Result of FASTA (omim) for
pFN21AE3928
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3928, 396 aa
1>>>pF1KE3928 396 - 396 aa - 396 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0948+/-0.000397; mu= 18.4624+/- 0.025
mean_var=72.1294+/-14.620, 0's: 0 Z-trim(111.7): 151 B-trim: 1228 in 1/50
Lambda= 0.151014
statistics sampled from 20193 (20345) to 20193 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.239), width: 16
Scan time: 7.390
The best scores are: opt bits E(85289)
NP_001287787 (OMIM: 613292) DENN domain-containing ( 396) 2657 588.4 1e-167
XP_016855960 (OMIM: 613292) PREDICTED: DENN domain ( 745) 2573 570.3 5.4e-162
XP_005244988 (OMIM: 613292) PREDICTED: DENN domain ( 755) 2444 542.2 1.6e-153
XP_011507549 (OMIM: 613292) PREDICTED: DENN domain ( 803) 2444 542.2 1.6e-153
NP_079096 (OMIM: 613633) DENN domain-containing pr ( 559) 1839 410.3 5.9e-114
XP_005252170 (OMIM: 613633) PREDICTED: DENN domain ( 574) 1839 410.3 6e-114
XP_011517189 (OMIM: 613633) PREDICTED: DENN domain ( 592) 1839 410.3 6.2e-114
NP_065997 (OMIM: 613633) DENN domain-containing pr (1009) 1839 410.5 9.3e-114
XP_005252168 (OMIM: 613633) PREDICTED: DENN domain (1024) 1839 410.5 9.4e-114
XP_011517188 (OMIM: 613633) PREDICTED: DENN domain (1042) 1839 410.5 9.6e-114
XP_016870437 (OMIM: 613633) PREDICTED: DENN domain (1052) 1839 410.5 9.6e-114
XP_011517185 (OMIM: 613633) PREDICTED: DENN domain (1066) 1839 410.5 9.7e-114
XP_006717258 (OMIM: 613633) PREDICTED: DENN domain (1067) 1839 410.5 9.7e-114
XP_005252166 (OMIM: 613633) PREDICTED: DENN domain (1070) 1839 410.5 9.8e-114
XP_011517184 (OMIM: 613633) PREDICTED: DENN domain (1085) 1839 410.5 9.9e-114
XP_011517187 (OMIM: 613633) PREDICTED: DENN domain (1049) 1836 409.8 1.5e-113
XP_016870436 (OMIM: 613633) PREDICTED: DENN domain (1058) 1782 398.1 5.3e-110
NP_659414 (OMIM: 613292) DENN domain-containing pr ( 426) 1693 378.4 1.8e-104
XP_016870440 (OMIM: 613633) PREDICTED: DENN domain (1020) 1694 378.9 3e-104
XP_011517186 (OMIM: 613633) PREDICTED: DENN domain (1056) 1694 378.9 3.1e-104
XP_016855959 (OMIM: 613292) PREDICTED: DENN domain ( 765) 1609 360.3 9.2e-99
XP_006711256 (OMIM: 613292) PREDICTED: DENN domain ( 765) 1609 360.3 9.2e-99
XP_011507551 (OMIM: 613292) PREDICTED: DENN domain ( 765) 1609 360.3 9.2e-99
XP_006711255 (OMIM: 613292) PREDICTED: DENN domain ( 765) 1609 360.3 9.2e-99
NP_001182144 (OMIM: 613292) DENN domain-containing ( 775) 1609 360.3 9.2e-99
XP_011507550 (OMIM: 613292) PREDICTED: DENN domain ( 788) 1609 360.3 9.4e-99
XP_011507548 (OMIM: 613292) PREDICTED: DENN domain ( 823) 1609 360.3 9.7e-99
XP_011507553 (OMIM: 613292) PREDICTED: DENN domain ( 447) 1395 313.5 6.6e-85
XP_016870439 (OMIM: 613633) PREDICTED: DENN domain (1025) 1349 303.7 1.3e-81
XP_016870438 (OMIM: 613633) PREDICTED: DENN domain (1043) 1349 303.7 1.3e-81
XP_011526620 (OMIM: 613634) PREDICTED: DENN domain ( 757) 999 227.4 9.2e-59
XP_006722969 (OMIM: 613634) PREDICTED: DENN domain ( 757) 999 227.4 9.2e-59
NP_001277260 (OMIM: 613634) DENN domain-containing ( 757) 999 227.4 9.2e-59
NP_079174 (OMIM: 613634) DENN domain-containing pr ( 801) 999 227.4 9.6e-59
XP_016855961 (OMIM: 613292) PREDICTED: DENN domain ( 491) 838 192.1 2.4e-48
XP_006711257 (OMIM: 613292) PREDICTED: DENN domain ( 469) 691 160.1 1e-38
XP_016870441 (OMIM: 613633) PREDICTED: DENN domain ( 811) 644 150.0 1.9e-35
XP_006722968 (OMIM: 613634) PREDICTED: DENN domain ( 715) 635 148.0 6.6e-35
XP_011518631 (OMIM: 140750) PREDICTED: suppression ( 717) 374 91.2 8.6e-18
XP_005253140 (OMIM: 140750) PREDICTED: suppression ( 717) 374 91.2 8.6e-18
NP_631896 (OMIM: 140750) suppression of tumorigeni ( 717) 374 91.2 8.6e-18
XP_011518628 (OMIM: 140750) PREDICTED: suppression ( 737) 374 91.2 8.8e-18
XP_011518630 (OMIM: 140750) PREDICTED: suppression ( 737) 374 91.2 8.8e-18
XP_016873676 (OMIM: 140750) PREDICTED: suppression ( 737) 374 91.2 8.8e-18
XP_011518629 (OMIM: 140750) PREDICTED: suppression ( 737) 374 91.2 8.8e-18
XP_011518627 (OMIM: 140750) PREDICTED: suppression ( 737) 374 91.2 8.8e-18
XP_011518626 (OMIM: 140750) PREDICTED: suppression ( 747) 374 91.2 8.9e-18
XP_011518625 (OMIM: 140750) PREDICTED: suppression ( 767) 374 91.2 9.1e-18
XP_016873675 (OMIM: 140750) PREDICTED: suppression ( 957) 374 91.3 1.1e-17
XP_016873673 (OMIM: 140750) PREDICTED: suppression ( 977) 374 91.3 1.1e-17
>>NP_001287787 (OMIM: 613292) DENN domain-containing pro (396 aa)
initn: 2657 init1: 2657 opt: 2657 Z-score: 3132.0 bits: 588.4 E(85289): 1e-167
Smith-Waterman score: 2657; 99.7% identity (99.7% similar) in 396 aa overlap (1-396:1-396)
10 20 30 40 50 60
pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVERVSQNQVGQHFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVERVSQNQVGQHFT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 FVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAKELENDLNETL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAKELENDLNETL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 RSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASML
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 HERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQSTATGDGVARAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQSTATGDGVARAF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 LRAQAALFGYYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQLFKQFIDGRLA
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQLFKQFIDGRLA
310 320 330 340 350 360
370 380 390
pF1KE3 KLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ
::::::::::::::::::::::::::::::::::::
NP_001 KLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ
370 380 390
>>XP_016855960 (OMIM: 613292) PREDICTED: DENN domain-con (745 aa)
initn: 2597 init1: 2573 opt: 2573 Z-score: 3029.4 bits: 570.3 E(85289): 5.4e-162
Smith-Waterman score: 2573; 99.0% identity (99.5% similar) in 387 aa overlap (1-387:1-387)
10 20 30 40 50 60
pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVERVSQNQVGQHFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVERVSQNQVGQHFT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 FVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAKELENDLNETL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAKELENDLNETL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 RSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASML
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 HERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQSTATGDGVARAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQSTATGDGVARAF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 LRAQAALFGYYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQLFKQFIDGRLA
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQLFKQFIDGRLA
310 320 330 340 350 360
370 380 390
pF1KE3 KLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ
::::::::::::::::::::::::. .
XP_016 KLNAGRGFSDVFEEEITSGGFCGGNPRSYQQWVHTVKKGGALFNTAMTKATPAVRTAYKF
370 380 390 400 410 420
>>XP_005244988 (OMIM: 613292) PREDICTED: DENN domain-con (755 aa)
initn: 2466 init1: 2442 opt: 2444 Z-score: 2877.4 bits: 542.2 E(85289): 1.6e-153
Smith-Waterman score: 2444; 98.6% identity (99.5% similar) in 370 aa overlap (18-387:28-397)
10 20 30 40 50
pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV
.::::::::::::::::::::::::::::::::
XP_005 MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE3 ELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVDVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVDVN
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE3 NMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAP
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE3 MPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQST
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE3 ATGDGVARAFLRAQAALFGYYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQL
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_005 ATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQL
310 320 330 340 350 360
360 370 380 390
pF1KE3 FKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ
::::::::::::::::::::::::::::::::::. .
XP_005 FKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPRSYQQWVHTVKKGGALFNTAMTKA
370 380 390 400 410 420
XP_005 TPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYGTCSSSVQYTPVYKLHNEKGGNSEK
430 440 450 460 470 480
>>XP_011507549 (OMIM: 613292) PREDICTED: DENN domain-con (803 aa)
initn: 2442 init1: 2442 opt: 2444 Z-score: 2877.0 bits: 542.2 E(85289): 1.6e-153
Smith-Waterman score: 2444; 98.6% identity (99.5% similar) in 370 aa overlap (18-387:76-445)
10 20 30 40
pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDV
.:::::::::::::::::::::::::::::
XP_011 NDYFAQEIRANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDV
50 60 70 80 90 100
50 60 70 80 90 100
pF1KE3 ERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADY
110 120 130 140 150 160
110 120 130 140 150 160
pF1KE3 LAKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAV
170 180 190 200 210 220
170 180 190 200 210 220
pF1KE3 DVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYC
230 240 250 260 270 280
230 240 250 260 270 280
pF1KE3 CAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKK
290 300 310 320 330 340
290 300 310 320 330 340
pF1KE3 QSTATGDGVARAFLRAQAALFGYYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAIN
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_011 QSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAIN
350 360 370 380 390 400
350 360 370 380 390
pF1KE3 LQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ
:::::::::::::::::::::::::::::::::::::. .
XP_011 LQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPRSYQQWVHTVKKGGALFNTAM
410 420 430 440 450 460
XP_011 TKATPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYGTCSSSVQYTPVYKLHNEKGGN
470 480 490 500 510 520
>>NP_079096 (OMIM: 613633) DENN domain-containing protei (559 aa)
initn: 1814 init1: 1606 opt: 1839 Z-score: 2166.8 bits: 410.3 E(85289): 5.9e-114
Smith-Waterman score: 1839; 70.6% identity (90.5% similar) in 378 aa overlap (16-392:28-404)
10 20 30 40
pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVE
.:.: : .::::..:::.::.. :::::: :.
NP_079 MGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVD
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 RVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYL
.. .::::.::::::::.::::::::::.::. :.:::::::::::.::::: ::::
NP_079 SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYT
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE3 AKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVD
.:. ::. :: :..:.. :.: .. :.::::::: .::. ::.:::.:::::::::::
NP_079 TKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVD
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE3 VNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCC
:::::.::::::.::::.:: :::::::::::::::.::::::::.::::::::::::::
NP_079 VNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCC
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE3 APMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQ
:::::::::: ::.:.:.: .:.:::.:::::::::.::.::..::.::.:.:::.:::
NP_079 APMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRLKKV
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE3 STATGDGVARAFLRAQAALFGYYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLETAIN
::.::::::::::.::::.:: ::.::. .: ::::::::.::.: ::..:.:::..: .
NP_079 STTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQ
310 320 330 340 350 360
350 360 370 380 390
pF1KE3 LQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ
:::::::::::: ::.:.::::::::::. : . .:.::: ...
NP_079 LQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEY-AGSDKLYHQWLSTVRKGSGAILNTV
370 380 390 400 410
NP_079 KTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLVEAK
420 430 440 450 460 470
>>XP_005252170 (OMIM: 613633) PREDICTED: DENN domain-con (574 aa)
initn: 1814 init1: 1606 opt: 1839 Z-score: 2166.7 bits: 410.3 E(85289): 6e-114
Smith-Waterman score: 1839; 70.6% identity (90.5% similar) in 378 aa overlap (16-392:43-419)
10 20 30 40
pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPF
.:.: : .::::..:::.::.. ::::::
XP_005 NETRKVCLWQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPF
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE3 DVERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLA
:. .. .::::.::::::::.::::::::::.::. :.:::::::::::.::::: ::
XP_005 YVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILA
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE3 DYLAKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFV
:: .:. ::. :: :..:.. :.: .. :.::::::: .::. ::.:::.::::::::
XP_005 DYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE3 AVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLD
::::::::.::::::.::::.:: :::::::::::::::.::::::::.:::::::::::
XP_005 AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLD
200 210 220 230 240 250
230 240 250 260 270 280
pF1KE3 YCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKL
::::::::::::: ::.:.:.: .:.:::.:::::::::.::.::..::.::.:.:::.:
XP_005 YCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRL
260 270 280 290 300 310
290 300 310 320 330 340
pF1KE3 KKQSTATGDGVARAFLRAQAALFGYYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLET
:: ::.::::::::::.::::.:: ::.::. .: ::::::::.::.: ::..:.:::..
XP_005 KKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQN
320 330 340 350 360 370
350 360 370 380 390
pF1KE3 AINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ
: .:::::::::::: ::.:.::::::::::. : . .:.::: ...
XP_005 ATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEY-AGSDKLYHQWLSTVRKGSGAIL
380 390 400 410 420 430
XP_005 NTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLV
440 450 460 470 480 490
>>XP_011517189 (OMIM: 613633) PREDICTED: DENN domain-con (592 aa)
initn: 1814 init1: 1606 opt: 1839 Z-score: 2166.5 bits: 410.3 E(85289): 6.2e-114
Smith-Waterman score: 1839; 70.6% identity (90.5% similar) in 378 aa overlap (16-392:43-419)
10 20 30 40
pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPF
.:.: : .::::..:::.::.. ::::::
XP_011 NETRKVCLWQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPF
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE3 DVERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLA
:. .. .::::.::::::::.::::::::::.::. :.:::::::::::.::::: ::
XP_011 YVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILA
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE3 DYLAKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFV
:: .:. ::. :: :..:.. :.: .. :.::::::: .::. ::.:::.::::::::
XP_011 DYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE3 AVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLD
::::::::.::::::.::::.:: :::::::::::::::.::::::::.:::::::::::
XP_011 AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLD
200 210 220 230 240 250
230 240 250 260 270 280
pF1KE3 YCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKL
::::::::::::: ::.:.:.: .:.:::.:::::::::.::.::..::.::.:.:::.:
XP_011 YCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRL
260 270 280 290 300 310
290 300 310 320 330 340
pF1KE3 KKQSTATGDGVARAFLRAQAALFGYYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLET
:: ::.::::::::::.::::.:: ::.::. .: ::::::::.::.: ::..:.:::..
XP_011 KKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQN
320 330 340 350 360 370
350 360 370 380 390
pF1KE3 AINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ
: .:::::::::::: ::.:.::::::::::. : . .:.::: ...
XP_011 ATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEY-AGSDKLYHQWLSTVRKGSGAIL
380 390 400 410 420 430
XP_011 NTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLV
440 450 460 470 480 490
>>NP_065997 (OMIM: 613633) DENN domain-containing protei (1009 aa)
initn: 1814 init1: 1606 opt: 1839 Z-score: 2163.3 bits: 410.5 E(85289): 9.3e-114
Smith-Waterman score: 1839; 70.6% identity (90.5% similar) in 378 aa overlap (16-392:28-404)
10 20 30 40
pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVE
.:.: : .::::..:::.::.. :::::: :.
NP_065 MGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVD
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 RVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYL
.. .::::.::::::::.::::::::::.::. :.:::::::::::.::::: ::::
NP_065 SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYT
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE3 AKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVD
.:. ::. :: :..:.. :.: .. :.::::::: .::. ::.:::.:::::::::::
NP_065 TKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVD
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE3 VNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCC
:::::.::::::.::::.:: :::::::::::::::.::::::::.::::::::::::::
NP_065 VNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCC
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE3 APMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQ
:::::::::: ::.:.:.: .:.:::.:::::::::.::.::..::.::.:.:::.:::
NP_065 APMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRLKKV
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE3 STATGDGVARAFLRAQAALFGYYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLETAIN
::.::::::::::.::::.:: ::.::. .: ::::::::.::.: ::..:.:::..: .
NP_065 STTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQ
310 320 330 340 350 360
350 360 370 380 390
pF1KE3 LQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ
:::::::::::: ::.:.::::::::::. : . .:.::: ...
NP_065 LQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEY-AGSDKLYHQWLSTVRKGSGAILNTV
370 380 390 400 410
NP_065 KTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLVEAK
420 430 440 450 460 470
>>XP_005252168 (OMIM: 613633) PREDICTED: DENN domain-con (1024 aa)
initn: 1814 init1: 1606 opt: 1839 Z-score: 2163.2 bits: 410.5 E(85289): 9.4e-114
Smith-Waterman score: 1839; 70.6% identity (90.5% similar) in 378 aa overlap (16-392:43-419)
10 20 30 40
pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPF
.:.: : .::::..:::.::.. ::::::
XP_005 NETRKVCLWQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPF
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE3 DVERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLA
:. .. .::::.::::::::.::::::::::.::. :.:::::::::::.::::: ::
XP_005 YVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILA
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE3 DYLAKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFV
:: .:. ::. :: :..:.. :.: .. :.::::::: .::. ::.:::.::::::::
XP_005 DYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE3 AVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLD
::::::::.::::::.::::.:: :::::::::::::::.::::::::.:::::::::::
XP_005 AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLD
200 210 220 230 240 250
230 240 250 260 270 280
pF1KE3 YCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKL
::::::::::::: ::.:.:.: .:.:::.:::::::::.::.::..::.::.:.:::.:
XP_005 YCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRL
260 270 280 290 300 310
290 300 310 320 330 340
pF1KE3 KKQSTATGDGVARAFLRAQAALFGYYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLET
:: ::.::::::::::.::::.:: ::.::. .: ::::::::.::.: ::..:.:::..
XP_005 KKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQN
320 330 340 350 360 370
350 360 370 380 390
pF1KE3 AINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ
: .:::::::::::: ::.:.::::::::::. : . .:.::: ...
XP_005 ATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEY-AGSDKLYHQWLSTVRKGSGAIL
380 390 400 410 420 430
XP_005 NTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLV
440 450 460 470 480 490
>>XP_011517188 (OMIM: 613633) PREDICTED: DENN domain-con (1042 aa)
initn: 1814 init1: 1606 opt: 1839 Z-score: 2163.1 bits: 410.5 E(85289): 9.6e-114
Smith-Waterman score: 1839; 70.6% identity (90.5% similar) in 378 aa overlap (16-392:43-419)
10 20 30 40
pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPF
.:.: : .::::..:::.::.. ::::::
XP_011 NETRKVCLWQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPF
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE3 DVERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLA
:. .. .::::.::::::::.::::::::::.::. :.:::::::::::.::::: ::
XP_011 YVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILA
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE3 DYLAKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFV
:: .:. ::. :: :..:.. :.: .. :.::::::: .::. ::.:::.::::::::
XP_011 DYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE3 AVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLD
::::::::.::::::.::::.:: :::::::::::::::.::::::::.:::::::::::
XP_011 AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLD
200 210 220 230 240 250
230 240 250 260 270 280
pF1KE3 YCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKL
::::::::::::: ::.:.:.: .:.:::.:::::::::.::.::..::.::.:.:::.:
XP_011 YCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRL
260 270 280 290 300 310
290 300 310 320 330 340
pF1KE3 KKQSTATGDGVARAFLRAQAALFGYYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLET
:: ::.::::::::::.::::.:: ::.::. .: ::::::::.::.: ::..:.:::..
XP_011 KKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQN
320 330 340 350 360 370
350 360 370 380 390
pF1KE3 AINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ
: .:::::::::::: ::.:.::::::::::. : . .:.::: ...
XP_011 ATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEY-AGSDKLYHQWLSTVRKGSGAIL
380 390 400 410 420 430
XP_011 NTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLV
440 450 460 470 480 490
396 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 08:51:36 2016 done: Sun Nov 6 08:51:37 2016
Total Scan time: 7.390 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]