Result of FASTA (omim) for
pFN21AE3689
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3689, 685 aa
1>>>pF1KE3689 685 - 685 aa - 685 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.0256+/-0.000523; mu= 17.5959+/- 0.032
mean_var=152.7310+/-32.168, 0's: 0 Z-trim(112.3): 155 B-trim: 0 in 0/50
Lambda= 0.103779
statistics sampled from 21064 (21244) to 21064 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.603), E-opt: 0.2 (0.249), width: 16
Scan time: 9.990
The best scores are: opt bits E(85289)
NP_005658 (OMIM: 602507) E3 ubiquitin-protein liga ( 685) 4731 721.5 2.6e-207
NP_001185880 (OMIM: 602507) E3 ubiquitin-protein l ( 681) 4601 702.0 1.9e-201
NP_001185881 (OMIM: 602507) E3 ubiquitin-protein l ( 122) 789 130.4 4.1e-30
XP_016879917 (OMIM: 610431) PREDICTED: E3 ubiquiti ( 227) 187 40.6 0.0082
XP_016869786 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 402) 189 41.2 0.0095
XP_016869785 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 402) 189 41.2 0.0095
XP_006716784 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 189 41.2 0.01
NP_919313 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 189 41.2 0.01
XP_005251425 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 189 41.2 0.01
XP_005251423 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 189 41.2 0.01
XP_005251424 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 189 41.2 0.01
XP_011516014 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 189 41.2 0.01
XP_011516015 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 189 41.2 0.01
NP_919309 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 189 41.2 0.01
XP_016869784 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 189 41.2 0.01
NP_919311 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 189 41.2 0.01
>>NP_005658 (OMIM: 602507) E3 ubiquitin-protein ligase R (685 aa)
initn: 4731 init1: 4731 opt: 4731 Z-score: 3842.9 bits: 721.5 E(85289): 2.6e-207
Smith-Waterman score: 4731; 100.0% identity (100.0% similar) in 685 aa overlap (1-685:1-685)
10 20 30 40 50 60
pF1KE3 MWLKLFFLLLYFLVLFVLARFFEAIVWYETGIFATQLVDPVALSFKKLKTILECRGLGYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MWLKLFFLLLYFLVLFVLARFFEAIVWYETGIFATQLVDPVALSFKKLKTILECRGLGYS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GLPEKKDVRELVEKSGDLMEGELYSALKEEEASESVSSTNFSGEMHFYELVEDTKDGIWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GLPEKKDVRELVEKSGDLMEGELYSALKEEEASESVSSTNFSGEMHFYELVEDTKDGIWL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 VQVIANDRSPLVGKIHWEKMVKKVSRFGIRTGTFNCSSDPRYCRRRGWVRSTLIMSVPQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VQVIANDRSPLVGKIHWEKMVKKVSRFGIRTGTFNCSSDPRYCRRRGWVRSTLIMSVPQT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 STSKGKVMLKEYSGRKIEVEHIFKWITAHAASRIKTIYNAEHLKEEWNKSDQYWLKIYLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 STSKGKVMLKEYSGRKIEVEHIFKWITAHAASRIKTIYNAEHLKEEWNKSDQYWLKIYLF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 ANLDQPPAFFSALSIKFTGRVEFIFVNVENWDNKSYMTDIGIYNMPSYILRTPEGIYRYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ANLDQPPAFFSALSIKFTGRVEFIFVNVENWDNKSYMTDIGIYNMPSYILRTPEGIYRYG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 NHTGEFISLQAMDSFLRSLQPEVNDLFVLSLVLVNLMAWMDLFITQGATIKRFVVLISTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NHTGEFISLQAMDSFLRSLQPEVNDLFVLSLVLVNLMAWMDLFITQGATIKRFVVLISTL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 GTYNSLLIISWLPVLGFLQLPYLDSFYEYSLKLLRYSNTTTLASWVRADWMFYSSHPALF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GTYNSLLIISWLPVLGFLQLPYLDSFYEYSLKLLRYSNTTTLASWVRADWMFYSSHPALF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 LSTYLGHGLLIDYFEKKRRRNNNNDEVNANNLEWLSSLWDWYTSYLFHPIASFQNFPVES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LSTYLGHGLLIDYFEKKRRRNNNNDEVNANNLEWLSSLWDWYTSYLFHPIASFQNFPVES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 DWDEDPDLFLERLAFPDLWLHPLIPTDYIKNLPMWRFKCLGVQSEEEMSEGSQDTENDSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DWDEDPDLFLERLAFPDLWLHPLIPTDYIKNLPMWRFKCLGVQSEEEMSEGSQDTENDSE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 SENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRSYGSYNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRSYGSYNT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 NEDMEPDWLTWPADMLHCTECVVCLENFENGCLLMGLPCGHVFHQNCIVMWLAGGRHCCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NEDMEPDWLTWPADMLHCTECVVCLENFENGCLLMGLPCGHVFHQNCIVMWLAGGRHCCP
610 620 630 640 650 660
670 680
pF1KE3 VCRWPSYKKKQPYAQHQPLSNDVPS
:::::::::::::::::::::::::
NP_005 VCRWPSYKKKQPYAQHQPLSNDVPS
670 680
>>NP_001185880 (OMIM: 602507) E3 ubiquitin-protein ligas (681 aa)
initn: 4601 init1: 4601 opt: 4601 Z-score: 3737.8 bits: 702.0 E(85289): 1.9e-201
Smith-Waterman score: 4601; 100.0% identity (100.0% similar) in 665 aa overlap (21-685:17-681)
10 20 30 40 50 60
pF1KE3 MWLKLFFLLLYFLVLFVLARFFEAIVWYETGIFATQLVDPVALSFKKLKTILECRGLGYS
::::::::::::::::::::::::::::::::::::::::
NP_001 MSRLRPRPPLIHGCGGFFEAIVWYETGIFATQLVDPVALSFKKLKTILECRGLGYS
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 GLPEKKDVRELVEKSGDLMEGELYSALKEEEASESVSSTNFSGEMHFYELVEDTKDGIWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLPEKKDVRELVEKSGDLMEGELYSALKEEEASESVSSTNFSGEMHFYELVEDTKDGIWL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE3 VQVIANDRSPLVGKIHWEKMVKKVSRFGIRTGTFNCSSDPRYCRRRGWVRSTLIMSVPQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQVIANDRSPLVGKIHWEKMVKKVSRFGIRTGTFNCSSDPRYCRRRGWVRSTLIMSVPQT
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE3 STSKGKVMLKEYSGRKIEVEHIFKWITAHAASRIKTIYNAEHLKEEWNKSDQYWLKIYLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STSKGKVMLKEYSGRKIEVEHIFKWITAHAASRIKTIYNAEHLKEEWNKSDQYWLKIYLF
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE3 ANLDQPPAFFSALSIKFTGRVEFIFVNVENWDNKSYMTDIGIYNMPSYILRTPEGIYRYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANLDQPPAFFSALSIKFTGRVEFIFVNVENWDNKSYMTDIGIYNMPSYILRTPEGIYRYG
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE3 NHTGEFISLQAMDSFLRSLQPEVNDLFVLSLVLVNLMAWMDLFITQGATIKRFVVLISTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHTGEFISLQAMDSFLRSLQPEVNDLFVLSLVLVNLMAWMDLFITQGATIKRFVVLISTL
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE3 GTYNSLLIISWLPVLGFLQLPYLDSFYEYSLKLLRYSNTTTLASWVRADWMFYSSHPALF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTYNSLLIISWLPVLGFLQLPYLDSFYEYSLKLLRYSNTTTLASWVRADWMFYSSHPALF
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE3 LSTYLGHGLLIDYFEKKRRRNNNNDEVNANNLEWLSSLWDWYTSYLFHPIASFQNFPVES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSTYLGHGLLIDYFEKKRRRNNNNDEVNANNLEWLSSLWDWYTSYLFHPIASFQNFPVES
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE3 DWDEDPDLFLERLAFPDLWLHPLIPTDYIKNLPMWRFKCLGVQSEEEMSEGSQDTENDSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DWDEDPDLFLERLAFPDLWLHPLIPTDYIKNLPMWRFKCLGVQSEEEMSEGSQDTENDSE
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE3 SENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRSYGSYNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRSYGSYNT
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE3 NEDMEPDWLTWPADMLHCTECVVCLENFENGCLLMGLPCGHVFHQNCIVMWLAGGRHCCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEDMEPDWLTWPADMLHCTECVVCLENFENGCLLMGLPCGHVFHQNCIVMWLAGGRHCCP
600 610 620 630 640 650
670 680
pF1KE3 VCRWPSYKKKQPYAQHQPLSNDVPS
:::::::::::::::::::::::::
NP_001 VCRWPSYKKKQPYAQHQPLSNDVPS
660 670 680
>>NP_001185881 (OMIM: 602507) E3 ubiquitin-protein ligas (122 aa)
initn: 789 init1: 789 opt: 789 Z-score: 661.6 bits: 130.4 E(85289): 4.1e-30
Smith-Waterman score: 789; 100.0% identity (100.0% similar) in 122 aa overlap (1-122:1-122)
10 20 30 40 50 60
pF1KE3 MWLKLFFLLLYFLVLFVLARFFEAIVWYETGIFATQLVDPVALSFKKLKTILECRGLGYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MWLKLFFLLLYFLVLFVLARFFEAIVWYETGIFATQLVDPVALSFKKLKTILECRGLGYS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GLPEKKDVRELVEKSGDLMEGELYSALKEEEASESVSSTNFSGEMHFYELVEDTKDGIWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLPEKKDVRELVEKSGDLMEGELYSALKEEEASESVSSTNFSGEMHFYELVEDTKDGIWL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 VQVIANDRSPLVGKIHWEKMVKKVSRFGIRTGTFNCSSDPRYCRRRGWVRSTLIMSVPQT
::
NP_001 VQ
>>XP_016879917 (OMIM: 610431) PREDICTED: E3 ubiquitin-pr (227 aa)
initn: 195 init1: 170 opt: 187 Z-score: 171.5 bits: 40.6 E(85289): 0.0082
Smith-Waterman score: 187; 39.6% identity (75.0% similar) in 48 aa overlap (621-668:107-154)
600 610 620 630 640 650
pF1KE3 KGRSYGSYNTNEDMEPDWLTWPADMLHCTECVVCLENFENGCLLMGLPCGHVFHQNCIVM
:..::...:.: : :::.:..:. :.
XP_016 ALNSSMFCPDLILPTCLISSTGFVGDQYDVCAICLDEYEDGDKLRVLPCAHAYHSRCVDP
80 90 100 110 120 130
660 670 680
pF1KE3 WLAGGRHCCPVCRWPSYKKKQPYAQHQPLSNDVPS
::. :. ::.:. : ..
XP_016 WLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEGDEGEPRDHPASERTPLLGSSPTLPT
140 150 160 170 180 190
>>XP_016869786 (OMIM: 612488) PREDICTED: E3 ubiquitin-pr (402 aa)
initn: 216 init1: 151 opt: 189 Z-score: 170.3 bits: 41.2 E(85289): 0.0095
Smith-Waterman score: 189; 34.6% identity (54.8% similar) in 104 aa overlap (565-663:291-391)
540 550 560 570 580 590
pF1KE3 TENDSESENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRS
: . . :.: : . :: :..
XP_016 RSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEA
270 280 290 300 310 320
600 610 620 630 640
pF1KE3 YGSYNTNEDME--PDWLTWPADMLHCTE---CVVCLENFENGCLLMGLPCGHVFHQNCIV
:. :.: :.. : . : .: ::::. .::. :: :::.: :: .:.
XP_016 KPRGLTKADIEQLPSYRFNPNN--HQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVD
330 340 350 360 370
650 660 670 680
pF1KE3 MWLAGGRHCCPVCRWPSYKKKQPYAQHQPLSNDVPS
:: ..: ::.::
XP_016 KWLKANR-TCPICRADASEVHRDSE
380 390 400
>>XP_016869785 (OMIM: 612488) PREDICTED: E3 ubiquitin-pr (402 aa)
initn: 216 init1: 151 opt: 189 Z-score: 170.3 bits: 41.2 E(85289): 0.0095
Smith-Waterman score: 189; 34.6% identity (54.8% similar) in 104 aa overlap (565-663:291-391)
540 550 560 570 580 590
pF1KE3 TENDSESENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRS
: . . :.: : . :: :..
XP_016 RSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEA
270 280 290 300 310 320
600 610 620 630 640
pF1KE3 YGSYNTNEDME--PDWLTWPADMLHCTE---CVVCLENFENGCLLMGLPCGHVFHQNCIV
:. :.: :.. : . : .: ::::. .::. :: :::.: :: .:.
XP_016 KPRGLTKADIEQLPSYRFNPNN--HQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVD
330 340 350 360 370
650 660 670 680
pF1KE3 MWLAGGRHCCPVCRWPSYKKKQPYAQHQPLSNDVPS
:: ..: ::.::
XP_016 KWLKANR-TCPICRADASEVHRDSE
380 390 400
>>XP_006716784 (OMIM: 612488) PREDICTED: E3 ubiquitin-pr (432 aa)
initn: 183 init1: 151 opt: 189 Z-score: 169.9 bits: 41.2 E(85289): 0.01
Smith-Waterman score: 189; 34.6% identity (54.8% similar) in 104 aa overlap (565-663:321-421)
540 550 560 570 580 590
pF1KE3 TENDSESENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRS
: . . :.: : . :: :..
XP_006 RSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEA
300 310 320 330 340 350
600 610 620 630 640
pF1KE3 YGSYNTNEDME--PDWLTWPADMLHCTE---CVVCLENFENGCLLMGLPCGHVFHQNCIV
:. :.: :.. : . : .: ::::. .::. :: :::.: :: .:.
XP_006 KPRGLTKADIEQLPSYRFNPNN--HQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVD
360 370 380 390 400
650 660 670 680
pF1KE3 MWLAGGRHCCPVCRWPSYKKKQPYAQHQPLSNDVPS
:: ..: ::.::
XP_006 KWLKANR-TCPICRADASEVHRDSE
410 420 430
>>NP_919313 (OMIM: 612488) E3 ubiquitin-protein ligase R (432 aa)
initn: 183 init1: 151 opt: 189 Z-score: 169.9 bits: 41.2 E(85289): 0.01
Smith-Waterman score: 189; 34.6% identity (54.8% similar) in 104 aa overlap (565-663:321-421)
540 550 560 570 580 590
pF1KE3 TENDSESENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRS
: . . :.: : . :: :..
NP_919 RSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEA
300 310 320 330 340 350
600 610 620 630 640
pF1KE3 YGSYNTNEDME--PDWLTWPADMLHCTE---CVVCLENFENGCLLMGLPCGHVFHQNCIV
:. :.: :.. : . : .: ::::. .::. :: :::.: :: .:.
NP_919 KPRGLTKADIEQLPSYRFNPNN--HQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVD
360 370 380 390 400
650 660 670 680
pF1KE3 MWLAGGRHCCPVCRWPSYKKKQPYAQHQPLSNDVPS
:: ..: ::.::
NP_919 KWLKANR-TCPICRADASEVHRDSE
410 420 430
>>XP_005251425 (OMIM: 612488) PREDICTED: E3 ubiquitin-pr (432 aa)
initn: 183 init1: 151 opt: 189 Z-score: 169.9 bits: 41.2 E(85289): 0.01
Smith-Waterman score: 189; 34.6% identity (54.8% similar) in 104 aa overlap (565-663:321-421)
540 550 560 570 580 590
pF1KE3 TENDSESENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRS
: . . :.: : . :: :..
XP_005 RSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEA
300 310 320 330 340 350
600 610 620 630 640
pF1KE3 YGSYNTNEDME--PDWLTWPADMLHCTE---CVVCLENFENGCLLMGLPCGHVFHQNCIV
:. :.: :.. : . : .: ::::. .::. :: :::.: :: .:.
XP_005 KPRGLTKADIEQLPSYRFNPNN--HQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVD
360 370 380 390 400
650 660 670 680
pF1KE3 MWLAGGRHCCPVCRWPSYKKKQPYAQHQPLSNDVPS
:: ..: ::.::
XP_005 KWLKANR-TCPICRADASEVHRDSE
410 420 430
>>XP_005251423 (OMIM: 612488) PREDICTED: E3 ubiquitin-pr (432 aa)
initn: 183 init1: 151 opt: 189 Z-score: 169.9 bits: 41.2 E(85289): 0.01
Smith-Waterman score: 189; 34.6% identity (54.8% similar) in 104 aa overlap (565-663:321-421)
540 550 560 570 580 590
pF1KE3 TENDSESENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRS
: . . :.: : . :: :..
XP_005 RSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEA
300 310 320 330 340 350
600 610 620 630 640
pF1KE3 YGSYNTNEDME--PDWLTWPADMLHCTE---CVVCLENFENGCLLMGLPCGHVFHQNCIV
:. :.: :.. : . : .: ::::. .::. :: :::.: :: .:.
XP_005 KPRGLTKADIEQLPSYRFNPNN--HQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVD
360 370 380 390 400
650 660 670 680
pF1KE3 MWLAGGRHCCPVCRWPSYKKKQPYAQHQPLSNDVPS
:: ..: ::.::
XP_005 KWLKANR-TCPICRADASEVHRDSE
410 420 430
685 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 23:32:20 2016 done: Sat Nov 5 23:32:22 2016
Total Scan time: 9.990 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]