Result of FASTA (omim) for
pFN21AE3923
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3923, 447 aa
1>>>pF1KE3923 447 - 447 aa - 447 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.8866+/-0.000369; mu= 15.9962+/- 0.023
mean_var=97.3011+/-19.590, 0's: 0 Z-trim(115.1): 32 B-trim: 1168 in 1/56
Lambda= 0.130022
statistics sampled from 25325 (25356) to 25325 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.666), E-opt: 0.2 (0.297), width: 16
Scan time: 8.060
The best scores are: opt bits E(85289)
NP_036309 (OMIM: 606013) F-box only protein 5 isof ( 447) 2990 571.3 1.8e-162
NP_001135994 (OMIM: 606013) F-box only protein 5 i ( 401) 2666 510.5 3.2e-144
NP_001025031 (OMIM: 609110) F-box only protein 43 ( 708) 356 77.4 1.4e-13
XP_011515292 (OMIM: 609110) PREDICTED: F-box only ( 717) 356 77.4 1.4e-13
XP_011515291 (OMIM: 609110) PREDICTED: F-box only ( 717) 356 77.4 1.4e-13
XP_011515289 (OMIM: 609110) PREDICTED: F-box only ( 751) 356 77.4 1.4e-13
>>NP_036309 (OMIM: 606013) F-box only protein 5 isoform (447 aa)
initn: 2990 init1: 2990 opt: 2990 Z-score: 3038.0 bits: 571.3 E(85289): 1.8e-162
Smith-Waterman score: 2990; 99.8% identity (100.0% similar) in 447 aa overlap (1-447:1-447)
10 20 30 40 50 60
pF1KE3 MSRRPCSCALRPPRCSCSASPSAVTAAGRPRPSDSCKEESSTLSVKMKCDFNCNHVHSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MSRRPCSCALRPPRCSCSASPSAVTAAGRPRPSDSCKEESSTLSVKMKCDFNCNHVHSGL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 KLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVELETESKRLHNKEN
::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::
NP_036 KLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVQLETESKRLHNKEN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 QHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENFGDSLQSCLLQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 QHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENFGDSLQSCLLQI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 QSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNFRLQNIIGRKMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 QSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNFRLQNIIGRKMG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LECVDILSELFRRGLRHVLATILAQLSDMDLINVSKVSTTWKKILEDDKGAFQLYSKAIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 LECVDILSELFRRGLRHVLATILAQLSDMDLINVSKVSTTWKKILEDDKGAFQLYSKAIQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 RVTENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGDQKGSTYSRHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 RVTENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGDQKGSTYSRHN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 EFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHTTKDCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 EFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHTTKDCS
370 380 390 400 410 420
430 440
pF1KE3 DGKLLKASCKIGPLPGTKKSKKNLRRL
:::::::::::::::::::::::::::
NP_036 DGKLLKASCKIGPLPGTKKSKKNLRRL
430 440
>>NP_001135994 (OMIM: 606013) F-box only protein 5 isofo (401 aa)
initn: 2666 init1: 2666 opt: 2666 Z-score: 2710.2 bits: 510.5 E(85289): 3.2e-144
Smith-Waterman score: 2666; 99.8% identity (100.0% similar) in 401 aa overlap (47-447:1-401)
20 30 40 50 60 70
pF1KE3 CSASPSAVTAAGRPRPSDSCKEESSTLSVKMKCDFNCNHVHSGLKLVKPDDIGRLVSYTP
::::::::::::::::::::::::::::::
NP_001 MKCDFNCNHVHSGLKLVKPDDIGRLVSYTP
10 20 30
80 90 100 110 120 130
pF1KE3 AYLEGSCKDCIKDYERLSCIGSPIVSPRIVELETESKRLHNKENQHVQQTLNSTNEIEAL
::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::
NP_001 AYLEGSCKDCIKDYERLSCIGSPIVSPRIVQLETESKRLHNKENQHVQQTLNSTNEIEAL
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE3 ETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENFGDSLQSCLLQIQSPDQYPNKNLLPVLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENFGDSLQSCLLQIQSPDQYPNKNLLPVLH
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE3 FEKVVCSTLKKNAKRNPKVDREMLKEIIARGNFRLQNIIGRKMGLECVDILSELFRRGLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEKVVCSTLKKNAKRNPKVDREMLKEIIARGNFRLQNIIGRKMGLECVDILSELFRRGLR
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE3 HVLATILAQLSDMDLINVSKVSTTWKKILEDDKGAFQLYSKAIQRVTENNNKFSPHASTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVLATILAQLSDMDLINVSKVSTTWKKILEDDKGAFQLYSKAIQRVTENNNKFSPHASTR
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE3 EYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGDQKGSTYSRHNEFSEVAKTLKKNESLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGDQKGSTYSRHNEFSEVAKTLKKNESLK
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE3 ACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHTTKDCSDGKLLKASCKIGPLPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHTTKDCSDGKLLKASCKIGPLPG
340 350 360 370 380 390
440
pF1KE3 TKKSKKNLRRL
:::::::::::
NP_001 TKKSKKNLRRL
400
>>NP_001025031 (OMIM: 609110) F-box only protein 43 [Hom (708 aa)
initn: 518 init1: 258 opt: 356 Z-score: 365.0 bits: 77.4 E(85289): 1.4e-13
Smith-Waterman score: 535; 31.4% identity (60.9% similar) in 379 aa overlap (80-447:352-708)
50 60 70 80 90 100
pF1KE3 DFNCNHVHSGLKLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVELE
::: .. .. .. .:. : . : .
NP_001 PEVRGSISTPEDSGFNSLSLEKSEDSLSDQEGSFQELLQKHKGTPKVGDTIRKTRHL---
330 340 350 360 370
110 120 130 140 150 160
pF1KE3 TESKRLHNKENQHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENF
.:.:: . ..: :. :. : ... . .. . . :..:: :.: ..
NP_001 GRSRRLSTLREQSSQS--------ETEEEKQIVHPDSEKRAAAASAISE---GQLSSDES
380 390 400 410 420
170 180 190 200 210 220
pF1KE3 GDSLQSCLLQIQSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNF
:: ..... .. : .:. : : : . :..:. . . .. : :: .
NP_001 GD----LTFSLKNLSKTPALQLVHEL-FMKSKRKRLQENSGH--EFLEQGDGEKIAVLQC
430 440 450 460 470 480
230 240 250 260 270 280
pF1KE3 RLQNIIGRKMGLECVDILSELFRRGLRHVLATILAQLSDMDLINVSKVSTTWKKILEDDK
: ..::.:::.: .:::.:: :.:.:.:: .: .:. .: .: ::: .:..:. .::
NP_001 ILAGLIGKKMGIEKLDILTELKYRNLKHILAMVLESLTAESLCSVWKVSRNWREIVVQDK
490 500 510 520 530 540
290 300 310 320 330 340
pF1KE3 GA---FQLYSKAIQRVTENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLS
.: ..: .. .:. :.:: .. :. : ::: .: . ... . ::
NP_001 NANRRRKFYITQLKTDSEGAVLNVEDAATRLQLLNRSALRSVQAQARIPGSQREQGSTLS
550 560 570 580 590 600
350 360 370 380 390
pF1KE3 NQGD------QKGSTY--SRHNEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKR
:. ... :. :...:. .::::: .:.:: : ::.:::::. : .:. :.:
NP_001 PWGEVLTPLASSSVTHLSSKQEEYVKVAKTLFTDEALKPCPRCQSPAKYQPYKKRGLCSR
610 620 630 640 650 660
400 410 420 430 440
pF1KE3 EGCGFDYCTKCLCNYHTTKDCSDGKLLKASCKIGPLPGTKKSKKNLRRL
.::::.:. ::: :: ...:: : : . :::. .::.::.::
NP_001 TACGFDFCVLCLCAYHGSEECSRGAA-KPRNRKDALPGSAQSKRNLKRL
670 680 690 700
>>XP_011515292 (OMIM: 609110) PREDICTED: F-box only prot (717 aa)
initn: 462 init1: 258 opt: 356 Z-score: 364.9 bits: 77.4 E(85289): 1.4e-13
Smith-Waterman score: 439; 28.2% identity (54.7% similar) in 422 aa overlap (80-447:318-717)
50 60 70 80 90 100
pF1KE3 DFNCNHVHSGLKLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVELE
::: .. .. .. .:. : . : .
XP_011 PEVRGSISTPEDSGFNSLSLEKSEDSLSDQEGSFQELLQKHKGTPKVGDTIRKTRHL---
290 300 310 320 330 340
110 120 130 140 150 160
pF1KE3 TESKRLHNKENQHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENF
.:.:: . ..: :. :. : ... . .. . . :..:: :.: ..
XP_011 GRSRRLSTLREQSSQS--------ETEEEKQIVHPDSEKRAAAASAISE---GQLSSDES
350 360 370 380 390
170 180 190 200 210 220
pF1KE3 GDSLQSCLLQIQSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNF
:: ..... .. : .:. : : : . :..:. . . .. : :: .
XP_011 GD----LTFSLKNLSKTPALQLVHEL-FMKSKRKRLQENSGH--EFLEQGDGEKIAVLQC
400 410 420 430 440
230 240 250 260 270
pF1KE3 RLQNIIGRKMGLECVDILSELFRRGLRHVLATILAQLSDMDLI-----------------
: ..::.:::.: .:::.:: :.:.:.:: .: .:. .:
XP_011 ILAGLIGKKMGIEKLDILTELKYRNLKHILAMVLESLTAESLCRTIRRQDPWECRGNEGE
450 460 470 480 490 500
280 290 300
pF1KE3 --------------------------NVSKVSTTWKKILEDDKGA---FQLYSKAIQRVT
.: ::: .:..:. .::.: ..: .. .
XP_011 KSCGTGFLQDDGYGGACGKLVSLFLDSVWKVSRNWREIVVQDKNANRRRKFYITQLKTDS
510 520 530 540 550 560
310 320 330 340 350
pF1KE3 ENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGD------QKGSTY-
:. :.:: .. :. : ::: .: . ... . :: :. ... :.
XP_011 EGAVLNVEDAATRLQLLNRSALRSVQAQARIPGSQREQGSTLSPWGEVLTPLASSSVTHL
570 580 590 600 610 620
360 370 380 390 400 410
pF1KE3 -SRHNEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHT
:...:. .::::: .:.:: : ::.:::::. : .:. :.: .::::.:. ::: ::
XP_011 SSKQEEYVKVAKTLFTDEALKPCPRCQSPAKYQPYKKRGLCSRTACGFDFCVLCLCAYHG
630 640 650 660 670 680
420 430 440
pF1KE3 TKDCSDGKLLKASCKIGPLPGTKKSKKNLRRL
...:: : : . :::. .::.::.::
XP_011 SEECSRGAA-KPRNRKDALPGSAQSKRNLKRL
690 700 710
>>XP_011515291 (OMIM: 609110) PREDICTED: F-box only prot (717 aa)
initn: 462 init1: 258 opt: 356 Z-score: 364.9 bits: 77.4 E(85289): 1.4e-13
Smith-Waterman score: 439; 28.2% identity (54.7% similar) in 422 aa overlap (80-447:318-717)
50 60 70 80 90 100
pF1KE3 DFNCNHVHSGLKLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVELE
::: .. .. .. .:. : . : .
XP_011 PEVRGSISTPEDSGFNSLSLEKSEDSLSDQEGSFQELLQKHKGTPKVGDTIRKTRHL---
290 300 310 320 330 340
110 120 130 140 150 160
pF1KE3 TESKRLHNKENQHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENF
.:.:: . ..: :. :. : ... . .. . . :..:: :.: ..
XP_011 GRSRRLSTLREQSSQS--------ETEEEKQIVHPDSEKRAAAASAISE---GQLSSDES
350 360 370 380 390
170 180 190 200 210 220
pF1KE3 GDSLQSCLLQIQSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNF
:: ..... .. : .:. : : : . :..:. . . .. : :: .
XP_011 GD----LTFSLKNLSKTPALQLVHEL-FMKSKRKRLQENSGH--EFLEQGDGEKIAVLQC
400 410 420 430 440
230 240 250 260 270
pF1KE3 RLQNIIGRKMGLECVDILSELFRRGLRHVLATILAQLSDMDLI-----------------
: ..::.:::.: .:::.:: :.:.:.:: .: .:. .:
XP_011 ILAGLIGKKMGIEKLDILTELKYRNLKHILAMVLESLTAESLCRTIRRQDPWECRGNEGE
450 460 470 480 490 500
280 290 300
pF1KE3 --------------------------NVSKVSTTWKKILEDDKGA---FQLYSKAIQRVT
.: ::: .:..:. .::.: ..: .. .
XP_011 KSCGTGFLQDDGYGGACGKLVSLFLDSVWKVSRNWREIVVQDKNANRRRKFYITQLKTDS
510 520 530 540 550 560
310 320 330 340 350
pF1KE3 ENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGD------QKGSTY-
:. :.:: .. :. : ::: .: . ... . :: :. ... :.
XP_011 EGAVLNVEDAATRLQLLNRSALRSVQAQARIPGSQREQGSTLSPWGEVLTPLASSSVTHL
570 580 590 600 610 620
360 370 380 390 400 410
pF1KE3 -SRHNEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHT
:...:. .::::: .:.:: : ::.:::::. : .:. :.: .::::.:. ::: ::
XP_011 SSKQEEYVKVAKTLFTDEALKPCPRCQSPAKYQPYKKRGLCSRTACGFDFCVLCLCAYHG
630 640 650 660 670 680
420 430 440
pF1KE3 TKDCSDGKLLKASCKIGPLPGTKKSKKNLRRL
...:: : : . :::. .::.::.::
XP_011 SEECSRGAA-KPRNRKDALPGSAQSKRNLKRL
690 700 710
>>XP_011515289 (OMIM: 609110) PREDICTED: F-box only prot (751 aa)
initn: 462 init1: 258 opt: 356 Z-score: 364.6 bits: 77.4 E(85289): 1.4e-13
Smith-Waterman score: 439; 28.2% identity (54.7% similar) in 422 aa overlap (80-447:352-751)
50 60 70 80 90 100
pF1KE3 DFNCNHVHSGLKLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVELE
::: .. .. .. .:. : . : .
XP_011 PEVRGSISTPEDSGFNSLSLEKSEDSLSDQEGSFQELLQKHKGTPKVGDTIRKTRHL---
330 340 350 360 370
110 120 130 140 150 160
pF1KE3 TESKRLHNKENQHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENF
.:.:: . ..: :. :. : ... . .. . . :..:: :.: ..
XP_011 GRSRRLSTLREQSSQS--------ETEEEKQIVHPDSEKRAAAASAISE---GQLSSDES
380 390 400 410 420
170 180 190 200 210 220
pF1KE3 GDSLQSCLLQIQSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNF
:: ..... .. : .:. : : : . :..:. . . .. : :: .
XP_011 GD----LTFSLKNLSKTPALQLVHEL-FMKSKRKRLQENSGH--EFLEQGDGEKIAVLQC
430 440 450 460 470 480
230 240 250 260 270
pF1KE3 RLQNIIGRKMGLECVDILSELFRRGLRHVLATILAQLSDMDLI-----------------
: ..::.:::.: .:::.:: :.:.:.:: .: .:. .:
XP_011 ILAGLIGKKMGIEKLDILTELKYRNLKHILAMVLESLTAESLCRTIRRQDPWECRGNEGE
490 500 510 520 530 540
280 290 300
pF1KE3 --------------------------NVSKVSTTWKKILEDDKGA---FQLYSKAIQRVT
.: ::: .:..:. .::.: ..: .. .
XP_011 KSCGTGFLQDDGYGGACGKLVSLFLDSVWKVSRNWREIVVQDKNANRRRKFYITQLKTDS
550 560 570 580 590 600
310 320 330 340 350
pF1KE3 ENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGD------QKGSTY-
:. :.:: .. :. : ::: .: . ... . :: :. ... :.
XP_011 EGAVLNVEDAATRLQLLNRSALRSVQAQARIPGSQREQGSTLSPWGEVLTPLASSSVTHL
610 620 630 640 650 660
360 370 380 390 400 410
pF1KE3 -SRHNEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHT
:...:. .::::: .:.:: : ::.:::::. : .:. :.: .::::.:. ::: ::
XP_011 SSKQEEYVKVAKTLFTDEALKPCPRCQSPAKYQPYKKRGLCSRTACGFDFCVLCLCAYHG
670 680 690 700 710 720
420 430 440
pF1KE3 TKDCSDGKLLKASCKIGPLPGTKKSKKNLRRL
...:: : : . :::. .::.::.::
XP_011 SEECSRGAA-KPRNRKDALPGSAQSKRNLKRL
730 740 750
447 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 08:54:36 2016 done: Sun Nov 6 08:54:37 2016
Total Scan time: 8.060 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]