Result of FASTA (omim) for
pFN21AE3707
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3707, 301 aa
1>>>pF1KE3707 301 - 301 aa - 301 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.0123+/-0.000426; mu= -8.7746+/- 0.027
mean_var=358.2484+/-70.466, 0's: 0 Z-trim(121.9): 56 B-trim: 49 in 1/58
Lambda= 0.067761
statistics sampled from 39249 (39305) to 39249 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.774), E-opt: 0.2 (0.461), width: 16
Scan time: 7.300
The best scores are: opt bits E(85289)
NP_001159490 (OMIM: 601583,609062) POU domain, cla ( 655) 926 103.9 8.6e-22
NP_009183 (OMIM: 601583,609062) POU domain, class ( 691) 658 77.8 6.9e-14
XP_011513415 (OMIM: 601583,609062) PREDICTED: POU ( 720) 658 77.8 7.1e-14
NP_001116229 (OMIM: 173110,613038) pituitary-speci ( 317) 487 60.8 4.2e-09
NP_000297 (OMIM: 173110,613038) pituitary-specific ( 291) 476 59.7 8.2e-09
XP_011507957 (OMIM: 164175) PREDICTED: POU domain, ( 671) 481 60.4 1.1e-08
XP_011507956 (OMIM: 164175) PREDICTED: POU domain, ( 743) 481 60.5 1.2e-08
NP_001185712 (OMIM: 164175) POU domain, class 2, t ( 755) 481 60.5 1.2e-08
NP_002688 (OMIM: 164175) POU domain, class 2, tran ( 766) 481 60.5 1.2e-08
XP_011507955 (OMIM: 164175) PREDICTED: POU domain, ( 769) 481 60.5 1.2e-08
NP_000298 (OMIM: 300039,304400) POU domain, class ( 361) 470 59.1 1.5e-08
NP_006227 (OMIM: 602480) POU domain, class 3, tran ( 500) 472 59.5 1.6e-08
NP_001193955 (OMIM: 164176) POU domain, class 2, t ( 467) 471 59.3 1.6e-08
NP_001193954 (OMIM: 164176) POU domain, class 2, t ( 479) 471 59.3 1.7e-08
XP_011525343 (OMIM: 164176) PREDICTED: POU domain, ( 501) 471 59.4 1.7e-08
XP_011525345 (OMIM: 164176) PREDICTED: POU domain, ( 537) 470 59.3 2e-08
XP_016882383 (OMIM: 164176) PREDICTED: POU domain, ( 602) 471 59.4 2e-08
XP_016882384 (OMIM: 164176) PREDICTED: POU domain, ( 602) 471 59.4 2e-08
XP_011525342 (OMIM: 164176) PREDICTED: POU domain, ( 624) 471 59.4 2e-08
NP_005595 (OMIM: 600494) POU domain, class 3, tran ( 443) 467 58.9 2.1e-08
NP_001185715 (OMIM: 164175) POU domain, class 2, t ( 703) 472 59.6 2.1e-08
XP_016882385 (OMIM: 164176) PREDICTED: POU domain, ( 600) 470 59.3 2.1e-08
XP_016882381 (OMIM: 164176) PREDICTED: POU domain, ( 701) 470 59.4 2.4e-08
XP_016882379 (OMIM: 164176) PREDICTED: POU domain, ( 711) 470 59.4 2.4e-08
XP_016882375 (OMIM: 164176) PREDICTED: POU domain, ( 711) 470 59.4 2.4e-08
XP_016882377 (OMIM: 164176) PREDICTED: POU domain, ( 711) 470 59.4 2.4e-08
XP_016882376 (OMIM: 164176) PREDICTED: POU domain, ( 711) 470 59.4 2.4e-08
XP_016882378 (OMIM: 164176) PREDICTED: POU domain, ( 711) 470 59.4 2.4e-08
XP_016882374 (OMIM: 164176) PREDICTED: POU domain, ( 723) 470 59.4 2.4e-08
XP_016882373 (OMIM: 164176) PREDICTED: POU domain, ( 723) 470 59.4 2.4e-08
NP_001234923 (OMIM: 164176) POU domain, class 2, t ( 400) 453 57.5 5e-08
NP_002689 (OMIM: 164176) POU domain, class 2, tran ( 463) 453 57.6 5.5e-08
XP_011525344 (OMIM: 164176) PREDICTED: POU domain, ( 485) 453 57.6 5.7e-08
XP_005259067 (OMIM: 164176) PREDICTED: POU domain, ( 586) 453 57.7 6.6e-08
XP_016882382 (OMIM: 164176) PREDICTED: POU domain, ( 608) 453 57.7 6.8e-08
XP_016872976 (OMIM: 607394) PREDICTED: POU domain, ( 356) 447 56.9 6.8e-08
XP_011541045 (OMIM: 607394) PREDICTED: POU domain, ( 403) 447 56.9 7.5e-08
XP_011541044 (OMIM: 607394) PREDICTED: POU domain, ( 403) 447 56.9 7.5e-08
XP_011541043 (OMIM: 607394) PREDICTED: POU domain, ( 403) 447 56.9 7.5e-08
XP_011541041 (OMIM: 607394) PREDICTED: POU domain, ( 432) 447 57.0 7.9e-08
XP_011541042 (OMIM: 607394) PREDICTED: POU domain, ( 432) 447 57.0 7.9e-08
NP_055167 (OMIM: 607394) POU domain, class 2, tran ( 436) 447 57.0 8e-08
NP_001231611 (OMIM: 607394) POU domain, class 2, t ( 438) 447 57.0 8e-08
XP_016882380 (OMIM: 164176) PREDICTED: POU domain, ( 707) 451 57.5 8.7e-08
NP_002690 (OMIM: 602479) POU domain, class 3, tran ( 451) 427 55.0 3.2e-07
NP_006228 (OMIM: 601632) POU domain, class 4, tran ( 419) 426 54.9 3.2e-07
NP_002692 (OMIM: 164177) POU domain, class 5, tran ( 360) 414 53.7 6.5e-07
NP_001153014 (OMIM: 615739) putative POU domain, c ( 359) 396 51.9 2.2e-06
NP_004566 (OMIM: 113725) POU domain, class 4, tran ( 409) 397 52.1 2.2e-06
NP_002691 (OMIM: 602459,602460) POU domain, class ( 338) 386 50.9 4.1e-06
>>NP_001159490 (OMIM: 601583,609062) POU domain, class 6 (655 aa)
initn: 1102 init1: 896 opt: 926 Z-score: 512.2 bits: 103.9 E(85289): 8.6e-22
Smith-Waterman score: 1117; 59.3% identity (80.7% similar) in 305 aa overlap (1-294:328-631)
10 20
pF1KE3 MPGISSQILTNAQGQVIGTLPWVVNSA-SV
. :...:..::::::.:::.: . : . :
NP_001 NNPLASQAAAAAAAMSSIASSQAFGNALSSLQGVTGQLVTNAQGQIIGTIPLMPNPGPSS
300 310 320 330 340 350
30 40 50 60 70 80
pF1KE3 AAPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPPPVAVRKPS-TPESPAKSEVQPIQ
: . .:.:::: .::::: :::::.:::. .. . : . .. . .: .:... :: :
NP_001 QAASGTQGLQVQPITPQLLTNAQGQIIATVIGNQILPVINTQGITLSPIKPGQQLHQPSQ
360 370 380 390 400 410
90 100 110 120 130
pF1KE3 PT--PTVPQPAVV-IA------SPAPAAKPSASAPIPITCSETPTVSQLVSKPHTPSLDE
. .. : .. .: : .:. . :.:. . : . .:.::::.:.: . .
NP_001 TSVGQAASQGNLLHLAHSQASMSQSPVRQASSSSSSS-SSSSALSVGQLVSNPQTAAGEV
420 430 440 450 460 470
140 150 160 170 180 190
pF1KE3 DGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQ
::.:::::::::: :::::::::::::::::::.::::::::::::::::::::::::::
NP_001 DGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICRFEKLDITPKSAQ
480 490 500 510 520 530
200 210 220 230 240 250
pF1KE3 KLKPVLEKWLNEAELRNQEGQQNLMEFVGGEPSKKRKRRTSFTPQAIEALNAYFEKNPLP
:.:::::.:. ::: :.. :.::: ::.:.::::::::::::::::.: :::.:::: :
NP_001 KIKPVLERWMAEAEARHRAGMQNLTEFIGSEPSKKRKRRTSFTPQALEILNAHFEKNTHP
540 550 560 570 580 590
260 270 280 290 300
pF1KE3 TGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKLNVFQIP
.:::.::::..::::::::::::::.::.:::: :
NP_001 SGQEMTEIAEKLNYDREVVRVWFCNKRQALKNTIKRLKQHEPATAVPLEPLTDSLEENS
600 610 620 630 640 650
>>NP_009183 (OMIM: 601583,609062) POU domain, class 6, t (691 aa)
initn: 1102 init1: 579 opt: 658 Z-score: 370.3 bits: 77.8 E(85289): 6.9e-14
Smith-Waterman score: 977; 53.2% identity (71.3% similar) in 327 aa overlap (15-294:342-667)
10 20 30 40
pF1KE3 MPGISSQILTNAQGQVIGTLPWVVNSA-SVAAPAPAQSLQVQAV
:.:::.: . : . : : . .:.:::: .
NP_009 MSSIASSQAFGNALSSLQGVTGQLVTNAQGQIIGTIPLMPNPGPSSQAASGTQGLQVQPI
320 330 340 350 360 370
50 60 70 80 90
pF1KE3 TPQLLLNAQGQVIATLASSPLPPPVAVRKPS-TPESPAKSEVQPIQPT--PTVPQPAVV-
::::: :::::.:::. .. . : . .. . .: .:... :: : . .. : ..
NP_009 TPQLLTNAQGQIIATVIGNQILPVINTQGITLSPIKPGQQLHQPSQTSVGQAASQGNLLH
380 390 400 410 420 430
100 110 120 130 140 150
pF1KE3 IA------SPAPAAKPSASAPIPITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKN
.: : .:. . :.:. . : . .:.::::.:.: . . ::.::::::::::
NP_009 LAHSQASMSQSPVRQASSSSSSS-SSSSALSVGQLVSNPQTAAGEVDGVNLEEIREFAKA
440 450 460 470 480 490
160 170 180
pF1KE3 FKIRRLSLGLTQTQVGQALTATEGPAYSQSAICR--------------------------
:::::::::::::::::::.::::::::::::::
NP_009 FKIRRLSLGLTQTQVGQALSATEGPAYSQSAICRHTILRSHFFLPQEAQENTIASSLTAK
500 510 520 530 540 550
190 200 210 220 230
pF1KE3 ----------FEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQQNLMEFVGGEPSKKRKR
:::::::::::::.:::::.:. ::: :.. :.::: ::.:.::::::::
NP_009 LNPGLLYPARFEKLDITPKSAQKIKPVLERWMAEAEARHRAGMQNLTEFIGSEPSKKRKR
560 570 580 590 600 610
240 250 260 270 280 290
pF1KE3 RTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKLNV
::::::::.: :::.:::: :.:::.::::..::::::::::::::.::.:::: :
NP_009 RTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKNTIKRLK
620 630 640 650 660 670
300
pF1KE3 FQIP
NP_009 QHEPATAVPLEPLTDSLEENS
680 690
>>XP_011513415 (OMIM: 601583,609062) PREDICTED: POU doma (720 aa)
initn: 1102 init1: 579 opt: 658 Z-score: 370.0 bits: 77.8 E(85289): 7.1e-14
Smith-Waterman score: 977; 53.2% identity (71.3% similar) in 327 aa overlap (15-294:371-696)
10 20 30 40
pF1KE3 MPGISSQILTNAQGQVIGTLPWVVNSA-SVAAPAPAQSLQVQAV
:.:::.: . : . : : . .:.:::: .
XP_011 MSSIASSQAFGNALSSLQGVTGQLVTNAQGQIIGTIPLMPNPGPSSQAASGTQGLQVQPI
350 360 370 380 390 400
50 60 70 80 90
pF1KE3 TPQLLLNAQGQVIATLASSPLPPPVAVRKPS-TPESPAKSEVQPIQPT--PTVPQPAVV-
::::: :::::.:::. .. . : . .. . .: .:... :: : . .. : ..
XP_011 TPQLLTNAQGQIIATVIGNQILPVINTQGITLSPIKPGQQLHQPSQTSVGQAASQGNLLH
410 420 430 440 450 460
100 110 120 130 140 150
pF1KE3 IA------SPAPAAKPSASAPIPITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKN
.: : .:. . :.:. . : . .:.::::.:.: . . ::.::::::::::
XP_011 LAHSQASMSQSPVRQASSSSSSS-SSSSALSVGQLVSNPQTAAGEVDGVNLEEIREFAKA
470 480 490 500 510
160 170 180
pF1KE3 FKIRRLSLGLTQTQVGQALTATEGPAYSQSAICR--------------------------
:::::::::::::::::::.::::::::::::::
XP_011 FKIRRLSLGLTQTQVGQALSATEGPAYSQSAICRHTILRSHFFLPQEAQENTIASSLTAK
520 530 540 550 560 570
190 200 210 220 230
pF1KE3 ----------FEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQQNLMEFVGGEPSKKRKR
:::::::::::::.:::::.:. ::: :.. :.::: ::.:.::::::::
XP_011 LNPGLLYPARFEKLDITPKSAQKIKPVLERWMAEAEARHRAGMQNLTEFIGSEPSKKRKR
580 590 600 610 620 630
240 250 260 270 280 290
pF1KE3 RTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKLNV
::::::::.: :::.:::: :.:::.::::..::::::::::::::.::.:::: :
XP_011 RTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKNTIKRLK
640 650 660 670 680 690
300
pF1KE3 FQIP
XP_011 QHEPATAVPLEPLTDSLEENS
700 710 720
>>NP_001116229 (OMIM: 173110,613038) pituitary-specific (317 aa)
initn: 466 init1: 274 opt: 487 Z-score: 284.5 bits: 60.8 E(85289): 4.2e-09
Smith-Waterman score: 487; 35.4% identity (64.6% similar) in 291 aa overlap (19-296:22-303)
10 20 30 40 50
pF1KE3 MPGISSQILTNAQGQVIGTLPWVVN-SASVAAPAPAQSLQVQAVTPQLLLNAQGQ--
::: ... ::. :. .. .:....:..: :
NP_001 MSCQAFTSADTFIPLNSDASATLPLIMHHSAAECLPVSNHATNVMSTVPSILSLIQTPKC
10 20 30 40 50 60
60 70 80 90 100
pF1KE3 -----VIATLASSPLPPPVAVRKPSTPESPAKSEVQPIQPTPTVPQ-PAVVIASPAPAAK
..::... .: . ..:. :. . :: . . : ... : .
NP_001 LCTHFSVTTLGNTATGLHYSVPSCHYGNQPSTYGVMAGSLTPCLYKFPDHTLSHGFPPIH
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE3 PSASAPIPITCS---ETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQ
: : . . : :.:: .: .: :. ...:...::..::.::..:: ::
NP_001 QPLLAEDPTAADFKQELRRKSKLVEEP----IDMDSPEIRELEKFANEFKVRRIKLGYTQ
130 140 150 160 170
170 180 190 200 210 220
pF1KE3 TQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQQNLME
:.::.::.:..: .::..:::::.:... :.: ::: .: :::.::: : : :..
NP_001 TNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAE---QVG--ALYN
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE3 FVGGEPSKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNR
: .::::::... : .::. .: .. :..::: ..:.::: ..::::::::::
NP_001 EKVGANERKRKRRTTISIAAKDALERHFGEQNKPSSQEIMRMAEELNLEKEVVRVWFCNR
240 250 260 270 280 290
290 300
pF1KE3 RQTLKNT-SKLNVFQIP
:: : . ..::
NP_001 RQREKRVKTSLNQSLFSISKEHLECR
300 310
>>NP_000297 (OMIM: 173110,613038) pituitary-specific pos (291 aa)
initn: 466 init1: 274 opt: 476 Z-score: 279.2 bits: 59.7 E(85289): 8.2e-09
Smith-Waterman score: 476; 43.1% identity (70.3% similar) in 209 aa overlap (89-296:82-277)
60 70 80 90 100 110
pF1KE3 LASSPLPPPVAVRKPSTPESPAKSEVQPIQPTPTVPQPAVVIASPAPAAKPSASAPIPIT
: :. . : .: : :.:.
NP_000 HYSVPSCHYGNQPSTYGVMAGSLTPCLYKFPDHTLSHGFPPIHQPLLAEDPTAAD----F
60 70 80 90 100
120 130 140 150 160 170
pF1KE3 CSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGP
.: :.:: .: .: :. ...:...::..::.::..:: :::.::.::.:..:
NP_000 KQELRRKSKLVEEP----IDMDSPEIRELEKFANEFKVRRIKLGYTQTNVGEALAAVHGS
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE3 AYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQQNLMEFVGGEPSKKRKRR
.::..:::::.:... :.: ::: .: :::.::: : : : ::.. .:::::
NP_000 EFSQTTICRFENLQLSFKNACKLKAILSKWLEEAE---QVGAL-YNEKVGANE-RKRKRR
170 180 190 200 210
240 250 260 270 280 290
pF1KE3 TSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNT-SKLNV
:... : .::. .: .. :..::: ..:.::: ..:::::::::::: : . ..::
NP_000 TTISIAAKDALERHFGEQNKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQ
220 230 240 250 260 270
300
pF1KE3 FQIP
NP_000 SLFSISKEHLECR
280 290
>>XP_011507957 (OMIM: 164175) PREDICTED: POU domain, cla (671 aa)
initn: 477 init1: 250 opt: 481 Z-score: 276.9 bits: 60.4 E(85289): 1.1e-08
Smith-Waterman score: 481; 37.2% identity (64.3% similar) in 269 aa overlap (35-290:199-461)
10 20 30 40 50 60
pF1KE3 SSQILTNAQGQVIGTLPWVVNSASVAAPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPL
::.:: : :: : : . . .. :
XP_011 SQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQ-QFVLVHPTTNL
170 180 190 200 210 220
70 80 90 100 110
pF1KE3 PPP--VAVRKPSTPESPAKSE---VQ-PIQPTPTV--PQPAVVIAS-PAPAAKPSASAPI
: . . :. .. ... .: : : .. ::.....: :: .. :..::
XP_011 QPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPI
230 240 250 260 270 280
120 130 140 150 160 170
pF1KE3 PITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTAT
. : .. .. ::::.: . .:::...:::.:: ::..::.:: .:: :.
XP_011 ----QTLPQSQSTPKRIDTPSLEEPS-DLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKL
290 300 310 320 330 340
180 190 200 210 220 230
pF1KE3 EGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQ---QNLMEFVGGEP-
: .::..: ::: :... :. ::::.::::::.:: ..... . .. : :
XP_011 YGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSPGIEGL
350 360 370 380 390 400
240 250 260 270 280 290
pF1KE3 SKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKN
:..::.:::. . ::. : .: ::..::: :: .::...::.::::::::: :
XP_011 SRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKR
410 420 430 440 450 460
300
pF1KE3 TSKLNVFQIP
XP_011 INPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSPVLPLTSAAVTNLSVTG
470 480 490 500 510 520
>>XP_011507956 (OMIM: 164175) PREDICTED: POU domain, cla (743 aa)
initn: 477 init1: 250 opt: 481 Z-score: 276.3 bits: 60.5 E(85289): 1.2e-08
Smith-Waterman score: 481; 37.2% identity (64.3% similar) in 269 aa overlap (35-290:173-435)
10 20 30 40 50 60
pF1KE3 SSQILTNAQGQVIGTLPWVVNSASVAAPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPL
::.:: : :: : : . . .. :
XP_011 SQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQ-QFVLVHPTTNL
150 160 170 180 190 200
70 80 90 100 110
pF1KE3 PPP--VAVRKPSTPESPAKSE---VQ-PIQPTPTV--PQPAVVIAS-PAPAAKPSASAPI
: . . :. .. ... .: : : .. ::.....: :: .. :..::
XP_011 QPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPI
210 220 230 240 250 260
120 130 140 150 160 170
pF1KE3 PITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTAT
. : .. .. ::::.: . .:::...:::.:: ::..::.:: .:: :.
XP_011 ----QTLPQSQSTPKRIDTPSLEEPS-DLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKL
270 280 290 300 310
180 190 200 210 220 230
pF1KE3 EGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQ---QNLMEFVGGEP-
: .::..: ::: :... :. ::::.::::::.:: ..... . .. : :
XP_011 YGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSPGIEGL
320 330 340 350 360 370
240 250 260 270 280 290
pF1KE3 SKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKN
:..::.:::. . ::. : .: ::..::: :: .::...::.::::::::: :
XP_011 SRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKR
380 390 400 410 420 430
300
pF1KE3 TSKLNVFQIP
XP_011 INPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSPVLPLTSAAVTNLSVTG
440 450 460 470 480 490
>>NP_001185712 (OMIM: 164175) POU domain, class 2, trans (755 aa)
initn: 477 init1: 250 opt: 481 Z-score: 276.2 bits: 60.5 E(85289): 1.2e-08
Smith-Waterman score: 481; 37.2% identity (64.3% similar) in 269 aa overlap (35-290:185-447)
10 20 30 40 50 60
pF1KE3 SSQILTNAQGQVIGTLPWVVNSASVAAPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPL
::.:: : :: : : . . .. :
NP_001 SQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQ-QFVLVHPTTNL
160 170 180 190 200 210
70 80 90 100 110
pF1KE3 PPP--VAVRKPSTPESPAKSE---VQ-PIQPTPTV--PQPAVVIAS-PAPAAKPSASAPI
: . . :. .. ... .: : : .. ::.....: :: .. :..::
NP_001 QPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPI
220 230 240 250 260 270
120 130 140 150 160 170
pF1KE3 PITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTAT
. : .. .. ::::.: . .:::...:::.:: ::..::.:: .:: :.
NP_001 ----QTLPQSQSTPKRIDTPSLEEPS-DLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKL
280 290 300 310 320
180 190 200 210 220 230
pF1KE3 EGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQ---QNLMEFVGGEP-
: .::..: ::: :... :. ::::.::::::.:: ..... . .. : :
NP_001 YGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSPGIEGL
330 340 350 360 370 380
240 250 260 270 280 290
pF1KE3 SKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKN
:..::.:::. . ::. : .: ::..::: :: .::...::.::::::::: :
NP_001 SRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKR
390 400 410 420 430 440
300
pF1KE3 TSKLNVFQIP
NP_001 INPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSPVLPLTSAAVTNLSVTG
450 460 470 480 490 500
>>NP_002688 (OMIM: 164175) POU domain, class 2, transcri (766 aa)
initn: 477 init1: 250 opt: 481 Z-score: 276.2 bits: 60.5 E(85289): 1.2e-08
Smith-Waterman score: 481; 37.2% identity (64.3% similar) in 269 aa overlap (35-290:196-458)
10 20 30 40 50 60
pF1KE3 SSQILTNAQGQVIGTLPWVVNSASVAAPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPL
::.:: : :: : : . . .. :
NP_002 SQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQ-QFVLVHPTTNL
170 180 190 200 210 220
70 80 90 100 110
pF1KE3 PPP--VAVRKPSTPESPAKSE---VQ-PIQPTPTV--PQPAVVIAS-PAPAAKPSASAPI
: . . :. .. ... .: : : .. ::.....: :: .. :..::
NP_002 QPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPI
230 240 250 260 270 280
120 130 140 150 160 170
pF1KE3 PITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTAT
. : .. .. ::::.: . .:::...:::.:: ::..::.:: .:: :.
NP_002 ----QTLPQSQSTPKRIDTPSLEEPS-DLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKL
290 300 310 320 330
180 190 200 210 220 230
pF1KE3 EGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQ---QNLMEFVGGEP-
: .::..: ::: :... :. ::::.::::::.:: ..... . .. : :
NP_002 YGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSPGIEGL
340 350 360 370 380 390
240 250 260 270 280 290
pF1KE3 SKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKN
:..::.:::. . ::. : .: ::..::: :: .::...::.::::::::: :
NP_002 SRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKR
400 410 420 430 440 450
300
pF1KE3 TSKLNVFQIP
NP_002 INPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSPVLPLTSAAVTNLSVTG
460 470 480 490 500 510
>>XP_011507955 (OMIM: 164175) PREDICTED: POU domain, cla (769 aa)
initn: 477 init1: 250 opt: 481 Z-score: 276.1 bits: 60.5 E(85289): 1.2e-08
Smith-Waterman score: 481; 37.2% identity (64.3% similar) in 269 aa overlap (35-290:199-461)
10 20 30 40 50 60
pF1KE3 SSQILTNAQGQVIGTLPWVVNSASVAAPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPL
::.:: : :: : : . . .. :
XP_011 SQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQ-QFVLVHPTTNL
170 180 190 200 210 220
70 80 90 100 110
pF1KE3 PPP--VAVRKPSTPESPAKSE---VQ-PIQPTPTV--PQPAVVIAS-PAPAAKPSASAPI
: . . :. .. ... .: : : .. ::.....: :: .. :..::
XP_011 QPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPI
230 240 250 260 270 280
120 130 140 150 160 170
pF1KE3 PITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTAT
. : .. .. ::::.: . .:::...:::.:: ::..::.:: .:: :.
XP_011 ----QTLPQSQSTPKRIDTPSLEEPS-DLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKL
290 300 310 320 330 340
180 190 200 210 220 230
pF1KE3 EGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQ---QNLMEFVGGEP-
: .::..: ::: :... :. ::::.::::::.:: ..... . .. : :
XP_011 YGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSPGIEGL
350 360 370 380 390 400
240 250 260 270 280 290
pF1KE3 SKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKN
:..::.:::. . ::. : .: ::..::: :: .::...::.::::::::: :
XP_011 SRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKR
410 420 430 440 450 460
300
pF1KE3 TSKLNVFQIP
XP_011 INPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSPVLPLTSAAVTNLSVTG
470 480 490 500 510 520
301 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 06:34:27 2016 done: Sun Nov 6 06:34:28 2016
Total Scan time: 7.300 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]