Result of FASTA (omim) for
pFN21AE3975
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3975, 247 aa
1>>>pF1KE3975 247 - 247 aa - 247 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6045+/-0.000427; mu= 14.6064+/- 0.026
mean_var=137.3515+/-29.498, 0's: 0 Z-trim(115.1): 132 B-trim: 1230 in 2/49
Lambda= 0.109435
statistics sampled from 25156 (25341) to 25156 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.681), E-opt: 0.2 (0.297), width: 16
Scan time: 6.130
The best scores are: opt bits E(85289)
NP_116062 (OMIM: 610231) polycomb group RING finge ( 259) 1693 278.6 7.3e-75
NP_005171 (OMIM: 164831) polycomb complex protein ( 326) 571 101.6 1.8e-21
XP_005257698 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 543 97.2 3.9e-20
XP_005257697 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 543 97.2 3.9e-20
NP_009075 (OMIM: 600346) polycomb group RING finge ( 344) 543 97.2 3.9e-20
XP_005257699 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 543 97.2 3.9e-20
XP_016880505 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 543 97.2 3.9e-20
NP_001011663 (OMIM: 607816) polycomb group RING fi ( 350) 524 94.2 3.2e-19
NP_115530 (OMIM: 607816) polycomb group RING finge ( 275) 310 60.3 4.1e-09
NP_001308678 (OMIM: 612489) RING finger protein 24 ( 148) 178 39.1 0.0052
NP_001127809 (OMIM: 612489) RING finger protein 24 ( 148) 178 39.1 0.0052
NP_009150 (OMIM: 612489) RING finger protein 24 is ( 148) 178 39.1 0.0052
XP_011527448 (OMIM: 612489) PREDICTED: RING finger ( 163) 178 39.2 0.0056
NP_001127810 (OMIM: 612489) RING finger protein 24 ( 169) 178 39.2 0.0057
XP_016883110 (OMIM: 612489) PREDICTED: RING finger ( 169) 178 39.2 0.0057
XP_011527447 (OMIM: 612489) PREDICTED: RING finger ( 169) 178 39.2 0.0057
XP_016883109 (OMIM: 612489) PREDICTED: RING finger ( 169) 178 39.2 0.0057
>>NP_116062 (OMIM: 610231) polycomb group RING finger pr (259 aa)
initn: 1693 init1: 1693 opt: 1693 Z-score: 1465.0 bits: 278.6 E(85289): 7.3e-75
Smith-Waterman score: 1693; 100.0% identity (100.0% similar) in 247 aa overlap (1-247:13-259)
10 20 30 40
pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTI
::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 MASPQGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTI
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 TECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 TECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEE
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE3 KRIREFYQSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 KRIREFYQSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGK
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE3 DKNKSVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHVQLLFDNEVLPDHMTMKQIWLSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 DKNKSVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHVQLLFDNEVLPDHMTMKQIWLSR
190 200 210 220 230 240
230 240
pF1KE3 WFGKPSPLLLQYSVKEKRR
:::::::::::::::::::
NP_116 WFGKPSPLLLQYSVKEKRR
250
>>NP_005171 (OMIM: 164831) polycomb complex protein BMI- (326 aa)
initn: 511 init1: 478 opt: 571 Z-score: 506.5 bits: 101.6 E(85289): 1.8e-21
Smith-Waterman score: 578; 41.6% identity (70.0% similar) in 233 aa overlap (23-243:6-228)
10 20 30 40 50 60
pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCI
:.:: .:: :..: ::.:::.::::: ::::.:::.::
NP_005 MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCI
10 20 30 40
70 80 90 100 110 120
pF1KE3 VKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGL
:.::.::::::.:....:.:.::::.. :...::::::::::: .: :: :.:: .
NP_005 VRYLETSKYCPICDVQVHKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAA---
50 60 70 80 90 100
130 140 150 160 170
pF1KE3 DRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLE-----RLSS--GKDKNKS
.:... :: . :..: . :: ..: .: ::. .:::.::
NP_005 ----HPSADAANGSNEDRGEVA-DEDK-RIITDDEIISLSIEFFDQNRLDRKVNKDKEKS
110 120 130 140 150
180 190 200 210 220
pF1KE3 ---VLQNKYVRCSVRAEVRHLRRVLCHRLML-NPQHVQLLFDNEVLPDHMTMKQI-WLSR
: ...:.:: . : :::. : .. . : ........: : :..:. .: ..
NP_005 KEEVNDKRYLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYT
160 170 180 190 200 210
230 240
pF1KE3 WFGKPSPLLLQYSVKEKRR
: . .:: :.: :.
NP_005 WR-RNGPLPLKYRVRPTCKRMKISHQRDGLTNAGELESDSGSDKANSPAGGIPSTSSCLP
220 230 240 250 260 270
>>XP_005257698 (OMIM: 600346) PREDICTED: polycomb group (344 aa)
initn: 513 init1: 486 opt: 543 Z-score: 482.4 bits: 97.2 E(85289): 3.9e-20
Smith-Waterman score: 552; 38.3% identity (69.8% similar) in 235 aa overlap (23-243:6-230)
10 20 30 40 50 60
pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCI
:.:: .:: :..: ::.:::.:::::.::::.:::.::
XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCI
10 20 30 40
70 80 90 100 110 120
pF1KE3 VKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGL
:.::.:.::::::....:.:.:::... :...::::::::::: .: :: :.:: . :
XP_005 VRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPL
50 60 70 80 90 100
130 140 150 160 170
pF1KE3 DRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGKDKN--KSVLQN-
.: :.: . ... ... :. :: ..: .: ...:.. :. :.:
XP_005 TEV--PNGSNEDRGEV------LEQEKGALSD-DEIVSLSIEFYEGARDRDEKKGPLENG
110 120 130 140 150
180 190 200 210 220
pF1KE3 ---------KYVRCSVRAEVRHLRRVLCHRLMLNPQH-VQLLFDNEVLPDHMTMKQI-WL
...:: . : :: . : ... . .. :..:...: : ...:. .: ..
XP_005 DGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYI
160 170 180 190 200 210
230 240
pF1KE3 SRWFGKPSPLLLQYSVKEKRR
: . .:: :.: :.
XP_005 YPWR-RNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATS
220 230 240 250 260 270
>>XP_005257697 (OMIM: 600346) PREDICTED: polycomb group (344 aa)
initn: 513 init1: 486 opt: 543 Z-score: 482.4 bits: 97.2 E(85289): 3.9e-20
Smith-Waterman score: 552; 38.3% identity (69.8% similar) in 235 aa overlap (23-243:6-230)
10 20 30 40 50 60
pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCI
:.:: .:: :..: ::.:::.:::::.::::.:::.::
XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCI
10 20 30 40
70 80 90 100 110 120
pF1KE3 VKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGL
:.::.:.::::::....:.:.:::... :...::::::::::: .: :: :.:: . :
XP_005 VRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPL
50 60 70 80 90 100
130 140 150 160 170
pF1KE3 DRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGKDKN--KSVLQN-
.: :.: . ... ... :. :: ..: .: ...:.. :. :.:
XP_005 TEV--PNGSNEDRGEV------LEQEKGALSD-DEIVSLSIEFYEGARDRDEKKGPLENG
110 120 130 140 150
180 190 200 210 220
pF1KE3 ---------KYVRCSVRAEVRHLRRVLCHRLMLNPQH-VQLLFDNEVLPDHMTMKQI-WL
...:: . : :: . : ... . .. :..:...: : ...:. .: ..
XP_005 DGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYI
160 170 180 190 200 210
230 240
pF1KE3 SRWFGKPSPLLLQYSVKEKRR
: . .:: :.: :.
XP_005 YPWR-RNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATS
220 230 240 250 260 270
>>NP_009075 (OMIM: 600346) polycomb group RING finger pr (344 aa)
initn: 513 init1: 486 opt: 543 Z-score: 482.4 bits: 97.2 E(85289): 3.9e-20
Smith-Waterman score: 552; 38.3% identity (69.8% similar) in 235 aa overlap (23-243:6-230)
10 20 30 40 50 60
pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCI
:.:: .:: :..: ::.:::.:::::.::::.:::.::
NP_009 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCI
10 20 30 40
70 80 90 100 110 120
pF1KE3 VKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGL
:.::.:.::::::....:.:.:::... :...::::::::::: .: :: :.:: . :
NP_009 VRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPL
50 60 70 80 90 100
130 140 150 160 170
pF1KE3 DRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGKDKN--KSVLQN-
.: :.: . ... ... :. :: ..: .: ...:.. :. :.:
NP_009 TEV--PNGSNEDRGEV------LEQEKGALSD-DEIVSLSIEFYEGARDRDEKKGPLENG
110 120 130 140 150
180 190 200 210 220
pF1KE3 ---------KYVRCSVRAEVRHLRRVLCHRLMLNPQH-VQLLFDNEVLPDHMTMKQI-WL
...:: . : :: . : ... . .. :..:...: : ...:. .: ..
NP_009 DGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYI
160 170 180 190 200 210
230 240
pF1KE3 SRWFGKPSPLLLQYSVKEKRR
: . .:: :.: :.
NP_009 YPWR-RNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATS
220 230 240 250 260 270
>>XP_005257699 (OMIM: 600346) PREDICTED: polycomb group (344 aa)
initn: 513 init1: 486 opt: 543 Z-score: 482.4 bits: 97.2 E(85289): 3.9e-20
Smith-Waterman score: 552; 38.3% identity (69.8% similar) in 235 aa overlap (23-243:6-230)
10 20 30 40 50 60
pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCI
:.:: .:: :..: ::.:::.:::::.::::.:::.::
XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCI
10 20 30 40
70 80 90 100 110 120
pF1KE3 VKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGL
:.::.:.::::::....:.:.:::... :...::::::::::: .: :: :.:: . :
XP_005 VRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPL
50 60 70 80 90 100
130 140 150 160 170
pF1KE3 DRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGKDKN--KSVLQN-
.: :.: . ... ... :. :: ..: .: ...:.. :. :.:
XP_005 TEV--PNGSNEDRGEV------LEQEKGALSD-DEIVSLSIEFYEGARDRDEKKGPLENG
110 120 130 140 150
180 190 200 210 220
pF1KE3 ---------KYVRCSVRAEVRHLRRVLCHRLMLNPQH-VQLLFDNEVLPDHMTMKQI-WL
...:: . : :: . : ... . .. :..:...: : ...:. .: ..
XP_005 DGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYI
160 170 180 190 200 210
230 240
pF1KE3 SRWFGKPSPLLLQYSVKEKRR
: . .:: :.: :.
XP_005 YPWR-RNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATS
220 230 240 250 260 270
>>XP_016880505 (OMIM: 600346) PREDICTED: polycomb group (344 aa)
initn: 513 init1: 486 opt: 543 Z-score: 482.4 bits: 97.2 E(85289): 3.9e-20
Smith-Waterman score: 552; 38.3% identity (69.8% similar) in 235 aa overlap (23-243:6-230)
10 20 30 40 50 60
pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCI
:.:: .:: :..: ::.:::.:::::.::::.:::.::
XP_016 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCI
10 20 30 40
70 80 90 100 110 120
pF1KE3 VKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGL
:.::.:.::::::....:.:.:::... :...::::::::::: .: :: :.:: . :
XP_016 VRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPL
50 60 70 80 90 100
130 140 150 160 170
pF1KE3 DRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGKDKN--KSVLQN-
.: :.: . ... ... :. :: ..: .: ...:.. :. :.:
XP_016 TEV--PNGSNEDRGEV------LEQEKGALSD-DEIVSLSIEFYEGARDRDEKKGPLENG
110 120 130 140 150
180 190 200 210 220
pF1KE3 ---------KYVRCSVRAEVRHLRRVLCHRLMLNPQH-VQLLFDNEVLPDHMTMKQI-WL
...:: . : :: . : ... . .. :..:...: : ...:. .: ..
XP_016 DGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYI
160 170 180 190 200 210
230 240
pF1KE3 SRWFGKPSPLLLQYSVKEKRR
: . .:: :.: :.
XP_016 YPWR-RNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATS
220 230 240 250 260 270
>>NP_001011663 (OMIM: 607816) polycomb group RING finger (350 aa)
initn: 443 init1: 443 opt: 524 Z-score: 466.1 bits: 94.2 E(85289): 3.2e-19
Smith-Waterman score: 524; 38.9% identity (74.4% similar) in 211 aa overlap (18-224:117-322)
10 20 30 40
pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATT
.::: .....:. .:.: .: ::..::::
NP_001 EEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATT
90 100 110 120 130 140
50 60 70 80 90 100
pF1KE3 ITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSE
::::::::::::::... :. :: ::: .:.:::: :..::: .:::::::: .:.. :
NP_001 ITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEERE
150 160 170 180 190 200
110 120 130 140 150 160
pF1KE3 EKRIREFYQSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLN--LCLERLS
.:....::. :::. : .:. .:. :. : . .. .: .:. : :: ..
NP_001 KKQMHDFYKERGLE-VPKPAVPQPVPSSKGRSKKVLES----VFRIPPELDMSLLLEFIG
210 220 230 240 250 260
170 180 190 200 210 220
pF1KE3 SGKDKNK-SVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQ-HVQLLFDNEVLPDHMTMKQ
... .. . :..:.:: : .: . :... : ... :.: .:... ...: ...:...
NP_001 ANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLRE
270 280 290 300 310 320
230 240
pF1KE3 IWLSRWFGKPSPLLLQYSVKEKRR
:
NP_001 IRRAIGDAAMQDGLLVLHYGLVVSPLKIT
330 340 350
>>NP_115530 (OMIM: 607816) polycomb group RING finger pr (275 aa)
initn: 325 init1: 307 opt: 310 Z-score: 284.7 bits: 60.3 E(85289): 4.1e-09
Smith-Waterman score: 310; 41.1% identity (72.3% similar) in 112 aa overlap (18-125:117-228)
10 20 30 40
pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATT
.::: .....:. .:.: .: ::..::::
NP_115 EEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATT
90 100 110 120 130 140
50 60 70 80 90 100
pF1KE3 ITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRV---MQDIVYKLVPGLQ
::::::::::::::... :. :: ::: .:.:::: :.. .. .. . :.:
NP_115 ITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNISANEGTGHFKPLEKKFVRVSG
150 160 170 180 190 200
110 120 130 140 150 160
pF1KE3 DSEEKRIREFYQSR-GLDRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLER
.. ....: . . ::: . :
NP_115 EATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYG
210 220 230 240 250 260
>>NP_001308678 (OMIM: 612489) RING finger protein 24 iso (148 aa)
initn: 175 init1: 137 opt: 178 Z-score: 175.0 bits: 39.1 E(85289): 0.0052
Smith-Waterman score: 178; 31.5% identity (59.8% similar) in 92 aa overlap (1-90:47-134)
10 20 30
pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLN
.:::.: .. . .. .. :.:.::
NP_001 FQNLPLNIYIVVFGTAIFVFILSLLFCCYLIRLRHQAHKEFYA---YKQVILKEKVKELN
20 30 40 50 60 70
40 50 60 70 80
pF1KE3 EHIVCCLCAGYFV--DATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKL
: .: .: : : : : :.: ..:..:.:.. : ::.::. . . : . :
NP_001 LHELCAVCLEDFKPRDELGICPCKHAFHRKCLIKWLEVRKVCPLCNMPVLQLAQL-HSKQ
80 90 100 110 120 130
90 100 110 120 130 140
pF1KE3 DRVMQDIVYKLVPGLQDSEEKRIREFYQSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKA
::
NP_001 DRGPPQGPLPGAENIV
140
247 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 08:25:58 2016 done: Sun Nov 6 08:25:59 2016
Total Scan time: 6.130 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]