Result of FASTA (omim) for
pFN21AE3773
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3773, 1743 aa
1>>>pF1KE3773 1743 - 1743 aa - 1743 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.3275+/-0.000546; mu= 14.4964+/- 0.034
mean_var=578.4020+/-131.365, 0's: 0 Z-trim(116.9): 1279 B-trim: 1316 in 1/56
Lambda= 0.053328
statistics sampled from 26707 (28471) to 26707 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.661), E-opt: 0.2 (0.334), width: 16
Scan time: 18.850
The best scores are: opt bits E(85289)
XP_006724656 (OMIM: 300358) PREDICTED: serine/thre (1743) 11405 895.5 0
NP_001002838 (OMIM: 300358) serine/threonine-prote (1743) 11405 895.5 0
XP_011529104 (OMIM: 300358) PREDICTED: serine/thre (1753) 10203 803.0 0
XP_016885234 (OMIM: 300358) PREDICTED: serine/thre (1790) 8181 647.5 3.2e-184
NP_065973 (OMIM: 300358) serine/threonine-protein (1800) 8181 647.5 3.2e-184
XP_016885233 (OMIM: 300358) PREDICTED: serine/thre (1800) 8181 647.5 3.2e-184
XP_016885231 (OMIM: 300358) PREDICTED: serine/thre (1800) 8181 647.5 3.2e-184
XP_016885230 (OMIM: 300358) PREDICTED: serine/thre (1800) 8181 647.5 3.2e-184
XP_016885232 (OMIM: 300358) PREDICTED: serine/thre (1800) 8181 647.5 3.2e-184
XP_016870544 (OMIM: 606249) PREDICTED: serine/thre (2162) 2232 189.9 2.1e-46
XP_016870543 (OMIM: 606249) PREDICTED: serine/thre (2163) 2232 189.9 2.1e-46
XP_005252201 (OMIM: 606249) PREDICTED: serine/thre (2185) 2232 190.0 2.1e-46
XP_011517238 (OMIM: 606249) PREDICTED: serine/thre (2190) 2232 190.0 2.1e-46
XP_011517237 (OMIM: 606249) PREDICTED: serine/thre (2205) 2232 190.0 2.1e-46
XP_016870542 (OMIM: 606249) PREDICTED: serine/thre (2208) 2232 190.0 2.1e-46
XP_016870541 (OMIM: 606249) PREDICTED: serine/thre (2209) 2232 190.0 2.1e-46
XP_016870540 (OMIM: 606249) PREDICTED: serine/thre (2215) 2232 190.0 2.1e-46
NP_006639 (OMIM: 606249) serine/threonine-protein (2217) 2232 190.0 2.1e-46
XP_005252198 (OMIM: 606249) PREDICTED: serine/thre (2217) 2232 190.0 2.1e-46
XP_005252197 (OMIM: 606249) PREDICTED: serine/thre (2224) 2232 190.0 2.1e-46
XP_016870539 (OMIM: 606249) PREDICTED: serine/thre (2226) 2232 190.0 2.1e-46
XP_016870538 (OMIM: 606249) PREDICTED: serine/thre (2227) 2232 190.0 2.1e-46
XP_016870537 (OMIM: 606249) PREDICTED: serine/thre (2241) 2232 190.0 2.2e-46
XP_016870536 (OMIM: 606249) PREDICTED: serine/thre (2242) 2232 190.0 2.2e-46
XP_011517234 (OMIM: 606249) PREDICTED: serine/thre (2252) 2232 190.0 2.2e-46
XP_011517233 (OMIM: 606249) PREDICTED: serine/thre (2254) 2232 190.0 2.2e-46
XP_016870535 (OMIM: 606249) PREDICTED: serine/thre (2256) 2232 190.0 2.2e-46
XP_011517232 (OMIM: 606249) PREDICTED: serine/thre (2257) 2232 190.0 2.2e-46
XP_016870534 (OMIM: 606249) PREDICTED: serine/thre (2259) 2232 190.0 2.2e-46
XP_005252194 (OMIM: 606249) PREDICTED: serine/thre (2260) 2232 190.0 2.2e-46
XP_011517231 (OMIM: 606249) PREDICTED: serine/thre (2269) 2232 190.0 2.2e-46
XP_011517230 (OMIM: 606249) PREDICTED: serine/thre (2284) 2232 190.0 2.2e-46
NP_001269323 (OMIM: 606249) serine/threonine-prote (2297) 2232 190.0 2.2e-46
XP_011517229 (OMIM: 606249) PREDICTED: serine/thre (2301) 2232 190.0 2.2e-46
XP_011517228 (OMIM: 606249) PREDICTED: serine/thre (2302) 2232 190.0 2.2e-46
XP_016875328 (OMIM: 201300,605232,614492) PREDICTE (2043) 2141 182.9 2.7e-44
XP_011519310 (OMIM: 201300,605232,614492) PREDICTE (2108) 2141 182.9 2.7e-44
XP_011519311 (OMIM: 201300,605232,614492) PREDICTE (2107) 2135 182.5 3.7e-44
XP_016875326 (OMIM: 201300,605232,614492) PREDICTE (2136) 2129 182.0 5.1e-44
NP_061852 (OMIM: 201300,605232,614492) serine/thre (2382) 2129 182.1 5.4e-44
XP_011519308 (OMIM: 201300,605232,614492) PREDICTE (2354) 2121 181.5 8.2e-44
NP_055638 (OMIM: 201300,605232,614492) serine/thre (2134) 2120 181.3 8.3e-44
XP_016875327 (OMIM: 201300,605232,614492) PREDICTE (2135) 2120 181.3 8.3e-44
XP_016875323 (OMIM: 201300,605232,614492) PREDICTE (2228) 2120 181.4 8.4e-44
XP_006719066 (OMIM: 201300,605232,614492) PREDICTE (2381) 2120 181.4 8.7e-44
XP_016875324 (OMIM: 201300,605232,614492) PREDICTE (2201) 2118 181.2 9.3e-44
XP_011519306 (OMIM: 201300,605232,614492) PREDICTE (2548) 2117 181.2 1.1e-43
XP_011519305 (OMIM: 201300,605232,614492) PREDICTE (2549) 2117 181.2 1.1e-43
XP_011519304 (OMIM: 201300,605232,614492) PREDICTE (2641) 2117 181.3 1.1e-43
NP_001171914 (OMIM: 201300,605232,614492) serine/t (2642) 2117 181.3 1.1e-43
>>XP_006724656 (OMIM: 300358) PREDICTED: serine/threonin (1743 aa)
initn: 11405 init1: 11405 opt: 11405 Z-score: 4768.9 bits: 895.5 E(85289): 0
Smith-Waterman score: 11405; 100.0% identity (100.0% similar) in 1743 aa overlap (1-1743:1-1743)
10 20 30 40 50 60
pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGVETEEMRSAIAPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGVETEEMRSAIAPD
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE3 PIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHS
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE3 SEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACE
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE3 TDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVA
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE3 KTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQE
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE3 VVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVD
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE3 NGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQS
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE3 QHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMP
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE3 HVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPP
1690 1700 1710 1720 1730 1740
pF1KE3 GPK
:::
XP_006 GPK
>>NP_001002838 (OMIM: 300358) serine/threonine-protein k (1743 aa)
initn: 11405 init1: 11405 opt: 11405 Z-score: 4768.9 bits: 895.5 E(85289): 0
Smith-Waterman score: 11405; 100.0% identity (100.0% similar) in 1743 aa overlap (1-1743:1-1743)
10 20 30 40 50 60
pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGVETEEMRSAIAPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGVETEEMRSAIAPD
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE3 PIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHS
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE3 SEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACE
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE3 TDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVA
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE3 KTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQE
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE3 VVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVD
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE3 NGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQS
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE3 QHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMP
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE3 HVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPP
1690 1700 1710 1720 1730 1740
pF1KE3 GPK
:::
NP_001 GPK
>>XP_011529104 (OMIM: 300358) PREDICTED: serine/threonin (1753 aa)
initn: 11385 init1: 10188 opt: 10203 Z-score: 4269.1 bits: 803.0 E(85289): 0
Smith-Waterman score: 11369; 99.4% identity (99.4% similar) in 1753 aa overlap (1-1743:1-1753)
10 20 30 40 50 60
pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGVETEEMRSAIAPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGVETEEMRSAIAPD
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE3 PIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHS
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE3 SEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACE
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE3 TDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVA
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE3 KTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQE
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE3 VVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVD
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610
pF1KE3 NGIVAT----------DPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLI
:::::: .:::::::::::::::::::::::::::::::::::::::::::
XP_011 NGIVATGKSCLINELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLI
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE3 KPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSF
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KE3 PGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTS
1690 1700 1710 1720 1730 1740
1740
pF1KE3 SVQNPATIPPGPK
:::::::::::::
XP_011 SVQNPATIPPGPK
1750
>>XP_016885234 (OMIM: 300358) PREDICTED: serine/threonin (1790 aa)
initn: 11391 init1: 8154 opt: 8181 Z-score: 3428.3 bits: 647.5 E(85289): 3.2e-184
Smith-Waterman score: 11198; 97.4% identity (97.4% similar) in 1775 aa overlap (1-1728:1-1775)
10 20 30 40 50 60
pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240
pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTG-------------
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL
1210 1220 1230 1240 1250 1260
1250 1260 1270
pF1KE3 ----------------------------------VETEEMRSAIAPDPIPLTRESTADTR
::::::::::::::::::::::::::
XP_016 KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KE3 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KE3 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KE3 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KE3 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550 1560 1570
pF1KE3 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATDPLCVES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATDPLCVES
1570 1580 1590 1600 1610 1620
1580 1590 1600 1610 1620 1630
pF1KE3 NAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHKLETENWNKVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHKLETENWNKVS
1630 1640 1650 1660 1670 1680
1640 1650 1660 1670 1680 1690
pF1KE3 ENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVCQYNAVAGAGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVCQYNAVAGAGY
1690 1700 1710 1720 1730 1740
1700 1710 1720 1730 1740
pF1KE3 PVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
:::::::::::::::::::::::::::::::::::
XP_016 PVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
1750 1760 1770 1780 1790
>>NP_065973 (OMIM: 300358) serine/threonine-protein kina (1800 aa)
initn: 11371 init1: 8154 opt: 8181 Z-score: 3428.2 bits: 647.5 E(85289): 3.2e-184
Smith-Waterman score: 11086; 96.7% identity (96.8% similar) in 1775 aa overlap (1-1718:1-1775)
10 20 30 40 50 60
pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240
pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTG-------------
:::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL
1210 1220 1230 1240 1250 1260
1250 1260 1270
pF1KE3 ----------------------------------VETEEMRSAIAPDPIPLTRESTADTR
::::::::::::::::::::::::::
NP_065 KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KE3 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KE3 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KE3 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KE3 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550 1560
pF1KE3 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVAT-------
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN
1570 1580 1590 1600 1610 1620
1570 1580 1590 1600 1610 1620
pF1KE3 ---DPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK
1630 1640 1650 1660 1670 1680
1630 1640 1650 1660 1670 1680
pF1KE3 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC
1690 1700 1710 1720 1730 1740
1690 1700 1710 1720 1730 1740
pF1KE3 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
:::::::::::::::::::::::::::::::::::
NP_065 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
1750 1760 1770 1780 1790 1800
>>XP_016885233 (OMIM: 300358) PREDICTED: serine/threonin (1800 aa)
initn: 11371 init1: 8154 opt: 8181 Z-score: 3428.2 bits: 647.5 E(85289): 3.2e-184
Smith-Waterman score: 11086; 96.7% identity (96.8% similar) in 1775 aa overlap (1-1718:1-1775)
10 20 30 40 50 60
pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240
pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTG-------------
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL
1210 1220 1230 1240 1250 1260
1250 1260 1270
pF1KE3 ----------------------------------VETEEMRSAIAPDPIPLTRESTADTR
::::::::::::::::::::::::::
XP_016 KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KE3 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KE3 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KE3 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KE3 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550 1560
pF1KE3 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVAT-------
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN
1570 1580 1590 1600 1610 1620
1570 1580 1590 1600 1610 1620
pF1KE3 ---DPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK
1630 1640 1650 1660 1670 1680
1630 1640 1650 1660 1670 1680
pF1KE3 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC
1690 1700 1710 1720 1730 1740
1690 1700 1710 1720 1730 1740
pF1KE3 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
:::::::::::::::::::::::::::::::::::
XP_016 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
1750 1760 1770 1780 1790 1800
>>XP_016885231 (OMIM: 300358) PREDICTED: serine/threonin (1800 aa)
initn: 11371 init1: 8154 opt: 8181 Z-score: 3428.2 bits: 647.5 E(85289): 3.2e-184
Smith-Waterman score: 11086; 96.7% identity (96.8% similar) in 1775 aa overlap (1-1718:1-1775)
10 20 30 40 50 60
pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240
pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTG-------------
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL
1210 1220 1230 1240 1250 1260
1250 1260 1270
pF1KE3 ----------------------------------VETEEMRSAIAPDPIPLTRESTADTR
::::::::::::::::::::::::::
XP_016 KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KE3 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KE3 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KE3 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KE3 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550 1560
pF1KE3 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVAT-------
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN
1570 1580 1590 1600 1610 1620
1570 1580 1590 1600 1610 1620
pF1KE3 ---DPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK
1630 1640 1650 1660 1670 1680
1630 1640 1650 1660 1670 1680
pF1KE3 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC
1690 1700 1710 1720 1730 1740
1690 1700 1710 1720 1730 1740
pF1KE3 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
:::::::::::::::::::::::::::::::::::
XP_016 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
1750 1760 1770 1780 1790 1800
>>XP_016885230 (OMIM: 300358) PREDICTED: serine/threonin (1800 aa)
initn: 11371 init1: 8154 opt: 8181 Z-score: 3428.2 bits: 647.5 E(85289): 3.2e-184
Smith-Waterman score: 11086; 96.7% identity (96.8% similar) in 1775 aa overlap (1-1718:1-1775)
10 20 30 40 50 60
pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240
pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTG-------------
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL
1210 1220 1230 1240 1250 1260
1250 1260 1270
pF1KE3 ----------------------------------VETEEMRSAIAPDPIPLTRESTADTR
::::::::::::::::::::::::::
XP_016 KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KE3 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KE3 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KE3 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KE3 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550 1560
pF1KE3 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVAT-------
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN
1570 1580 1590 1600 1610 1620
1570 1580 1590 1600 1610 1620
pF1KE3 ---DPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK
1630 1640 1650 1660 1670 1680
1630 1640 1650 1660 1670 1680
pF1KE3 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC
1690 1700 1710 1720 1730 1740
1690 1700 1710 1720 1730 1740
pF1KE3 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
:::::::::::::::::::::::::::::::::::
XP_016 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
1750 1760 1770 1780 1790 1800
>>XP_016885232 (OMIM: 300358) PREDICTED: serine/threonin (1800 aa)
initn: 11371 init1: 8154 opt: 8181 Z-score: 3428.2 bits: 647.5 E(85289): 3.2e-184
Smith-Waterman score: 11086; 96.7% identity (96.8% similar) in 1775 aa overlap (1-1718:1-1775)
10 20 30 40 50 60
pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240
pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTG-------------
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL
1210 1220 1230 1240 1250 1260
1250 1260 1270
pF1KE3 ----------------------------------VETEEMRSAIAPDPIPLTRESTADTR
::::::::::::::::::::::::::
XP_016 KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KE3 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KE3 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KE3 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KE3 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550 1560
pF1KE3 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVAT-------
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN
1570 1580 1590 1600 1610 1620
1570 1580 1590 1600 1610 1620
pF1KE3 ---DPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK
1630 1640 1650 1660 1670 1680
1630 1640 1650 1660 1670 1680
pF1KE3 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC
1690 1700 1710 1720 1730 1740
1690 1700 1710 1720 1730 1740
pF1KE3 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
:::::::::::::::::::::::::::::::::::
XP_016 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
1750 1760 1770 1780 1790 1800
>>XP_016870544 (OMIM: 606249) PREDICTED: serine/threonin (2162 aa)
initn: 2890 init1: 2094 opt: 2232 Z-score: 954.0 bits: 189.9 E(85289): 2.1e-46
Smith-Waterman score: 2232; 58.6% identity (72.1% similar) in 674 aa overlap (69-725:117-774)
40 50 60 70 80 90
pF1KE3 LKEKNSTFSASGETVERKRFFRKSVEMTEDDKVAESSPKDERIKAAMNI-PRVDKLPSNV
. :. . : . : ::.. : : : .
XP_016 ERARGRPAAPAPAALVAQPGAPGAPADAGPEPVGTQEPGPDPIAAAVETAPAPDGGPREE
90 100 110 120 130 140
100 110 120 130 140 150
pF1KE3 LRGGQEVKYEQCSKSTSEISKDCFKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGA
. . . : ... : .. ... :.: ..: ..:::::: .:::::::::::::.
XP_016 AAATVRKEDEGAAEAKPEPGRT-RRDEPEEEEDDEDDLKAVATSLDGRFLKFDIELGRGS
150 160 170 180 190 200
160 170 180 190 200 210
pF1KE3 FKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESIL
:::::::::::::::::::::::::::: :.::::::::::::::::::::::: :::
XP_016 FKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFKEEAEMLKGLQHPNIVRFYDFWESSA
210 220 230 240 250 260
220 230 240 250 260 270
pF1KE3 KGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLK
:::.:::::::::::::::::::::::::::::::::::::::: :::::::::::::::
XP_016 KGKRCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLK
270 280 290 300 310 320
280 290 300 310 320 330
pF1KE3 CDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMC
::::::::::::::::::::::: :.::::::::::::::::::::::::::::::::::
XP_016 CDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMC
330 340 350 360 370 380
340 350 360 370 380 390
pF1KE3 MLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIR
::::::::::::::::::::::::: :::::::.:: :::.:::: :: .:: :: :.
XP_016 MLEMATSEYPYSECQNAAQIYRKVTCGIKPASFEKVHDPEIKEIIGECICKNKEERYEIK
390 400 410 420 430 440
400 410 420 430 440 450
pF1KE3 DLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETD
:::.:::::::::.:::::::: .:..::::::::::::::: ::: ::::.:.:: .
XP_016 DLLSHAFFAEDTGVRVELAEEDHGRKSTIALRLWVEDPKKLKGKPKDNGAIEFTFDLEKE
450 460 470 480 490 500
460 470 480 490 500 510
pF1KE3 TPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKK-PAGCLEERRD--SQCKSM
::.::: ::..:::::::: : :::::::::. :. ::. :: .:..: : :.
XP_016 TPDEVAQEMIESGFFHESDVKIVAKSIRDRVALIQWRRERIWPALQPKEQQDVGSPDKAR
510 520 530 540 550 560
520 530 540 550 560 570
pF1KE3 GNVFPQPQNTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAA
: : ..: .: : :: :.:::. : : . .:...:. ..: .
XP_016 GPPVPLQVQVTYHAQAGQPGPPEPEEPEADQHLLPPTL---PTS-ATSLASDSTFDSGQG
570 580 590 600 610 620
580 590 600 610 620
pF1KE3 SVIHSDT-SSQPSVAYSSNQTMG---SQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVS--
:...::. ::: :: .: . .: : . : .: : : : .: ::: .
XP_016 STVYSDSQSSQQSVMLGSLADAAPSPAQCVCSPPVSEGPVLPQSLPS---LGAYQQPTAA
630 640 650 660 670
630 640 650 660 670 680
pF1KE3 -GLQKHSKLTQPQILPLVQGQSTVLPVHVLGPTVVSQPQVSPLTV---QKVP---QIKPV
:: : . : : .: : :. ..: : : .:. . : .: : :.
XP_016 PGLPVGS-VPAPACPPSLQ-QHFPDPAMSFAP--VLPPPSTPMPTGPGQPAPPGQQPPPL
680 690 700 710 720 730
690 700 710 720 730 740
pF1KE3 SQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKG
.::. : .: :. : : : : .: . : :
XP_016 AQPTPLPQ---VLAPQPVVPL-QPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQ
740 750 760 770 780 790
750 760 770 780 790 800
pF1KE3 TKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKE
XP_016 VPPQMPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPA
800 810 820 830 840 850
>--
initn: 832 init1: 348 opt: 749 Z-score: 337.4 bits: 75.9 E(85289): 4.7e-12
Smith-Waterman score: 945; 25.8% identity (52.4% similar) in 1242 aa overlap (519-1676:970-2117)
490 500 510 520 530 540
pF1KE3 TPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQT--GAECEETEVDQH
::: :. : : .
XP_016 PQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALP
940 950 960 970 980 990
550 560 570 580 590 600
pF1KE3 VRQQLLQRK-PQQHCSSVTGDNLSEAGAASVIHSDTSSQ-PSVAYSSNQTMGSQMVSNI-
:: . :: . :.: ..: . : . :...: :.: ... . .
XP_016 VRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLL
1000 1010 1020 1030 1040 1050
610 620 630 640 650 660
pF1KE3 PQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPTVVS
: : .: :. :: :. : : . : : :: : . . : :::
XP_016 PAAPELLP-QFPSSLATVSASVQSVPTQTAT-LLPPANPPLPGGPGIASPC----PTV--
1060 1070 1080 1090 1100 1110
670 680 690 700 710 720
pF1KE3 QPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPSGNG
: : :. ... : :: . : . :. .. .::.. :: .: .. :.:
XP_016 QLTVEPVQEEQASQDKPPGLPQSCESYGG-----------SDVTSGKELSDSCEGAFGGG
1120 1130 1140 1150 1160
730 740 750 760 770
pF1KE3 KQD----RIKQRRASCPRP--EKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDV
. . : ..::.. : :.... .::.:.: ..::.::::::::::.::::::::.
XP_016 RLEGRAARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDL
1170 1180 1190 1200 1210 1220
780 790 800 810 820 830
pF1KE3 DGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDS
:::::..:: :::: .:.:..:.: :.:... .. .:...: ..:.. .
XP_016 DGDAPDEIATYMVEHDFILQAERETFIEQMKDVMDKAEDMLSEDTDADRGSDPGTSPPHL
1230 1240 1250 1260 1270 1280
840 850 860 870 880 890
pF1KE3 NSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQH-SMSA
.. :..:. . ..... . .... ... :: : : . .. ..: : .:.
XP_016 STCGLGTGEESRQSQANAPVYQQNVLHTGK--RW-FIICPVAEHPAPEAPESSPPLPLSS
1290 1300 1310 1320 1330
900 910 920 930 940 950
pF1KE3 VPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQ
.: :. .... .: : . :. : : :. . . : . ..
XP_016 LP-------PEASQDSAPYKDQLSSKEQ-PSFLASQQLLSQ-AGPSNPPGAPPAPLAPSS
1340 1350 1360 1370 1380
960 970 980 990 1000 1010
pF1KE3 PAILYQVEDNRQIMAPVTNS---SSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQ
: . .:. ::.:.. . .:.: . :. .:::.. :. :..
XP_016 PPVTALPQDG---AAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLA
1390 1400 1410 1420 1430 1440
1020 1030 1040 1050 1060
pF1KE3 ADALM-----SHPG-ESTQTSGNS-----LTTLAFDQKPQTLSVQQPAMDAEFISQEGET
.. :. :. :...: : : : . .:.. .. :::. . .
XP_016 VQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHS-GTPQPALGQPAPLLPAAV
1450 1460 1470 1480 1490 1500
1070 1080 1090 1100 1110 1120
pF1KE3 TVNTEASSPKTVIPTQTPGLEPTTL-QPTTVLESDGERPP-KLEFADNRIKTLDEKLRNL
. . :.: .: .: : ::. :: ..:::::: :: .. :.:. ::.::::::.:
XP_016 GAVSLATSQ---LP--SPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTL
1510 1520 1530 1540 1550
1130 1140 1150 1160
pF1KE3 LYQEH----SISSIYPESQKDTQSIDSPFSSSAEDTLSC-------PVTEVIAISHCGIK
::::: : :. : : . :. .. . : :: . . .. .
XP_016 LYQEHVPTSSASAGTPVEVGDRDFTLEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLP
1560 1570 1580 1590 1600 1610
1170 1180 1190 1200 1210 1220
pF1KE3 DSPVQSPNFQQTGSKLL-----SNVAASQPANISVFKRDLNVITSVPSELCLHEMSSDAS
. :.. .. : . .. :... :.: .. . :: ....::.
XP_016 QPLVEKSELAPTRGAVMEQGTSSSMTESSPRSMLGYDRDG------------RQVASDSH
1620 1630 1640 1650 1660
1230 1240 1250 1260 1270 1280
pF1KE3 L-PGDPEAYPAAVSSGGAIHL-QTGVETEEMRSAIAPDPIPLTRESTADTRALNRCKAMS
. :. :. :: : . . . : :. : . :. . . ... ..:. .:..
XP_016 VVPSVPQDVPAFVRPARVEPTDRDGGEAGESSAEPPPSDMGTVGGQASHPQTLG-ARALG
1670 1680 1690 1700 1710 1720
1290 1300 1310 1320 1330 1340
pF1KE3 GSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQLVEIEPATQN
. .: . : .. : . .. :.. .:. .: . .: ... .: . : .. : ..
XP_016 SPRKRPEQQDVSSPAKTVGR---FSV--VSTQDEWTLASPHSLRYSAPPD-VYLDEAPSS
1730 1740 1750 1760 1770 1780
1350 1360 1370 1380 1390 1400
pF1KE3 PKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFEETSATGSSM
: .... .. :. . . . : : ..:. . . : .. ..::
XP_016 PDVKLAVRRAQT-ASSIEVGVGEPVSSDS-------GDEGPRARPPVQKQASLPVSGSV-
1790 1800 1810 1820 1830
1410 1420 1430 1440 1450 1460
pF1KE3 QSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHHEEQAYAQTQ
..... : .: ..:: ::: :::. : . . .
XP_016 --AGDFVKKATAFL---QRPSR--------AGS------LGPET----PSRVGMKVPTIS
1840 1850 1860
1470 1480 1490 1500 1510 1520
pF1KE3 SSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSI
. :.: :: .:::..::.:: :.: ::: :::::..:. .::.::..:.. ::.::
XP_016 VTSFHSQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLG--
1870 1880 1890 1900 1910 1920
1530 1540 1550 1560 1570
pF1KE3 KDSKTQSTEIPLPPASPRRPRSFKSKLRS--------RPQSLTHVDNGIVATDPLCV--E
: . . : . :: .. ::::.. : ... ..: : ::. :
XP_016 KPLPPNVGFFHTAPPTGRRRKTSKSKLKAGKLLNPLVRQLKVVASSTG-SALKRLCLGKE
1930 1940 1950 1960 1970 1980
1580 1590 1600 1610
pF1KE3 SNAASCQQS----------PA-----------SKKGMFTDDLHKLVDDWTKEAVGNSLIK
.. : .: :: .::: ::::::::::.::...:: . .:
XP_016 HSSRSSTSSLAPGPEPGPQPALHVQAQVNNSNNKKGTFTDDLHKLVDEWTSKTVGAAQLK
1990 2000 2010 2020 2030 2040
1620 1630 1640 1650 1660
pF1KE3 PSLNQLKQSQHKLETE---NWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQG----
:.::::::.:. . : .: .: : ... . : : . :.. :
XP_016 PTLNQLKQTQKLQDMEAQAGWAAPGEARAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPT
2050 2060 2070 2080 2090 2100
1670 1680 1690 1700 1710 1720
pF1KE3 LSLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNM
::.:. : :..
XP_016 LSVPTPDGALGTARRNQVWFGLRVPPTACCGHSTQPRGGQRVGSKTASFAASDPVRS
2110 2120 2130 2140 2150 2160
1743 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 22:36:33 2016 done: Sat Nov 5 22:36:36 2016
Total Scan time: 18.850 Total Display time: 1.530
Function used was FASTA [36.3.4 Apr, 2011]