSGRETPQPVPAQ
430 440
>>XP_005254586 (OMIM: 612516) PREDICTED: uveal autoantig (1392 aa)
initn: 236 init1: 92 opt: 221 Z-score: 177.1 bits: 43.5 E(85289): 0.004
Smith-Waterman score: 221; 27.0% identity (57.3% similar) in 248 aa overlap (18-260:37-277)
10 20 30 40
pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSY-VASEE
: .::.. :. .: . . : . :.. .
XP_005 SCTPKNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGV-NPGKLDVEGRSVFHVVTSK
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 SRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTA
. . :. .: . . . . ::: :. : . . ::... . : . ::
XP_005 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHAD-LQGRTA
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE3 LHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNA
:: :.. . :. ..:: :::.:: .: . .:: ::.. . : : :.: :::::.
XP_005 LHDAAMADCPSSIQLLCDHGASVNAKD-VDGRTPLVLATQMSRPTIC-QLLIDRGADVNS
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE3 ADKHGKTALLHA--LASSDGVQ--IHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLG
::...:::. . . :.:. :.: .: :: : : . .. ::.. :. :
XP_005 RDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNL---DILTLL
190 200 210 220 230
230 240 250 260 270 280
pF1KE3 ETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLE
.:.. . .... . . .. . :.: : . .:.
XP_005 KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRK
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE3 SGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQL
XP_005 IQQEQRILLDKVNGLQLQLNEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGS
300 310 320 330 340 350
>>XP_016877884 (OMIM: 612516) PREDICTED: uveal autoantig (1399 aa)
initn: 236 init1: 92 opt: 221 Z-score: 177.1 bits: 43.5 E(85289): 0.004
Smith-Waterman score: 221; 27.0% identity (57.3% similar) in 248 aa overlap (18-260:33-273)
10 20 30 40
pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSY-VASEE
: .::.. :. .: . . : . :.. .
XP_016 MREKTYKHAADWNKYDDRLMKAAERGDVEKVTSILAKKGV-NPGKLDVEGRSVFHVVTSK
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 SRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTA
. . :. .: . . . . ::: :. : . . ::... . : . ::
XP_016 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHAD-LQGRTA
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE3 LHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNA
:: :.. . :. ..:: :::.:: .: . .:: ::.. . : : :.: :::::.
XP_016 LHDAAMADCPSSIQLLCDHGASVNAKD-VDGRTPLVLATQMSRPTIC-QLLIDRGADVNS
130 140 150 160 170
170 180 190 200 210 220
pF1KE3 ADKHGKTALLHA--LASSDGVQ--IHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLG
::...:::. . . :.:. :.: .: :: : : . .. ::.. :. :
XP_016 RDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNL---DILTLL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE3 ETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLE
.:.. . .... . . .. . :.: : . .:.
XP_016 KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRK
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE3 SGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQL
XP_016 IQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNR
300 310 320 330 340 350
>>NP_001008225 (OMIM: 612516) uveal autoantigen with coi (1403 aa)
initn: 236 init1: 92 opt: 221 Z-score: 177.1 bits: 43.5 E(85289): 0.004
Smith-Waterman score: 221; 27.0% identity (57.3% similar) in 248 aa overlap (18-260:37-277)
10 20 30 40
pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSY-VASEE
: .::.. :. .: . . : . :.. .
NP_001 SCTPKNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGV-NPGKLDVEGRSVFHVVTSK
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 SRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTA
. . :. .: . . . . ::: :. : . . ::... . : . ::
NP_001 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHAD-LQGRTA
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE3 LHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNA
:: :.. . :. ..:: :::.:: .: . .:: ::.. . : : :.: :::::.
NP_001 LHDAAMADCPSSIQLLCDHGASVNAKD-VDGRTPLVLATQMSRPTIC-QLLIDRGADVNS
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE3 ADKHGKTALLHA--LASSDGVQ--IHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLG
::...:::. . . :.:. :.: .: :: : : . .. ::.. :. :
NP_001 RDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNL---DILTLL
190 200 210 220 230
230 240 250 260 270 280
pF1KE3 ETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLE
.:.. . .... . . .. . :.: : . .:.
NP_001 KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRK
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE3 SGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQL
NP_001 IQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNR
300 310 320 330 340 350
>>XP_016877883 (OMIM: 612516) PREDICTED: uveal autoantig (1405 aa)
initn: 236 init1: 92 opt: 221 Z-score: 177.1 bits: 43.5 E(85289): 0.004
Smith-Waterman score: 221; 27.0% identity (57.3% similar) in 248 aa overlap (18-260:50-290)
10 20 30 40
pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSY-VASEE
: .::.. :. .: . . : . :.. .
XP_016 GAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGV-NPGKLDVEGRSVFHVVTSK
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE3 SRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTA
. . :. .: . . . . ::: :. : . . ::... . : . ::
XP_016 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHAD-LQGRTA
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE3 LHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNA
:: :.. . :. ..:: :::.:: .: . .:: ::.. . : : :.: :::::.
XP_016 LHDAAMADCPSSIQLLCDHGASVNAKD-VDGRTPLVLATQMSRPTIC-QLLIDRGADVNS
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE3 ADKHGKTALLHA--LASSDGVQ--IHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLG
::...:::. . . :.:. :.: .: :: : : . .. ::.. :. :
XP_016 RDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNL---DILTLL
200 210 220 230 240 250
230 240 250 260 270 280
pF1KE3 ETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLE
.:.. . .... . . .. . :.: : . .:.
XP_016 KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRK
260 270 280 290 300 310
290 300 310 320 330 340
pF1KE3 SGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQL
XP_016 IQQEQRILLDKVNGLQLQLNEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGS
320 330 340 350 360 370
>>NP_060473 (OMIM: 612516) uveal autoantigen with coiled (1416 aa)
initn: 236 init1: 92 opt: 221 Z-score: 177.0 bits: 43.5 E(85289): 0.004
Smith-Waterman score: 221; 27.0% identity (57.3% similar) in 248 aa overlap (18-260:50-290)
10 20 30 40
pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSY-VASEE
: .::.. :. .: . . : . :.. .
NP_060 GAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGV-NPGKLDVEGRSVFHVVTSK
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE3 SRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTA
. . :. .: . . . . ::: :. : . . ::... . : . ::
NP_060 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHAD-LQGRTA
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE3 LHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNA
:: :.. . :. ..:: :::.:: .: . .:: ::.. . : : :.: :::::.
NP_060 LHDAAMADCPSSIQLLCDHGASVNAKD-VDGRTPLVLATQMSRPTIC-QLLIDRGADVNS
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE3 ADKHGKTALLHA--LASSDGVQ--IHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLG
::...:::. . . :.:. :.: .: :: : : . .. ::.. :. :
NP_060 RDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNL---DILTLL
200 210 220 230 240 250
230 240 250 260 270 280
pF1KE3 ETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLE
.:.. . .... . . .. . :.: : . .:.
NP_060 KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRK
260 270 280 290 300 310
290 300 310 320 330 340
pF1KE3 SGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQL
NP_060 IQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNR
320 330 340 350 360 370
421 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 08:09:43 2016 done: Sun Nov 6 08:09:44 2016
Total Scan time: 8.140 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]