Result of FASTA (omim) for
pFN21AE3810
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3810, 407 aa
1>>>pF1KE3810 407 - 407 aa - 407 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1576+/-0.000387; mu= 18.3261+/- 0.024
mean_var=68.7708+/-13.687, 0's: 0 Z-trim(112.8): 20 B-trim: 1031 in 1/52
Lambda= 0.154658
statistics sampled from 21885 (21904) to 21885 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.627), E-opt: 0.2 (0.257), width: 16
Scan time: 7.520
The best scores are: opt bits E(85289)
NP_002602 (OMIM: 602525) pyruvate dehydrogenase ki ( 407) 2723 616.7 3.2e-176
NP_001186828 (OMIM: 602525) pyruvate dehydrogenase ( 343) 2292 520.5 2.5e-147
NP_001186827 (OMIM: 602525) pyruvate dehydrogenase ( 343) 2292 520.5 2.5e-147
NP_002601 (OMIM: 602524) [Pyruvate dehydrogenase ( ( 436) 1959 446.2 7e-125
NP_005382 (OMIM: 300906) pyruvate dehydrogenase ki ( 406) 1876 427.7 2.5e-119
NP_001135858 (OMIM: 300906) pyruvate dehydrogenase ( 415) 1876 427.7 2.5e-119
NP_002603 (OMIM: 602527) pyruvate dehydrogenase ki ( 411) 1850 421.9 1.4e-117
XP_011509647 (OMIM: 602524) PREDICTED: pyruvate de ( 360) 1764 402.7 7.5e-112
XP_011509649 (OMIM: 602524) PREDICTED: pyruvate de ( 380) 1487 340.9 3.2e-93
XP_011509645 (OMIM: 602524) PREDICTED: pyruvate de ( 380) 1487 340.9 3.2e-93
XP_011509646 (OMIM: 602524) PREDICTED: pyruvate de ( 380) 1487 340.9 3.2e-93
NP_001265478 (OMIM: 602524) [Pyruvate dehydrogenas ( 456) 1487 340.9 3.7e-93
NP_001186829 (OMIM: 602525) pyruvate dehydrogenase ( 199) 1146 264.6 1.5e-70
XP_006712658 (OMIM: 602524) PREDICTED: pyruvate de ( 244) 1146 264.7 1.8e-70
XP_006712657 (OMIM: 602524) PREDICTED: pyruvate de ( 281) 474 114.8 2.7e-25
NP_005872 (OMIM: 614901,614923) [3-methyl-2-oxobut ( 412) 288 73.4 1.2e-12
NP_001116429 (OMIM: 614901,614923) [3-methyl-2-oxo ( 365) 258 66.7 1.1e-10
XP_016878348 (OMIM: 614901,614923) PREDICTED: 3-me ( 410) 258 66.7 1.2e-10
>>NP_002602 (OMIM: 602525) pyruvate dehydrogenase kinase (407 aa)
initn: 2723 init1: 2723 opt: 2723 Z-score: 3284.7 bits: 616.7 E(85289): 3.2e-176
Smith-Waterman score: 2723; 100.0% identity (100.0% similar) in 407 aa overlap (1-407:1-407)
10 20 30 40 50 60
pF1KE3 MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 NRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 VPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 ERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL
310 320 330 340 350 360
370 380 390 400
pF1KE3 KALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
:::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
370 380 390 400
>>NP_001186828 (OMIM: 602525) pyruvate dehydrogenase kin (343 aa)
initn: 2292 init1: 2292 opt: 2292 Z-score: 2766.0 bits: 520.5 E(85289): 2.5e-147
Smith-Waterman score: 2292; 100.0% identity (100.0% similar) in 343 aa overlap (65-407:1-343)
40 50 60 70 80 90
pF1KE3 QFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLD
::::::::::::::::::::::::::::::
NP_001 MKEINLLPDRVLSTPSVQLVQSWYVQSLLD
10 20 30
100 110 120 130 140 150
pF1KE3 IMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYF
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE3 LDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDK
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE3 YYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIK
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE3 VMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISR
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE3 LYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVP
280 290 300 310 320 330
400
pF1KE3 STEPKNTSTYRVS
:::::::::::::
NP_001 STEPKNTSTYRVS
340
>>NP_001186827 (OMIM: 602525) pyruvate dehydrogenase kin (343 aa)
initn: 2292 init1: 2292 opt: 2292 Z-score: 2766.0 bits: 520.5 E(85289): 2.5e-147
Smith-Waterman score: 2292; 100.0% identity (100.0% similar) in 343 aa overlap (65-407:1-343)
40 50 60 70 80 90
pF1KE3 QFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLD
::::::::::::::::::::::::::::::
NP_001 MKEINLLPDRVLSTPSVQLVQSWYVQSLLD
10 20 30
100 110 120 130 140 150
pF1KE3 IMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYF
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE3 LDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDK
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE3 YYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIK
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE3 VMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISR
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE3 LYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVP
280 290 300 310 320 330
400
pF1KE3 STEPKNTSTYRVS
:::::::::::::
NP_001 STEPKNTSTYRVS
340
>>NP_002601 (OMIM: 602524) [Pyruvate dehydrogenase (acet (436 aa)
initn: 1964 init1: 840 opt: 1959 Z-score: 2363.0 bits: 446.2 E(85289): 7e-125
Smith-Waterman score: 1959; 69.6% identity (89.2% similar) in 398 aa overlap (11-405:37-434)
10 20 30 40
pF1KE3 MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFG
:: :.: .. ...:::::::::::::::
NP_002 LRGAALAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMKQFLDFG
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 SSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLD
: :::::::: :::::::::::::::::.:::: .: :::::::::::.::: ....: :
NP_002 SVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKD
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE3 KDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYL
:. :: ... .:::... ::::::::.:::::::.:::...: :::..::.::::::::.
NP_002 KSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYM
130 140 150 160 170 180
170 180 190 200 210
pF1KE3 SRISIRMLINQHTLIFDGST--NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMA
::::::::.:::.:.: :. .:.: ::::::.::::: ::.::.:. :. ::: ::.
NP_002 SRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYIN
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE3 SPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVA
::.::..:.:: . :::..::::::::::.:::::::::::.: : . . :::.: :.
NP_002 SPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVT
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE3 LGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTG-GTPLAGFGYGLPISRLYA
::.:::..::::::::::::::.:::.::::::: :. :. ..::::::::::::::::
NP_002 LGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYA
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE3 KYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTE
.::::::.:.:.::.:::::::.:::::::.::::::::.::.::.: .:: :::::: :
NP_002 QYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSRE
370 380 390 400 410 420
400
pF1KE3 PKNTSTYRVS
::. .:.:
NP_002 PKDMTTFRSA
430
>>NP_005382 (OMIM: 300906) pyruvate dehydrogenase kinase (406 aa)
initn: 1852 init1: 1217 opt: 1876 Z-score: 2263.3 bits: 427.7 E(85289): 2.5e-119
Smith-Waterman score: 1876; 67.1% identity (87.5% similar) in 407 aa overlap (2-405:5-403)
10 20 30 40 50
pF1KE3 MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQEL
:: :::. .:: ::..:.:::::::.::::::: .:::::::. :::.::
NP_005 MRLFRW---LLKQP----VPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKEL
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 PVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALV
:::::: :.:.::::: .:. ::: ::::::.::.:...:. .:.::: ..:..: ..:.
NP_005 PVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE3 TIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFD
.:::::::::::::::.:::. .: :: . :::::::::: .:::.:::::::::.:
NP_005 KVRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 GSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIH
:.:::.::::::::::.:::..::::::. ::.::..::...:.::..:.:: .::.
NP_005 GDTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE3 MVYVPSHLYHMLFELFKNAMRATVESHES-SLILPPIKVMVALGEEDLSIKMSDRGGGVP
.:::::::.:::::::::.:::::: .:. . : .:..:.::.::::::.:: :::::
NP_005 VVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVP
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE3 LRKIERLFSYMYSTAPTP--QPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGT
::::.:::.::::::: : .: : ..::::::::::::::::.::::::.:.:::: ::
NP_005 LRKIDRLFNYMYSTAPRPSLEP-TRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGT
300 310 320 330 340 350
360 370 380 390 400
pF1KE3 DAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
::::::::::..: :::::.::::::::.: :: :: ::.::...: :.
NP_005 DAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQ
360 370 380 390 400
>>NP_001135858 (OMIM: 300906) pyruvate dehydrogenase kin (415 aa)
initn: 1852 init1: 1217 opt: 1876 Z-score: 2263.2 bits: 427.7 E(85289): 2.5e-119
Smith-Waterman score: 1876; 67.1% identity (87.5% similar) in 407 aa overlap (2-405:5-403)
10 20 30 40 50
pF1KE3 MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQEL
:: :::. .:: ::..:.:::::::.::::::: .:::::::. :::.::
NP_001 MRLFRW---LLKQP----VPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKEL
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 PVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALV
:::::: :.:.::::: .:. ::: ::::::.::.:...:. .:.::: ..:..: ..:.
NP_001 PVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE3 TIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFD
.:::::::::::::::.:::. .: :: . :::::::::: .:::.:::::::::.:
NP_001 KVRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 GSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIH
:.:::.::::::::::.:::..::::::. ::.::..::...:.::..:.:: .::.
NP_001 GDTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE3 MVYVPSHLYHMLFELFKNAMRATVESHES-SLILPPIKVMVALGEEDLSIKMSDRGGGVP
.:::::::.:::::::::.:::::: .:. . : .:..:.::.::::::.:: :::::
NP_001 VVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVP
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE3 LRKIERLFSYMYSTAPTP--QPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGT
::::.:::.::::::: : .: : ..::::::::::::::::.::::::.:.:::: ::
NP_001 LRKIDRLFNYMYSTAPRPSLEP-TRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGT
300 310 320 330 340 350
360 370 380 390 400
pF1KE3 DAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
::::::::::..: :::::.::::::::.: :: :: ::.::...: :.
NP_001 DAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQDKIKTN
360 370 380 390 400 410
NP_001 RTF
>>NP_002603 (OMIM: 602527) pyruvate dehydrogenase kinase (411 aa)
initn: 1109 init1: 1109 opt: 1850 Z-score: 2231.9 bits: 421.9 E(85289): 1.4e-117
Smith-Waterman score: 1850; 65.2% identity (89.1% similar) in 405 aa overlap (1-400:1-404)
10 20 30 40 50
pF1KE3 MRWVWALLKNA-SLAGA---PKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQE
:. . .:..: :: :: :. .::::..:::::::::.::::: ::::.:::.:::::
NP_002 MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 LPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDAL
::::::::.:::..:: ....: :::::.:::.:::.:..:: .:.:.:...::.:.:.:
NP_002 LPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE3 VTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIF
. .::::..::::::::..::::. :::.:::.::::::::..::: :::.::: :::
NP_002 IKVRNRHHNVVPTMAQGIIEYKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE3 DGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPI
. : . ..:.:::::::::.: ::.::.. ...:::.::..::.:.. ..:. :::
NP_002 SDSQT-GNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQPI
190 200 210 220 230
240 250 260 270 280 290
pF1KE3 HMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVP
:.:::::::.:::::::::::::::: .:.. : ::.:.:.::.:::.::.::::::::
NP_002 HIVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIVVLGKEDLTIKISDRGGGVP
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE3 LRKIERLFSYMYSTAPTP-QPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTD
:: :.::::: ::::::: . .. ..:::::::::::::::::::::::.:.:. :.:::
NP_002 LRIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTD
300 310 320 330 340 350
360 370 380 390 400
pF1KE3 AVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
:.:::::::..:.:.:::.::::..::: .:: :::.:: ::::
NP_002 AIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM
360 370 380 390 400 410
>>XP_011509647 (OMIM: 602524) PREDICTED: pyruvate dehydr (360 aa)
initn: 1746 init1: 645 opt: 1764 Z-score: 2129.0 bits: 402.7 E(85289): 7.5e-112
Smith-Waterman score: 1764; 69.7% identity (89.9% similar) in 357 aa overlap (52-405:2-358)
30 40 50 60 70 80
pF1KE3 HFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSV
:::::::::::::::::.:::: .: ::::
XP_011 MFLRQELPVRLANIMKEISLLPDNLLRTPSV
10 20 30
90 100 110 120 130 140
pF1KE3 QLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTY
:::::::.::: ....: ::. :: ... .:::... ::::::::.:::::::.:::...
XP_011 QLVQSWYIQSLQELLDFKDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESF
40 50 60 70 80 90
150 160 170 180 190
pF1KE3 GDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST--NPAHPKHIGSIDPNCNVSE
: :::..::.::::::::.::::::::.:::.:.: :. .:.: ::::::.::::: :
XP_011 GVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE3 VVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRA
:.::.:. :. ::: ::. ::.::..:.:: . :::..::::::::::.::::::::::
XP_011 VIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRA
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE3 TVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTG
:.: : . . :::.: :.::.:::..::::::::::::::.:::.::::::: :. :.
XP_011 TMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETS
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE3 -GTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSA
..::::::::::::::::.::::::.:.:.::.:::::::.:::::::.::::::::.:
XP_011 RAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAA
280 290 300 310 320 330
380 390 400
pF1KE3 WRHYQTIQEAGDWCVPSTEPKNTSTYRVS
:.::.: .:: :::::: :::. .:.:
XP_011 WKHYNTNHEADDWCVPSREPKDMTTFRSA
340 350 360
>>XP_011509649 (OMIM: 602524) PREDICTED: pyruvate dehydr (380 aa)
initn: 1734 init1: 642 opt: 1487 Z-score: 1794.7 bits: 340.9 E(85289): 3.2e-93
Smith-Waterman score: 1717; 66.8% identity (85.1% similar) in 377 aa overlap (52-405:2-378)
30 40 50 60 70 80
pF1KE3 HFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSV
:::::::::::::::::.:::: .: ::::
XP_011 MFLRQELPVRLANIMKEISLLPDNLLRTPSV
10 20 30
90 100 110 120
pF1KE3 QLVQSWYVQSLLDIMEFLDKDPED--------HRTLSQ------------FTDALVTIRN
:::::::.::: ....: ::. :: .:: : :::... :::
XP_011 QLVQSWYIQSLQELLDFKDKSAEDAKAIYERPRRTWLQVSSLCCMACKMIFTDTVIRIRN
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE3 RHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST-
:::::.:::::::.:::...: :::..::.::::::::.::::::::.:::.:.: :.
XP_011 RHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGK
100 110 120 130 140 150
190 200 210 220 230
pF1KE3 -NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMV
.:.: ::::::.::::: ::.::.:. :. ::: ::. ::.::..:.:: . :::..:
XP_011 GSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVV
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE3 YVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRK
:::::::::.:::::::::::.: : . . :::.: :.::.:::..:::::::::::::
XP_011 YVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRK
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE3 IERLFSYMYSTAPTPQPGTG-GTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVI
:.:::.::::::: :. :. ..::::::::::::::::.::::::.:.:.::.::::::
XP_011 IDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVI
280 290 300 310 320 330
360 370 380 390 400
pF1KE3 YLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
:.:::::::.::::::::.::.::.: .:: :::::: :::. .:.:
XP_011 YIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA
340 350 360 370 380
>>XP_011509645 (OMIM: 602524) PREDICTED: pyruvate dehydr (380 aa)
initn: 1734 init1: 642 opt: 1487 Z-score: 1794.7 bits: 340.9 E(85289): 3.2e-93
Smith-Waterman score: 1717; 66.8% identity (85.1% similar) in 377 aa overlap (52-405:2-378)
30 40 50 60 70 80
pF1KE3 HFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSV
:::::::::::::::::.:::: .: ::::
XP_011 MFLRQELPVRLANIMKEISLLPDNLLRTPSV
10 20 30
90 100 110 120
pF1KE3 QLVQSWYVQSLLDIMEFLDKDPED--------HRTLSQ------------FTDALVTIRN
:::::::.::: ....: ::. :: .:: : :::... :::
XP_011 QLVQSWYIQSLQELLDFKDKSAEDAKAIYERPRRTWLQVSSLCCMACKMIFTDTVIRIRN
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE3 RHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST-
:::::.:::::::.:::...: :::..::.::::::::.::::::::.:::.:.: :.
XP_011 RHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGK
100 110 120 130 140 150
190 200 210 220 230
pF1KE3 -NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMV
.:.: ::::::.::::: ::.::.:. :. ::: ::. ::.::..:.:: . :::..:
XP_011 GSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVV
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE3 YVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRK
:::::::::.:::::::::::.: : . . :::.: :.::.:::..:::::::::::::
XP_011 YVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRK
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE3 IERLFSYMYSTAPTPQPGTG-GTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVI
:.:::.::::::: :. :. ..::::::::::::::::.::::::.:.:.::.::::::
XP_011 IDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVI
280 290 300 310 320 330
360 370 380 390 400
pF1KE3 YLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
:.:::::::.::::::::.::.::.: .:: :::::: :::. .:.:
XP_011 YIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA
340 350 360 370 380
407 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 06:38:08 2016 done: Sun Nov 6 06:38:09 2016
Total Scan time: 7.520 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]