Result of FASTA (omim) for
pFN21AE3939
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3939, 518 aa
1>>>pF1KE3939 518 - 518 aa - 518 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.9266+/-0.000792; mu= 9.2105+/- 0.047
mean_var=193.1664+/-43.172, 0's: 0 Z-trim(108.6): 780 B-trim: 1142 in 2/47
Lambda= 0.092280
statistics sampled from 15789 (16730) to 15789 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.555), E-opt: 0.2 (0.196), width: 16
Scan time: 7.280
The best scores are: opt bits E(85289)
NP_057199 (OMIM: 605760) ankyrin repeat and SOCS b ( 518) 3478 477.3 4.9e-134
NP_665862 (OMIM: 605760) ankyrin repeat and SOCS b ( 445) 2997 413.1 8.4e-115
NP_001188894 (OMIM: 605760) ankyrin repeat and SOC ( 445) 2997 413.1 8.4e-115
XP_011535137 (OMIM: 605759) PREDICTED: ankyrin rep ( 533) 638 99.2 3.3e-20
NP_057234 (OMIM: 605759) ankyrin repeat and SOCS b ( 587) 638 99.2 3.5e-20
XP_016876858 (OMIM: 605759) PREDICTED: ankyrin rep ( 600) 638 99.2 3.5e-20
XP_005267815 (OMIM: 605759) PREDICTED: ankyrin rep ( 635) 638 99.3 3.7e-20
NP_001189358 (OMIM: 605759) ankyrin repeat and SOC ( 635) 638 99.3 3.7e-20
NP_065210 (OMIM: 182900,612641) ankyrin-1 isoform (1719) 548 87.8 2.8e-16
XP_011542807 (OMIM: 182900,612641) PREDICTED: anky (1751) 548 87.8 2.8e-16
XP_011542806 (OMIM: 182900,612641) PREDICTED: anky (1752) 548 87.8 2.8e-16
XP_016868818 (OMIM: 182900,612641) PREDICTED: anky (1759) 548 87.8 2.8e-16
NP_065208 (OMIM: 182900,612641) ankyrin-1 isoform (1856) 548 87.8 2.9e-16
NP_000028 (OMIM: 182900,612641) ankyrin-1 isoform (1880) 548 87.9 3e-16
NP_065209 (OMIM: 182900,612641) ankyrin-1 isoform (1881) 548 87.9 3e-16
XP_011542804 (OMIM: 182900,612641) PREDICTED: anky (1889) 548 87.9 3e-16
NP_001135918 (OMIM: 182900,612641) ankyrin-1 isofo (1897) 548 87.9 3e-16
XP_011542803 (OMIM: 182900,612641) PREDICTED: anky (1913) 548 87.9 3e-16
XP_011542802 (OMIM: 182900,612641) PREDICTED: anky (1914) 548 87.9 3e-16
XP_005273533 (OMIM: 182900,612641) PREDICTED: anky (1921) 548 87.9 3e-16
XP_016868813 (OMIM: 182900,612641) PREDICTED: anky (1922) 548 87.9 3e-16
XP_016868812 (OMIM: 182900,612641) PREDICTED: anky (1936) 548 87.9 3e-16
XP_016868811 (OMIM: 182900,612641) PREDICTED: anky (1937) 548 87.9 3e-16
XP_016868810 (OMIM: 182900,612641) PREDICTED: anky (1940) 548 87.9 3e-16
XP_011542805 (OMIM: 182900,612641) PREDICTED: anky (1791) 506 82.2 1.4e-14
XP_016868817 (OMIM: 182900,612641) PREDICTED: anky (1792) 506 82.2 1.4e-14
XP_016868816 (OMIM: 182900,612641) PREDICTED: anky (1807) 506 82.2 1.4e-14
XP_016868815 (OMIM: 182900,612641) PREDICTED: anky (1892) 506 82.3 1.4e-14
XP_016868814 (OMIM: 182900,612641) PREDICTED: anky (1908) 506 82.3 1.4e-14
XP_011542798 (OMIM: 182900,612641) PREDICTED: anky (1944) 506 82.3 1.5e-14
XP_016868809 (OMIM: 182900,612641) PREDICTED: anky (1946) 506 82.3 1.5e-14
XP_011542797 (OMIM: 182900,612641) PREDICTED: anky (1953) 506 82.3 1.5e-14
XP_011542796 (OMIM: 182900,612641) PREDICTED: anky (1954) 506 82.3 1.5e-14
XP_016868808 (OMIM: 182900,612641) PREDICTED: anky (1961) 506 82.3 1.5e-14
XP_011542793 (OMIM: 182900,612641) PREDICTED: anky (1968) 506 82.3 1.5e-14
XP_011542792 (OMIM: 182900,612641) PREDICTED: anky (1969) 506 82.3 1.5e-14
XP_016863596 (OMIM: 106410,600919) PREDICTED: anky (1797) 502 81.7 2e-14
XP_016863595 (OMIM: 106410,600919) PREDICTED: anky (1806) 502 81.7 2e-14
XP_016863591 (OMIM: 106410,600919) PREDICTED: anky (1838) 502 81.7 2e-14
XP_016863589 (OMIM: 106410,600919) PREDICTED: anky (1846) 502 81.7 2e-14
XP_016863586 (OMIM: 106410,600919) PREDICTED: anky (1858) 502 81.7 2.1e-14
XP_016863580 (OMIM: 106410,600919) PREDICTED: anky (1879) 502 81.7 2.1e-14
XP_016863601 (OMIM: 106410,600919) PREDICTED: anky (1689) 484 79.3 1e-13
XP_016863600 (OMIM: 106410,600919) PREDICTED: anky (1755) 484 79.3 1e-13
XP_016863599 (OMIM: 106410,600919) PREDICTED: anky (1763) 484 79.3 1e-13
XP_016863598 (OMIM: 106410,600919) PREDICTED: anky (1770) 484 79.3 1e-13
XP_016863597 (OMIM: 106410,600919) PREDICTED: anky (1772) 484 79.3 1e-13
XP_016863594 (OMIM: 106410,600919) PREDICTED: anky (1810) 484 79.3 1.1e-13
XP_016863592 (OMIM: 106410,600919) PREDICTED: anky (1816) 484 79.3 1.1e-13
XP_016863593 (OMIM: 106410,600919) PREDICTED: anky (1818) 484 79.3 1.1e-13
>>NP_057199 (OMIM: 605760) ankyrin repeat and SOCS box p (518 aa)
initn: 3478 init1: 3478 opt: 3478 Z-score: 2527.4 bits: 477.3 E(85289): 4.9e-134
Smith-Waterman score: 3478; 100.0% identity (100.0% similar) in 518 aa overlap (1-518:1-518)
10 20 30 40 50 60
pF1KE3 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 ENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 FRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 FRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSID
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 TLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 TLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLR
430 440 450 460 470 480
490 500 510
pF1KE3 SDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
::::::::::::::::::::::::::::::::::::::
NP_057 SDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
490 500 510
>>NP_665862 (OMIM: 605760) ankyrin repeat and SOCS box p (445 aa)
initn: 2997 init1: 2997 opt: 2997 Z-score: 2182.0 bits: 413.1 E(85289): 8.4e-115
Smith-Waterman score: 2997; 100.0% identity (100.0% similar) in 445 aa overlap (74-518:1-445)
50 60 70 80 90 100
pF1KE3 WMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGA
::::::::::::::::::::::::::::::
NP_665 MKTFEGFCALHLAASQGHWKIVQILLEAGA
10 20 30
110 120 130 140 150 160
pF1KE3 DPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 DPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIK
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE3 LLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 LLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEG
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE3 HTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 HTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSP
160 170 180 190 200 210
290 300 310 320 330 340
pF1KE3 VYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 VYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQ
220 230 240 250 260 270
350 360 370 380 390 400
pF1KE3 INELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 INELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGF
280 290 300 310 320 330
410 420 430 440 450 460
pF1KE3 DPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 DPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLT
340 350 360 370 380 390
470 480 490 500 510
pF1KE3 HLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 HLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
400 410 420 430 440
>>NP_001188894 (OMIM: 605760) ankyrin repeat and SOCS bo (445 aa)
initn: 2997 init1: 2997 opt: 2997 Z-score: 2182.0 bits: 413.1 E(85289): 8.4e-115
Smith-Waterman score: 2997; 100.0% identity (100.0% similar) in 445 aa overlap (74-518:1-445)
50 60 70 80 90 100
pF1KE3 WMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGA
::::::::::::::::::::::::::::::
NP_001 MKTFEGFCALHLAASQGHWKIVQILLEAGA
10 20 30
110 120 130 140 150 160
pF1KE3 DPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIK
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE3 LLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEG
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE3 HTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSP
160 170 180 190 200 210
290 300 310 320 330 340
pF1KE3 VYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQ
220 230 240 250 260 270
350 360 370 380 390 400
pF1KE3 INELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGF
280 290 300 310 320 330
410 420 430 440 450 460
pF1KE3 DPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLT
340 350 360 370 380 390
470 480 490 500 510
pF1KE3 HLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
400 410 420 430 440
>>XP_011535137 (OMIM: 605759) PREDICTED: ankyrin repeat (533 aa)
initn: 525 init1: 281 opt: 638 Z-score: 483.8 bits: 99.2 E(85289): 3.3e-20
Smith-Waterman score: 684; 28.9% identity (60.2% similar) in 543 aa overlap (17-502:10-531)
10 20 30 40 50 60
pF1KE3 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ
: ..:. ..:. ..:.:... ...::.:.:::::...: ::.
XP_011 MRPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLK
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAV
.: : . : ..:.. :..::. .:: . ::.:::.:. .. . :::. :
XP_011 VLQRA--YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKAC
60 70 80 90 100 110
130 140 150 160 170
pF1KE3 ENGQIDVLRLLLQHGANVNGSHSMC--GWNSLHQASFQENAEIIKLLLRKGANKECQDDF
: . .....:.::.:..: : : ::..::.. ... :....:. ::. : .. .
XP_011 ERKNAEAVKILVQHNADTN--HR-CNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAY
120 130 140 150 160
180 190 200 210 220 230
pF1KE3 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP
:::::::::: :.::.: .: . ::..: :: :.:. :. : .. : . ::.:::.:::
XP_011 GITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADA
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE3 DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEI
. :.:. ::.: :.. :. .:...:.:.:.:. . :::.. :. .:.. ::
XP_011 N-KTNKDGL-LPLHIASKKGNYRIVQMLLPVTSRT-RIRRSGVSPLHLAAERNHDEVLEA
230 240 250 260 270 280
300 310 320
pF1KE3 LLRNGY---SPDA-----------QACLVFGFS----------------------SPVCM
:: . .: : .. : :. ::. .
XP_011 LLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLV
290 300 310 320 330 340
330 340 350 360 370
pF1KE3 AFQKDCEFFGIVNILLKYGAQINEL---H-LAY----CLKYEKFSIFRYFLRKGCSLGP-
:... : . ...:: .::.:. : :. . .. .:...... ::. :
XP_011 AIRHGC--LRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPC
350 360 370 380 390 400
380 390 400 410 420
pF1KE3 WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDP-LILLC--------NSWIDSVSIDTLIF
.. .: : : . . . .: .: .. .: . : . ::.:
XP_011 FSCLYGNGPHPPAPQPSSR--FNDAPAADKEPSVVQFCEFVSAPEVSRWAGPI-IDVL--
410 420 430 440 450
430 440 450 460 470 480
pF1KE3 TLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPS-LTHLCRLEIRSSLKSERLRSDS
:.... : ... ... . : . .. : : :.:::::..:... . :..
XP_011 -LDYVGNVQLCSRLKEHIDSFED--WAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIK---
460 470 480 490 500 510
490 500 510
pF1KE3 YISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
.. :::: : :: ::.
XP_011 LLDTLPLPGRLIRYLKYENTQ
520 530
>>NP_057234 (OMIM: 605759) ankyrin repeat and SOCS box p (587 aa)
initn: 525 init1: 281 opt: 638 Z-score: 483.3 bits: 99.2 E(85289): 3.5e-20
Smith-Waterman score: 684; 28.9% identity (60.2% similar) in 543 aa overlap (17-502:64-585)
10 20 30 40
pF1KE3 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMP
: ..:. ..:. ..:.:... ...::.:
NP_057 PMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLP
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE3 IHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPN
.:::::...: ::..: : . : ..:.. :..::. .:: . ::.:::.:.
NP_057 LHEAAYYGQVGCLKVLQRA--YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPD
100 110 120 130 140 150
110 120 130 140 150 160
pF1KE3 ATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC--GWNSLHQASFQENAEIIKL
.. . :::. : : . .....:.::.:..: : : ::..::.. ... :....
NP_057 ISNKSRETPLYKACERKNAEAVKILVQHNADTN--HR-CNRGWTALHESVSRNDLEVMQI
160 170 180 190 200
170 180 190 200 210 220
pF1KE3 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH
:. ::. : .. .:::::::::: :.::.: .: . ::..: :: :.:. :. : .. :
NP_057 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEH
210 220 230 240 250 260
230 240 250 260 270 280
pF1KE3 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV
. ::.:::.::: . :.:. ::.: :.. :. .:...:.:.:.:. . :::.
NP_057 EEVVEFLLSQGADAN-KTNKDGL-LPLHIASKKGNYRIVQMLLPVTSRT-RIRRSGVSPL
270 280 290 300 310 320
290 300 310
pF1KE3 YSAVFGGHEDCLEILLRNGY---SPDA-----------QACLVFGFS-------------
. :. .:.. :: :: . .: : .. : :.
NP_057 HLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQH
330 340 350 360 370 380
320 330 340 350 360
pF1KE3 ---------SPVCMAFQKDCEFFGIVNILLKYGAQINEL---H-LAY----CLKYEKFSI
::. .:... : . ...:: .::.:. : :. . .. .:.
NP_057 GADPNRDVISPLLVAIRHGC--LRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSL
390 400 410 420 430 440
370 380 390 400 410
pF1KE3 FRYFLRKGCSLGP-WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDP-LILLC--------
..... ::. : .. .: : : . . . .: .: .. .:
NP_057 LKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSR--FNDAPAADKEPSVVQFCEFVSAPEV
450 460 470 480 490 500
420 430 440 450 460
pF1KE3 NSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPS-LTHLCRLE
. : . ::.: :.... : ... ... . : . .. : : :.:::::.
NP_057 SRWAGPI-IDVL---LDYVGNVQLCSRLKEHIDSFED--WAVIKEKAEPPRPLAHLCRLR
510 520 530 540 550
470 480 490 500 510
pF1KE3 IRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
.:... . :.. .. :::: : :: ::.
NP_057 VRKAIGKYRIK---LLDTLPLPGRLIRYLKYENTQ
560 570 580
>>XP_016876858 (OMIM: 605759) PREDICTED: ankyrin repeat (600 aa)
initn: 525 init1: 281 opt: 638 Z-score: 483.2 bits: 99.2 E(85289): 3.5e-20
Smith-Waterman score: 684; 28.9% identity (60.2% similar) in 543 aa overlap (17-502:77-598)
10 20 30 40
pF1KE3 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMP
: ..:. ..:. ..:.:... ...::.:
XP_016 TTAEATASACTNRQPAHFYPWTRPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLP
50 60 70 80 90 100
50 60 70 80 90 100
pF1KE3 IHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPN
.:::::...: ::..: : . : ..:.. :..::. .:: . ::.:::.:.
XP_016 LHEAAYYGQVGCLKVLQRA--YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPD
110 120 130 140 150 160
110 120 130 140 150 160
pF1KE3 ATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC--GWNSLHQASFQENAEIIKL
.. . :::. : : . .....:.::.:..: : : ::..::.. ... :....
XP_016 ISNKSRETPLYKACERKNAEAVKILVQHNADTN--HR-CNRGWTALHESVSRNDLEVMQI
170 180 190 200 210 220
170 180 190 200 210 220
pF1KE3 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH
:. ::. : .. .:::::::::: :.::.: .: . ::..: :: :.:. :. : .. :
XP_016 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEH
230 240 250 260 270 280
230 240 250 260 270 280
pF1KE3 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV
. ::.:::.::: . :.:. ::.: :.. :. .:...:.:.:.:. . :::.
XP_016 EEVVEFLLSQGADAN-KTNKDGL-LPLHIASKKGNYRIVQMLLPVTSRT-RIRRSGVSPL
290 300 310 320 330
290 300 310
pF1KE3 YSAVFGGHEDCLEILLRNGY---SPDA-----------QACLVFGFS-------------
. :. .:.. :: :: . .: : .. : :.
XP_016 HLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQH
340 350 360 370 380 390
320 330 340 350 360
pF1KE3 ---------SPVCMAFQKDCEFFGIVNILLKYGAQINEL---H-LAY----CLKYEKFSI
::. .:... : . ...:: .::.:. : :. . .. .:.
XP_016 GADPNRDVISPLLVAIRHGC--LRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSL
400 410 420 430 440 450
370 380 390 400 410
pF1KE3 FRYFLRKGCSLGP-WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDP-LILLC--------
..... ::. : .. .: : : . . . .: .: .. .:
XP_016 LKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSR--FNDAPAADKEPSVVQFCEFVSAPEV
460 470 480 490 500 510
420 430 440 450 460
pF1KE3 NSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPS-LTHLCRLE
. : . ::.: :.... : ... ... . : . .. : : :.:::::.
XP_016 SRWAGPI-IDVL---LDYVGNVQLCSRLKEHIDSFED--WAVIKEKAEPPRPLAHLCRLR
520 530 540 550 560
470 480 490 500 510
pF1KE3 IRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
.:... . :.. .. :::: : :: ::.
XP_016 VRKAIGKYRIK---LLDTLPLPGRLIRYLKYENTQ
570 580 590 600
>>XP_005267815 (OMIM: 605759) PREDICTED: ankyrin repeat (635 aa)
initn: 525 init1: 281 opt: 638 Z-score: 483.0 bits: 99.3 E(85289): 3.7e-20
Smith-Waterman score: 684; 28.9% identity (60.2% similar) in 543 aa overlap (17-502:112-633)
10 20 30 40
pF1KE3 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMP
: ..:. ..:. ..:.:... ...::.:
XP_005 PMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLP
90 100 110 120 130 140
50 60 70 80 90 100
pF1KE3 IHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPN
.:::::...: ::..: : . : ..:.. :..::. .:: . ::.:::.:.
XP_005 LHEAAYYGQVGCLKVLQRA--YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPD
150 160 170 180 190
110 120 130 140 150 160
pF1KE3 ATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC--GWNSLHQASFQENAEIIKL
.. . :::. : : . .....:.::.:..: : : ::..::.. ... :....
XP_005 ISNKSRETPLYKACERKNAEAVKILVQHNADTN--HR-CNRGWTALHESVSRNDLEVMQI
200 210 220 230 240 250
170 180 190 200 210 220
pF1KE3 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH
:. ::. : .. .:::::::::: :.::.: .: . ::..: :: :.:. :. : .. :
XP_005 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEH
260 270 280 290 300 310
230 240 250 260 270 280
pF1KE3 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV
. ::.:::.::: . :.:. ::.: :.. :. .:...:.:.:.:. . :::.
XP_005 EEVVEFLLSQGADAN-KTNKDGL-LPLHIASKKGNYRIVQMLLPVTSRT-RIRRSGVSPL
320 330 340 350 360 370
290 300 310
pF1KE3 YSAVFGGHEDCLEILLRNGY---SPDA-----------QACLVFGFS-------------
. :. .:.. :: :: . .: : .. : :.
XP_005 HLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQH
380 390 400 410 420 430
320 330 340 350 360
pF1KE3 ---------SPVCMAFQKDCEFFGIVNILLKYGAQINEL---H-LAY----CLKYEKFSI
::. .:... : . ...:: .::.:. : :. . .. .:.
XP_005 GADPNRDVISPLLVAIRHGC--LRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSL
440 450 460 470 480 490
370 380 390 400 410
pF1KE3 FRYFLRKGCSLGP-WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDP-LILLC--------
..... ::. : .. .: : : . . . .: .: .. .:
XP_005 LKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSR--FNDAPAADKEPSVVQFCEFVSAPEV
500 510 520 530 540
420 430 440 450 460
pF1KE3 NSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPS-LTHLCRLE
. : . ::.: :.... : ... ... . : . .. : : :.:::::.
XP_005 SRWAGPI-IDVL---LDYVGNVQLCSRLKEHIDSFED--WAVIKEKAEPPRPLAHLCRLR
550 560 570 580 590 600
470 480 490 500 510
pF1KE3 IRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
.:... . :.. .. :::: : :: ::.
XP_005 VRKAIGKYRIK---LLDTLPLPGRLIRYLKYENTQ
610 620 630
>>NP_001189358 (OMIM: 605759) ankyrin repeat and SOCS bo (635 aa)
initn: 525 init1: 281 opt: 638 Z-score: 483.0 bits: 99.3 E(85289): 3.7e-20
Smith-Waterman score: 684; 28.9% identity (60.2% similar) in 543 aa overlap (17-502:112-633)
10 20 30 40
pF1KE3 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMP
: ..:. ..:. ..:.:... ...::.:
NP_001 PMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLP
90 100 110 120 130 140
50 60 70 80 90 100
pF1KE3 IHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPN
.:::::...: ::..: : . : ..:.. :..::. .:: . ::.:::.:.
NP_001 LHEAAYYGQVGCLKVLQRA--YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPD
150 160 170 180 190
110 120 130 140 150 160
pF1KE3 ATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC--GWNSLHQASFQENAEIIKL
.. . :::. : : . .....:.::.:..: : : ::..::.. ... :....
NP_001 ISNKSRETPLYKACERKNAEAVKILVQHNADTN--HR-CNRGWTALHESVSRNDLEVMQI
200 210 220 230 240 250
170 180 190 200 210 220
pF1KE3 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH
:. ::. : .. .:::::::::: :.::.: .: . ::..: :: :.:. :. : .. :
NP_001 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEH
260 270 280 290 300 310
230 240 250 260 270 280
pF1KE3 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV
. ::.:::.::: . :.:. ::.: :.. :. .:...:.:.:.:. . :::.
NP_001 EEVVEFLLSQGADAN-KTNKDGL-LPLHIASKKGNYRIVQMLLPVTSRT-RIRRSGVSPL
320 330 340 350 360 370
290 300 310
pF1KE3 YSAVFGGHEDCLEILLRNGY---SPDA-----------QACLVFGFS-------------
. :. .:.. :: :: . .: : .. : :.
NP_001 HLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQH
380 390 400 410 420 430
320 330 340 350 360
pF1KE3 ---------SPVCMAFQKDCEFFGIVNILLKYGAQINEL---H-LAY----CLKYEKFSI
::. .:... : . ...:: .::.:. : :. . .. .:.
NP_001 GADPNRDVISPLLVAIRHGC--LRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSL
440 450 460 470 480 490
370 380 390 400 410
pF1KE3 FRYFLRKGCSLGP-WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDP-LILLC--------
..... ::. : .. .: : : . . . .: .: .. .:
NP_001 LKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSR--FNDAPAADKEPSVVQFCEFVSAPEV
500 510 520 530 540
420 430 440 450 460
pF1KE3 NSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPS-LTHLCRLE
. : . ::.: :.... : ... ... . : . .. : : :.:::::.
NP_001 SRWAGPI-IDVL---LDYVGNVQLCSRLKEHIDSFED--WAVIKEKAEPPRPLAHLCRLR
550 560 570 580 590 600
470 480 490 500 510
pF1KE3 IRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
.:... . :.. .. :::: : :: ::.
NP_001 VRKAIGKYRIK---LLDTLPLPGRLIRYLKYENTQ
610 620 630
>>NP_065210 (OMIM: 182900,612641) ankyrin-1 isoform 2 [H (1719 aa)
initn: 1119 init1: 212 opt: 548 Z-score: 413.2 bits: 87.8 E(85289): 2.8e-16
Smith-Waterman score: 548; 32.1% identity (62.8% similar) in 371 aa overlap (9-370:271-627)
10 20 30
pF1KE3 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDV
: . . :::.:.:.. . :: .: ...
NP_065 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA
250 260 270 280 290 300
40 50 60 70 80 90
pF1KE3 ADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQIL
. : ::: :: . ..:...:.. :. . : :.. . ::.:: :: .....:
NP_065 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI---TLDHLTPLHVAAHCGHHRVAKVL
310 320 330 340 350
100 110 120 130 140 150
pF1KE3 LEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQEN
:. :: ::. .:. ::: .: ..... :..:::. ::.... . : . :: :::. .
NP_065 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV-TESGLTPLHVASFMGH
360 370 380 390 400 410
160 170 180 190 200 210
pF1KE3 AEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFI
:.: ::..::. . .. ::: .::. :. : . :... :.:: .: : :::
NP_065 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC
420 430 440 450 460 470
220 230 240 250 260 270
pF1KE3 AAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTK-ILDLLIPLTNRACDTG
::. :::. :.::: ..:.:.: . . :.: ::. ::.. .: :: ...:: :
NP_065 AARIGHTNMVKLLLENNANPNLATTAG--HTPLHIAAREGHVETVLALLEKEASQACMTK
480 490 500 510 520 530
280 290 300 310 320 330
pF1KE3 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNIL
. .:.. :. :. :.::. :.: . :.. :. .: ... . ::..:
NP_065 -KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN--GLT-PLHVAVHHNN--LDIVKLL
540 550 560 570 580
340 350 360 370 380
pF1KE3 LKYGAQ--------INELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQA
: :.. . ::.: : .. . : .:. : :
NP_065 LPRGGSPHSPAWNGYTPLHIA--AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG
590 600 610 620 630 640
390 400 410 420 430 440
pF1KE3 KYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNA
NP_065 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH
650 660 670 680 690 700
>--
initn: 434 init1: 192 opt: 291 Z-score: 228.3 bits: 53.6 E(85289): 5.6e-06
Smith-Waterman score: 307; 33.8% identity (67.5% similar) in 157 aa overlap (75-231:631-786)
50 60 70 80 90 100
pF1KE3 MPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGAD
.. .: :::::..:: ..: .:: :.
NP_065 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN
610 620 630 640 650 660
110 120 130 140 150 160
pF1KE3 PNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKL
: . ::: :....:.. : .:..::. :... : :.. :: :: : ...:.
NP_065 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRM-GYTPLHVASHYGNIKLVKF
670 680 690 700 710
170 180 190 200 210 220
pF1KE3 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH
::.. :. . . .: .:: ::: :. . ...:...::. : . : .::: :: . :.
NP_065 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY
720 730 740 750 760 770
230 240 250 260 270 280
pF1KE3 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV
. ...:
NP_065 ISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDE
780 790 800 810 820 830
>--
initn: 383 init1: 200 opt: 266 Z-score: 210.3 bits: 50.3 E(85289): 5.6e-05
Smith-Waterman score: 366; 32.2% identity (67.4% similar) in 233 aa overlap (9-236:39-263)
10 20 30
pF1KE3 MDFTEAYADTCSTVGL-----AAREGNVKVLRKLLKKG
.::. :: :..::.::.. .::.:
NP_065 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE3 RSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWK
.... ..: .: :: .. : .. :.: .. : ..: :: :..::...: .
NP_065 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK---GFTPLYMAAQENHLE
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE3 IVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQA
.:..::: ::. :..: . ::: .:...:. .:. :...:.. :. . .:: :
NP_065 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK--GKVRL---PALHIA
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE3 SFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKA
. ..... .::.. : . . :.::: .::.: .:. ..:.. ::.:: .
NP_065 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE3 TPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRA
::: ::...:.. :.:::. ::
NP_065 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA
250 260 270 280 290 300
>>XP_011542807 (OMIM: 182900,612641) PREDICTED: ankyrin- (1751 aa)
initn: 1119 init1: 212 opt: 548 Z-score: 413.1 bits: 87.8 E(85289): 2.8e-16
Smith-Waterman score: 548; 32.1% identity (62.8% similar) in 371 aa overlap (9-370:304-660)
10 20 30
pF1KE3 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDV
: . . :::.:.:.. . :: .: ...
XP_011 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA
280 290 300 310 320 330
40 50 60 70 80 90
pF1KE3 ADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQIL
. : ::: :: . ..:...:.. :. . : :.. . ::.:: :: .....:
XP_011 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI---TLDHLTPLHVAAHCGHHRVAKVL
340 350 360 370 380 390
100 110 120 130 140 150
pF1KE3 LEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQEN
:. :: ::. .:. ::: .: ..... :..:::. ::.... . : . :: :::. .
XP_011 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV-TESGLTPLHVASFMGH
400 410 420 430 440
160 170 180 190 200 210
pF1KE3 AEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFI
:.: ::..::. . .. ::: .::. :. : . :... :.:: .: : :::
XP_011 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC
450 460 470 480 490 500
220 230 240 250 260 270
pF1KE3 AAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTK-ILDLLIPLTNRACDTG
::. :::. :.::: ..:.:.: . . :.: ::. ::.. .: :: ...:: :
XP_011 AARIGHTNMVKLLLENNANPNLATTAG--HTPLHIAAREGHVETVLALLEKEASQACMTK
510 520 530 540 550 560
280 290 300 310 320 330
pF1KE3 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNIL
. .:.. :. :. :.::. :.: . :.. :. .: ... . ::..:
XP_011 -KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN--GLT-PLHVAVHHNN--LDIVKLL
570 580 590 600 610 620
340 350 360 370 380
pF1KE3 LKYGAQ--------INELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQA
: :.. . ::.: : .. . : .:. : :
XP_011 LPRGGSPHSPAWNGYTPLHIA--AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG
630 640 650 660 670
390 400 410 420 430 440
pF1KE3 KYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNA
XP_011 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH
680 690 700 710 720 730
>--
initn: 434 init1: 192 opt: 291 Z-score: 228.2 bits: 53.6 E(85289): 5.7e-06
Smith-Waterman score: 307; 33.8% identity (67.5% similar) in 157 aa overlap (75-231:664-819)
50 60 70 80 90 100
pF1KE3 MPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGAD
.. .: :::::..:: ..: .:: :.
XP_011 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN
640 650 660 670 680 690
110 120 130 140 150 160
pF1KE3 PNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKL
: . ::: :....:.. : .:..::. :... : :.. :: :: : ...:.
XP_011 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRM-GYTPLHVASHYGNIKLVKF
700 710 720 730 740 750
170 180 190 200 210 220
pF1KE3 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH
::.. :. . . .: .:: ::: :. . ...:...::. : . : .::: :: . :.
XP_011 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY
760 770 780 790 800 810
230 240 250 260 270 280
pF1KE3 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV
. ...:
XP_011 ISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDE
820 830 840 850 860 870
>--
initn: 403 init1: 200 opt: 266 Z-score: 210.2 bits: 50.3 E(85289): 5.7e-05
Smith-Waterman score: 366; 32.2% identity (67.4% similar) in 233 aa overlap (9-236:72-296)
10 20 30
pF1KE3 MDFTEAYADTCSTVGL-----AAREGNVKVLRKLLKKG
.::. :: :..::.::.. .::.:
XP_011 KADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE
50 60 70 80 90 100
40 50 60 70 80 90
pF1KE3 RSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWK
.... ..: .: :: .. : .. :.: .. : ..: :: :..::...: .
XP_011 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK---GFTPLYMAAQENHLE
110 120 130 140 150
100 110 120 130 140 150
pF1KE3 IVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQA
.:..::: ::. :..: . ::: .:...:. .:. :...:.. :. . .:: :
XP_011 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK--GKVRL---PALHIA
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE3 SFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKA
. ..... .::.. : . . :.::: .::.: .:. ..:.. ::.:: .
XP_011 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE3 TPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRA
::: ::...:.. :.:::. ::
XP_011 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA
280 290 300 310 320 330
518 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 08:46:16 2016 done: Sun Nov 6 08:46:17 2016
Total Scan time: 7.280 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]