Result of FASTA (omim) for
pFN21AE3963
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3963, 468 aa
1>>>pF1KE3963 468 - 468 aa - 468 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.2726+/-0.000353; mu= 11.1013+/- 0.022
mean_var=200.6023+/-42.339, 0's: 0 Z-trim(121.2): 269 B-trim: 1607 in 1/55
Lambda= 0.090554
statistics sampled from 37225 (37538) to 37225 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.778), E-opt: 0.2 (0.44), width: 16
Scan time: 8.390
The best scores are: opt bits E(85289)
NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468) 3249 436.9 5.6e-122
XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467) 3231 434.6 2.8e-121
XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 391) 1554 215.4 2.3e-55
NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 1315 184.3 6.4e-46
XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 1315 184.3 6.4e-46
XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 1315 184.3 6.4e-46
XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 1315 184.3 6.4e-46
NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 1315 184.3 6.4e-46
NP_003132 (OMIM: 109092) E3 ubiquitin-protein liga ( 475) 1231 173.3 1.3e-42
XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 450) 1177 166.2 1.7e-40
NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 1156 163.5 1.2e-39
NP_001128327 (OMIM: 606123) E3 ubiquitin-protein l ( 343) 899 129.8 1.2e-29
NP_060543 (OMIM: 613184) E3 ubiquitin-protein liga ( 485) 844 122.7 2.2e-27
NP_065091 (OMIM: 606124) tripartite motif-containi ( 452) 805 117.6 7.1e-26
NP_001291425 (OMIM: 613184) E3 ubiquitin-protein l ( 262) 786 114.9 2.8e-25
XP_016856907 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 782 114.3 4e-25
XP_016856908 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 782 114.3 4e-25
NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 761 111.9 4.2e-24
NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 754 111.0 7.6e-24
NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 754 111.0 7.8e-24
NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 735 108.5 4.4e-23
NP_001003827 (OMIM: 605684) tripartite motif-conta ( 488) 715 105.9 2.6e-22
NP_067629 (OMIM: 605684) tripartite motif-containi ( 488) 715 105.9 2.6e-22
NP_006065 (OMIM: 606559) E3 ubiquitin-protein liga ( 498) 675 100.7 9.8e-21
NP_001723 (OMIM: 601610) butyrophilin subfamily 1 ( 526) 673 100.4 1.2e-20
XP_005249397 (OMIM: 601610) PREDICTED: butyrophili ( 626) 673 100.5 1.4e-20
XP_005253240 (OMIM: 608487) PREDICTED: tripartite ( 493) 664 99.2 2.6e-20
NP_149023 (OMIM: 608487) tripartite motif-containi ( 493) 664 99.2 2.6e-20
XP_016873951 (OMIM: 608487) PREDICTED: tripartite ( 300) 652 97.4 5.6e-20
NP_149084 (OMIM: 608487) tripartite motif-containi ( 326) 652 97.5 5.9e-20
XP_005253241 (OMIM: 608487) PREDICTED: tripartite ( 326) 652 97.5 5.9e-20
NP_149083 (OMIM: 608487) tripartite motif-containi ( 347) 652 97.5 6.2e-20
NP_001186502 (OMIM: 606559) E3 ubiquitin-protein l ( 494) 652 97.7 7.8e-20
NP_741983 (OMIM: 617007) tripartite motif-containi ( 493) 642 96.4 1.9e-19
XP_011512533 (OMIM: 613591) PREDICTED: butyrophili ( 313) 622 93.5 8.8e-19
NP_001184168 (OMIM: 613591) butyrophilin subfamily ( 313) 622 93.5 8.8e-19
XP_016865656 (OMIM: 613591) PREDICTED: butyrophili ( 407) 622 93.7 1e-18
NP_853509 (OMIM: 613591) butyrophilin subfamily 2 ( 407) 622 93.7 1e-18
XP_005248855 (OMIM: 613591) PREDICTED: butyrophili ( 407) 622 93.7 1e-18
XP_016865655 (OMIM: 613591) PREDICTED: butyrophili ( 461) 622 93.7 1.1e-18
XP_011512531 (OMIM: 613591) PREDICTED: butyrophili ( 461) 622 93.7 1.1e-18
NP_008926 (OMIM: 613591) butyrophilin subfamily 2 ( 523) 622 93.8 1.2e-18
XP_011512530 (OMIM: 613591) PREDICTED: butyrophili ( 523) 622 93.8 1.2e-18
NP_001184166 (OMIM: 613591) butyrophilin subfamily ( 523) 622 93.8 1.2e-18
XP_006715016 (OMIM: 613591) PREDICTED: butyrophili ( 523) 622 93.8 1.2e-18
XP_005248854 (OMIM: 613591) PREDICTED: butyrophili ( 523) 622 93.8 1.2e-18
NP_001229732 (OMIM: 613595) butyrophilin subfamily ( 374) 614 92.6 2e-18
NP_932078 (OMIM: 613595) butyrophilin subfamily 3 ( 535) 614 92.7 2.6e-18
NP_008925 (OMIM: 613595) butyrophilin subfamily 3 ( 584) 614 92.8 2.7e-18
XP_006715046 (OMIM: 613593) PREDICTED: butyrophili ( 419) 594 90.0 1.3e-17
>>NP_660215 (OMIM: 607868) E3 ubiquitin-protein ligase T (468 aa)
initn: 3249 init1: 3249 opt: 3249 Z-score: 2310.9 bits: 436.9 E(85289): 5.6e-122
Smith-Waterman score: 3249; 100.0% identity (100.0% similar) in 468 aa overlap (1-468:1-468)
10 20 30 40 50 60
pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 PQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 PQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 WAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 WAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 EFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 LGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPEL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 ILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 ILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 ENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 ENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSA
370 380 390 400 410 420
430 440 450 460
pF1KE3 TDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ
::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 TDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ
430 440 450 460
>>XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquitin-pr (467 aa)
initn: 2015 init1: 2015 opt: 3231 Z-score: 2298.2 bits: 434.6 E(85289): 2.8e-121
Smith-Waterman score: 3231; 99.8% identity (99.8% similar) in 468 aa overlap (1-468:1-467)
10 20 30 40 50 60
pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 PQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 WAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLG
:::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::
XP_016 WAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQ-MVESQRQNVLG
130 140 150 160 170
190 200 210 220 230 240
pF1KE3 EFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPA
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE3 LGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPEL
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE3 ILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE3 ENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSA
360 370 380 390 400 410
430 440 450 460
pF1KE3 TDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ
420 430 440 450 460
>>XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquitin-pr (391 aa)
initn: 1544 init1: 1544 opt: 1554 Z-score: 1115.1 bits: 215.4 E(85289): 2.3e-55
Smith-Waterman score: 2600; 83.5% identity (83.5% similar) in 468 aa overlap (1-468:1-391)
10 20 30 40 50 60
pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 PQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 WAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLG
::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQ------------
130 140 150 160
190 200 210 220 230 240
pF1KE3 EFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPA
XP_011 ------------------------------------------------------------
250 260 270 280 290 300
pF1KE3 LGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPEL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 -----DIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPEL
170 180 190 200 210 220
310 320 330 340 350 360
pF1KE3 ILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR
230 240 250 260 270 280
370 380 390 400 410 420
pF1KE3 ENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSA
290 300 310 320 330 340
430 440 450 460
pF1KE3 TDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ
::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ
350 360 370 380 390
>>NP_057186 (OMIM: 606123) E3 ubiquitin-protein ligase T (477 aa)
initn: 1068 init1: 453 opt: 1315 Z-score: 945.3 bits: 184.3 E(85289): 6.4e-46
Smith-Waterman score: 1315; 46.8% identity (68.8% similar) in 459 aa overlap (1-442:1-456)
10 20 30 40 50
pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCW----GQP-----EGPY
: : .:. .:::::::.:::::::::::: ::::::: ::. : :. .: .
NP_057 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 ACPECRELSPQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLC
::::::.:::::: ::: :.:.::::.. :: : .: :.::: :: . .:
NP_057 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HPGLQ-KQDLCQEHHEPLKLFCQKDQSPIC
70 80 90 100 110
120 130 140 150 160 170
pF1KE3 AACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMV
..:..: :: ::: : ..:.. : :::...:.::.:. . .::. ... . :: :
NP_057 VVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 ESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAE
. .:. .. :::.. :.::::.::: :: :: :. ::::..: : .:. : :. .
NP_057 KERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE3 LEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVP-MELRTVCRVPGLVETLRRFRGDVT
:: : : .:::.:. : : ..:..: :::.: . :::::::: .:.:: : ::.
NP_057 LEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVV
240 250 260 270 280 290
300 310 320 330 340
pF1KE3 LDPDTANPELILSEDRRSVQRGDLRQALP-DSPERFDPGPCVLGQERFTSGRHYWEVEV-
: .: : :.: :.:. :. .. : .:: ::..:: :.:::::::: .
NP_057 PDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMN
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE3 --GDRTSWALGVCRENVNRKEKGELSAGNGFWILVFL-GSYYNSSERALAP--LRDPPRR
:: . :::::::.::.::.. ::::.. . :. : :. ::.: : .:: .
NP_057 ITGD-ALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSH
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE3 VGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGD
.:::::.:::..::::..::: : . . : : :.:.:
NP_057 MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMWVKG
420 430 440 450 460 470
pF1KE3 TLAPQ
>>XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa)
initn: 1068 init1: 453 opt: 1315 Z-score: 945.3 bits: 184.3 E(85289): 6.4e-46
Smith-Waterman score: 1315; 46.8% identity (68.8% similar) in 459 aa overlap (1-442:1-456)
10 20 30 40 50
pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCW----GQP-----EGPY
: : .:. .:::::::.:::::::::::: ::::::: ::. : :. .: .
XP_011 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 ACPECRELSPQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLC
::::::.:::::: ::: :.:.::::.. :: : .: :.::: :: . .:
XP_011 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HPGLQ-KQDLCQEHHEPLKLFCQKDQSPIC
70 80 90 100 110
120 130 140 150 160 170
pF1KE3 AACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMV
..:..: :: ::: : ..:.. : :::...:.::.:. . .::. ... . :: :
XP_011 VVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 ESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAE
. .:. .. :::.. :.::::.::: :: :: :. ::::..: : .:. : :. .
XP_011 KERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE3 LEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVP-MELRTVCRVPGLVETLRRFRGDVT
:: : : .:::.:. : : ..:..: :::.: . :::::::: .:.:: : ::.
XP_011 LEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVV
240 250 260 270 280 290
300 310 320 330 340
pF1KE3 LDPDTANPELILSEDRRSVQRGDLRQALP-DSPERFDPGPCVLGQERFTSGRHYWEVEV-
: .: : :.: :.:. :. .. : .:: ::..:: :.:::::::: .
XP_011 PDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMN
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE3 --GDRTSWALGVCRENVNRKEKGELSAGNGFWILVFL-GSYYNSSERALAP--LRDPPRR
:: . :::::::.::.::.. ::::.. . :. : :. ::.: : .:: .
XP_011 ITGD-ALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSH
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE3 VGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGD
.:::::.:::..::::..::: : . . : : :.:.:
XP_011 MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMWVKG
420 430 440 450 460 470
pF1KE3 TLAPQ
>>XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa)
initn: 1068 init1: 453 opt: 1315 Z-score: 945.3 bits: 184.3 E(85289): 6.4e-46
Smith-Waterman score: 1315; 46.8% identity (68.8% similar) in 459 aa overlap (1-442:1-456)
10 20 30 40 50
pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCW----GQP-----EGPY
: : .:. .:::::::.:::::::::::: ::::::: ::. : :. .: .
XP_006 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 ACPECRELSPQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLC
::::::.:::::: ::: :.:.::::.. :: : .: :.::: :: . .:
XP_006 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HPGLQ-KQDLCQEHHEPLKLFCQKDQSPIC
70 80 90 100 110
120 130 140 150 160 170
pF1KE3 AACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMV
..:..: :: ::: : ..:.. : :::...:.::.:. . .::. ... . :: :
XP_006 VVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 ESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAE
. .:. .. :::.. :.::::.::: :: :: :. ::::..: : .:. : :. .
XP_006 KERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE3 LEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVP-MELRTVCRVPGLVETLRRFRGDVT
:: : : .:::.:. : : ..:..: :::.: . :::::::: .:.:: : ::.
XP_006 LEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVV
240 250 260 270 280 290
300 310 320 330 340
pF1KE3 LDPDTANPELILSEDRRSVQRGDLRQALP-DSPERFDPGPCVLGQERFTSGRHYWEVEV-
: .: : :.: :.:. :. .. : .:: ::..:: :.:::::::: .
XP_006 PDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMN
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE3 --GDRTSWALGVCRENVNRKEKGELSAGNGFWILVFL-GSYYNSSERALAP--LRDPPRR
:: . :::::::.::.::.. ::::.. . :. : :. ::.: : .:: .
XP_006 ITGD-ALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSH
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE3 VGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGD
.:::::.:::..::::..::: : . . : : :.:.:
XP_006 MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMWVKG
420 430 440 450 460 470
pF1KE3 TLAPQ
>>XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa)
initn: 1068 init1: 453 opt: 1315 Z-score: 945.3 bits: 184.3 E(85289): 6.4e-46
Smith-Waterman score: 1315; 46.8% identity (68.8% similar) in 459 aa overlap (1-442:1-456)
10 20 30 40 50
pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCW----GQP-----EGPY
: : .:. .:::::::.:::::::::::: ::::::: ::. : :. .: .
XP_011 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 ACPECRELSPQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLC
::::::.:::::: ::: :.:.::::.. :: : .: :.::: :: . .:
XP_011 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HPGLQ-KQDLCQEHHEPLKLFCQKDQSPIC
70 80 90 100 110
120 130 140 150 160 170
pF1KE3 AACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMV
..:..: :: ::: : ..:.. : :::...:.::.:. . .::. ... . :: :
XP_011 VVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 ESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAE
. .:. .. :::.. :.::::.::: :: :: :. ::::..: : .:. : :. .
XP_011 KERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE3 LEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVP-MELRTVCRVPGLVETLRRFRGDVT
:: : : .:::.:. : : ..:..: :::.: . :::::::: .:.:: : ::.
XP_011 LEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVV
240 250 260 270 280 290
300 310 320 330 340
pF1KE3 LDPDTANPELILSEDRRSVQRGDLRQALP-DSPERFDPGPCVLGQERFTSGRHYWEVEV-
: .: : :.: :.:. :. .. : .:: ::..:: :.:::::::: .
XP_011 PDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMN
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE3 --GDRTSWALGVCRENVNRKEKGELSAGNGFWILVFL-GSYYNSSERALAP--LRDPPRR
:: . :::::::.::.::.. ::::.. . :. : :. ::.: : .:: .
XP_011 ITGD-ALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSH
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE3 VGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGD
.:::::.:::..::::..::: : . . : : :.:.:
XP_011 MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMWVKG
420 430 440 450 460 470
pF1KE3 TLAPQ
>>NP_001020111 (OMIM: 606123) E3 ubiquitin-protein ligas (477 aa)
initn: 1068 init1: 453 opt: 1315 Z-score: 945.3 bits: 184.3 E(85289): 6.4e-46
Smith-Waterman score: 1315; 46.8% identity (68.8% similar) in 459 aa overlap (1-442:1-456)
10 20 30 40 50
pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCW----GQP-----EGPY
: : .:. .:::::::.:::::::::::: ::::::: ::. : :. .: .
NP_001 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 ACPECRELSPQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLC
::::::.:::::: ::: :.:.::::.. :: : .: :.::: :: . .:
NP_001 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HPGLQ-KQDLCQEHHEPLKLFCQKDQSPIC
70 80 90 100 110
120 130 140 150 160 170
pF1KE3 AACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMV
..:..: :: ::: : ..:.. : :::...:.::.:. . .::. ... . :: :
NP_001 VVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 ESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAE
. .:. .. :::.. :.::::.::: :: :: :. ::::..: : .:. : :. .
NP_001 KERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE3 LEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVP-MELRTVCRVPGLVETLRRFRGDVT
:: : : .:::.:. : : ..:..: :::.: . :::::::: .:.:: : ::.
NP_001 LEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVV
240 250 260 270 280 290
300 310 320 330 340
pF1KE3 LDPDTANPELILSEDRRSVQRGDLRQALP-DSPERFDPGPCVLGQERFTSGRHYWEVEV-
: .: : :.: :.:. :. .. : .:: ::..:: :.:::::::: .
NP_001 PDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMN
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE3 --GDRTSWALGVCRENVNRKEKGELSAGNGFWILVFL-GSYYNSSERALAP--LRDPPRR
:: . :::::::.::.::.. ::::.. . :. : :. ::.: : .:: .
NP_001 ITGD-ALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSH
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE3 VGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGD
.:::::.:::..::::..::: : . . : : :.:.:
NP_001 MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMWVKG
420 430 440 450 460 470
pF1KE3 TLAPQ
>>NP_003132 (OMIM: 109092) E3 ubiquitin-protein ligase T (475 aa)
initn: 1158 init1: 894 opt: 1231 Z-score: 886.1 bits: 173.3 E(85289): 1.3e-42
Smith-Waterman score: 1232; 43.8% identity (68.6% similar) in 475 aa overlap (1-464:1-473)
10 20 30 40 50 60
pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
::. : . ::.:: :::: :..:: .:::.::.::: . :. : .:: ::.
NP_003 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQV-GKGGGS-VCPVCRQRF
10 20 30 40 50
70 80 90 100 110
pF1KE3 PQRNLRPNRPLAKMAEMARRLHPPS-PVPQGV-CPAHREPLAAFCGDELRLLCAACERSG
.:::::: ::.:.. ... . :: : .: : : :: . . :: .: .:
NP_003 LLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE3 EHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNV
.: : . ::..::.. . ::. .: .::.... : .... . :.: ::.:.. .
NP_003 KHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRI
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 LGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQL
.:: . . .:.::::. ::.::..: : : : : :.:.::: : :::.::. ::.
NP_003 HAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHS
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE3 PALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANP
:: :::.. .:.: .. .:. ... :::.::.:::: . :: .:::::::::
NP_003 SALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANP
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE3 ELILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGV
::::::::.:. :: .:..: . :::: : ::: ..: ::.:::::.: . .: :::
NP_003 WLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGV
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE3 CRENVNRKEKGELSAGNGFW-ILVFLGSYYNSSERALAPL--RDPPRRVGIFLDYEAGHL
::..: :: . ::. .::: : .. . :... .:: . :: .:::::::::: .
NP_003 CRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMV
360 370 380 390 400 410
420 430 440 450 460
pF1KE3 SFYSATD-GSLLFIFPEIPFSGTLRPLFSPL----SSSPTPMTICRPKGGS-GDTLAPQ
:::. :: :::.. : : :.: :::.::: ... .:.:.: . :: :.:
NP_003 SFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY
420 430 440 450 460 470
>>XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (450 aa)
initn: 982 init1: 453 opt: 1177 Z-score: 848.2 bits: 166.2 E(85289): 1.7e-40
Smith-Waterman score: 1177; 45.1% identity (67.6% similar) in 432 aa overlap (28-442:1-429)
10 20 30 40 50
pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCW----GQP-----EGPY
:: ::::::: ::. : :. .: .
XP_011 MTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30
60 70 80 90 100 110
pF1KE3 ACPECRELSPQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLC
::::::.:::::: ::: :.:.::::.. :: : .: :.::: :: . .:
XP_011 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HPGLQ-KQDLCQEHHEPLKLFCQKDQSPIC
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE3 AACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMV
..:..: :: ::: : ..:.. : :::...:.::.:. . .::. ... . :: :
XP_011 VVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKV
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE3 ESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAE
. .:. .. :::.. :.::::.::: :: :: :. ::::..: : .:. : :. .
XP_011 KERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQ
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE3 LEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVP-MELRTVCRVPGLVETLRRFRGDVT
:: : : .:::.:. : : ..:..: :::.: . :::::::: .:.:: : ::.
XP_011 LEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVV
220 230 240 250 260 270
300 310 320 330 340
pF1KE3 LDPDTANPELILSEDRRSVQRGDLRQALP-DSPERFDPGPCVLGQERFTSGRHYWEVEV-
: .: : :.: :.:. :. .. : .:: ::..:: :.:::::::: .
XP_011 PDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMN
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE3 --GDRTSWALGVCRENVNRKEKGELSAGNGFWILVFL-GSYYNSSERALAP--LRDPPRR
:: . :::::::.::.::.. ::::.. . :. : :. ::.: : .:: .
XP_011 ITGD-ALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSH
340 350 360 370 380 390
410 420 430 440 450 460
pF1KE3 VGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGD
.:::::.:::..::::..::: : . . : : :.:.:
XP_011 MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMWVKG
400 410 420 430 440 450
pF1KE3 TLAPQ
468 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 08:31:21 2016 done: Sun Nov 6 08:31:22 2016
Total Scan time: 8.390 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]