Result of FASTA (omim) for
pFN21AE3943
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3943, 374 aa
1>>>pF1KE3943 374 - 374 aa - 374 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3064+/-0.000331; mu= 16.9317+/- 0.021
mean_var=82.8748+/-16.355, 0's: 0 Z-trim(115.6): 36 B-trim: 0 in 0/55
Lambda= 0.140884
statistics sampled from 26048 (26084) to 26048 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.306), width: 16
Scan time: 8.090
The best scores are: opt bits E(85289)
NP_060848 (OMIM: 609077) F-box/LRR-repeat protein ( 374) 2500 517.9 1.5e-146
NP_036290 (OMIM: 605653) F-box/LRR-repeat protein ( 428) 199 50.3 9.8e-06
XP_005266393 (OMIM: 605653) PREDICTED: F-box/LRR-r ( 428) 199 50.3 9.8e-06
NP_036291 (OMIM: 609087) F-box/LRR-repeat protein ( 434) 170 44.4 0.00059
>>NP_060848 (OMIM: 609077) F-box/LRR-repeat protein 8 [H (374 aa)
initn: 2500 init1: 2500 opt: 2500 Z-score: 2752.3 bits: 517.9 E(85289): 1.5e-146
Smith-Waterman score: 2500; 100.0% identity (100.0% similar) in 374 aa overlap (1-374:1-374)
10 20 30 40 50 60
pF1KE3 MAEPGEGLPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCECELEGML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MAEPGEGLPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCECELEGML
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 PPYLSACLDHIHNLRLEFEPSRKPSRRAAIELLMVLAGRAPGLRGLRLECRGEKPLFDAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PPYLSACLDHIHNLRLEFEPSRKPSRRAAIELLMVLAGRAPGLRGLRLECRGEKPLFDAG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 RDVLEAVHAVCGAASQLRHLDLRRLSFTLDDALVLQAARSCPELHSLFLDNSTLVGSVGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RDVLEAVHAVCGAASQLRHLDLRRLSFTLDDALVLQAARSCPELHSLFLDNSTLVGSVGP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 GSVLELLEACPRLRALGLHLASLSHAILEALAAPDRAPFALLALRCACPEDARASPLPNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GSVLELLEACPRLRALGLHLASLSHAILEALAAPDRAPFALLALRCACPEDARASPLPNE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 AWVALRRRHPGLAVELELEPALPAESVTRVLQPAVPVAALRLNLSGDTVGPVRFAAHHYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 AWVALRRRHPGLAVELELEPALPAESVTRVLQPAVPVAALRLNLSGDTVGPVRFAAHHYA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 ATLCALEVRAAASAELNAALEELAARCAALREVHCFCVVSHSVLDAFRAHCPRLRTYTLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ATLCALEVRAAASAELNAALEELAARCAALREVHCFCVVSHSVLDAFRAHCPRLRTYTLK
310 320 330 340 350 360
370
pF1KE3 LTREPHPWRPTLVA
::::::::::::::
NP_060 LTREPHPWRPTLVA
370
>>NP_036290 (OMIM: 605653) F-box/LRR-repeat protein 3 [H (428 aa)
initn: 95 init1: 64 opt: 199 Z-score: 223.9 bits: 50.3 E(85289): 9.8e-06
Smith-Waterman score: 199; 24.0% identity (50.0% similar) in 362 aa overlap (8-351:39-383)
10 20 30
pF1KE3 MAEPGEGLPEEVLALIFRHLSLRDRAAAARVCRAWAA
: .... .:..: : ::: :..::: :
NP_036 DRNSSEEGTAEKSKKLRTTNEHSQTCDWGNLLQDIILQVFKYLPLLDRAHASQVCRNWNQ
10 20 30 40 50 60
40 50 60 70 80
pF1KE3 AATCSAVWHDTKISC-ECELEGMLPPYLSACLDHI-------HNLRLEFEP----SRKPS
. .:. : : ::. ::.: .. :. .:.. : : :
NP_036 VFHMPDLWR-----CFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKES
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE3 RRAAIELLMVLAGRAPGLRGLRLECRGEKPLFDAGRD-VLEAVHAVCGAASQLRHLDLRR
.:: ..: :.. . :. : : .. ..: .. . :. .: ...: : .
NP_036 AEAACDILSQLVNCS--LKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDD
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE3 LSFTLDDALVLQAARSCPELHSLFLDNSTLVGSVGPGSVLELLEACPRLRALGLHLASLS
: .: . .: . :. : ... :.:...: . . : :: :.:. ::
NP_036 TPVD-DPSLKVLVANNSDTLKLLKMSSCP---HVSPAGILCVADQCHGLRELALNYHLLS
190 200 210 220 230
210 220 230 240 250 260
pF1KE3 HAILEALAAPDRAPFALLALRCAC--PEDARASPLPNEAWVALRRRHPGLAVELELEPAL
.: ::.. .. . : . . : ... . . .: :. :. : :.: . :
NP_036 DELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSP--KVNLVMYFFL
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE3 PAESVTRVLQPAVPVAALRL--NLSGDTVGPVRFAAHHYAATLCALEVRAAASAELNAAL
: .. .:.. : . ..: :..: : .. . : : : : . :. :
NP_036 YEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPR----LVELVVCANGLRPLDEEL
300 310 320 330 340 350
330 340 350 360 370
pF1KE3 EELAARCAALREVHC-FCVVSHSVLDAFRAHCPRLRTYTLKLTREPHPWRPTLVA
..: :: : . : :: :.. : :
NP_036 IRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWE
360 370 380 390 400 410
NP_036 VSKHLGRVWFPDMMPTW
420
>>XP_005266393 (OMIM: 605653) PREDICTED: F-box/LRR-repea (428 aa)
initn: 95 init1: 64 opt: 199 Z-score: 223.9 bits: 50.3 E(85289): 9.8e-06
Smith-Waterman score: 199; 24.0% identity (50.0% similar) in 362 aa overlap (8-351:39-383)
10 20 30
pF1KE3 MAEPGEGLPEEVLALIFRHLSLRDRAAAARVCRAWAA
: .... .:..: : ::: :..::: :
XP_005 DRNSSEEGTAEKSKKLRTTNEHSQTCDWGNLLQDIILQVFKYLPLLDRAHASQVCRNWNQ
10 20 30 40 50 60
40 50 60 70 80
pF1KE3 AATCSAVWHDTKISC-ECELEGMLPPYLSACLDHI-------HNLRLEFEP----SRKPS
. .:. : : ::. ::.: .. :. .:.. : : :
XP_005 VFHMPDLWR-----CFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKES
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE3 RRAAIELLMVLAGRAPGLRGLRLECRGEKPLFDAGRD-VLEAVHAVCGAASQLRHLDLRR
.:: ..: :.. . :. : : .. ..: .. . :. .: ...: : .
XP_005 AEAACDILSQLVNCS--LKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDD
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE3 LSFTLDDALVLQAARSCPELHSLFLDNSTLVGSVGPGSVLELLEACPRLRALGLHLASLS
: .: . .: . :. : ... :.:...: . . : :: :.:. ::
XP_005 TPVD-DPSLKVLVANNSDTLKLLKMSSCP---HVSPAGILCVADQCHGLRELALNYHLLS
190 200 210 220 230
210 220 230 240 250 260
pF1KE3 HAILEALAAPDRAPFALLALRCAC--PEDARASPLPNEAWVALRRRHPGLAVELELEPAL
.: ::.. .. . : . . : ... . . .: :. :. : :.: . :
XP_005 DELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSP--KVNLVMYFFL
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE3 PAESVTRVLQPAVPVAALRL--NLSGDTVGPVRFAAHHYAATLCALEVRAAASAELNAAL
: .. .:.. : . ..: :..: : .. . : : : : . :. :
XP_005 YEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPR----LVELVVCANGLRPLDEEL
300 310 320 330 340 350
330 340 350 360 370
pF1KE3 EELAARCAALREVHC-FCVVSHSVLDAFRAHCPRLRTYTLKLTREPHPWRPTLVA
..: :: : . : :: :.. : :
XP_005 IRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWE
360 370 380 390 400 410
XP_005 VSKHLGRVWFPDMMPTW
420
>>NP_036291 (OMIM: 609087) F-box/LRR-repeat protein 21 [ (434 aa)
initn: 156 init1: 101 opt: 170 Z-score: 192.0 bits: 44.4 E(85289): 0.00059
Smith-Waterman score: 170; 23.3% identity (48.5% similar) in 369 aa overlap (8-364:45-401)
10 20 30
pF1KE3 MAEPGEGLPEEVLALIFRHLSLRDRAAAARVCRAWAA
::..:. ::..: : ::: :. ::: :
NP_036 LSGAAKQPKVGFYSSLNQTHTHTVLLDWGSLPHHVVLQIFQYLPLLDRACASSVCRRWNE
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE3 AATCSAVWHDTKI----SCECELEGMLPPYLSACLD-HIHNLR-LEFE-PSRKPSRRAAI
. : .:. .. : ... : .. . :. .:. . :. : : .::
NP_036 VFHISDLWRKFEFELNQSATSSFKSTHPDLIQQIIKKHFAHLQYVSFKVDSSAESAEAAC
80 90 100 110 120 130
100 110 120 130 140
pF1KE3 ELLMVLAGRAPGLRGLRLECRGEKPLFDAGRD--VLEAVHAVCGAASQLRHLDLRRLSFT
..: :.. . :: :: : . . :. .: ...: . ..
NP_036 DILSQLVNCSIQTLGL---ISTAKPSFMNVSESHFVSALTVVFINSKSLSSIKIEDTPVD
140 150 160 170 180 190
150 160 170 180 190 200
pF1KE3 LDDALVLQAARSCPELHSLFLDNSTLVGSVGPGSVLELLEACPRLRALGLHLASLSHAIL
: .: . .: . :. ... :.: : .: . . : :: :.:. :. ..
NP_036 -DPSLKILVANNSDTLRLPKMSSCPHVSSDG---ILCVADRCQGLRELALNYYILTDELF
200 210 220 230 240
210 220 230 240 250 260
pF1KE3 EALAAPDRAPFALLALRCAC--PEDARASPLPNEAWVALRRRHPGLAVELELEPALPAES
::.. .. . : . . : . . . ...: :: .. : . : ... : :
NP_036 LALSSETHVNLEHLRIDVVSENPGQIKFHAVKKHSWDALIKHSPRVNVVMHFF--LYEEE
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE3 VTRVLQPAVPVAALRLNLSGDTVGPVRFAAHHYAATLCALEVRAAASAELNAALEELAAR
.. .::. : .. : . : : . . : : : : :. : .: .
NP_036 FETFFKEETPVTHLYFGRSVSKVVLGRVGLN--CPRLIELVVCANDLQPLDNELICIAEH
310 320 330 340 350 360
330 340 350 360 370
pF1KE3 CAALREVHCF-CVVSHSVLDAFRAHCPRLRTYTLKLTREPHPWRPTLVA
:. : . : :: :.. : : : : :.. .:
NP_036 CTNLTALGLSKCEVSCSAFIRFVRLCER-RLTQLSVMEEVLIPDEDYSLDEIHTEVSKYL
370 380 390 400 410 420
NP_036 GRVWFPDVMPLW
430
374 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 08:43:42 2016 done: Sun Nov 6 08:43:43 2016
Total Scan time: 8.090 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]