Result of FASTA (omim) for
pFN21AE3691
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3691, 655 aa
1>>>pF1KE3691 655 - 655 aa - 655 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2959+/-0.000392; mu= 19.4236+/- 0.024
mean_var=71.7441+/-15.185, 0's: 0 Z-trim(110.7): 400 B-trim: 1820 in 3/53
Lambda= 0.151419
statistics sampled from 18606 (19062) to 18606 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.58), E-opt: 0.2 (0.223), width: 16
Scan time: 7.620
The best scores are: opt bits E(85289)
NP_277030 (OMIM: 300655) kelch-like protein 13 iso ( 655) 4429 977.5 0
XP_011529713 (OMIM: 300655) PREDICTED: kelch-like ( 655) 4429 977.5 0
NP_001161773 (OMIM: 300655) kelch-like protein 13 ( 639) 4200 927.5 0
XP_016885439 (OMIM: 300655) PREDICTED: kelch-like ( 639) 4200 927.5 0
NP_001161774 (OMIM: 300655) kelch-like protein 13 ( 639) 4200 927.5 0
NP_001161772 (OMIM: 300655) kelch-like protein 13 ( 649) 4200 927.5 0
NP_001161771 (OMIM: 300655) kelch-like protein 13 ( 658) 4200 927.5 0
XP_011529711 (OMIM: 300655) PREDICTED: kelch-like ( 661) 4200 927.5 0
XP_011529712 (OMIM: 300655) PREDICTED: kelch-like ( 661) 4200 927.5 0
NP_001161775 (OMIM: 300655) kelch-like protein 13 ( 613) 4142 914.8 0
NP_061335 (OMIM: 611201) kelch-like protein 9 [Hom ( 617) 3911 864.3 0
NP_001003760 (OMIM: 610749) kelch-like protein 31 ( 634) 1314 297.0 1.4e-79
XP_005249164 (OMIM: 610749) PREDICTED: kelch-like ( 634) 1314 297.0 1.4e-79
XP_016866347 (OMIM: 610749) PREDICTED: kelch-like ( 634) 1314 297.0 1.4e-79
NP_065856 (OMIM: 613772) kelch-like protein 14 [Ho ( 628) 1188 269.5 2.7e-71
XP_011512001 (OMIM: 608064) PREDICTED: kelch-like ( 804) 1047 238.7 6.1e-62
XP_016863762 (OMIM: 608064) PREDICTED: kelch-like ( 804) 1047 238.7 6.1e-62
XP_016863763 (OMIM: 608064) PREDICTED: kelch-like ( 804) 1047 238.7 6.1e-62
NP_001007076 (OMIM: 608064) kelch-like protein 5 i ( 709) 1040 237.2 1.6e-61
NP_057074 (OMIM: 608064) kelch-like protein 5 isof ( 755) 1040 237.2 1.7e-61
XP_016863764 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1040 237.2 1.7e-61
XP_005262712 (OMIM: 608064) PREDICTED: kelch-like ( 789) 1040 237.2 1.7e-61
XP_011512003 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1039 237.0 2e-61
XP_016863765 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1039 237.0 2e-61
XP_011512002 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1039 237.0 2e-61
NP_001165125 (OMIM: 608064) kelch-like protein 5 i ( 568) 1034 235.8 3.3e-61
NP_950240 (OMIM: 608064) kelch-like protein 5 isof ( 694) 977 223.4 2.2e-57
NP_061990 (OMIM: 300348) kelch-like protein 4 isof ( 718) 944 216.2 3.3e-55
NP_476503 (OMIM: 300348) kelch-like protein 4 isof ( 720) 944 216.2 3.3e-55
NP_065917 (OMIM: 605332) kelch-like protein 1 isof ( 748) 941 215.6 5.4e-55
XP_016876167 (OMIM: 605332) PREDICTED: kelch-like ( 575) 922 211.3 7.7e-54
NP_009177 (OMIM: 605774) kelch-like protein 2 isof ( 593) 918 210.5 1.5e-53
NP_001154993 (OMIM: 605774) kelch-like protein 2 i ( 597) 918 210.5 1.5e-53
XP_016863163 (OMIM: 605774) PREDICTED: kelch-like ( 555) 914 209.6 2.5e-53
XP_011529874 (OMIM: 605774) PREDICTED: kelch-like ( 633) 913 209.4 3.3e-53
NP_059111 (OMIM: 605775,614495) kelch-like protein ( 587) 909 208.5 5.6e-53
NP_085127 (OMIM: 300980,300982) kelch-like protein ( 604) 907 208.1 7.8e-53
XP_006724581 (OMIM: 300980,300982) PREDICTED: kelc ( 604) 907 208.1 7.8e-53
NP_001244123 (OMIM: 605775,614495) kelch-like prot ( 555) 901 206.7 1.8e-52
NP_001273654 (OMIM: 605332) kelch-like protein 1 i ( 687) 888 204.0 1.5e-51
NP_001289980 (OMIM: 614522) kelch-like protein 12 ( 606) 886 203.5 1.9e-51
XP_011508137 (OMIM: 614522) PREDICTED: kelch-like ( 623) 886 203.5 1.9e-51
NP_067646 (OMIM: 614522) kelch-like protein 12 iso ( 568) 882 202.6 3.3e-51
XP_016876168 (OMIM: 605332) PREDICTED: kelch-like ( 525) 870 199.9 1.9e-50
NP_689680 (OMIM: 608778,615081) kelch-like protein ( 608) 868 199.6 2.9e-50
NP_001316524 (OMIM: 608778,615081) kelch-like prot ( 608) 868 199.6 2.9e-50
XP_011508139 (OMIM: 614522) PREDICTED: kelch-like ( 522) 796 183.8 1.4e-45
NP_001290038 (OMIM: 614522) kelch-like protein 12 ( 467) 792 182.9 2.3e-45
NP_569713 (OMIM: 614214) kelch-like protein 6 [Hom ( 621) 789 182.3 4.6e-45
XP_011508138 (OMIM: 614522) PREDICTED: kelch-like ( 526) 734 170.2 1.7e-41
>>NP_277030 (OMIM: 300655) kelch-like protein 13 isoform (655 aa)
initn: 4429 init1: 4429 opt: 4429 Z-score: 5227.1 bits: 977.5 E(85289): 0
Smith-Waterman score: 4429; 100.0% identity (100.0% similar) in 655 aa overlap (1-655:1-655)
10 20 30 40 50 60
pF1KE3 MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 AMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 AMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 DFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 DFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 AFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 AFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 FMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 FMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 GGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 GGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR
550 560 570 580 590 600
610 620 630 640 650
pF1KE3 CMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 CMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
610 620 630 640 650
>>XP_011529713 (OMIM: 300655) PREDICTED: kelch-like prot (655 aa)
initn: 4429 init1: 4429 opt: 4429 Z-score: 5227.1 bits: 977.5 E(85289): 0
Smith-Waterman score: 4429; 100.0% identity (100.0% similar) in 655 aa overlap (1-655:1-655)
10 20 30 40 50 60
pF1KE3 MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 AMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 DFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 AFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 FMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 GGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR
550 560 570 580 590 600
610 620 630 640 650
pF1KE3 CMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
610 620 630 640 650
>>NP_001161773 (OMIM: 300655) kelch-like protein 13 isof (639 aa)
initn: 4200 init1: 4200 opt: 4200 Z-score: 4956.9 bits: 927.5 E(85289): 0
Smith-Waterman score: 4200; 100.0% identity (100.0% similar) in 622 aa overlap (34-655:18-639)
10 20 30 40 50 60
pF1KE3 KWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKA
::::::::::::::::::::::::::::::
NP_001 MDHLHRGELVAAILRNRSLVEEEDQHMKLSLGGSEMGLSSHLQSSKA
10 20 30 40
70 80 90 100 110 120
pF1KE3 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE3 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE3 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE3 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE3 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE3 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE3 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE3 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE3 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV
530 540 550 560 570 580
610 620 630 640 650
pF1KE3 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
590 600 610 620 630
>>XP_016885439 (OMIM: 300655) PREDICTED: kelch-like prot (639 aa)
initn: 4200 init1: 4200 opt: 4200 Z-score: 4956.9 bits: 927.5 E(85289): 0
Smith-Waterman score: 4200; 100.0% identity (100.0% similar) in 622 aa overlap (34-655:18-639)
10 20 30 40 50 60
pF1KE3 KWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKA
::::::::::::::::::::::::::::::
XP_016 MDHLHRGELVAAILRNRSLVEEEDQHMKLSLGGSEMGLSSHLQSSKA
10 20 30 40
70 80 90 100 110 120
pF1KE3 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE3 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE3 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE3 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE3 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE3 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE3 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE3 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE3 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV
530 540 550 560 570 580
610 620 630 640 650
pF1KE3 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
590 600 610 620 630
>>NP_001161774 (OMIM: 300655) kelch-like protein 13 isof (639 aa)
initn: 4200 init1: 4200 opt: 4200 Z-score: 4956.9 bits: 927.5 E(85289): 0
Smith-Waterman score: 4200; 100.0% identity (100.0% similar) in 622 aa overlap (34-655:18-639)
10 20 30 40 50 60
pF1KE3 KWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKA
::::::::::::::::::::::::::::::
NP_001 MDHLHRGELVAAILRNRSLVEEEDQHMKLSLGGSEMGLSSHLQSSKA
10 20 30 40
70 80 90 100 110 120
pF1KE3 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE3 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE3 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE3 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE3 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE3 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE3 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE3 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE3 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV
530 540 550 560 570 580
610 620 630 640 650
pF1KE3 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
590 600 610 620 630
>>NP_001161772 (OMIM: 300655) kelch-like protein 13 isof (649 aa)
initn: 4200 init1: 4200 opt: 4200 Z-score: 4956.8 bits: 927.5 E(85289): 0
Smith-Waterman score: 4200; 100.0% identity (100.0% similar) in 622 aa overlap (34-655:28-649)
10 20 30 40 50 60
pF1KE3 KWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKA
::::::::::::::::::::::::::::::
NP_001 MLRFISHLYCCSSKEDCSEDDKCILSRSLVEEEDQHMKLSLGGSEMGLSSHLQSSKA
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE3 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE3 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE3 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE3 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE3 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE3 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE3 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE3 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV
540 550 560 570 580 590
610 620 630 640 650
pF1KE3 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
600 610 620 630 640
>>NP_001161771 (OMIM: 300655) kelch-like protein 13 isof (658 aa)
initn: 4200 init1: 4200 opt: 4200 Z-score: 4956.7 bits: 927.5 E(85289): 0
Smith-Waterman score: 4200; 100.0% identity (100.0% similar) in 622 aa overlap (34-655:37-658)
10 20 30 40 50 60
pF1KE3 KWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKA
::::::::::::::::::::::::::::::
NP_001 LREKWAYWRRRQLSLKQADFKDIFKKSTSGSLVEEEDQHMKLSLGGSEMGLSSHLQSSKA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV
550 560 570 580 590 600
610 620 630 640 650
pF1KE3 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
610 620 630 640 650
>>XP_011529711 (OMIM: 300655) PREDICTED: kelch-like prot (661 aa)
initn: 4200 init1: 4200 opt: 4200 Z-score: 4956.7 bits: 927.5 E(85289): 0
Smith-Waterman score: 4200; 100.0% identity (100.0% similar) in 622 aa overlap (34-655:40-661)
10 20 30 40 50 60
pF1KE3 KWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKA
::::::::::::::::::::::::::::::
XP_011 VAAILRNRRRRQLSLKQADFKDIFKKSTSGSLVEEEDQHMKLSLGGSEMGLSSHLQSSKA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV
550 560 570 580 590 600
610 620 630 640 650
pF1KE3 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
610 620 630 640 650 660
>>XP_011529712 (OMIM: 300655) PREDICTED: kelch-like prot (661 aa)
initn: 4200 init1: 4200 opt: 4200 Z-score: 4956.7 bits: 927.5 E(85289): 0
Smith-Waterman score: 4200; 100.0% identity (100.0% similar) in 622 aa overlap (34-655:40-661)
10 20 30 40 50 60
pF1KE3 KWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKA
::::::::::::::::::::::::::::::
XP_011 VAAILRNRRRRQLSLKQADFKDIFKKSTSGSLVEEEDQHMKLSLGGSEMGLSSHLQSSKA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV
550 560 570 580 590 600
610 620 630 640 650
pF1KE3 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
610 620 630 640 650 660
>>NP_001161775 (OMIM: 300655) kelch-like protein 13 isof (613 aa)
initn: 4142 init1: 4142 opt: 4142 Z-score: 4888.7 bits: 914.8 E(85289): 0
Smith-Waterman score: 4142; 100.0% identity (100.0% similar) in 613 aa overlap (43-655:1-613)
20 30 40 50 60 70
pF1KE3 WKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSN
::::::::::::::::::::::::::::::
NP_001 MKLSLGGSEMGLSSHLQSSKAGPTRIFTSN
10 20 30
80 90 100 110 120 130
pF1KE3 THSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 THSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDL
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE3 MCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVT
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE3 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE3 TELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE3 LEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSL
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE3 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE3 FFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYI
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE3 SGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYD
460 470 480 490 500 510
560 570 580 590 600 610
pF1KE3 DVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPD
520 530 540 550 560 570
620 630 640 650
pF1KE3 KDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
:::::::::::::::::::::::::::::::::::::::::::
NP_001 KDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
580 590 600 610
655 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 06:18:34 2016 done: Sun Nov 6 06:18:35 2016
Total Scan time: 7.620 Total Display time: 0.130
Function used was FASTA [36.3.4 Apr, 2011]