Result of FASTA (omim) for
pFN21AE3679
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3679, 304 aa
1>>>pF1KE3679 304 - 304 aa - 304 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7105+/-0.000305; mu= 15.3125+/- 0.019
mean_var=123.1085+/-26.004, 0's: 0 Z-trim(120.3): 185 B-trim: 496 in 2/49
Lambda= 0.115593
statistics sampled from 35063 (35329) to 35063 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.774), E-opt: 0.2 (0.414), width: 16
Scan time: 7.990
The best scores are: opt bits E(85289)
NP_919442 (OMIM: 615177) E3 ubiquitin-protein liga ( 311) 720 130.7 3.7e-30
XP_005259651 (OMIM: 615177) PREDICTED: E3 ubiquiti ( 284) 654 119.6 7.1e-27
NP_057578 (OMIM: 612490) E3 ubiquitin-protein liga ( 153) 276 56.3 4.5e-08
NP_071763 (OMIM: 300420) E3 ubiquitin-protein liga ( 455) 253 53.0 1.3e-06
XP_005262349 (OMIM: 300420) PREDICTED: E3 ubiquiti ( 588) 253 53.1 1.6e-06
NP_001027568 (OMIM: 300420) E3 ubiquitin-protein l ( 588) 253 53.1 1.6e-06
XP_011529313 (OMIM: 300420) PREDICTED: E3 ubiquiti ( 643) 253 53.2 1.7e-06
NP_660095 (OMIM: 300420) E3 ubiquitin-protein liga ( 643) 253 53.2 1.7e-06
NP_078815 (OMIM: 300439) E3 ubiquitin-protein liga ( 402) 220 47.4 5.5e-05
NP_919445 (OMIM: 300439) E3 ubiquitin-protein liga ( 428) 220 47.5 5.7e-05
XP_016869786 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 402) 217 46.9 7.8e-05
XP_016869785 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 402) 217 46.9 7.8e-05
NP_919309 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 217 47.0 8.2e-05
XP_005251425 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 217 47.0 8.2e-05
XP_011516014 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 217 47.0 8.2e-05
XP_006716784 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 217 47.0 8.2e-05
XP_016869784 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 217 47.0 8.2e-05
NP_919311 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 217 47.0 8.2e-05
XP_005251423 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 217 47.0 8.2e-05
XP_011516015 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 217 47.0 8.2e-05
XP_005251424 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 217 47.0 8.2e-05
NP_919313 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 217 47.0 8.2e-05
XP_016869783 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 444) 217 47.0 8.3e-05
NP_919310 (OMIM: 612488) E3 ubiquitin-protein liga ( 465) 217 47.0 8.6e-05
NP_073618 (OMIM: 612488) E3 ubiquitin-protein liga ( 515) 217 47.0 9.2e-05
XP_016868491 (OMIM: 144700,603046) PREDICTED: E3 u ( 537) 209 45.7 0.00024
NP_009149 (OMIM: 144700,603046) E3 ubiquitin-prote ( 664) 209 45.8 0.00027
NP_898864 (OMIM: 133239,604242) E3 ubiquitin-prote ( 685) 209 45.9 0.00028
NP_898865 (OMIM: 133239,604242) E3 ubiquitin-prote ( 685) 209 45.9 0.00028
XP_011533479 (OMIM: 133239,604242) PREDICTED: E3 u ( 685) 209 45.9 0.00028
XP_005266542 (OMIM: 133239,604242) PREDICTED: E3 u ( 685) 209 45.9 0.00028
XP_005266543 (OMIM: 133239,604242) PREDICTED: E3 u ( 685) 209 45.9 0.00028
NP_005968 (OMIM: 133239,604242) E3 ubiquitin-prote ( 685) 209 45.9 0.00028
NP_001307291 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 198 43.6 0.0006
NP_001307292 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 198 43.6 0.0006
NP_001307294 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 198 43.6 0.0006
NP_001307293 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 198 43.6 0.0006
NP_001307289 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 198 43.7 0.00064
NP_056343 (OMIM: 610431) E3 ubiquitin-protein liga ( 350) 198 43.7 0.00064
NP_001307285 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 198 43.7 0.00064
NP_001307286 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 198 43.7 0.00064
NP_001307290 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 198 43.7 0.00064
NP_001307288 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 198 43.7 0.00064
XP_016879916 (OMIM: 610431) PREDICTED: E3 ubiquiti ( 350) 198 43.7 0.00064
NP_001307287 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 198 43.7 0.00064
NP_115549 (OMIM: 612062) E3 ubiquitin-protein liga ( 836) 197 44.0 0.0013
XP_016884479 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 197 44.0 0.0013
XP_011528737 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 197 44.0 0.0013
XP_011528740 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 197 44.0 0.0013
XP_011528739 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 197 44.0 0.0013
>>NP_919442 (OMIM: 615177) E3 ubiquitin-protein ligase R (311 aa)
initn: 832 init1: 605 opt: 720 Z-score: 662.4 bits: 130.7 E(85289): 3.7e-30
Smith-Waterman score: 875; 47.1% identity (69.0% similar) in 306 aa overlap (19-296:10-306)
10 20 30 40 50 60
pF1KE3 MAEASAAGADSGAAVAAHRFFCHFCKGEVSPKLPEYICPRCESGFIEEVTDDSSFLGGGG
:.::: :. :. :.::.:::::::::::::. ... .:.
NP_919 MAEASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSTENGS
10 20 30 40 50
70 80 90 100
pF1KE3 SRIDNTTTTHFAELWGHLDHTMF-------------FQD-FR-PFLSSSPLDQDNRA---
. : : :.:. .: :.: :. : . . .:.:
NP_919 APSTAPTDQSRPPLE-HVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPES
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE3 -NERGHQTHTDFWGARPPRLPLGRRYRSRGSSRPDRSPAIEGILQHIFAGFFANSAIPGS
:: : .. . ::: :: : : :...: . :..:::.:.. :... ..:: :
NP_919 RRERDHPSRHRY-GARQPRARLTTR---RATGRHEGVPTLEGIIQQLVNGIITPATIP-S
120 130 140 150 160
170 180 190 200 210 220
pF1KE3 PHPFSWSGMLHSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQ
: : :.::::: ::::: .:::::.::::.:.::::::::::::: .:::: ::.:.
NP_919 LGP--W-GVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEH
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE3 VDMGLECPVCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQ-
: ::::::::.::.. :.::::::::.::..::::::: ::.::::::::.:.... .
NP_919 VGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNP
230 240 250 260 270 280
290 300
pF1KE3 --------SQSTEASASNRFSNDSQLHDRWTF
:.:. .:.:. ::..
NP_919 PGLTGVSFSSSSSSSSSSSPSNENATSNS
290 300 310
>>XP_005259651 (OMIM: 615177) PREDICTED: E3 ubiquitin-pr (284 aa)
initn: 808 init1: 605 opt: 654 Z-score: 603.4 bits: 119.6 E(85289): 7.1e-27
Smith-Waterman score: 809; 46.0% identity (69.2% similar) in 289 aa overlap (19-296:10-279)
10 20 30 40 50 60
pF1KE3 MAEASAAGADSGAAVAAHRFFCHFCKGEVSPKLPEYICPRCESGFIEEVTDDSSFLGGGG
:.::: :. :. :.::.:::::::::::::. ... .:.
XP_005 MAEASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSTENGS
10 20 30 40 50
70 80 90 100 110
pF1KE3 SRIDNTTTTHFAELWGHLDHTMFF--QDFRPFLSSSPLDQDNRANERGHQTHTDFWGARP
. : : :.:. .: : . : . . .:.. . ...:
XP_005 APSTAPTDQSRPPLE-HVDQHLFTLPQGYGQF-AFGIFDDSFEIPTFPPGAQAD-----D
60 70 80 90 100
120 130 140 150 160 170
pF1KE3 PRLPLGRRYRSRGSSRPDRSPAIEGILQHIFAGFFANSAIPGSPHPFSWSGMLHSNPGDY
: : .:: :.. :. . :.:.. :... ..:: : : : :.::::: ::
XP_005 GRDPESRRERDH--------PSRHRIIQQLVNGIITPATIP-SLGP--W-GVLHSNPMDY
110 120 130 140 150
180 190 200 210 220 230
pF1KE3 AWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLECPVCKEDYTVE
::: .:::::.::::.:.::::::::::::: .:::: ::.:.: ::::::::.::..
XP_005 AWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALG
160 170 180 190 200 210
240 250 260 270 280
pF1KE3 EEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQ---------SQSTEASAS
:.::::::::.::..::::::: ::.::::::::.:.... . :.:. .:.:
XP_005 ERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSS
220 230 240 250 260 270
290 300
pF1KE3 NRFSNDSQLHDRWTF
. ::..
XP_005 SSPSNENATSNS
280
>>NP_057578 (OMIM: 612490) E3 ubiquitin-protein ligase R (153 aa)
initn: 295 init1: 217 opt: 276 Z-score: 265.9 bits: 56.3 E(85289): 4.5e-08
Smith-Waterman score: 276; 37.8% identity (68.4% similar) in 98 aa overlap (201-294:51-146)
180 190 200 210 220 230
pF1KE3 LHSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLECPV
:::: : . .:: ... :.. :.:::
NP_057 TNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTVVENLPRTVIRGSQAE--LKCPV
30 40 50 60 70
240 250 260 270 280
pF1KE3 CKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDST----RQSQSTEA
: .. :: . ..::.:.::::::.::: ..::.:: : .:.: :.... .
NP_057 CLLEFEEEETAIEMPCHHLFHSSCILPWLSKTNSCPLCRYELPTDDDTYEEHRRDKARKQ
80 90 100 110 120 130
290 300
pF1KE3 SASNRFSNDSQLHDRWTF
. ..:. :
NP_057 QQQHRLENLHGAMYT
140 150
>>NP_071763 (OMIM: 300420) E3 ubiquitin-protein ligase P (455 aa)
initn: 190 init1: 190 opt: 253 Z-score: 239.6 bits: 53.0 E(85289): 1.3e-06
Smith-Waterman score: 253; 45.7% identity (71.4% similar) in 70 aa overlap (202-269:379-448)
180 190 200 210 220
pF1KE3 HSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLE--CP
:::.::.: .:: . ::... .: : ::
NP_071 YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCP
350 360 370 380 390 400
230 240 250 260 270 280
pF1KE3 VCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQSQSTEASAS
.: .:. : . .:::.:.::. :. ::. ::::::
NP_071 ICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL
410 420 430 440 450
290 300
pF1KE3 NRFSNDSQLHDRWTF
>>XP_005262349 (OMIM: 300420) PREDICTED: E3 ubiquitin-pr (588 aa)
initn: 225 init1: 190 opt: 253 Z-score: 238.3 bits: 53.1 E(85289): 1.6e-06
Smith-Waterman score: 253; 45.7% identity (71.4% similar) in 70 aa overlap (202-269:512-581)
180 190 200 210 220
pF1KE3 HSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLE--CP
:::.::.: .:: . ::... .: : ::
XP_005 YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCP
490 500 510 520 530 540
230 240 250 260 270 280
pF1KE3 VCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQSQSTEASAS
.: .:. : . .:::.:.::. :. ::. ::::::
XP_005 ICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL
550 560 570 580
290 300
pF1KE3 NRFSNDSQLHDRWTF
>>NP_001027568 (OMIM: 300420) E3 ubiquitin-protein ligas (588 aa)
initn: 225 init1: 190 opt: 253 Z-score: 238.3 bits: 53.1 E(85289): 1.6e-06
Smith-Waterman score: 253; 45.7% identity (71.4% similar) in 70 aa overlap (202-269:512-581)
180 190 200 210 220
pF1KE3 HSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLE--CP
:::.::.: .:: . ::... .: : ::
NP_001 YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCP
490 500 510 520 530 540
230 240 250 260 270 280
pF1KE3 VCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQSQSTEASAS
.: .:. : . .:::.:.::. :. ::. ::::::
NP_001 ICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL
550 560 570 580
290 300
pF1KE3 NRFSNDSQLHDRWTF
>>XP_011529313 (OMIM: 300420) PREDICTED: E3 ubiquitin-pr (643 aa)
initn: 225 init1: 190 opt: 253 Z-score: 237.8 bits: 53.2 E(85289): 1.7e-06
Smith-Waterman score: 253; 45.7% identity (71.4% similar) in 70 aa overlap (202-269:567-636)
180 190 200 210 220
pF1KE3 HSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLE--CP
:::.::.: .:: . ::... .: : ::
XP_011 YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCP
540 550 560 570 580 590
230 240 250 260 270 280
pF1KE3 VCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQSQSTEASAS
.: .:. : . .:::.:.::. :. ::. ::::::
XP_011 ICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL
600 610 620 630 640
290 300
pF1KE3 NRFSNDSQLHDRWTF
>>NP_660095 (OMIM: 300420) E3 ubiquitin-protein ligase P (643 aa)
initn: 225 init1: 190 opt: 253 Z-score: 237.8 bits: 53.2 E(85289): 1.7e-06
Smith-Waterman score: 253; 45.7% identity (71.4% similar) in 70 aa overlap (202-269:567-636)
180 190 200 210 220
pF1KE3 HSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLE--CP
:::.::.: .:: . ::... .: : ::
NP_660 YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCP
540 550 560 570 580 590
230 240 250 260 270 280
pF1KE3 VCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQSQSTEASAS
.: .:. : . .:::.:.::. :. ::. ::::::
NP_660 ICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL
600 610 620 630 640
290 300
pF1KE3 NRFSNDSQLHDRWTF
>>NP_078815 (OMIM: 300439) E3 ubiquitin-protein ligase R (402 aa)
initn: 173 init1: 173 opt: 220 Z-score: 210.5 bits: 47.4 E(85289): 5.5e-05
Smith-Waterman score: 220; 38.7% identity (62.3% similar) in 106 aa overlap (204-300:223-328)
180 190 200 210 220
pF1KE3 NPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEK-ITSLPTVTVTQEQVDMGLE---CP
:: .: : : :. : . ..: . :
NP_078 TAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCA
200 210 220 230 240 250
230 240 250 260 270 280
pF1KE3 VCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCR----KSLNGE-DSTRQSQST
:: : : .. :: : :::.::..:. ::: : :::.:. :.:. : : : :
NP_078 VCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSL
260 270 280 290 300 310
290 300
pF1KE3 EASASNRFSNDSQLHDRWTF
.. .::..::... :.
NP_078 QVPVSNEISNSASSHEEDNRSETASSGYASVQGTDEPPLEEHVQSTNESLQLVNHEANSV
320 330 340 350 360 370
>>NP_919445 (OMIM: 300439) E3 ubiquitin-protein ligase R (428 aa)
initn: 197 init1: 173 opt: 220 Z-score: 210.2 bits: 47.5 E(85289): 5.7e-05
Smith-Waterman score: 220; 38.7% identity (62.3% similar) in 106 aa overlap (204-300:249-354)
180 190 200 210 220
pF1KE3 NPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEK-ITSLPTVTVTQEQVDMGLE---CP
:: .: : : :. : . ..: . :
NP_919 TAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCA
220 230 240 250 260 270
230 240 250 260 270 280
pF1KE3 VCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCR----KSLNGE-DSTRQSQST
:: : : .. :: : :::.::..:. ::: : :::.:. :.:. : : : :
NP_919 VCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSL
280 290 300 310 320 330
290 300
pF1KE3 EASASNRFSNDSQLHDRWTF
.. .::..::... :.
NP_919 QVPVSNEISNSASSHEEDNRSETASSGYASVQGTDEPPLEEHVQSTNESLQLVNHEANSV
340 350 360 370 380 390
304 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 18:57:09 2016 done: Sun Nov 6 18:57:11 2016
Total Scan time: 7.990 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]